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PRODID:Faculty of Science and Engineering - Research
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SUMMARY:Jaime Agudo-Canalejo (UCL)
DESCRIPTION;ENCODING=QUOTED-PRINTABLE: Emergent phenomena in protein complexes out of equilibrium: from topologically-protected states to computation=0D=0A=
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Protein complexes, often made up of a few identical subunits, are very common in biology. These subunits can additionally undergo post-translational modifications, such as phosphorylation and dephosphorylation, resulting in a high dimensional state space for the protein complex. Importantly, such modifications are catalysed by enzymes that are driven out of equilibrium by the consumption of a fuel such as ATP. I will discuss, from a theoretical perspective, how very simple enzyme-catalysed operations at the single subunit level can result in emergent behaviour at the level of the entire protein complex. First, I will discuss how topologically-protected edge currents emerge and become enhanced in arbitrarily high-dimensional stochastic systems representing the state of the complex, extending previous results for two-dimensional stochastic systems [1]. Second, I will discuss how enzymes that act on a subunit in a context-dependent manner provide a molecular implementation of stochastic cellular automata, that can be exploited to engineer molecular-scale computing devices, such as an error-tolerant memory or a finite-state machine [2].=0D=0A=
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[1] E. Tang*, J. Agudo-Canalejo*, and R. Golestanian, Phys. Rev. X 11, 031015 (2021)=0D=0A=
[2] J. Kocka, K. Husain, and J. Agudo-Canalejo, arXiv:2508.15603 (2025)
LOCATION:MB-503
DTSTART:20260924T130000
DTEND:20260924T140000
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