Events
The Goldilocks Histone: How Genomic Stability Requires Centromeres to Be Epigenetically “Just Right”
Centre for Molecular Cell Biology
Date: 29 June 2026 Time: 11:00 - 12:00 
Location: Fogg Lecture Theatre, Mile End Campus
Dr Yael Nechemia-Arbely
Assistant Professor of Pharmacology and Chemical Biology, University of Pittsburg, PA, USA
Summary
Centromere protein A (CENP-A) is a heritable epigenetic mark that determines centromere identity and is essential for the accurate segregation of chromosomes during cell division. Here I will discuss the role of DNA methylation in maintaining centromere and neocentromere position, size, and function, and how CENP-A overexpression drives genome instability and oncogenic epigenetic reprogramming during tumor progression.
More information about Dr Nechemia-Arbely and her lab: https://www.nechemia-arbelylab.org/
Updated by: Christoph Engl