Dr Ian Sealy

Digenic inheritance involving a muscle-specific protein kinase and the giant titin protein causes a skeletal muscle myopathy
Töpf A, Cox D, Zaharieva IT, Di Leo V, Sarparanta J, Jonson PH, Sealy IM, Smolnikov A, White RJ, Vihola A, Savarese M, Merteroglu M, Wali N, Laricchia KM, Venturini C, Vroling B, Stenton SL, Cummings BB, Harris E, Marini-Bettolo C, et al.
Nature Genetics, Springer Nature vol. 56 (3), 395-407.  
01-03-2024

Transcriptional profiling of zebrafish identifies host factors controlling susceptibility to Shigella flexneri
Torraca V, White RJ, Sealy IM, Mazon-Moya M, Duggan G, Willis A, Busch-Nentwich EM and Mostowy S
Disease Models & Mechanisms, The Company of Biologists vol. 17 (1) 
01-01-2024

VP.81 In vivo modulation of novel genetic modifiers for LAMA2-RD
Pini V, Weisburd B, Merteroglu M, Sealy I, White R, Busch-Nentwich E and Muntoni F
Neuromuscular Disorders, Elsevier vol. 32, s124-s125.  
01-10-2022

Loss of slc39a14 causes simultaneous manganese hypersensitivity and deficiency in zebrafish
Tuschl K, White RJ, Trivedi C, Valdivia LE, Niklaus S, Bianco IH, Dadswell C, González-Méndez R, Sealy IM, Neuhauss SCF, Houart C, Rihel J, Wilson SW and Busch-Nentwich EM
Disease Models and Mechanisms, The Company of Biologists vol. 15 (6) 
15-06-2022

Translational relevance of forward genetic screens in animal models for the study of psychiatric disease
Sheardown E, Mech AM, Petrazzini MEM, Leggieri A, Gidziela A, Hosseinian S, Sealy IM, Torres-Perez JV, Busch-Nentwich EM, Malanchini M and Brennan CH
Neuroscience and Biobehavioral Reviews, Elsevier vol. 135 
04-02-2022

Behavioral and Gene Regulatory Responses to Developmental Drug Exposures in Zebrafish
Mech AM, Merteroglu M, Sealy IM, Teh M-T, White RJ, Havelange W, Brennan CH and Busch-Nentwich EM
Frontiers in Psychiatry, Frontiers vol. 12 
10-01-2022

Common and distinct transcriptional signatures of mammalian embryonic lethality
Collins JE, White RJ, Staudt N, Sealy IM, Packham I, Wali N, Tudor C, Mazzeo C, Green A, Siragher E, Ryder E, White JK, Papatheodoru I, Tang A, Füllgrabe A, Billis K, Geyer SH, Weninger WJ, Galli A, Hemberger M, et al.
Nature Communications, Springer Nature vol. 10 (1) 
26-06-2019

The gene regulatory basis of genetic compensation during neural crest induction
Dooley CM, Wali N, Sealy IM, White RJ, Stemple DL, Collins JE and Busch-Nentwich EM
Plos Genetics, Public Library of Science (Plos) vol. 15 (6) 
14-06-2019

Compensatory growth renders Tcf7l1a dispensable for eye formation despite its requirement in eye field specification
Young RM, Hawkins TA, Cavodeassi F, Stickney HL, Schwarz Q, Lawrence LM, Wierzbicki C, Cheng BY, Luo J, Ambrosio EM, Klosner A, Sealy IM, Rowell J, Trivedi CA, Bianco IH, Allende ML, Busch-Nentwich EM, Gestri G and Wilson SW
Elife, Elife vol. 8 
19-02-2019

The age of heterozygous telomerase mutant parents influences the adult phenotype of their offspring irrespective of genotype in zebrafish
Scahill CM, Digby Z, Sealy IM, White RJ, Wali N, Collins JE, Stemple DL and Busch-Nentwich EM
Wellcome Open Research, F1000research vol. 2 
22-02-2018

CAPZB: A Potential Novel Key Player in Cardiac Development and Congenital Heart Defects
Radloff A, Breckpot J, Hoff K, Kramer HH, Panáková D, Mercks A, Devriendt K, Gewillig M, Sealy I, Collins J, Busch-Nentwich E, Kahlert AK and Hitz MP
50th Annual Meeting of the German Society for Pediatric Cardiology (DGPK). vol. 66, s111-s138.  
01-01-2018

A high-resolution mRNA expression time course of embryonic development in zebrafish
White RJ, Collins JE, Sealy IM, Wali N, Dooley CM, Digby Z, Stemple DL, Murphy DN, Billis K, Hourlier T, Füllgrabe A, Davis MP, Enright AJ and Busch-Nentwich EM
Elife, Elife vol. 6 
16-11-2017

Loss of the chromatin modifier Kdm2aa causes BrafV600E-independent spontaneous melanoma in zebrafish
Scahill CM, Digby Z, Sealy IM, Wojciechowska S, White RJ, Collins JE, Stemple DL, Bartke T, Mathers ME, Patton EE and Busch-Nentwich EM
Plos Genetics, Public Library of Science (Plos) vol. 13 (8) 
14-08-2017

gEVAL — a web-based browser for evaluating genome assemblies
Chow W, Brugger K, Caccamo M, Sealy I, Torrance J and Howe K
Bioinformatics, Oxford University Press (OUP) vol. 32 (16), 2508-2510.  
07-04-2016

Genome-wide mapping of Hif-1α binding sites in zebrafish
Greenald D, Jeyakani J, Pelster B, Sealy I, Mathavan S and van Eeden FJ
Bmc Genomics, Springer Nature vol. 16 (1) 
11-11-2015

G.P.239 Zebrafish models of inherited skeletal muscle disorders
Patrick J, Wali N, Sealy I, Collins J, Busch-Nentwich E and Stemple D
Neuromuscular Disorders, Elsevier vol. 25 
01-10-2015

High-throughput and quantitative genome-wide messenger RNA sequencing for molecular phenotyping
Collins JE, Wali N, Sealy IM, Morris JA, White RJ, Leonard SR, Jackson DK, Jones MC, Smerdon NC, Zamora J, Dooley CM, Carruthers SN, Barrett JC, Stemple DL and Busch-Nentwich EM
Bmc Genomics, Springer Nature vol. 16 (1) 
05-08-2015

Identification of a plant isoflavonoid that causes biliary atresia
Lorent K, Gong W, Koo KA, Waisbourd-Zinman O, Karjoo S, Zhao X, Sealy I, Kettleborough RN, Stemple DL, Windsor PA, Whittaker SJ, Porter JR, Wells RG and Pack M
Science Translational Medicine, American Association For The Advancement of Science (Aaas) vol. 7 (286) 
06-05-2015

Correction: Corrigendum: The zebrafish reference genome sequence and its relationship to the human genome
Howe K, Clark MD, Torroja CF, Torrance J, Berthelot C, Muffato M, Collins JE, Humphray S, McLaren K, Matthews L, McLaren S, Sealy I, Caccamo M, Churcher C, Scott C, Barrett JC, Koch R, Rauch G-J, White S, Chow W, et al.
Nature, Springer Nature vol. 505 (7482), 248-248.  
11-12-2013

Identification of the zebrafish maternal and paternal transcriptomes
Harvey SA, Sealy I, Kettleborough R, Fenyes F, White R, Stemple D and Smith JC
Development, The Company of Biologists vol. 140 (13), 2703-2710.  
29-05-2013

The zebrafish reference genome sequence and its relationship to the human genome
Howe K, Clark MD, Torroja CF, Torrance J, Berthelot C, Muffato M, Collins JE, Humphray S, McLaren K, Matthews L, McLaren S, Sealy I, Caccamo M, Churcher C, Scott C, Barrett JC, Koch R, Rauch G-J, White S, Chow W, et al.
Nature, Springer Nature vol. 496 (7446), 498-503.  
01-04-2013

A systematic genome-wide analysis of zebrafish protein-coding gene function
Kettleborough RNW, Busch-Nentwich EM, Harvey SA, Dooley CM, de Bruijn E, van Eeden F, Sealy I, White RJ, Herd C, Nijman IJ, Fényes F, Mehroke S, Scahill C, Gibbons R, Wali N, Carruthers S, Hall A, Yen J, Cuppen E and Stemple DL
Nature, Springer Nature vol. 496 (7446), 494-497.  
01-04-2013

Ensembl 2008
Flicek P, Aken BL, Beal K, Ballester B, Caccamo M, Chen Y, Clarke L, Coates G, Cunningham F, Cutts T, Down T, Dyer SC, Eyre T, Fitzgerald S, Fernandez-Banet J, Gräf S, Haider S, Hammond M, Holland R, Howe KL, et al.
Nucleic Acids Research, Oxford University Press (OUP) vol. 36 (suppl_1), d707-d714.  
23-12-2007

Genomic regulatory blocks encompass multiple neighboring genes and maintain conserved synteny in vertebrates
Kikuta H, Laplante M, Navratilova P, Komisarczuk AZ, Engström PG, Fredman D, Akalin A, Caccamo M, Sealy I, Howe K, Ghislain J, Pezeron G, Mourrain P, Ellingsen S, Oates AC, Thisse C, Thisse B, Foucher I, Adolf B, Geling A, et al.
Genome Research, Cold Spring Harbor Laboratory vol. 17 (5), 545-555.  
26-03-2007

Ensembl 2007
Hubbard TJP, Aken BL, Beal K, Ballester B, Caccamo M, Chen Y, Clarke L, Coates G, Cunningham F, Cutts T, Down T, Dyer SC, Fitzgerald S, Fernandez-Banet J, Graf S, Haider S, Hammond M, Herrero J, Holland R, Howe K, et al.
Nucleic Acids Research, Oxford University Press (OUP) vol. 35 (suppl_1), d610-d617.  
05-12-2006

Ensembl 2006
Birney E, Andrews D, Caccamo M, Chen Y, Clarke L, Coates G, Cox T, Cunningham F, Curwen V, Cutts T, Down T, Durbin R, Fernandez-Suarez XM, Flicek P, Gräf S, Hammond M, Herrero J, Howe K, Iyer V, Jekosch K, et al.
Nucleic Acids Research, Oxford University Press (OUP) vol. 34 (suppl_1), d556-d561.  
01-01-2006