Prof Rob Krams
Professor of Molecular Bioengineering
Scientific Director of the CVDHub
School of Engineering and Materials Science
Queen Mary University of London
Queen Mary University of London
Research
Cardiovascular Disease, Atherosclerosis, Biomaterials, Epigenetic, Mechanobiology, Fluid Structure Interaction
Interests
Professor Krams' research is focussed on the molecular mechanism underlying biomechanical stimuli applied to blood vessels and endothelial cells. To that end he uses a combination of engineering techniques (imaging, systems biology and synthetic biology) and molecular techniques (high throughput, qPCR, CRISPR/ life cell imaging) to study the interaction of gene expression and shear stress and wall stress on cells in culture and in whole animals.His research has led to the development of new devices for patient and experimental studies and to the development of new analysis techniques for images obtained by microscopes. The work that hase started in London consists of imaging of animals, FSI modelling and application of system biology and mult-scale modelling to vascular biology. We have developed a pipeline consisting of accurate identification of the mechanical environment of endothelial cells in vivo, their isolation by laser capture, RNA isolation and coding anf non-coding gene network synthesis. As bioinformatics tools are still in their infancy, we have a high throughput CRISPr validation platform for evaluation of the interactome. Finally, methods to replace diseased modules by synthetic biology are being explored as well. We specially focus on small and long noncoding RNA in our group.
Publications
Publications of specific relevance to the Centre for Bioengineering2024
Krama T, Munkevics M, Krams R, Grigorjeva T, Trakimas G, Jõers P, Popovs S, Zants K, Elferts D, Rantala MJ, Sledevskis E, Contreras-Garduño J, de Bivort BL and Krams IA (2024). Corrigendum: Development under predation risk increases serotonin-signaling, variability of turning behavior and survival in adult fruit flies Drosophila melanogaster. Frontiers in Behavioral Neuroscience, Frontiers vol. 18 22-03-2024
Somere K, Munkevics M, Krams R, Rača G, Luoto S and Krams I (2024). The effect of yin yoga intervention on state and trait anxiety during the COVID-19 pandemic. Frontiers in Psychiatry, Frontiers vol. 15 14-03-2024
Bourantas C, Torii R, Karabasov S and Krams R (2024). Editorial: Computational modelling of cardiovascular hemodynamics and machine learning. Frontiers in Cardiovascular Medicine, Frontiers vol. 11 22-02-2024
Savvopoulos F, Keeling MC, Carassiti D, Fogell NA, Patel MB, Naser J, Gavara N, de Silva R and Krams R (2024). Assessment of the nano-mechanical properties of healthy and atherosclerotic coronary arteries by atomic force microscopy. Journal of The Royal Society Interface, The Royal Society vol. 21 (211) 01-02-2024
Popovs S, Munkevics M, Krama T, Krams R, Sledevskis E, Trakimas G, Zants K, Grigorjeva T, Mizers V, Kolbjonoks V, Jõers P and Krams I (2024). Explaining the survival of the sickest: altered walking patterns are linked with improved adult survival in Drosophila melanogaster grown with predators during larval development. Behaviour, Brill Academic Publishers vol. 161 (2), 133-148. 09-01-2024
2023
Bajaj R, Huang X, Alves-Kotzev N, Weyers J, Levine M, Garg M, Maung S, Bransby K, Torii R, Krams R, Garcia-Garcia HM, Raber L, Mathur A, Baumbach A, Zhang Q, Courtney B and Bourantas C (2023). TCT-613 Comparison of Histology-Trained Deep Learning Approach With Human Expert Analysts for Automated Plaque Component Classification in Hybrid Intravascular Ultrasound-Optical Coherence Tomography Images. Journal of the American College of Cardiology, Elsevier vol. 82 (17), b246-b247. 01-10-2023
Morgan B, Murali AR, Preston G, Sima YA, Chamorro LM, Bourantas C, Torii R, Mathur A, Baumbach A, Jacob M, Karabasov S and Krams R (2023). A physics-based machine learning technique
rapidly reconstructs the wall-shear stress and
pressure fields in coronary arteries. Frontiers in Cardiovascular Medicine, Frontiers Media 29-09-2023
Fogell NAT, Patel M, Yang P, Ruis RM, Garcia DB, Naser J, Savvopoulos F, Davies Taylor C, Post AL, Pedrigi RM, de Silva R and Krams R (2023). Considering the Influence of Coronary Motion on Artery-Specific Biomechanics Using Fluid–Structure Interaction Simulation. Annals of Biomedical Engineering, Springer vol. 51 (9), 1950-1964. 12-07-2023
Krams R, Herault S, Jaitly A, Bala R, Calistus A and Towhidi L (2023). BS15 Ultra-highly flexible, accurate, high throughput platform for knock-in studies. Basic Science. 01-06-2023
Krams R and Towhidi L (2023). BS13 Ultra-highly flexible, accurate, high throughput platform for personalised drug screening studies. Basic Science. 01-06-2023
Krams R, Preston G, Chamorro L, Morgan B, Sima Y, Murali A, Bourantas C, Torii R, Mathur A, Baumbach A and Karabasov S (2023). BS12 A novel physics-based artificial intelligence technique rapidly reconstructs the 3D velocity, shear stress and pressure fields in coronary arteries. Basic Science. 01-06-2023
Krams R, Chamorro L, Komo Z, Bashir A, Torii R, Bourantas C, Zhang Q, Mathur A, Baumbach A, Pedrigi R and de Silva R (2023). BS14 A fully automated vulnerable plaque classifier for oct using co-registered histological images and transfer learning learning. Basic Science. 01-06-2023
Çap M, Torii R, Onuma Y, Krams R, Bennett MR, Stone PH, Serruys PW and Bourantas CV (2023). Editorial: Computational modeling for assessing coronary artery pathophysiology. Frontiers in Cardiovascular Medicine, Frontiers Media vol. 10 17-01-2023
2022
Souilhol C, Ayllon BT, Li X, Diagbouga MR, Zhou Z, Canham L, Roddie H, Pirri D, Chambers EV, Dunning MJ, Ariaans M, Li J, Fang Y, Jørgensen HF, Simons M, Krams R, Waltenberger J, Fragiadaki M, Ridger V, De Val S, et al. (2022). JAG1-NOTCH4 mechanosensing drives atherosclerosis. Science Advances, American Association for the Advancement of Science vol. 8 (35) 02-09-2022
Bajaj R, Huang X, Alves N, Weyers J, Levine M, Garg M, Maung S, Bransby K, Torii R, Krams R, Garcia-Garcia H, Mathur A, Baumbach A, Zhang Q, Courtney B and Bourantas C (2022). TCT-254 Histology-Trained Deep Learning Methodology for Automated Coronary Plaque Component Classification in Combined Intravascular Ultrasound-Optical Coherence Tomography Images. Journal of the American College of Cardiology, Elsevier vol. 80 (12) 01-09-2022
Bajaj R, Huang X, Alves N, Weyers J, Levine M, Garg M, Maung S, Bransby K, Torii R, Krams R, Garcia-Garcia H, Mathur A, Baumbach A, Zhang Q, Courtney B and Bourantas C (2022). Histology- Trained Deep Learning Methodology for Automated Coronary Plaque Component Classification in Combined Intravascular Ultrasound-Optical Coherence Tomography Images. 01-01-2022
2021
Herault S, Naser J, Carassiti D, Chooi KY, Nikolopoulou R, Font ML, Patel M, Pedrigi R and Krams R (2021). Mechanosensitive pathways are regulated by mechanosensitive miRNA clusters in endothelial cells. Biophysical Reviews, Springer (part of Springer Nature) vol. 13 (5), 787-796. 23-10-2021
Naser J, Fogell N, Patel M, Yang P, Krams R, Wentzel JJ, Aben JP and De Silva R (2021). Moving shear stress towards the clinic: preclinical comparison of optical coherence tomography-based versus angiography-based time-averaged wall shear stress estimations. European Heart Journal vol. 42 (Supplement_1) 12-10-2021
(2021). Correction: BS18 Profiling endothelial gene expression in coronary atherosclerotic plaques in a human-like D374Y-PCSK9 hyperlipidaemic porcine model. Heart, BMJ vol. 107 (19), e10-e10. 14-09-2021
Patel M, Savvopoulos F, Berggren CC, Aslanidou L, Timmins LH, de Silva R, Pedrigi RM and Krams R (2021). Considerations for analysis of endothelial shear stress and strain in FSI models of atherosclerosis. Journal of Biomechanics, Elsevier vol. 128 28-08-2021
Naser J, Mein CA, Wozniak E, Carassiti D, Mahomed AS, Krams R and de Silva R (2021). BS18 Profiling endothelial gene expression in coronary atherosclerotic plaques in a human-like D374Y-PCSK9 hyperlipidaemic porcine model. Heart. 04-06-2021
2020
Post AL, Cernohorsky P, Pedrigi RM, Streekstra GJ, d’Hooghe JNS, Annema JT, Strackee SD, Krams R, van Leeuwen TG, de Bruin DM and Faber DJ (2020). 3D co-registration algorithm for catheter-based optical coherence tomography. Optics Continuum, Optica Publishing Group vol. 3 (10) 17-09-2020
Bourantas CV, Zanchin T, Torii R, Serruys PW, Karagiannis A, Ramasamy A, Safi H, Coskun AU, Koning G, Onuma Y, Zanchin C, Krams R, Mathur A, Baumbach A, Mintz G, Windecker S, Lansky A, Maehara A, Stone PH, Raber L, et al. (2020). Shear Stress Estimated by Quantitative Coronary Angiography Predicts Plaques Prone to Progress and Cause Events. JACC Cardiovascular Imaging, Elsevier vol. 13 (10), 2206-2219. 13-05-2020
Evans RJ, Lavin B, Phinikaridou A, Chooi KY, Mohri Z, Wong E, Boyle JJ, Krams R, Botnar R and Long NJ (2020). Targeted Molecular Iron Oxide Contrast Agents for Imaging Atherosclerotic Plaque. Nanotheranostics, Ivyspring International Publisher vol. 4 (4), 184-194. 01-01-2020
2019
Gijsen F, Katagiri Y, Barlis P, Bourantas C, Collet C, Coskun U, Daemen J, Dijkstra J, Edelman E, Evans P, van der Heiden K, Hose R, Koo B-K, Krams R, Marsden A, Migliavacca F, Onuma Y, Ooi A, Poon E, Samady H, et al. (2019). Expert recommendations on the assessment of wall shear stress in human coronary arteries: existing methodologies, technical considerations, and clinical applications. European Heart Journal, Oxford University Press (OUP) 30-09-2019
Baumbach A (2019). Reliable in Vivo Intravascular Imaging Plaque Characterisation: A Challenge Unmet. American Heart Journal, Elsevier 23-07-2019
Mohri Z, Del Rio Hernandez A and Krams R (2019). The emerging role of YAP/TAZ in mechanotransduction. J Thorac Dis vol. 9 (5), E507-E509. 01-05-2019
Baeriswyl DC, Prionisti I, Peach T, Tsolkas G, Chooi KY, Vardakis J, Morel S, Diagbouga MR, Bijlenga P, Cuhlmann S, Evans P, Kwak BR, Ventikos Y and Krams R (2019). Disturbed flow induces a sustained, stochastic NF-κB activation which may support intracranial aneurysm growth in vivo. Sci Rep vol. 9 (1), 4738-4738. 18-03-2019
Poulsen CB, Pedrigi RM, Pareek N, Kilic ID, Holm NR, Bentzon JF, Bøtker HE, Falk E, Krams R and de Silva R (2019). Plaque burden influences accurate classification of fibrous cap atheroma by in vivo optical coherence tomography in a porcine model of advanced coronary atherosclerosis. EuroIntervention vol. 14 (10), 1129-1135. 20-02-2019
2018
Evans RJ, Hernández-Gil J, Mohri Z, Chooi KY, Lavin-Plaza B, Phinikaridou A, Pease JE, Krams R, Botnar R and Long NJ (2018). P11 DEVELOPING NEW TARGETED MOLECULAR CONTRAST AGENTS FOR IMAGING INFLAMMATION OF VULNERABLE PLAQUES. 01-09-2018
Yang P, Silva R, Pedrigi R, Patel M, Chooi Y, Ahmed R, Naser J and Krams R (2018). P34 FLUID-STRUCTURE INTERACTION MODELLING FOR ANALYSING ADVANCED CORONARY ATHEROSCLEROTIC PLAQUE FORMATION IN TRANSGENIC HYPERLIPIDAEMIC MINIPIGS. 01-09-2018
Abuammah A, Maimari N, Towhidi L, Frueh J, Chooi KY, Warboys C and Krams R (2018). New developments in mechanotransduction: Cross talk of the Wnt, TGF-β and Notch signalling pathways in reaction to shear stress. Current Opinion in Biomedical Engineering vol. 5, 96-104. 01-03-2018
2017
Seneviratne AN, Edsfeldt A, Cole JE, Kassiteridi C, Swart M, Park I, Green P, Khoyratty T, Saliba D, Goddard ME, Sansom SN, Goncalves I, Krams R, Udalova IA and Monaco C (2017). Interferon Regulatory Factor 5 Controls Necrotic Core Formation in Atherosclerotic Lesions by Impairing Efferocytosis. Circulation, American Heart Association, Inc vol. 136 (12), 1140-1154. 11-07-2017
Denis J-F, Scheckenbach KEL, Pfenniger A, Meens MJ, Krams R, Miquerol L, Taffet S, Chanson M, Delmar M and Kwak BR (2017). Connexin40 controls endothelial activation by dampening NFκB activation. Oncotarget, Impact Journals vol. 8 (31), 50972-50986. 22-03-2017
Poulsen CB, Pedrigi R, Holm N, Pareek N, Kilic I, Post AL, Di Mario C, Bentzon J, Botker H, Falk E, Krams R and de Silva R (2017). COMPARISON OF IN VIVO OPTICAL COHERENCE TOMOGRAPHY DERIVED PLAQUE PHENOTYPE AND BURDEN WITH HISTOLOGY IN A PORCINE MODEL OF ADVANCED CORONARY ATHEROSCLEROSIS. 01-03-2017
2016
Serbanovic-Canic J, de Luca A, Warboys C, Ferreira PF, Luong LA, Hsiao S, Gauci I, Mahmoud M, Feng S, Souilhol C, Bowden N, Ashton J-P, Walczak H, Firmin D, Krams R, Mason JC, Haskard DO, Sherwin S, Ridger V, Chico TJA, et al. (2016). Zebrafish Model for Functional Screening of Flow-Responsive Genes. Arterioscler Thromb Vasc Biol, Wolters Kluwer Health, Inc vol. 37 (1), 130-143. 10-11-2016
Pedrigi RM, Papadimitriou KI, Kondiboyina A, Sidhu S, Chau J, Patel MB, Baeriswyl DC, Drakakis EM and Krams R (2016). Disturbed Cyclical Stretch of Endothelial Cells Promotes Nuclear Expression of the Pro-Atherogenic Transcription Factor NF-κB. Ann Biomed Eng, Springer Nature vol. 45 (4), 898-909. 27-10-2016
Pedrigi RM, Mehta VV, Bovens SM, Mohri Z, Poulsen CB, Gsell W, Tremoleda JL, Towhidi L, de Silva R, Petretto E and Krams R (2016). Influence of shear stress magnitude and direction on atherosclerotic plaque composition. Royal Society Open Science, The Royal Society vol. 3 (10) 01-10-2016
Kis Z, Rodin T, Zafar A, Lai Z, Freke G, Fleck O, Del Rio Hernandez A, Towhidi L, Pedrigi RM, Homma T and Krams R (2016). Development of a synthetic gene network to modulate gene expression by mechanical forces. Sci Rep, Springer Nature vol. 6, 29643-29643. 12-07-2016
Denis J-F, Scheckenbach L, Pfenniger A, Meens M, Krams R, Miquerol L, Taffet S, Chanson M, Delmar M and Kwak B (2016). 0109 : Connexin40 controls endothelial activation by dampening NF B activation. Archives of Cardiovascular Diseases Supplements vol. 8 (3), 203-203. 01-04-2016
Antonacci G, Pedrigi R, Krams R and Török P (2016). Quantification of plaque stiffness by Brillouin microscopy (Conference Presentation). Optical Elastography and Tissue Biomechanics III. 09-03-2016
Towhidi L, Khodadadi D, Maimari N, Pedrigi RM, Ip H, Kis Z, Kwak BR, Petrova TW, Delorenzi M and Krams R (2016). Comparison between direct and reverse electroporation of cells in situ: a simulation study. Physiological Reports, Wiley vol. 4 (6) 01-03-2016
Seneviratne AN, Cole JE, Goddard ME, Park I, Mohri Z, Sansom S, Udalova I, Krams R and Monaco C (2016). Corrigendum to “Low shear stress induces M1 macrophage polarization in murine thin-cap atherosclerotic plaques” [J Mol Cell Cardiol] 89B (2015) 168–172. Journal of Molecular and Cellular Cardiology, Elsevier vol. 91 01-02-2016
Maimari N, Pedrigi RM, Russo A, Broda K and Krams R (2016). Integration of flow studies for robust selection of mechanoresponsive genes. Thrombosis and Haemostasis, Thieme vol. 115 (03), 474-483. 01-01-2016
Krams RM, Pedrigi RM and Kis Z (2016). A novel assay for regulating transcription factors by flow. 01-01-2016
2015
Antonacci G, Pedrigi RM, Kondiboyina A, Mehta VV, de Silva R, Paterson C, Krams R and Török P (2015). Quantification of plaque stiffness by Brillouin microscopy in experimental thin cap fibroatheroma. Journal of The Royal Society Interface, The Royal Society vol. 12 (112) 01-11-2015
Seneviratne AN, Cole JE, Goddard ME, Park I, Mohri Z, Sansom S, Udalova I, Krams R and Monaco C (2015). Low shear stress induces M1 macrophage polarization in murine thin-cap atherosclerotic plaques. Journal of Molecular and Cellular Cardiology, Elsevier vol. 89 (Pt B), 168-172. 30-10-2015
Pfenniger A, Meens MJ, Pedrigi RM, Foglia B, Sutter E, Pelli G, Rochemont V, Petrova TV, Krams R and Kwak BR (2015). Shear stress-induced atherosclerotic plaque composition in ApoE−/− mice is modulated by connexin37. Atherosclerosis, Elsevier vol. 243 (1), 1-10. 25-08-2015
Pedrigi RM, Poulsen CB, Mehta VV, Ramsing Holm N, Pareek N, Post AL, Kilic ID, Banya WAS, Dall'Ara G, Mattesini A, Bjørklund MM, Andersen NP, Grøndal AK, Petretto E, Foin N, Davies JE, Di Mario C, Fog Bentzon J, Erik Bøtker H, Falk E, et al. (2015). Inducing Persistent Flow Disturbances Accelerates Atherogenesis and Promotes Thin Cap Fibroatheroma Development in D374Y-PCSK9 Hypercholesterolemic Minipigs. Circulation, Wolters Kluwer vol. 132 (11), 1003-1012. 15-07-2015
Shamout FE, Pouliopoulos AN, Lee P, Bonaccorsi S, Towhidi L, Krams R and Choi JJ (2015). Enhancement of Non-Invasive Trans-Membrane Drug Delivery Using Ultrasound and Microbubbles During Physiologically Relevant Flow. Ultrasound in Medicine & Biology, Elsevier vol. 41 (9), 2435-2448. 09-06-2015
da Conceicao Pereira G and Krams R (2015). 182 Flow Characteristics Enhanced by the Compliant Arteries and their effects in Vulnerable Plaque Formation. 01-06-2015
Kis Z, Pereira HS, Homma T, Pedrigi RM and Krams R (2015). Mammalian synthetic biology: emerging medical applications. Journal of The Royal Society Interface, The Royal Society vol. 12 (106) 01-05-2015
Poulsen CB, Pedrigi RM, Mehta VV, Post A, Pareek N, Holm NR, Kilic D, El-Bahnasawi M, Bjørklund MM, Andersen NP, Grøndal AK, Nachiappan A, Foin N, Davies JER, Di Mario C, Bøtker HE, Bentzon JF, Falk E, Krams R and de Silva R (2015). INDUCTION OF PERTURBED SHEAR STRESS LEADS TO FOCAL ADVANCED ATHEROSCLEROTIC PLAQUE FORMATION IN TRANSGENIC MINIPIGS WITH HYPERCHOLESTEROLEMIA. 01-03-2015
Dent MR, López-Duarte I, Dickson CJ, Geoghegan ND, Cooper JM, Gould IR, Krams R, Bull JA, Brooks NJ and Kuimova MK (2015). Imaging phase separation in model lipid membranes through the use of BODIPY based molecular rotors. Physical Chemistry Chemical Physics, Royal Society of Chemistry (RSC) vol. 17 (28), 18393-18402. 01-01-2015
Villanueva ME, Pereira HSA, Rajyaguru J, Krams R and Chachuat B (2015). Bifurcation and stability analysis of nonlinear dynamic systems using complete search. 01-01-2015
2014
Mohri Z, Rowland EM, Clarke LA, De Luca A, Peiffer V, Krams R, Sherwin SJ and Weinberg PD (2014). Elevated Uptake of Plasma Macromolecules by Regions of Arterial Wall Predisposed to Plaque Instability in a Mouse Model. PLOS ONE, Public Library of Science (PLoS) vol. 9 (12) 22-12-2014
Homma T, Caurette P, Silva HJ, Yamada I, Makrydaki E, Bovens S, Pedrigi R, Petretto EG and Krams R (2014). Transcriptome analysis of local shear dependent gene expression in endothelial cells during thin-cap fibroatheroma(TCFA) development. 01-12-2014
Towhidi L, Maimari N, Kis Z, Khodadadi D and Krams R (2014). A novel high-throughput platform for siRNA transfection of primary mammalian cells. Atherosclerosis, Elsevier vol. 237 (2) 01-12-2014
Pereira G and Krams R (2014). Forecasting vulnerable plaque response to aemorheological flow. Atherosclerosis, Elsevier vol. 237 (2) 01-12-2014
Mehta VV, Pedrigi RM, Bovens SM, Tremoleda JL, Gsell W and Krams R (2014). Longitudinal predictive analysis of vulnerable plaques in a mouse model of atherosclerosis. Atherosclerosis, Elsevier vol. 237 (2) 01-12-2014
Maimari N, Towhidi L, Oh D, Broda K, Russo A and Krams R (2014). A novel integrated platform for gene network inference and validation: beyond the dream consortium. Atherosclerosis, Elsevier vol. 237 (2) 01-12-2014
Maimari N, Broda K, Kakas A, Russo A and Krams R (2014). Symbolic representation and inference of regulatory networks: uncovering mechanosensitive gene networks. Atherosclerosis, Elsevier vol. 237 (2) 01-12-2014
Kwak BR, Bäck M, Bochaton-Piallat M-L, Caligiuri G, Daemen MJAP, Davies PF, Hoefer IE, Holvoet P, Jo H, Krams R, Lehoux S, Monaco C, Steffens S, Virmani R, Weber C, Wentzel JJ and Evans PC (2014). Biomechanical factors in atherosclerosis: mechanisms and clinical implications†. European Heart Journal, Oxford University Press (OUP) vol. 35 (43), 3013-3020. 17-09-2014
Cuhlmann S, Gsell W, Van der Heiden K, Habib J, Tremoleda JL, Khalil M, Turkheimer F, Meens MJ, Kwak BR, Bird J, Davenport AP, Clark J, Haskard D, Krams R, Jones H and Evans PC (2014). In Vivo Mapping of Vascular Inflammation Using the Translocator Protein Tracer 18F-FEDAA1106. Molecular Imaging, SAGE Publications vol. 13 (6) 01-08-2014
Cuhlmann S, Gsell W, Van der Heiden K, Habib J, Tremoleda JL, Khalil M, Turkheimer F, Meens MJ, Kwak BR, Bird J, Davenport AP, Clark J, Haskard D, Krams R, Jones H and Evans PC (2014). In Vivo Mapping of Vascular Inflammation Using the Translocator Protein Tracer 18F-FEDAA1106. Mol Imaging vol. 13 (6) 01-08-2014
Pedrigi RM, de Silva R, Bovens SM, Mehta VV, Petretto E and Krams R (2014). Thin-Cap Fibroatheroma Rupture Is Associated With a Fine Interplay of Shear and Wall Stress. Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 34 (10), 2224-2231. 24-07-2014
Maimari N, Broda K, Kakas A, Krams R and Russo A (2014). Symbolic Representation and Inference of Regulatory Network Structures. Logical Modeling of Biological Systems 1-48. 10-07-2014
Caro CG, Seneviratne A, Heraty KB, Monaco C, Burke MG, Krams R, Chang CC, Gilson P and Coppola G (2014). Intimal hyperplasia following implantation of helical-centreline and straight-centreline stents in common carotid arteries in healthy pigs: influence of intraluminal flow. Journal of The Royal Society Interface, The Royal Society vol. 11 (92) 06-03-2014
Mohri Z, Rowland E, Clarke LA, De Luca A, Krams R and Weinberg PD (2014). Elevated arterial wall permeability may cause vulnerable plaque formation in mice. 01-02-2014
Pereira G, Krams R and van Wachem B (2014). Modelling the Mechanics of the Circulation: Blood Rheology and Atherosclerosis. 01-01-2014
Kis Z, Towhidi L, Ip H, Drakakis E, Bharath A and Krams R (2014). An In situ electroporation and flow device for mechanotransduction studies. Microarrays: Principles, Applications and Technologies 49-67. 01-01-2014
2013
Caro CG, Seneviratne A, Heraty KB, Monaco C, Burke MG, Krams R, Chang CC, Coppola G and Gilson P (2013). Intimal hyperplasia following implantation of helical-centreline and straight-centreline stents in common carotid arteries in healthy pigs: influence of intraluminal flow†. Journal of The Royal Society Interface, The Royal Society vol. 10 (89) 06-12-2013
Maimari N, Turliuc CR, Broda K, Kakas A, Krams R and Russo A (2013). ARNI: Abductive inference of complex regulatory network structures. 28-10-2013
Ylä-Herttuala S, Bentzon JF, Daemen M, Falk E, Garcia-Garcia HM, Herrmann J, Hoefer I, Jauhiainen S, Jukema JW, Krams R, Kwak BR, Marx N, Naruszewicz M, Newby A, Pasterkamp G, Serruys PWJC, Waltenberger J, Weber C, Tokgözoglu L and Biology EWGOAAV (2013). Stabilization of atherosclerotic plaques: an update. European Heart Journal, Oxford University Press (OUP) vol. 34 (42), 3251-3258. 21-08-2013
Seneviratne AN, Cole JE, Goddard ME, Udalova I, Krams R and Monaco C (2013). M1 macrophages are an early feature of shear stress modulated vulnerable atherosclerotic plaques. European Heart Journal, Oxford University Press (OUP) vol. 34 (suppl_1) 02-08-2013
Bovens SM, Foin N, O'Clery N, Van Der Heiden K, Cuhlmann S, Carlsen H, Barahona M, Evans PC and Krams R (2013). Shear stress and nitric oxide transport affect NFkB dynamics in endothelial cells. European Heart Journal, Oxford University Press (OUP) vol. 34 (suppl_1) 02-08-2013
Foin N, Sen S, Petraco R, Nijjer S, Torii R, Kousera C, Broyd C, Mehta V, Xu Y, Mayet J, Hughes A, Di Mario C, Krams R, Francis D and Davies J (2013). Method for Percutaneously Introducing, and Removing, Anatomical Stenosis of Predetermined Severity In Vivo: The “Stenotic Stent”. Journal of Cardiovascular Translational Research, Springer Nature vol. 6 (4), 640-648. 04-06-2013
Frueh J, Maimari N, Homma T, Bovens SM, Pedrigi RM, Towhidi L and Krams R (2013). Systems biology of the functional and dysfunctional endothelium. Cardiovascular Research, Oxford University Press (OUP) vol. 99 (2), 334-341. 06-05-2013
Seneviratne A, Cole J, Goddard M, Udalova I, Krams R and Monaco C (2013). 181 M1 MACROPHAGES AND IRF5 EXACERBATE ATHEROSCLEROTIC DISEASE. 01-05-2013
Harrison M, Smith E, Ross E, Krams R, Segers D, Buckley CD, Nash GB and Rainger GE (2013). The Role of Platelet-Endothelial Cell Adhesion Molecule-1 in Atheroma Formation Varies Depending on the Site-Specific Hemodynamic Environment. Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 33 (4), 694-701. 31-01-2013
Olivon VC, Fraga-Silva RA, Segers D, Demougeot C, de Oliveira AM, Savergnini SS, Berthelot A, de Crom R, Krams R, Stergiopulos N and da Silva RF (2013). Arginase inhibition prevents the low shear stress-induced development of vulnerable atherosclerotic plaques in ApoE−/− mice. Atherosclerosis, Elsevier vol. 227 (2), 236-243. 17-01-2013
Bovens SM, Foin N, O'Clery N, Van der Heiden K, Cuhlmann S, Carlsen H, Barahona M, Evans PC and Krams R (2013). Shear stress and nitric oxide transport affect NFkB dynamics in endothelial cells. 01-01-2013
Seneviratne AN, Cole JE, Goddard ME, Udalova I, Krams R and Monaco C (2013). M1 macrophages are an early feature of shear stress modulated vulnerable atherosclerotic plaques. 01-01-2013
2012
Falck-Hansen MA, Goddard ME, Cole JE, Astola N, Cross AJ, Krams R and Monaco C (2012). Macrophage activation during chronic inflammation in atherosclerosis. 01-12-2012
Seneviratne AN, Cole JE, Goddard ME, Mohri Z, Krams R and Monaco C (2012). Macrophage polarisation in shear stress modulated atherosclerotic plaque vulnerability. 01-12-2012
Shami A, Gustafsson R, Kalamajski S, Krams R, Segers D, Rauch U, Roos G, Nilsson J, Oldberg Å and Hultgårdh-Nilsson A (2012). Fibromodulin Deficiency Reduces Low-Density Lipoprotein Accumulation in Atherosclerotic Plaques in Apolipoprotein E–Null Mice. Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 33 (2), 354-361. 29-11-2012
Foin N, Sen S, Petraco R, Torii R, Nijjer S, Xu YX, Mehta V, Mayet J, Hughes A, Francis D, Di Mario C, Krams R and Davies J (2012). TCT-231 Investigation of Fractional Flow Reserve Correlation with Direct Anatomical Parameters Using a Percutaneous Model of Coronary Artery Stenosis. 01-10-2012
Pfenniger A, Wong C, Sutter E, Cuhlmann S, Dunoyer-Geindre S, Mach F, Horrevoets AJ, Evans PC, Krams R and Kwak BR (2012). Shear stress modulates the expression of the atheroprotective protein Cx37 in endothelial cells. Journal of Molecular and Cellular Cardiology, Elsevier vol. 53 (2), 299-309. 29-05-2012
Frueh J, Maimari N, Lui Y, Kis Z, Mehta V, Pormehr N, Grant C, Chalkias E, Falck-Hansen M, Bovens S, Pedrigi R, Homma T, Coppola G and Krams R (2012). Systems and synthetic biology of the vessel wall. FEBS Letters, Wiley vol. 586 (15), 2164-2170. 03-05-2012
van Bochove GS, Sanders HMHF, de Smet M, Keizer HM, Mulder WJM, Krams R, Strijkers GJ and Nicolay K (2012). Molecular MR Imaging of Collagen in Mouse Atherosclerosis by Using Paramagnetic CNA35 Micelles. European Journal of Inorganic Chemistry, Wiley vol. 2012 (12), 2115-2125. 28-03-2012
Schlueter J, Brand T, Henderson DJ, Boczonadi V, Humbert P, Chaudhry B, Sedmera D, Svatunkova J, Kockova R, Sankova B, , Lopez Sanchez C, Franco D, Aranega A, Garcia-Martinez V, Demina E, Miroshikova V, Denisenko A, Schwarzman A, Sanchez-Cabo F, et al. (2012). Poster session 1. Cardiovascular Research, Oxford University Press (OUP) vol. 93 (suppl_1), s9-s45. 15-03-2012
Nanka O, Krejci E, Pesevski Z, Sedmera D, Smart N, Rossdeutsch A, Dube KN, Riegler J, Price AN, Taylor A, Muthurangu V, Turner M, Lythgoe MF, Riley PR, Kryvorot S, Vladimirskaya T, Shved I, Schwarzl M, Seiler S, Huber S, et al. (2012). Poster session 3. Cardiovascular Research, Oxford University Press (OUP) vol. 93 (suppl_1), s92-s127. 15-03-2012
Kuhlmann MT, Cuhlmann S, Hoppe I, Krams R, Evans PC, Strijkers GJ, Nicolay K, Hermann S and Schäfers M (2012). Implantation of a carotid cuff for triggering shear-stress induced atherosclerosis in mice. Journal of Visualized Experiments, MyJove (59) 13-01-2012
Kuhlmann MT, Cuhlmann S, Hoppe I, Krams R, Evans PC, Strijkers GJ, Nicolay K, Hermann S and Schäfers M (2012). Implantation of a Carotid Cuff for Triggering Shear-stress Induced Atherosclerosis in Mice. Journal of Visualized Experiments, MyJove (59) 13-01-2012
Foin N, Torii R, Mortier P, De Beule M, Viceconte N, Chan PH, Davies JE, Xu XY, Krams R and Di Mario C (2012). Kissing Balloon or Sequential Dilation of the Side Branch and Main Vessel for Provisional Stenting of Bifurcations Lessons From Micro-Computed Tomography and Computational Simulations. JACC Cardiovascular Interventions, Elsevier vol. 5 (1), 47-56. 01-01-2012
Seneviratne AN, Cole JE, Goddard ME, Mohri Z, Cross AJ, Krams R and Monaco C (2012). Macrophage heterogeneity in shear stress modulated atherosclerotic plaque development. 01-01-2012
Caro CG, Seneviratne A, Monaco C, Hou D, Singh J, Gilson P, Burke MG, Heraty KB, Krams R and Coppola G (2012). Arterial stent-associated intimal hyperplasia and wall hypoxia. 01-01-2012
Falck-Hansen M, Goddard ME, Cole JE, Astola N, Cross AJ, Krams R and Monaco C (2012). Expression of the regulatory receptor CD200R on macrophages is regulated by polarization signals in atherosclerosis. 01-01-2012
2011
Foin N, Secco GG, Ghilencea L, Krams R and Di Mario C (2011). Final proximal post-dilatation is necessary after kissing balloon in bifurcation stenting. EuroIntervention, Europa Digital & Publishing vol. 7 (5), 597-604. 01-09-2011
Foin N, Viceconte N, Chan PH, Lindsay AC, Krams R and Di Mario C (2011). Jailed side branches. Journal of Cardiovascular Medicine, Wolters Kluwer vol. 12 (8), 581-582. 01-08-2011
De Crom R, Leenen P, Nicolay K and Krams R (2011). Shear stress is a major determinant for getting a heart attack. Hart Bulletin vol. 42 (3), 67-70. 01-06-2011
Foin N, Secco G, Ghilencea L, Krams R and Di Mario C (2011). FINAL PROXIMAL POST-DILATATION IS NECESSARY AFTER KISSING BALLOON IN BIFURCATIONS STENTING. 01-04-2011
Cuhlmann S, Van der Heiden K, Saliba D, Tremoleda JL, Khalil M, Zakkar M, Chaudhury H, Luong LA, Mason JC, Udalova I, Gsell W, Jones H, Haskard DO, Krams R and Evans PC (2011). Disturbed Blood Flow Induces RelA Expression via c-Jun N-Terminal Kinase 1. Circulation Research, Wolters Kluwer vol. 108 (8), 950-959. 24-02-2011
Zakkar M, Luong LA, Chaudhury H, Ruud O, Punjabi PP, Anderson JR, Mullholand JW, Clements AT, Krams R, Foin N, Athanasiou T, Leen ELS, Mason JC, Haskard DO and Evans PC (2011). Dexamethasone Arterializes Venous Endothelial Cells by Inducing Mitogen-Activated Protein Kinase Phosphatase-1. Circulation, Wolters Kluwer vol. 123 (5), 524-532. 24-01-2011
Gsell W, Cuhlmann S, Van der Heiden K, Tremoleda JL, Khalil M, Clark J, Bird J, Jones H, Krams R and Evans PC (2011). 18FEDAA is a more specific probe than 18FDG for imaging vascular inflammation. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING vol. 38, S210-S210. 01-01-2011
Pfenniger A, Sutter E, Cuhlmann S, Evans PC, Krams R and Kwak BR (2011). Endothelial Cx37 expression is regulated by the shear stress responsive transcription factor KLF2. 01-01-2011
Ylä-Herttuala S, Bentzon JF, Daemen M, Falk E, Garcia-Garcia HM, Herrmann J, Hoefer I, Jukema JW, Krams R, Kwak BR, Marx N, Naruszewicz M, Newby A, Pasterkamp G, Serruys PWJC, Waltenberger J, Weber C and Tokgözoglu L (2011). Stabilisation of atherosclerotic plaques. Thrombosis and Haemostasis, Thieme vol. 106 (01), 1-19. 01-01-2011
Segers D, Lipton JA, Leenen PJM, Cheng C, Tempel D, Pasterkamp G, Moll FL, de Crom R and Krams R (2011). Atherosclerotic Plaque Stability Is Affected by the Chemokine CXCL10 in Both Mice and Humans. International Journal of Inflammation, Hindawi vol. 2011 01-01-2011
Foin N, Secco G, Sen S, Davies JE, Krams R and Di Mario C (2011). Bench Micro-CT study and OCT Experience of a Final Proximal Post-dilatation to Optimize Results in Bifurcation Stenting. 01-01-2011
Foin N, Torii R, Mortier P, De Beule M, Viceconte N, Davies JE, Xu XY, Krams R and Di Mario C (2011). Sequential Side Branch and Main Vessel Dilatation instead of Kissing Balloon after Provisional Bifurcation Stenting: Lessons from Micro-CT and Computational Simulations. 01-01-2011
Falck-Hansen M, Goddard ME, Cole JE, Astola N, Cross AJ, Krams R and Monaco C (2011). Expression of the regulatory receptor CD200R on macrophages is regulated by polarization signals in atherosclerosis. 01-01-2011
Olivon VC, Segers D, de Oliveira AM, Demougeot C, Bertholet A, de Crom R, Krams R, Stergiopulos N and da Silva RF (2011). Effects of arginase inhibition on shear stress-induced plaque size and composition. 01-01-2011
2010
Halliday I, Atherton M, Care CM, Collins MW, Evans D, Evans PC, Hose DR, Khir AW, König CS, Krams R, Lawford PV, Lishchuk SV, Pontrelli G, Ridger V, Spencer TJ, Ventikos Y, Walker DC and Watton PN (2010). Multi-scale interaction of particulate flow and the artery wall. Medical Engineering & Physics, Elsevier vol. 33 (7), 840-848. 29-10-2010
van Bochove GS, Paulis LEM, Segers D, Mulder WJM, Krams R, Nicolay K and Strijkers GJ (2010). Contrast enhancement by differently sized paramagnetic MRI contrast agents in mice with two phenotypes of atherosclerotic plaque. Contrast Media & Molecular Imaging, Wiley vol. 6 (1), 35-45. 29-09-2010
Debernardi N, Roijers RB, Krams R, De Crom R, Mutsaers PHA and Van Der Vusse GJ (2010). Microcalcifications in atherosclerotic lesion of apolipoprotein E‐deficient mouse. International Journal of Experimental Pathology, Wiley vol. 91 (6), 485-494. 27-08-2010
Cuhlmann S, van der Heiden K, Zakkar M, Chaudhury H, Luong LA, Mason J, Haskard DO, Carlsen H, Krams R and Evans PC (2010). YIA4 C Jun N-terminal kinase promotes endothelial activation at atherosclerosis-susceptible sites by enhancing expression of NF-κB transcription factors. Heart, BMJ vol. 96 (17) 26-08-2010
Plata AM, Sherwin SJ and Krams R (2010). Endothelial Nitric Oxide Production and Transport in Flow Chambers: The Importance of Convection. Annals of Biomedical Engineering, Springer Nature vol. 38 (9), 2805-2816. 14-04-2010
Helderman F, Manoch IJ, Breeuwer M, Kose U, Boersma H, van Sambeek MRHM, Pattynama PMT, Schouten O, Poldermans D, Wisselink W, van der Steen AFW and Krams R (2010). Predicting Patient-Specific Expansion of Abdominal Aortic Aneurysms. European Journal of Vascular and Endovascular Surgery, Elsevier vol. 40 (1), 47-53. 25-03-2010
van Bochove GS, Straathof R, Krams R, Nicolay K and Strijkers GJ (2010). MRI-determined carotid artery flow velocities and wall shear stress in a mouse model of vulnerable and stable atherosclerotic plaque. Magnetic Resonance Materials in Physics, Biology and Medicine, Springer Nature vol. 23 (2), 77-84. 13-03-2010
Friedman MH, Krams R and Chandran KB (2010). Flow Interactions with Cells and Tissues: Cardiovascular Flows and Fluid–Structure Interactions. Annals of Biomedical Engineering, Springer Nature vol. 38 (3), 1178-1187. 14-01-2010
Chaudhury H, Zakkar M, Boyle J, Cuhlmann S, van der Heiden K, Luong LA, Davis J, Platt A, Mason JC, Krams R, Haskard DO, Clark AR and Evans PC (2010). c-Jun N-Terminal Kinase Primes Endothelial Cells at Atheroprone Sites for Apoptosis. Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 30 (3), 546-553. 07-01-2010
Pfenniger A, Galan K, Wong C, Cuhlmann S, Evans PC, Krams R and Kwak BR (2010). Shear Stress Modulates the Expression of the Vasoprotective Protein Cx37 in Endothelial Cells. 01-01-2010
Zakkar M, Punjabi P, Anderson J, Smith P, Krams R, Haskard D and Evans P (2010). Dexamethasone arterializes venous endothelial cells by inducing MAP Kinase phosphatase-1 (MKP-1). A novel anti-inflammatory treatment for vein grafts. 01-01-2010
Friedman MH, Krams R and Chandran KB (2010). Flow Interactions with Cells and Tissues: Cardiovascular Flows and Fluid-Structure Interactions. 01-01-2010
Krams R, Cuhlmann S, Foin N and Evans P (2010). Shear stress, inflammation and Atherosclerosis. Artery Research, Springer Nature vol. 4 (2), 41-46. 01-01-2010
da Silva RF, Olivon VC, Segers D, de Crom R, Krams R and Stergiopuloss N (2010). Ex Vivo and In Vivo Regulation of Arginase in Response to Wall Shear Stress. 01-01-2010
2009
Poelma C, Mari JM, Foin N, Tang M-X, Krams R, Caro CG, Weinberg PD and Westerweel J (2009). 3D Flow reconstruction using ultrasound PIV. 10-11-2009
Zakkar M, Van der Heiden K, Luong LA, Chaudhury H, Cuhlmann S, Hamdulay SS, Krams R, Edirisinghe I, Rahman I, Carlsen H, Haskard DO, Mason JC and Evans PC (2009). Activation of Nrf2 in Endothelial Cells Protects Arteries From Exhibiting a Proinflammatory State. Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 29 (11), 1851-1857. 03-09-2009
Cheng C, Tempel D, van Haperen R, van Damme L, Algür M, Krams R and de Crom R (2009). Activation of MMP8 and MMP13 by angiotensin II correlates to severe intra-plaque hemorrhages and collagen breakdown in atherosclerotic lesions with a vulnerable phenotype. Atherosclerosis, Elsevier vol. 204 (1), 26-33. 24-01-2009
Cuhlmann S, van der Heiden K, Zakkar M, Chaudhury H, Luong LA, Mason JM, Haskard DO, Krams R and Evans PC (2009). HIGH SHEAR STRESS SUPPRESSES THE EXPRESSION AND ACTIVITY OF NF-KAPPAB TRANSCRIPTION FACTORS IN ARTERIAL ENDOTHELIUM. 01-01-2009
Chaudhury HA, Zakkar M, Boyle J, Dennis J, van der Heiden K, Luong L, Cuhlmann S, Mason JM, Krams R, Haskard DO and Evans PC (2009). ENDOTHELIAL CELLS AT ATHEROSUSCEPTIBLE SITES EXPRESS ACTIVATED C-JUN N-TERMINAL KINASE WHICH INDUCES PRO-APOPTOTIC MOLECULES. 01-01-2009
Foin N, Plata-Garcia A, Cuhlmann S, Evans PC, Caro CG and Krams R (2009). SHEAR STRESS AND NITRIC OXIDE TRANSPORT AFFECT NF-KB DYNAMICS IN ENDOTHELIAL CELLS. 01-01-2009
Zakkar M, van der Heiden K, Chaudhury H, Krams R, Haskard DO, Mason JC and Evans PC (2009). ACTIVATION OF NF-E2 RELATED FACTOR-2 (NRF2) PROTECTS ARTERIES FROM EXHIBITING A PRO-INFLAMMATORY STATE. 01-01-2009
Foin N, Plata-Garcia A, Qin Q, Cuhlmann S, Evans PC, Caro CG and Krams R (2009). Shear Stress and Nitric Oxide Transport Affect NF-κB Dynamics In Endothelial Cells. 01-01-2009
Foin N, Plata-Garcia A, Cuhlmann S, Evans P, Caro C and Krams R (2009). SHEAR STRESS AND MASS TRANSPORT AFFECTS NFκB DYNAMICS IN ENDOTHELIAL CELLS. JOURNAL OF PHYSIOLOGICAL SCIENCES vol. 59, 324-324. 01-01-2009
2008
Susa D, van de Engel S, van Damme LCA, Roest HP, Krams R, IJzermans JNM and de Bruin RWF (2008). Donor pre-treatment with tacrolimus reduces transplant vasculopathy. Pharmacological Research, Elsevier vol. 59 (4), 273-278. 30-12-2008
Segers D, Weinberg P and Krams R (2008). Atherosclerosis: cell biology and lipoproteins - shear stress and inflammation in plaque formation: new evidence. Current Opinion in Lipidology, Wolters Kluwer vol. 19 (6), 627-628. 01-12-2008
Segers D, Cheng C, Crom RD, Kirschbaum SWM, Oostlander AE, Helderman F, Wamel AV, Slager CJ, Serruys PW, Steen AFWVD and Krams R (2008). Monocyte Adhesion in Atherosclerosis: A Biomechanical Approach. Vascular Disease Prevention, Bentham Science Publishers vol. 2 (1), 227-235. 01-12-2008
Krams R, Breeuwer M and van de Vosse F (2008). Personalised imaging and biomechanical modelling of large vessels. Medical & Biological Engineering & Computing, Springer Nature vol. 46 (11), 1057-1058. 01-11-2008
Segers D, Garcia-Garcia HM, Cheng C, de Crom R, Krams R, Wentzel JJ, van der Steen AFW, Serruys PW, Leenen PJM and Laman JD (2008). A primer on the immune system in the pathogenesis and treatment of atherosclerosis. EuroIntervention, Europa Digital & Publishing vol. 4 (3), 378-390. 01-11-2008
Robbers‐Visser D, Helderman F, Strengers JL, van Osch‐Gevers L, Kapusta L, Pattynama PM, Bogers AJ, Krams R and Helbing WA (2008). Pulmonary artery size and function after Fontan operation at a young age. Journal of Magnetic Resonance Imaging, Wiley vol. 28 (5), 1101-1107. 28-10-2008
Robbers-Visser D, Helderman F, Strengers JL, van Osch-Gevers L, Kapusta L, Pattynama PM, Bogers AJ, Krams R and Helbing WA (2008). 1057 Pulmonary artery size and function after Fontan operation at young age: assessment with phase contrast magnetic resonance imaging. Journal of Cardiovascular Magnetic Resonance, Elsevier vol. 10 01-10-2008
Breeuwer M, de Putter S, Kose U, Speelman L, Visser K, Gerritsen F, Hoogeveen R, Krams R, van den Bosch H, Buth J, Gunther T, Wolters B, van Dam E and van de Vosse F (2008). Towards patient-specific risk assessment of abdominal aortic aneurysm. Medical & Biological Engineering & Computing, Springer Nature vol. 46 (11), 1085-1095. 23-09-2008
de Crom R, Cheng C, Helderman F and Krams R (2008). Large variations in absolute wall shear stress levels within one species and between species. Atherosclerosis, Elsevier vol. 204 (1), 16-17. 22-08-2008
Zakkar M, Chaudhury H, Sandvik G, Enesa K, Luong LA, Cuhlmann S, Mason JC, Krams R, Clark AR, Haskard DO and Evans PC (2008). Increased Endothelial Mitogen-Activated Protein Kinase Phosphatase-1 Expression Suppresses Proinflammatory Activation at Sites That Are Resistant to Atherosclerosis. Circulation Research, Wolters Kluwer vol. 103 (7), 726-732. 21-08-2008
Ridger V, Krams R, Carpi A and Evans PC (2008). Hemodynamic parameters regulating vascular inflammation and atherosclerosis: A brief update. Biomedicine & Pharmacotherapy, Elsevier vol. 62 (8), 536-540. 08-08-2008
Zakkar M, Chaudhury H, Krams R, Mason JC, Clark AR, Haskard DO and Evans PC (2008). MAP KINASE PHOSPHATASE-1 SUPPRESSES ENDOTHELIAL ACTIVATION IN REGIONS OF THE ARTERIAL TREE THAT ARE RESISTANT TO ATHEROSCLEROSIS. 01-08-2008
de Bruin RWF, Susa D, van den Engel S, van Damme LA, Roest HP, Krams R and Jzermans JNMI (2008). DONOR PRE-TREATMENT WITH TACROLIMUS EDUCES TRANSPLANT VASCULOPATHY. Transplantation, Wolters Kluwer vol. 86 (2S) 27-07-2008
da Silva RF, Olivon VC, Segers D, de Crom R, Krams R and Stergiopulos N (2008). REGULATION OF ARGINASE IN RESPONSE SHEAR STRESS: NEW POTENTIAL THERAPEUTIC TARGET ATHEROSCLEROSIS? Journal of Biomechanics, Elsevier vol. 41 01-07-2008
Helderman F, Manoch IJ, Breeuwer M, Kose U, Schouten O, van Sambeek MRM, Poldermans D, Pattynama PTM, Wisselink W, van der Steen AFW and Krams R (2008). A numerical model to predict abdominal aortic aneurysm expansion based on local wall stress and stiffness. Medical & Biological Engineering & Computing, Springer Nature vol. 46 (11) 03-06-2008
Foin N, Evans P and Krams R (2008). Atherosclerosis: cell biology and lipoproteins – new developments in imaging of inflammation of the vulnerable plaque. Current Opinion in Lipidology, Wolters Kluwer vol. 19 (1), 98-100. 01-02-2008
da Silva RF, Olivon VC, Segers D, de Crom R, Krams R and Stergiopulos N (2008). Role of arginase pathway in response to shear stress: new potential therapeutic targets for atherosclerosis? 01-01-2008
da Silva RF, Olivon VC, Segers D, de Crom R, Krams R and Stergiopulos N (2008). P1.57 Modulation of Arginase in Response to Wall Shear Stress. Artery Research, Springer Nature vol. 2 (3), 105-106. 01-01-2008
2007
Cheng C, Tempel D, Oostlander A, Helderman F, Gijsen F, Wentzel J, van Haperen R, Haitsma DB, Serruys PW, van der Steen AFW, de Crom R and Krams R (2007). Rapamycin modulates the eNOS vs. shear stress relationship. Cardiovascular Research, Oxford University Press (OUP) vol. 78 (1), 123-129. 13-12-2007
Segers D, de Crom R, Leenen P, Pasterkamp G and Krams R (2007). Abstract 879: The Chemokine CXCL10 Is Involved In The Development Of Atherosclerotic Plaque Vulnerability. Circulation, Wolters Kluwer vol. 116 (suppl_16) 16-10-2007
Helderman F, Segers D, de Crom R, Hierck BP, Poelmann RE, Evans PC and Krams R (2007). Effect of shear stress on vascular inflammation and plaque development. Current Opinion in Lipidology, Wolters Kluwer vol. 18 (5), 527-533. 01-10-2007
Goertz DE, Frijlink ME, Tempel D, Krams R, De Jong N and van der Steen AF (2007). Subharmonic Contrast Intravascular Ultrasound. 2007 IEEE Ultrasonics Symposium Proceedings. 01-10-2007
Goertz DE, Frijlink ME, Tempel D, Bhagwandas V, Gisolf A, Krams R, de Jong N and van der Steen AFW (2007). Subharmonic Contrast Intravascular Ultrasound for Vasa Vasorum Imaging. Ultrasound in Medicine & Biology, Elsevier vol. 33 (12), 1859-1872. 02-08-2007
Van der Heiden K, Hierck BP, Krams R, de Crom R, Cheng C, Baiker M, Pourquie MJBM, Alkemade FE, DeRuiter MC, Groot ACG-D and Poelmann RE (2007). Endothelial primary cilia in areas of disturbed flow are at the base of atherosclerosis. Atherosclerosis, Elsevier vol. 196 (2), 542-550. 13-07-2007
Wentzel J, Gijsen F, Krams R, de Crom R, Cheng C, Groen H, van der Giessen A and van der Steen A (2007). Shear stress and the vulnerable plaque. The Vulnerable Plaque, Second Edition 233-244. 13-06-2007
Kofflard MJ, Michels M, Krams R, Kliffen M, Geleijnse ML, Cate FJT and Serruys PW (2007). Coronary flow reserve in hypertrophic cardiomyopathy: relation with microvascular dysfunction and pathophysiological characteristics. Netherlands Heart Journal, Springer Nature vol. 15 (6), 209-215. 01-06-2007
Jackson CL, Bennett MR, Biessen EAL, Johnson JL and Krams R (2007). Assessment of Unstable Atherosclerosis in Mice. Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 27 (4), 714-720. 01-03-2007
Cheng C, Tempel D, van Haperen R, de Boer HC, Segers D, Huisman M, van Zonneveld AJ, Leenen PJM, van der Steen A, Serruys PW, de Crom R and Krams R (2007). Shear stress–induced changes in atherosclerotic plaque composition are modulated by chemokines. Journal of Clinical Investigation, American Society for Clinical Investigation vol. 117 (3), 616-626. 15-02-2007
Goertz DE, Frijlink ME, Krams R, de Jong N and van der Steen AFW (2007). Vasa vasorum and molecular imaging of atherosclerotic plaques using nonlinear contrast intravascular ultrasound. Netherlands Heart Journal, Springer Nature vol. 15 (2), 77-80. 01-02-2007
Segers D, Helderman F, Cheng C, van Damme LCA, Tempel D, Boersma E, Serruys PW, de Crom R, van der Steen AFW, Holvoet P and Krams R (2007). Gelatinolytic Activity in Atherosclerotic Plaques Is Highly Localized and Is Associated With Both Macrophages and Smooth Muscle Cells In Vivo. Circulation, Wolters Kluwer vol. 115 (5), 609-616. 22-01-2007
Susa D, van den Engel S, van Damme LA, Roest HP, Krams R, IJiermans JNM and De Bruin RWF (2007). Donor pre-treatment with tacrolimus reduces transplant vasculopathy. 01-01-2007
Segers D, de Crom R, Leenen P, Pasterkamp G and Krams R (2007). The chemokine CXCL10 is involved in the development of atherosclerotic plaque vulnerability. 01-01-2007
Da Silva RF, Gambillara V, Krams R and Stergiopulos N (2007). Modulation of arginases by different patterns of shear stress: new signaling pathway in atherogenesis? Computer Methods in Biomechanics & Biomedical Engineering, Taylor & Francis vol. 10 (sup1), 77-78. 01-01-2007
da Silva RF, Gambillara V, Cheng C, Segers D, de Crom R, Krams R and Stergiopulos N (2007). P.096 Role of Arginase Pathway in Response to Shear Stress: New Potential Therapeutic Targets for Atherosclerosis? Artery Research, Springer Nature vol. 1 (2), 74-75. 01-01-2007
Thury A, Wentzel JJ, Gijsen FJH, Schuurbiers JCH, Krams R, de Feyter PJ, Serruys PW and Slager CJ (2007). The Influence of Shear Stress on Restenosis. Essentials of Restenosis 59-83. 01-01-2007
2006
Cheng C, Helderman F, Tempel D, Segers D, Hierck B, Poelmann R, van Tol A, Duncker DJ, Robbers-Visser D, Ursem NTC, van Haperen R, Wentzel JJ, Gijsen F, van der Steen AFW, de Crom R and Krams R (2006). Large variations in absolute wall shear stress levels within one species and between species. Atherosclerosis, Elsevier vol. 195 (2), 225-235. 12-12-2006
Cheng C, Tempel D, van der Baan A, Krams R, Daemen MJAP, van Haperen R, Grosveld F and de Crom R (2006). Response to Letter Regarding Article, “Atherosclerotic Lesion Size and Vulnerability Are Determined by Patterns of Fluid Shear Stress”. Circulation, Wolters Kluwer vol. 114 (22) 28-11-2006
Frijlink ME, Goertz DE, Vos HJ, Tesselaar E, Blacquière G, Gisolf A, Krams R and van der Steen AFW (2006). Harmonic intravascular ultrasound imaging with a dual-frequency catheter. Ultrasound in Medicine & Biology, Elsevier vol. 32 (11), 1649-1654. 01-11-2006
Frijlink ME, Goertz DE, van Damme LCA, Krams R and van der Steen AFW (2006). Intravascular ultrasound tissue harmonic imaging in vivo. IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control, Institute of Electrical and Electronics Engineers (IEEE) vol. 53 (10), 1844-1852. 01-10-2006
Cheng C, Tempel D, van Damme L, van Haperen R, Krams R and de Crom R (2006). Angiotensin II induces severe intra-plaque hemorrhages in lesions with a vulnerable plaque phenotype. Vascular Pharmacology, Elsevier vol. 45 (3), e91-e92. 01-09-2006
Cheng C, Tempel D, van Damme L, van Haperen R, Krams R and de Crom R (2006). Patterns of fluid shear stress determine atherosclerotic lesion size and vulnerability. Vascular Pharmacology, Elsevier vol. 45 (3) 01-09-2006
Goertz DE, Frijlink ME, Tempel D, van Damme LCA, Krams R, Schaar JA, Cate FJT, Serruys PW, de Jong N and van der Steen AFW (2006). Contrast Harmonic Intravascular Ultrasound. Investigative Radiology, Wolters Kluwer vol. 41 (8), 631-638. 01-08-2006
Krams R, Cheng C, Helderman F, Verheye S, van Damme LCA, Mousavi Gourabi B, Tempel D, Segers D, de Feyter P, Pasterkamp G, De Klein D, de Crom R, van der Steen AFW and Serruys PW (2006). Shear stress is associated with markers of plaque vulnerability and MMP-9 activity. EuroIntervention vol. 2 (2), 250-256. 01-08-2006
Cheng C, Tempel D, van Haperen R, van der Baan A, Grosveld F, Daemen MJAP, Krams R and de Crom R (2006). Atherosclerotic Lesion Size and Vulnerability Are Determined by Patterns of Fluid Shear Stress. Circulation, Wolters Kluwer vol. 113 (23), 2744-2753. 05-06-2006
Nette RW, Ie EHY, Vletter WB, Krams R, Weimar W and Zietse R (2006). Norepinephrine-induced vasoconstriction results in decreased blood volume in dialysis patients. Nephrology Dialysis Transplantation, Oxford University Press (OUP) vol. 21 (5), 1305-1311. 31-01-2006
Lipton J, Segers D, Cheng C, Duckers H, Krams R, Tempel D, Busser E, De Kleijn D, Moll FL and Pasterkamp G (2006). High IP-10 levels identify plaques with a vulnerable phenotype. 01-01-2006
Cheng C, Tempel D, van Haperen R, van der Baan A, Grosveld F, Daemen MJAP, Krams R and de Crom R (2006). Atherosclerotic lesion size and vulnerability are determined by patterns of fluid shear stress. CIRCULATION vol. 113 (23), 2744-2753. 01-01-2006
Krams R, Schaar J, Helderman F, Cheng C, Gourabi BM, van Damme LCA, Segers D, Regar E, Slager CJ, de Feyter PJ, van der Steen AFW and Serruys PW (2006). Visualization of the Vulnerable Plaque. Cardiovascular Research 221-234. 01-01-2006
Helderman F, Schouten O, Manoch I, Buffart H, van der Steen AFW and Krams R (2006). Numerical model for predicting dilatation of an Abdominal Aortic Aneurysm (AAA). Journal of Biomechanics, Elsevier vol. 39 01-01-2006
Krams R (2006). Shear stress and atherosclerosis. Journal of Biomechanics, Elsevier vol. 39 01-01-2006
2005
Davies PF, Spaan JA and Krams R (2005). Shear Stress Biology of the Endothelium. Annals of Biomedical Engineering, Springer Nature vol. 33 (12), 1714-1718. 01-12-2005
Krams R, Verheye S, van Damme LCA, Tempel D, Mousavi Gourabi B, Boersma E, Kockx MM, Knaapen MWM, Strijder C, van Langenhove G, Pasterkamp G, van der Steen AFW and Serruys PW (2005). In vivo temperature heterogeneity is associated with plaque regions of increased MMP-9 activity. European Heart Journal, Oxford University Press (OUP) vol. 26 (20), 2200-2205. 05-09-2005
Ie EHY, Krams R, Vletter WB, Nette RW, Weimar W and Zietse R (2005). Myocardial contractility does not determine the haemodynamic response during dialysis. Nephrology Dialysis Transplantation, Oxford University Press (OUP) vol. 20 (11), 2465-2471. 23-08-2005
Cheng C, van Haperen R, de Waard M, van Damme LCA, Tempel D, Hanemaaijer L, van Cappellen GWA, Bos J, Slager CJ, Duncker DJ, van der Steen AFW, de Crom R and Krams R (2005). Shear stress affects the intracellular distribution of eNOS: direct demonstration by a novel in vivo technique. Blood, American Society of Hematology vol. 106 (12), 3691-3698. 16-08-2005
Segers D, Cheng C, Crom RD, Kirschbaum SWM, Oostlander AE, Helderman F, Wamel AV, Slager CJ, Serruys PW, Steen AFWVD and Krams R (2005). Monocyte Adhesion in Atherosclerosis: A Biomechanical Approach. Vascular Disease Prevention, Bentham Science Publishers vol. 2 (3), 227-235. 01-07-2005
Krams R, Bambi G, Guidi F, Helderman F, van der Steen AFW and Tortoli P (2005). Effect of vessel curvature on Doppler derived velocity profiles and fluid flow. Ultrasound in Medicine & Biology, Elsevier vol. 31 (5), 663-671. 01-05-2005
Wentzel JJ, Krams R and Slager CJ (2005). Letter Regarding Article by Korshunov and Berk, “Strain-Dependent Vascular Remodeling: The ‘Glagov Phenomenon’ Is Genetically Determined”. Circulation, Wolters Kluwer vol. 111 (9), e119-e119. 21-02-2005
Schaar* JA, de Korte* CL, Mastik F, van Damme LCA, Krams R, Serruys PW and van der Steen AFW (2005). Three-Dimensional Palpography of Human Coronary Arteries. Herz, Springer Nature vol. 30 (2), 125-133. 01-02-2005
Cheng C, Tempel D, van Haperen R, de Crom R and Krams R (2005). Vulnerable lesions induced by low shear stress are characterized by expression of specific inflammatory chemokines. 01-01-2005
Cheng C, Tempel D, van Damme L, van Haperen R, Krams R and de Crom R (2005). Patterns of fluid shear stress determine Atherosclerotic lesion size and vulnerability. 01-01-2005
Susa D, de Engel SV, van Damme LCA, Roest HP, Krams R, Ijzermans JNM and de Bruin RWF (2005). Donor pre-treatment with tacrolimus reduces matrix metallo proteinase activity and transplant arteriosclerosis. 01-01-2005
Cheng C, Tempel D, van Damme L, van Gaalen K, van Haperen R, Krams R and de Crom R (2005). Angiotensin II induces severe intra-plaque hemorrhages in lesions with a vulnerable plaque phenotype in apoE KO mice. 01-01-2005
2004
Wentzel JJ, Gijsen FJH, Schuurbiers JCH, Krams R, Serruys PW, De Feyter PJ and Slager CJ (2004). Geometry guided data averaging enables the interpretation of shear stress related plaque development in human coronary arteries. Journal of Biomechanics, Elsevier vol. 38 (7), 1551-1555. 23-12-2004
Krams R, Cate FJT, Carlier SG, van der Steen AFW and Serruys PW (2004). Diastolic coronary vascular reserve: a new index to detect changes in the coronary microcirculation in hypertrophic cardiomyopathy. Journal of the American College of Cardiology, Elsevier vol. 43 (4), 670-677. 01-02-2004
Verheye S, De Meyer GRY, Krams R, Kockx MM, Van Damme LCA, Mousavi Gourabi B, Knaapen MWM, Van Langenhove G and Serruys PW (2004). Intravascular thermography: Immediate functional and morphological vascular findings. European Heart Journal, Oxford University Press (OUP) vol. 25 (2), 158-165. 01-01-2004
Frijlink ME, Goertz DE, Van Damme LCA, Krams R and Van Der Steen AFW (2004). Intravascular Ultrasound Tissue Harmonic Imaging In Vivo. IEEE Ultrasonics Symposium, 2004. 01-01-2004
Cheng C, de Crom R, van Haperen R, Helderman F, Gourabi BM, van Damme LCA, Kirschbaum SW, Slager CJ, van der Steen AFW and Krams R (2004). The role of shear stress in atherosclerosis. Cell Biochemistry and Biophysics, Springer Nature vol. 41 (2), 279-294. 01-01-2004
Cheng C, van Haperen R, de Waard M, de Crom R and Krams R (2004). In vivo induced changes in shear stress patterns affect the expression and the intracellular localization of endothelial nitric oxide synthase. 01-01-2004
Cheng C, de Waard M, van Haperen R, Tempel D, van der Baan A, Krams R and de Crom R (2004). In vivo induction of low shear stress and oscillatory shear stress causes atherosclerosis. 01-01-2004
van Ooijen PMA, Irwan R, Slager CJ, Wentzel JJ, Schuurbiers JCH, Oomen JAF, Gijsen FJH, Krams R, van der Giessen WJ, Serruys PW and de Feyter PJ (2004). Multi-Dimensional Computed Coronary Visualization. Coronary Radiology 227-282. 01-01-2004
2003
van Haperen R, Cheng C, Mees BME, van Deel E, de Waard M, van Damme LCA, van Gent T, van Aken T, Krams R, Duncker DJ and de Crom R (2003). Functional Expression of Endothelial Nitric Oxide Synthase Fused to Green Fluorescent Protein in Transgenic Mice. American Journal Of Pathology, Elsevier vol. 163 (4), 1677-1686. 01-10-2003
Diamantopoulos L, Liu X, De Scheerder I, Krams R, Li S, Van Cleemput J, Desmet W and Serruys PW (2003). The effect of reduced blood-flow on the coronary wall temperature. European Heart Journal, Oxford University Press (OUP) vol. 24 (19), 1788-1795. 01-10-2003
de Feyter PJ, Serruys PW, Nieman K, Mollet N, Cademartiri F, van Geuns RJ, Slager C, van der Steen AFW, Krams R, Schaar JA, Wielopolski P, Pattynama PMT, Arampatzis A, van der Lugt A, Regar E, Ligthart J and Smits P (2003). Imaging of coronary atherosclerosis and identification of the vulnerable plaque. Netherlands Heart Journal vol. 11 (9), 347-358. 01-09-2003
Wentzel JJ, Janssen E, Vos J, Schuurbiers JCH, Krams R, Serruys PW, de Feyter PJ and Slager CJ (2003). Extension of Increased Atherosclerotic Wall Thickness Into High Shear Stress Regions Is Associated With Loss of Compensatory Remodeling. Circulation, Wolters Kluwer vol. 108 (1), 17-23. 23-06-2003
Carlier SG, van Damme LCA, Blommerde CP, Wentzel JJ, van Langehove G, Verheye S, Kockx MM, Knaapen MWM, Cheng C, Gijsen F, Duncker DJ, Stergiopulos N, Slager CJ, Serruys PW and Krams R (2003). Augmentation of Wall Shear Stress Inhibits Neointimal Hyperplasia After Stent Implantation. Circulation, Wolters Kluwer vol. 107 (21), 2741-2746. 12-05-2003
Wentzel JJ, Gijsen FJH, Stergiopulos N, Serruys PW, Slager CJ and Krams R (2003). Shear stress, vascular remodeling and neointimal formation. Journal of Biomechanics, Elsevier vol. 36 (5), 681-688. 01-05-2003
KRAMS R, SEGERS D, GOURABI BM, MAAT W, CHENG C, VAN PELT C, VAN DAMME LCA, DE FEYTER P, VAN DER STEEN T, DE KORTE CL and SERRUYS PW (2003). Inflammation and Atherosclerosis:. Journal of Interventional Cardiology, Wiley vol. 16 (2), 107-113. 01-04-2003
KRAMS R (2003). 929 Plaque temperature heterogeneity is associated with macrophage accumulation and metalloproteinase activity. 01-03-2003
GOURABI B (2003). P1760 Local macrophage accumulation in atherosclerotic rabbit aortas as determined by a novel three-dimensional histology technique. 01-03-2003
KRAMS R (2003). P2242 Augmentation of wall shear stress inhibits neo intimal hyperplasia and inflammation after stent implantation. 01-03-2003
KRAMS R (2003). P2207 High shear stress is predictive for markers of plaque inflammation. 01-03-2003
Cheng C, van Haperen R, de Waard M, de Crom R and Krams R (2003). eNOS expression responds to changes in shear stress: Direct demonstration in a novel in vivo mouse model. 01-01-2003
Krams R, van Damme L, Tempel D, Gourabi BM and van der Steen AF (2003). Shear stress is associated with markers of plaque vulnerability. 01-01-2003
Wentzel JJ, Cheng C, de Crom R, Stergiopulos N, Serruys PW, Slager CJ and Krams R (2003). Shear stress and the IVUS derived vessel wall thickness. Vascular Ultrasound 148-164. 01-01-2003
Schaar JA, van der Steen AFW, Arampatzis CA, Krams R, Slager CJ, ten Have AG, van de Poll SW, Gijsen FJ, Wentzel JJ, de Feyter PJ and Serruys PW (2003). Diagnosis of vulnerable plaques in the cardiac catheterization laboratory. Vascular Ultrasound 220-234. 01-01-2003
Slager CJ, Wentzel JJ, Schuurbiers JCH, Oomen JAF, Gijsen FJH, Krams R, van der Giessen WJ, Serruys PW and de Feyter PJ (2003). Coronary 3-D angiography, 3-D ultrasound and their fusion. Vascular Ultrasound 121-147. 01-01-2003
2002
Thury A, van Langenhove G, Carlier SG, Albertal M, Kozuma K, Regar E, Sianos G, Wentzel JJ, Krams R, Slager CJ, Piek JJ, Serruys PW and Investigators D (2002). High shear stress after successful balloon angioplasty is associated with restenosis and target lesion revascularization. American Heart Journal, Elsevier vol. 144 (1), 136-143. 01-07-2002
Thury A, Wentzel JJ, Vinke RVH, Gijsen FJH, Schuurbiers JCH, Krams R, de Feyter PJ, Serruys PW and Slager CJ (2002). Focal In-Stent Restenosis Near Step-Up. Circulation, Wolters Kluwer vol. 105 (23), 185e-1187. 11-06-2002
Wentzel JJ, Janssen EH, Krams R, Schuurbiers JCH, van der Giessen WJ, Serruys PW, de Feyter PJ and Slager CJ (2002). Determination of shear stress in patients confirms that lumen preservation in atherosclerosis is associated with shear stress regulation. 01-03-2002
Trines SAIP, Smits CAG, van der Moer J, Slager CJ, Verdouw PD and Krams R (2002). Calcium Sensitizer EMD 57033, But Not the β 1 -Adrenoreceptor Agonist Dobutamine, Increases Mechanical Efficiency in Stunned Myocardium. Journal of Cardiovascular Pharmacology, Wolters Kluwer vol. 39 (1), 61-72. 01-01-2002
de Korte CL, Schaar JA, Mastik F, van Damme LCA, Krams R, Serruys PW and van der Steen AFW (2002). Vulnerable plaque detection with 3-dimensional palpography. 01-01-2002
Wentzel JJ, Janssen E, Vos J, Schuurbiers JCH, Krams R, Serruys PW, de Feyter PJ and Slager CJ (2002). The relationship between wall thickness and shear stress in coronary arteries of patients. 01-01-2002
Thury A, Wentzel JJ, Vinke RVH, Gijsen FJH, Schuurbiers JCH, Krams R, de Feyter PJ, Serruys PW and Slager CJ (2002). Focal in-stent restenosis near step-up - Roles of low and oscillating shear stress? CIRCULATION vol. 105 (23), E185-E187. 01-01-2002
Ie EHY, Krams R, Vletter WB, ten Cate FJ, Nette RW, Weimar W and Zietse R (2002). Reduced end-systolic elastance indicating poor left ventricular contractility in hemodialysis patients. 01-01-2002
2001
Thury A, Wentzel JJ, Schuurbiers JCH, Ligthart JMR, Krams R, de Feyter PJ, Serruys PW and Slager CJ (2001). Prominent Role of Tensile Stress in Propagation of a Dissection After Coronary Stenting. Circulation, Wolters Kluwer vol. 104 (11), e53-e54. 11-09-2001
Willemsen MJJMF, Duncker DJ, Krams R, Dijkman MA, Lamberts RR, Sipkema P and Westerhof N (2001). Decrease in coronary vascular volume in systole augments cardiac contraction. AJP Heart and Circulatory Physiology, American Physiological Society vol. 281 (2), h731-h737. 01-08-2001
Wentzel JJ, Kloet J, Andhyiswara I, Oomen JAF, Schuurbiers JCH, de Smet BJGL, Post MJ, de Kleijn D, Pasterkamp G, Borst C, Slager CJ and Krams R (2001). Shear-Stress and Wall-Stress Regulation of Vascular Remodeling After Balloon Angioplasty. Circulation, Wolters Kluwer vol. 104 (1), 91-96. 03-07-2001
Trines SAIP, Slager CJ, Onderwater TAM, Lamers JMJ, Verdouw PD and Krams R (2001). Oxygen wastage of stunned myocardium in vivo is due to an increased oxygen cost of contractility and a decreased myofibrillar efficiency. Cardiovascular Research, Oxford University Press (OUP) vol. 51 (1), 122-130. 01-07-2001
Wentzel JJ, Krams R, Schuurbiers JCH, Oomen JA, Kloet J, van der Giessen WJ, Serruys PW and Slager CJ (2001). Relationship Between Neointimal Thickness and Shear Stress After Wallstent Implantation in Human Coronary Arteries. Circulation, Wolters Kluwer vol. 103 (13), 1740-1745. 03-04-2001
Wolters B, Slager C, Gijsen F, Wentzel J, Krams R and van FDV (2001). On the Numerical Analysis of Coronary Artery Wall Shear Stress. Computers in Cardiology 2001. Vol.28 (Cat. No.01CH37287). 01-01-2001
Trines SAIP, Slager CJ, Onderwater TAM, Lamers JMJ, Verdouw PD and Krams R (2001). Oxygen wastage of stunned myocardium in vivo is due to an increased oxygen cost of contractility and a decreased myofibrillar efficiency. 01-01-2001
Carlier SG, van Damme LC, Blommerde CP, Van Langenhove G, Wentzel JJ, van der Giessen WJ, Verdouw PD, Krams R, Serruys PW and Slager C (2001). An increased wall shear stress inhibits neointimal hyperplasia after stent implantation: preliminary in vivo experience of the ARED flow divider in a rabbit model of restenosis. 01-01-2001
Krams R, van Damme LCA, Wentzel JJ, De Crom R, Haperen R and Van Aken T (2001). Functional assessment of eNOS transgenesis in mice aortas. 01-01-2001
Thury A, Wentzel JJ, Janssen EH, Krams R, Oomen JA, Schuurbiers JCH, Ligthart JMR, Serruys PW and Slager CJ (2001). Novel method for in vivo calculation of absolute sheer stress at any location of a stented human coronary artery. 01-01-2001
Thury A, van Langenhove G, Carlier SG, Albertal M, Kozuma K, Regar E, Wentzel JJ, Krams R, Slager CJ, Piek JJ and Serruys PW (2001). High shear stress after successful balloon angioplasty is associated with restenosis and target lesion revascularization. 01-01-2001
Willemsen MJJMF, Duncker DJ, Krams R, Dijkman MA, Lamberts RR, Sipkema P and Westerhof N (2001). Decrease in coronary vascular volume in systole augments cardiac contraction. American Journal of Physiology - Heart and Circulatory Physiology vol. 281 (2 50-2) 01-01-2001
2000
Wentzel JJ, Whelan DM, van der Giessen WJ, van Beusekom HMM, Andhyiswara I, Serruys PW, Slager CJ and Krams R (2000). Coronary stent implantation changes 3-D vessel geometry and 3-D shear stress distribution. Journal of Biomechanics, Elsevier vol. 33 (10), 1287-1295. 01-10-2000
de Zeeuw S, Trines SAIP, Krams R, Duncker DJ and Verdouw PD (2000). In vivo evidence that EMD 57033 restores myocardial responsiveness to intracoronary Ca2+ in stunned myocardium. European Journal of Pharmacology, Elsevier vol. 403 (1-2), 99-109. 01-09-2000
Trines SAIP, Slager CJ, Van der Moer J, Verdouw PD and Krams R (2000). Efficiency of energy transfer, but not external work, is maximized in stunned myocardium. AJP Heart and Circulatory Physiology, American Physiological Society vol. 279 (3), h1264-h1273. 01-09-2000
Slager CJ, Wentzel JJ, Schuurbiers JCH, Oomen JAF, Kloet J, Krams R, von Birgelen C, van der Giessen WJ, Serruys PW and de Feyter PJ (2000). True 3-Dimensional Reconstruction of Coronary Arteries in Patients by Fusion of Angiography and IVUS (ANGUS) and Its Quantitative Validation. Circulation, Wolters Kluwer vol. 102 (5), 511-516. 01-08-2000
Van Langenhove G, Wentzel JJ, Krams R, Slager CJ, Hamburger JN and Serruys PW (2000). Helical Velocity Patterns in a Human Coronary Artery. Circulation, Wolters Kluwer vol. 102 (3), e22-e24. 18-07-2000
De Zeeuw S, Trines SAIP, Krams R, Verdouw PD and Duncker DJ (2000). Cardiovascular profile of the calcium sensitizer EMD 57033 in open‐chest anaesthetized pigs with regionally stunned myocardium. British Journal of Pharmacology, Wiley vol. 129 (7), 1413-1422. 01-04-2000
Bom N, de Korte CL, Wentzel JJ, Krams R, Carlier SG, van der Steen AWF, Slager CJ and Roelandt JRTC (2000). Quantification of plaque volume, shear stress on the endothelium, and mechanical properties of the arterial wall with intravascular ultrasound imaging. Clinical Research in Cardiology, Springer Nature vol. 89 (Suppl 2), s105-s111. 01-02-2000
Willemsen MJJMF, Duncker DJ, Krams R, Dijkman MA, Sipkema P and Westerhof N (2000). Coronary systolic flow impediment is functional in cardiac contraction. 01-01-2000
Trines SAIP, Slager CJ, Van Der Moer J, Verdouw PD and Krams R (2000). Efficiency of energy transfer, but not external work, is maximized in stunned myocardium. American Journal of Physiology - Heart and Circulatory Physiology vol. 279 (3 48-3) 01-01-2000
1999
Soei LK, de Zeeuw S, Krams R, Duncker DJ and Verdouw PD (1999). Ca2+ sensitization and diastolic function of normal and stunned porcine myocardium. European Journal of Pharmacology, Elsevier vol. 386 (1), 55-67. 01-12-1999
Krams R, Wentzel JJ, Cespedes I, Vinke R, Carlier S, van der Steen AFW, Lancee CT and Slager CJ (1999). Effect of catheter placement on 3-D velocity profiles in curved tubes resembling the human coronary system. Ultrasound in Medicine & Biology, Elsevier vol. 25 (5), 803-810. 01-06-1999
Oomen JA, Trines SAIP, Vermeulen WB, Krams R, Schuurbiers JCH, Vletter WB, Roelandt JRTC and Slager CJ (1999). Towards assessment of regional wall stress of the left ventricle using 3D ultrasound imaging. Computers in Cardiology 1999. Vol.26 (Cat. No.99CH37004). 01-01-1999
Wentzel JJ, Kloet J, Krams R, Serruys PW and Slager CJ (1999). The relationship between neo intimal thickness and shear stress after wallstent implantation in human coronary arteries at 6 months follow up. 01-01-1999
Trines SA, Van der Moer J, Krams R, Slager CJ, Van Meegen JR and Verdouw PD (1999). External work recruitment can be restored in stunned myocardium without increasing oxygen consumption using EMD 57033, a calcium sensitizer. 01-01-1999
1998
Osterop APRM, Kofflard MJM, Sandkuijl LA, Cate FJT, Krams R, Schalekamp MADH and Danser AHJ (1998). AT1 Receptor A/C1166 Polymorphism Contributes to Cardiac Hypertrophy in Subjects With Hypertrophic Cardiomyopathy. Hypertension, Wolters Kluwer vol. 32 (5), 825-830. 01-11-1998
Krams R, Wentzel JJ, Oomen JA, Schuurbiers JC, Andhyiswara I, Kloet J, Post M, de Smet B, Borst C, Slager CJ and Serruys PW (1998). Shear stress in atherosclerosis, and vascular remodelling. Seminars in interventional cardiology vol. 3 (1), 39-44. 01-03-1998
van der Steen AFW, Rijsterborgh H, Lancée CT, Mastik F, Krams R, Roelandt JRT and Bom N (1998). Cyclic variation of integrated backscatter and wall thickness in stunned porcine myocardium. European Journal of Ultrasound, Elsevier vol. 7 01-02-1998
Krams R, Kofflard MJM, Duncker DJ, Von Birgelen C, Carlier S, Kliffen M, Cate FJT and Serruys PW (1998). Decreased Coronary Flow Reserve in Hypertrophic Cardiomyopathy Is Related to Remodeling of the Coronary Microcirculation. Circulation, Wolters Kluwer vol. 97 (3), 230-233. 27-01-1998
Osterop APRM, Kofflard MJM, Sandkuijl LA, Ten Cate FJ, Krams R, Schalekamp MADH and Danser AHJ (1998). AT01-01-1998
van der Steen AFW, Cespedes EI, de Korte CL, Carlier SG, Li W, Mastik F, Lancee CT, Borsbroom J, Lupotti F, Krams R, Serruys PW and Bom N (1998). Novel developments in intravascular imaging. 1998 IEEE Ultrasonics Symposium. Proceedings (Cat. No. 98CH36102). 01-01-1998
Stager CJ, Wentzel JJ, Schuurbiers JC, Oomen JA, Krams R, Achterberg H, Kloet J and deFeyter PJ (1998). True 3-D reconstruction of coronary arteries in patients shows accurate correspondence between x-ray and IVUS derived dimensions. 01-01-1998
1997
Krams R, Wentzel JJ, Oomen J, Schuurbier J, Vinke R and Slager CJ (1997). Evidence for a pivotal role of shear stress on the endothelium in human atherosclerosis. 01-12-1997
Dongsheng FA, Kie Soei LO, Stubenitsky R, Boersma E, Duncker DJ, Verdouw PD and Krams ROB (1997). Contribution of asynchrony and nonuniformity to mechanical interaction in normal and stunned myocardium. American Journal of Physiology - Heart and Circulatory Physiology vol. 42 (5) 01-12-1997
Fan D, Soei LK, Stubenitsky R, Boersma E, Duncker DJ, Verdouw PD and Krams R (1997). Contribution of asynchrony and nonuniformity to mechanical interaction in normal and stunned myocardium. American Journal of Physiology, American Physiological Society vol. 273 (5), h2146-h2154. 01-11-1997
Krams R, Wentzel JJ, Oomen JAF, Vinke R, Schuurbiers JCH, de Feyter PJ, Serruys PW and Slager CJ (1997). Evaluation of Endothelial Shear Stress and 3D Geometry as Factors Determining the Development of Atherosclerosis and Remodeling in Human Coronary Arteries in Vivo. Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 17 (10), 2061-2065. 01-10-1997
van Blankenstein JH, Slager CJ, Soei LK, Boersma H, Stijnen T, Schuurbiers JCH, Krams R, Lachmann B and Verdouw PD (1997). Cardiac depression after experimental air embolism in pigs: role of addition of a surface-active agent1. Cardiovascular Research, Oxford University Press (OUP) vol. 34 (3), 473-482. 01-06-1997
Slager CJ, Wentzel JJ, Oomen JA, Schuurbiers JC, Krams R, von Birgelen C, Tjon A, Serruys PW and de Feyter PJ (1997). True reconstruction of vessel geometry from combined X-ray angiographic and intracoronary ultrasound data. Seminars in interventional cardiology vol. 2 (1), 43-47. 01-03-1997
van der Steen AFW, Rijsterborgh H, Lancée CT, Mastik F, Krams R, Verdouw PD, Roelandt JRTC and Bom N (1997). Influence of data processing on cyclic variation of integrated backscatter and wall thickness in stunned porcine myocardium. Ultrasound in Medicine & Biology, Elsevier vol. 23 (3), 405-414. 01-01-1997
Wentzel JJ, Krams R, van der Steen AFW, Li W, Cespedes E, Bom N and Slager CJ (1997). Disturbance of 3D velocity profiles induced by an IVUS catheter: evaluation with computational fluid dynamics. Computers in Cardiology 1997. 01-01-1997
Wentzel JJ, Krams R, Oomen JAF, Schuurbiers JCH, Vinke R, Bom N and Slager CJ (1997). Applying computational fluid dynamics to a spatially correct 3D reconstruction of a coronary arterial segment in the individual patient. Proceedings of 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 01-01-1997
deZeeuw S, Soei L, vanMeegen JR, Trines SA, Krams R, Duncker DJ and Verdouw PD (1997). Recovery of systolic function of stunned myocardium by the Ca2+-sensitizer EMD 57033 is not accompanied by impairment of diastolic function. 01-01-1997
Wentzel JJ, Krams R, vanBeusekom HMN, Whelan DM, vanderGeissen WJ, Krabbendam SC, Andhyiswara I, Tjien ATJ, Schuurbiers JC, Oomen JA, Bom N and Slager CJ (1997). Stent implantation causes alterations in 3D-geometry and 3D-shear stress distribution at the endothelium of coronary arteries. 01-01-1997
Fan D, Soei LK, Stubenitsky R, Boersma E, Duncker DJ, Verdouw PD and Krams R (1997). Contribution of asynchrony and nonuniformity to mechanical interaction in normal and stunned myocardium. American Journal of Physiology - Heart and Circulatory Physiology vol. 273 (5 42-5) 01-01-1997
1996
Soei LK, Krams R, Duncker DJ and Verdouw PD (1996). The ca2+ sensmser emd 60263 only impairs diastolic function of stunned myocardium at high doses in anesthetized swine. 01-12-1996
Bezstarosti K, Soei LK, Krams R, Cate FJT, Verdouw PD and Lamers JMJ (1996). The effect of a thiadiazinone derived Ca2+ sensitizer on the responsiveness of Mg2+-ATPase to Ca2+ in myofibrils isolated from stunned and nonstunned porcine and human myocardium. Biochemical Pharmacology, Elsevier vol. 51 (9), 1211-1220. 01-05-1996
Rijsterborgh H, van der Steen AFW, Krams R, Mastik F, Lancee CT, Verdouw PD, Roelandt JRTC and Bom N (1996). The relationship between myocardial integrated backscatter, perfusion pressure and wall thickness during isovolumic contraction: An isolated pig heart study. Ultrasound in Medicine & Biology, Elsevier vol. 22 (1), 43-52. 01-01-1996
1995
Di Mario C, Gil R, Krams R, De Feyter PJ and Serruys W (1995). New invasive techniques of assessment of the physiological significance of coronary stenoses in humans. European Heart Journal, Oxford University Press (OUP) vol. 16 (suppl_I), 104-114. 01-08-1995
Wilson RA, Di Mario C, Krams R, Loe Kie Soei , Wenguang L, Laird AC, The SHK, Gussenhoven E, Verdouw P and Roelandt JRTC (1995). In Vivo Measurement of Regional Large Artery Compliance by Intravascular Ultrasound Under Pentobarbital Anesthesia. Angiology, SAGE Publications vol. 46 (6), 481-488. 01-06-1995
Fan D (1995). Mechanical efficiency of stunned myocardium is modulated by increased afterload dependency. Cardiovascular Research, Oxford University Press (OUP) vol. 29 (3), 428-437. 01-03-1995
Slager CJ, Laban M, von Birgelen C, Krams R, Oomen JAF, Boer AD, Wenguang L, de Feyter PJ, Serruys PW and Roelandt JRTC (1995). 734-6 ANGUS: A New Approach to Three-dimensional Reconstruction of Geometry and Orientation of Coronary Lumen and Plaque by Combined Use of Coronary Angiography and IVUS. Journal of the American College of Cardiology, Elsevier vol. 25 (2) 01-02-1995
Laban M, Oomen JA, Slager CJ, Wentzel JJ, Krams R, Schuurbiers JCH, Beer AD, von Birgelen C, Serruys PW and de Feijter PJ (1995). ANGUS: a new approach to three-dimensional reconstruction of coronary vessels by combined use of angiography and intravascular ultrasound. Computers in Cardiology 1995. 01-01-1995
VONBIRGELEN C, KRAMS R, DIMARIO C, GIL R, KOFFLARD M, TENCATE FJ, REIMERS B, SLAGER CJ, ROELANDT J and SERRUYS PW (1995). SYSTEMATIC STUDY OF FLOW VELOCITY PROFILES IN EPICARDIAL CORONARY-ARTERIES OF PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY AND SUBAORTIC OUTFLOW GRADIENT. 01-01-1995
VONBIRGELEN C, KRAMS R, GIL R, TENGATE FJ and DIMARIO C (1995). HOW SHOULD WE EVALUATE THE VASODILATORY CAPACITY OF CORONARY RESISTANCE VESSELS IN PATIENTS WITH ASYMMETRIC HYPERTROPHIC CARDIOMYOPATHY. 01-01-1995
1994
Krams R, Janssen M, Van der Lee C, Van Meegen J, De Jong JW, Slager CJ and Verdouw PD (1994). Loss of elastic recoil in postischemic myocardium induces rightward shift of the systolic pressure-volume relationship. American Journal of Physiology, American Physiological Society vol. 267 (4), h1557-h1564. 01-10-1994
Di Mario C, Krams R, Gil R and Serruys PW (1994). Slope of the instantaneous hyperemic diastolic coronary flow velocity-pressure relation. A new index for assessment of the physiological significance of coronary stenosis in humans. Circulation, Wolters Kluwer vol. 90 (3), 1215-1224. 01-09-1994
Fan D, Soei LK, Sassen LM, Krams R and Verdouw PD (1994). Mechanical efficiency of stunned myocardium is modulated by increased afterload dependency. Cardiovascular Research vol. 28 (9), 428-437. 01-09-1994
Soei LK, Sassen LM, Fan DS, van Veen T, Krams R and Verdouw PD (1994). Myofibrillar Ca2+ sensitization predominantly enhances function and mechanical efficiency of stunned myocardium. Circulation, Wolters Kluwer vol. 90 (2), 959-969. 01-08-1994
FAN D, SOEI LK, SASSEN LMA, KRAMS R, HENDRIK E and VERDOUW PD (1994). On the Reversal of Myocardial Stunning: A Role for Ca2+‐Sensitizers. Annals of the New York Academy of Sciences, Wiley vol. 723 (1), 364-367. 01-06-1994
Fan D, Kie Soei L, Sassen LMA, Krams R, Hendrik E and Verdouw PD (1994). On the Reversal of Myocardial Stunning: A Role for Ca2+-Sensitizers. Ann N Y Acad Sci vol. 723 (1), 364-367. 01-06-1994
Krams R, Janssen M, Van der Lee C, Van Meegen J, De Jong JW, Slager CJ and Verdouw PD (1994). Loss of elastic recoil in postischemic myocardium induces rightward shift of the systolic pressure-volume relationship. American Journal of Physiology - Heart and Circulatory Physiology vol. 267 (4 36-4) 01-01-1994
Fan D, Sassen LMA, Trines SAIP, Soei LK, Krams R and Verdouw PD (1994). Increasing the Ca++ sensitivity reverses the increased afterload dependency of external work and the efficiency of energy conversion of stunned myocardium. Applied Cardiopulmonary Pathophysiology vol. 5 (2), 63-72. 01-01-1994
KRAMS R, JANSSEN M, VANDERLEE C, VANMEEGEN J, DEJONG JW, SLAGER CJ and VERDOUW PD (1994). LOSS OF ELASTIC RECOIL IN POSTISCHEMIC MYOCARDIUM INDUCES RIGHTWARD SHIFT OF THE SYSTOLIC PRESSURE-VOLUME RELATIONSHIP. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY vol. 267 (4), H1557-H1564. 01-01-1994
FAN DS, KRAMS R, SOEI LK, SASSEN LMA and VERDOUW PD (1994). REVERSAL OF INCREASED LOAD-DEPENDENCY OF EFFICIENCY OF ENERGY-CONVERSION IN STUNNED MYOCARDIUM BY INCREASING THE CA2+ SENSITIVITY. 01-01-1994
FAN DS, KRAMS R, SOEI LK, SASSEN LMA and VERDOUW PD (1994). VARIABILITY IN OXYGEN-CONSUMPTION MEASUREMENTS DURING MYOCARDIAL STUNNING CAN BE EXPLAINED BY A PRONOUNCED AFTERLOAD DEPENDENCY OF SEGMENT LENGTH SHORTENING, EXTERNAL WORK AND MECHANICAL EFFICIENCY. 01-01-1994
Di Mario C, Krams R, Gil R, Meneveau N and Serruys PW (1994). The instantaneous hyperemic pressure-flow relationship in conscious humans. Progress in quantitative coronary arteriography 247-268. 01-01-1994
1993
Krams R, Soei LK, McFalls EO, Prins EAW, Sassen LM and Verdouw PD (1993). End-systolic pressure length relations of stunned right and left ventricles after inotropic stimulation. American Journal of Physiology, American Physiological Society vol. 265 (6), h2099-h2109. 01-12-1993
Koning MMG, Krams R, Xiao CS, van Meegen JR, Bezstarosti K, Lamers JMJ and Verdouw PD (1993). Intracoronary trimetazidine does not improve recovery of regional function in a porcine model of repeated ischemia. Cardiovascular Drugs and Therapy, Springer Nature vol. 7 (5), 801-807. 01-11-1993
Duncker DJ, Sassen LMA, Bartels GL, van Meegen JR, McFalls EO, Krams R, Bezstarosti K, Lamers JMJ and Verdouw PD (1993). L-Propionylcarnitine Does Not Affect Myocardial Metabolic or Functional Response to Chronotropic and Inotropic Stimulation After Repetitive Ischemia in Anesthetized Pigs. Journal of Cardiovascular Pharmacology, Wolters Kluwer vol. 22 (3), 488-498. 01-09-1993
Krams R, Duncker DJ, McFalls EO, Hogendoorn A and Verdouw PD (1993). Dobutamine restores the reduced efficiency of energy transfer from total mechanical work to external mechanical work in stunned porcine myocardium. Cardiovascular Research, Oxford University Press (OUP) vol. 27 (5), 740-747. 01-05-1993
McFalls EO, Duncker DJ, Sassen LM, Krams R, Man in't Veld AJ, Ruffolo RR and Verdouw PD (1993). Altered coronary flow reserve in the hypertrophied heart: implications for therapy. Journal of Human Hypertension vol. 7 Suppl 1, s29-s36. 01-02-1993
KRAMS R, SOEI LK, MCFALLS EO, PRINS EAW, SASSEN LMA and VERDOUW PD (1993). END-SYSTOLIC PRESSURE LENGTH RELATIONS OF STUNNED RIGHT-AND-LEFT-VENTRICLES AFTER INOTROPIC STIMULATION. AMERICAN JOURNAL OF PHYSIOLOGY vol. 265 (6), H2099-H2109. 01-01-1993
Krams R, Duncker DJ, McFalls EO, Hogendoorn A and Verdouw PD (1993). Dobutamine restores the reduced efficiency of energy transfer from total mechanical work to external mechanical work in stunned porcine myocardium. Cardiovascular Research vol. 27 (5), 740-747. 01-01-1993
Bruining N, Krams R, Passchier H, Meij S, de Feijter P and Keane D (1993). A modular hard and software system for the analysis of cardiac signals: application to real time pressure-volume loops. Proceedings of Computers in Cardiology Conference. 01-01-1993
DIMARIO C, KRAMS R, BALK A, VERDOUW PD and ROELANDT J (1993). CAN THE ZERO-FLOW PRESSURE BE EXTRAPOLATED FROM THE FLOW VELOCITY-PRESSURE RELATION DURING LONG DIASTOLIC PAUSES IN HUMANS. 01-01-1993
Krams R, Loe Kie Soei , McFalls EO, Prins EAW, Sassen LMA and Verdouw PD (1993). End-systolic pressure length relations of stunned right and left ventricles after inotropic stimulation. American Journal of Physiology - Heart and Circulatory Physiology vol. 265 (6 34-6) 01-01-1993
De Jong JW, Huizer T, Janssen M, Krams R, Tavenier M and Verdouw PD (1993). High-energy phosphates and their catabolites. Ischemia-reperfusion in cardiac surgery 295-315. 01-01-1993
1992
McFalls EO, Duncker DJ, Krams R, Sassen LM, Hoogendoorn A and Verdouw PD (1992). Recruitment of myocardial work and metabolism in regionally stunned porcine myocardium. American Journal of Physiology, American Physiological Society vol. 263 (6), h1724-h1731. 01-12-1992
Sassen LMA, Duncker DJ, Hogendoorn A, McFalls EO, Krams R, Bezstarosti K, Lamers JMJ and Verdouw PD (1992). L-propionylcarnitine and myocardial performance in stunned porcine myocardium. Molecular and Cellular Biochemistry, Springer Nature vol. 116 (1-2), 147-153. 01-10-1992
Duncker DJ, McFalls EO, Krams R and Verdouw PD (1992). Pressure-maximal coronary flow relationship in regionally stunned porcine myocardium. American Journal of Physiology, American Physiological Society vol. 262 (6), h1744-h1751. 01-06-1992
Verdouw PD, Krams R, McFalls EO, Duncker DJ, Hogendoorn A and Kie Soei L (1992). Amiodarone increases ATP and decreases NaK ATPase activity and protein content of cultured rat heart myocytes. Journal of Molecular and Cellular Cardiology, Elsevier vol. 24 01-05-1992
Verdouw PD, Krams R, McFalls EO, Duncker DJ, Hogendoorn A and Soei LK (1992). Inotropic stimulation restores efficiency of energy transfer from pressure-segment length area to external mechanical work in stunned porcine myocardium. Journal of Molecular and Cellular Cardiology, Elsevier vol. 24 01-05-1992
McFalls EO, Duncker DJ, Krams R, Sassen LMA, Hoogendoorn A and Verdouw PD (1992). Recruitment of myocardial work and metabolism in regionally stunned porcine myocardium. American Journal of Physiology - Heart and Circulatory Physiology vol. 263 (6 32-6) 01-01-1992
DUNCKER DJ, MCFALLS EO, KRAMS R and VERDOUW PD (1992). PRESSURE-MAXIMAL CORONARY FLOW RELATIONSHIP IN REGIONALLY STUNNED PORCINE MYOCARDIUM. AMERICAN JOURNAL OF PHYSIOLOGY vol. 262 (6), H1744-H1751. 01-01-1992
Duncker DJ, McFalls EO, Krams R and Verdouw PD (1992). Pressure-maximal coronary flow relationship in regionally stunned porcine myocardium. American Journal of Physiology - Heart and Circulatory Physiology vol. 262 (6 31-6) 01-01-1992
MCFALLS EO, DUNCKER DJ, KRAMS R, SASSEN LMA, HOOGENDOORN A and VERDOUW PD (1992). RECRUITMENT OF MYOCARDIAL WORK AND METABOLISM IN REGIONALLY STUNNED PORCINE MYOCARDIUM. AMERICAN JOURNAL OF PHYSIOLOGY vol. 263 (6), H1724-H1731. 01-01-1992
MCFALLS EO, KRAMS R, DUNCKER DJ, SASSEN LMA, HOOGENDOORN A and VERDOUW PD (1992). RECRUITMENT OF REGIONAL EXTERNAL WORK AND OXYGEN-CONSUMPTION IN STUNNED PORCINE MYOCARDIUM. 01-01-1992
Sassen LMA, Duncker DJ, Hogendoorn A, McFalls EO, Krams R, Bezstarosti K, Lamers JMJ and Verdouw PD (1992). L-propionylcarnitine and myocardial performance in stunned porcine myocardium. Lipid Metabolism in the Healthy and Disease Heart 147-153. 01-01-1992
1991
McFalls EO, Duncker DJ, Krams R, Ward H, Gornick C and Verdouw PD (1991). Endothelium dependent vasodilatation following brief ischaemia and reperfusion in anaesthetised swine. Cardiovascular Research, Oxford University Press (OUP) vol. 25 (8), 659-665. 01-08-1991
Krams R, Duncker DJ, McFalls EO and Verdouw PD (1991). Changes in oxygen-pressure volume area's (O2-PVA) studied after brief periods of ischemia. Journal of Molecular and Cellular Cardiology, Elsevier vol. 23 01-07-1991
Krams R, Duncker DJ, McFalls EO and Verdouw PD (1991). Elastic recoil: A sensitive measure of loss of function during brief periods of ischemia and reperfusion. Journal of Molecular and Cellular Cardiology, Elsevier vol. 23 01-07-1991
Krams R, McFalls E, van der Giessen WJ, Serruys PW, Verdoun PD and Roelandt J (1991). Does intravenous milrinone have a direct effect on diastolic function? Am Heart J vol. 121 (6 Pt 2), 1951-1955. 01-06-1991
Mcfalls EO, Duncker DJ, Krams R, Ward H, Gornick C and Verdouw PD (1991). Endothelium dependent vasodilatation following brief ischaemia and reperfusion in anaesthetised swine. Cardiovascular Research vol. 25 (8), 659-665. 01-01-1991
KRAMS R, MCFALLS E, VANDERGIESSEN WJ, SERRUYS PW and ROELANDT J (1991). THE EFFECT OF MILRINONE ON DIASTOLIC FUNCTION - DIRECT OR INDIRECT EFFECT. 01-01-1991
1990
Resar J, Livingston JZ, Halperin HR, Sipkema P, Krams R and Yin FC (1990). Effect of wall stretch on coronary hemodynamics in isolated canine interventricular septum. American Journal of Physiology, American Physiological Society vol. 259 (6), h1869-h1880. 01-12-1990
Westerhof N, Sipkema P and Krams R (1990). Myocardial modulation of coronary circulation Reply). American Journal of Physiology - Heart and Circulatory Physiology vol. 259 (6 28-6) 01-12-1990
Krams R, Sipkema P and Westerhof N (1990). Coronary oscillatory flow amplitude is more affected by perfusion pressure than ventricular pressure. American Journal of Physiology, American Physiological Society vol. 258 (6), h1889-h1898. 01-06-1990
WESTERHOF N, SIPKEMA P and KRAMS R (1990). MYOCARDIAL MODULATION OF CORONARY CIRCULATION - REPLY. AMERICAN JOURNAL OF PHYSIOLOGY vol. 259 (6), H1936-H1937. 01-01-1990
RESAR J, LIVINGSTON JZ, HALPERIN HR, SIPKEMA P, KRAMS R and YIN FCP (1990). EFFECT OF WALL STRETCH ON CORONARY HEMODYNAMICS IN ISOLATED CANINE INTERVENTRICULAR SEPTUM. AMERICAN JOURNAL OF PHYSIOLOGY vol. 259 (6), H1869-H1880. 01-01-1990
Resar J, Livingston JZ, Halperin HR, Sipkema P, Krams R and Yin FCP (1990). Effect of wall stretch on coronary hemodynamics in isolated canine interventricular septum. American Journal of Physiology - Heart and Circulatory Physiology vol. 259 (6 28-6) 01-01-1990
Krams R, Sipkema P and Westerhof N (1990). Coronary oscillatory flow amplitude is more affected by perfusion pressure than ventricular pressure. American Journal of Physiology - Heart and Circulatory Physiology vol. 258 (6 27-6) 01-01-1990
KRAMS R, SIPKEMA P and WESTERHOF N (1990). CORONARY OSCILLATORY FLOW AMPLITUDE IS MORE AFFECTED BY PERFUSION-PRESSURE THAN VENTRICULAR PRESSURE. AMERICAN JOURNAL OF PHYSIOLOGY vol. 258 (6), H1889-H1898. 01-01-1990
1989
Krams R, Sipkema P, Zegers J and Westerhof N (1989). Contractility is the main determinant of coronary systolic flow impediment. American Journal of Physiology - Heart and Circulatory Physiology vol. 257 (6) 01-12-1989
Krams R, Sipkema P and Westerhof N (1989). Varying elastance concept may explain coronary systolic flow impediment. American Journal of Physiology, American Physiological Society vol. 257 (5), h1471-h1479. 01-11-1989
Krams R, Sipkema P and Westerhof N (1989). Varying elastance concept may explain coronary systolic flow impediment. Am J Physiol vol. 257 (5 Pt 2), H1471-H1479. 01-11-1989
Krams R, van Haelst ACTA, Sipkema P and Westerhof N (1989). Can coronary systolic-diastolic flow differences be predicted by left ventricular pressure or time-varying intramyocardial elastance? Basic Research in Cardiology, Springer Nature vol. 84 (2), 149-159. 01-03-1989
1988
Van Dijk LC, Krams R, Sipkema P and Westerhof N (1988). Changes in coronary pressure-flow relation after transition from blood to Tyrode perfusion. American Journal of Physiology, American Physiological Society vol. 255 (3), h476-h482. 01-09-1988
YIN F, SIPKEMA P, KRAMS R, STRUMPF R and RESAR J (1988). EFFECTS OF STRETCH ON THE PRESSURE-FLOW RELATION OF THE ISOLATED ARRESTED DOG SEPTUM. 01-01-1988
Van Dijk LC, Krams R, Sipkema P and Westerhof N (1988). Changes in coronary pressure-flow relation after transition from blood to Tyrode perfusion. American Journal of Physiology - Heart and Circulatory Physiology vol. 255 (3) 01-01-1988
SIPKEMA P, KRAMS R and WESTERHOF N (1988). SYSTOLIC CORONARY FLOW IMPEDIMENT EXPLAINED ON BASIS OF THE TIME-VARYING ELASTANCE CONCEPT. 01-01-1988
1986
Westerhof N and Krams R (1986). Comments on Pressure and tone dependence of coronary diastolic input impedance and capacitance. American Journal of Physiology, American Physiological Society vol. 250 (2), h330-h331. 01-02-1986
Westerhof N and Krams R (1986). Comments on Pressure and tone dependence of coronary diastolic input impedance and capacitance. Am J Physiol vol. 250 (2 Pt 2), H330-H331. 01-02-1986
Westerhof N, Krams R and Canty JM (1986). Comments on 'pressure and tone dependence of coronary diastolic input impedance and capacitance'. American Journal of Physiology - Heart and Circulatory Physiology vol. 250 (2 (19/2)) 01-01-1986
1985
KRAMS R, SIPKEMA P and WESTERHOF N (1985). DOES LEFT-VENTRICULAR PRESSURE INFLUENCE THE CORONARY PRESSURE-FLOW RELATION IN THE CAT. 01-01-1985
1984
Sipkema P, Burattini R, van Haelst ACTA, Krams R and Westerhof N (1984). EFFECTS OF CARDIAC CONTRACTION ON CORONARY FLOW. 01-12-1984
Borgdorff P, Braakman R, van Haelst AC, van Huis GA, de Jong JP, Krams R, Langewouters GJ, Sipkema P and Westerhof N (1984). Consistent parallel relationships among myocardial oxygen consumption, coronary blood flow, and pericardial infusate adenosine concentration with various interventions and beta-blockade in the dog. Circulation Research, Wolters Kluwer vol. 54 (3), 348-348. 01-03-1984
Westerhof N, Krams R, Van Haelst ACTA and Sipkema P (1984). Can left ventricular pressure explain coronary flow impediment? 01-01-1984
1982
BRAAKMAN R, VANDERHORN GJ, VONHUIS GA, KRAMS R, LANGEWOUTERS GJ, SIPKEMA P and WESTERHOF N (1982). THE EFFECTS OF THE CORONARY CAPACITANCE ON THE INTERPRETATION OF DIASTOLIC PRESSURE-FLOW RELATIONSHIPS - COMMENTS. CIRCULATION RESEARCH vol. 51 (6), 822-822. 01-01-1982
Grants
Grants of specific relevance to the Centre for BioengineeringG1F1Application of a new high throughput platform for validation of mechanosensitive miRNARob Krams and Gleb Sukhorukov
£117,986 BHF British Heart Foundation (01-09-2023 - 31-08-2026)
Inorganic nitrate treatment reduces inflammation in humans: assessment of mechanismsAmrita Ahluwalia, Rob Krams, Federica Marelli-Berg and Jacqueline Cooper
£206,297 BHF British Heart Foundation (19-08-2019 - 18-02-2022)