Reader in Regenerative Medicine
EDI & Athena Swan Lead, Intercalated Programme Director
Regenerative medicine, Mechanobiology, Biomechanics
Publications of specific relevance to the Centre for Bioengineering
A call to standardize the nomenclature of human fetal membrane at the feto-maternal interfaceRole of Myofibroblasts in the Repair of Iatrogenic Preterm Membranes Subjected to Mechanical StimulationCx43 regulates mechanotransduction mechanisms in human preterm amniotic membrane defectsMachine learning and disease prediction in obstetricsCx43 mediates changes in myofibroblast contraction and collagen release in human amniotic membrane defects after traumaThe Mechanical Interplay Between Differentiating Mesenchymal Stem Cells and Gelatin-Based Substrates Measured by Atomic Force MicroscopyPotential sealing and repair of human FM defects after trauma with peptide amphiphiles and Cx43 antisenseMulticomponent hydrogels for the formation of vascularized bone-like constructs in vitroMicrowave Frequency Dependent Dielectric Properties of Blood as a Potential Technique to Measure HydrationMagnetically responsive layer-by-layer microcapsules can be retained in cells and under flow conditions to promote local drug release without triggering ROS productionStrategies to Repair Defects in the Fetal MembraneTargeting mechanotransduction mechanisms and tissue weakening signals in the human amniotic membraneCorrigendum for Engels, Joyeux, Van der Merwe, et al. (2017) DOI: 10.1002/pd.5191Tissuepatch is biocompatible and seals iatrogenic membrane defects in a rabbit modelTrauma induces overexpression of Cx43 in human fetal membrane defectsConnexin 43 is overexpressed in human fetal membrane defects after fetoscopic surgeryOxygen tension modulates the effects of TNFα in compressed chondrocytesVergleich von konventionellem Kollagen vs. modifiziertem Kollagen zum Verschluss eines iatrogenen Blasensprungs im Kaninchen-ModellImaging modalities for the in vivo surveillance of mesenchymal stromal cells.C-type natriuretic peptide signalling drives homeostatic effects in human chondrocytesPolyelectrolyte microencapsules loaded with C-type natriuretic peptide protect cartilage from IL-1B induced damageControlled Release of C‑Type Natriuretic Peptide by Microencapsulation Dampens Proinflammatory Effects Induced by IL-1β in Cartilage ExplantsRole of C-type natriuretic peptide signalling in maintaining cartilage and bone functionRole of C-type natriuretic peptide signaling in maintaining cartilage and bone function.Imaging modalities for the in vivo surveillance of mesenchymal stromal cellsPFM.37 Cyclic tensile strain increases PGE2 release leading to weakening of the human term amniotic membraneα5β1 integrin mediates compression-induced inhibition of catabolic effects induced by fibronectin fragments in an oxygen-dependent mannerLow oxygen tension increased FN-f induced catabolic activities - response prevented with biomechanical signalsNatriuretic peptide receptors regulate cytoprotective effects in a human ex vivo 3D/bioreactor modelOptimisation of quantitative real-time PCR studies in cartilage mechanobiologyFN-f induced catabolic activities are dependent on oxygen tension in chondrocyte/agarose constructs subjected to biomechanical signalsBiological vascular grafts for hemodialysis access.Optimization of Quantitative Real-Time PCR for Studies in Cartilage MechanobiologyBiomechanical conditioning enhanced matrix synthesis in nucleus pulposus cells cultured in agarase constructs with TGFβMECHANICAL SIGNALS MODULATE THE C-TYPE NATRIURETIC PEPTIDE RECEPTORS VIA CGMP AND PKG DEPENDENT PATHWAYSBiomechanical signals and the C-type natriuretic peptide counteract catabolic activities induced by IL-1β in chondrocyte/agarose constructsBiomechanical influence of cartilage homeostasis in health and disease.Quantification of mRNA using real-time PCR and Western blot analysis of MAPK events in chondrocyte/agarose constructs.BIOMECHANICAL MODULATION OF COLLAGEN FRAGMENT INDUCED ANABOLIC AND CATABOLIC ACTIVITIES IN CHONDROCYTE/AGAROSE CONSTRUCTSBiomechanical modulation of collagen fragment-induced anabolic and catabolic activities in chondrocyte/agarose constructsMechanical loading modulates chondrocyte primary cilia incidence and lengthDynamic compression alters NFκB activation and IκB-α expression in IL-1β-stimulated chondrocyte/agarose constructsQuantification of glucose and cytosine hydrochloride by THz-TDS458 DYNAMIC COMPRESSION ALTERS NF?B ACTIVATION AND I?B-α EXPRESSION IN IL-1β STIMULATED CHONDROCYTE/AGAROSE CONSTRUCTSDynamic compression inhibits fibronectin fragment induced iNOS and COX-2 expression in chondrocyte/agarose constructs451 DYNAMIC COMPRESSION COUNTERACTS FIBRONECTIN-FRAGMENT INDUCED INOS AND COX-2 EXPRESSION IN CHONDROCYTE/AGAROSE CONSTRUCTSSignal transduction pathways involving p38 MAPK, JNK, NF kappa B and AP-1 influences the response of chondrocytes cultured in agarose constructs to IL-1 beta and dynamic compressionDynamic compression influences IL-1β induced NO and PGE2 release, via alterations in iNOS and COX-2 activityDynamic compression counteracts IL-1beta induced inducible nitric oxide synthase and cyclo-oxygenase-2 expression in chondrocyte/agarose constructs.Dynamic compression influences interleukin-1 beta-induced nitric oxide and prostaglandin E-2 release by articular chondrocytes via alterations in iNOS and COX-2 expression52 REAL-TIME PCR USING MOLECULAR BEACONS TO DETECT INOS AND COX-2 EXPRESSION IN CHONDROCYTE/AGAROSE CONSTRUCTS SUBJECTED TO IL-1β AND DYNAMIC COMPRESSIONLoading alters actin dynamics and up-regulates cofilin gene expression in chondrocytesDynamic compression counteracts IL-1 beta b induced iNOS and COX-2 expression in chondrocytes cultured in agarose constructsPurinergic pathway suppresses the release of NO and stimulates proteoglycan synthesis in chondrocyte/agarose constructs subjected to dynamic compressionIntegrin-mediated mechanotransduction in IL-1 beta stimulated chondrocytes.Anti-inflammatory effects of IL-4 and dynamic compression in IL-1beta stimulated chondrocytes.Dynamic compression counteracts IL-1β induced iNOS and COX-2 activity by human chondrocytes cultured in agarose constructsMechanical Compression Reduces Chondrocyte Primary Cilia Expression In VitroDynamic compression counteracts IL-1beta induced iNOS and COX-2 activity by human chondrocytes cultured in agarose constructs.P140 DYNAMIC COMPRESSION COUNTERACTS FIBRONECTIN FRAGMENT INDUCED UPREGULATION OF NITRIC OXIDEDynamic compression counteracts IL-1-induced iNOS and COX-2 activity by human chondrocytes cultured in agarose constructsIntegrin mediated mechanotransduction in IL-1 stimulated bovine chondrocytes cultured in agarose constructsDynamic compression counteracts IL-1β induced INOS and COX-2 activity by human chondrocytes cultured in agarose constructsDynamic compression influences the biochemical response of human mesenchymal stem cells cultured in agarose constructsDynamic compression counteracts IL-1 beta-induced iNOS and COX-2 activity in human chondrocytes cultured in agarose constructsIntegrin-mediated mechanotransduction in IL-1 beta-stimulated chondrocytesBritish Society for Matrix Biology Autumn Meeting Joint with the UK Tissue & Cell Engineering Society, University of Bristol, UKIntegrin-mediated mechanotransduction processes in TGFbeta-stimulated monolayer-expanded chondrocytes.Crosslinking density influences chondrocyte metabolism in dynamically loaded photocrosslinked poly(ethylene glycol) hydrogels.Dynamic compression counteracts IL-1 beta-induced iNOS and COX-2 activity in human chondrocytes cultured in agarose constructsIntegrin-mediated mechanotransduction in IL-1β stimulated chondrocytesalpha 5 beta 1 integrin mediates mechanotransduction processes in TGF-beta stimulated human chondrocytes seeded in agarose constructs and subjected to dynamic compression.Combined anti-inflammatory effects of IL-4 and dynamic compression in IL-1beta stimulated bovine chondrocytes cultured in agarose constructs.Temporal regulation of chondrocyte metabolism in agarose constructs subjected to dynamic compression.Dynamic compression counteracts IL-1 beta-induced release of nitric oxide and PGE2 by superficial zone chondrocytes cultured in agarose constructs.alpha5beta1 integrin mediates mechanotransduction processes in TGFbeta3-stimulated human chondrocytes seeded in agarose constructs and subjected to dynamic compression.alpha5beta1 integrin mediates mechanotransduction processes in TGFbeta-stimulated human chondrocyte / agarose constructs and subjected to dynamic compression.Control of mechanotrasduction processes in dynamically stimulated human and bovine chondrocytes cultured in agarose constructs.An in vitro investigation of cartilage mechanotransductionDynamic compression inhibits the synthesis of nitric oxide and PGE(2) by IL-1beta-stimulated chondrocytes cultured in agarose constructs.Dynamic compression influences the synthesis of nitric oxide by IL-1beta stimulated chondrocyte sub-populations cultured in agarose constructs.Dynamic compression inhibits the synthesis of nitric oxide by IL-1β stimulated chondrocytes cultured in agarose constructsTensile strain increased COX-2 expression and PGE2 release leading to weakening of the human amniotic membraneGrants of specific relevance to the Centre for BioengineeringVagina microbiome organ chip for testing of biotherapeutics to treat BVThe power of AI to transform women?s careers - towards an equal futureCOacT Feasibility of the CallaVid Platform for the Delivery of Live Biotherapeutics for the Restoration of the Vaginal MicrobiomeMechanisms underlying preterm birth in women with HIV in rural ZimbabweExtreme heat and preterm birth in rural ZimbabweTommy’s National Preterm Birth Research CentreEngineering the fetal membranesEngineer the storyEngineering the fetal membranes with bioinspired materials- linked to WT 560845Healing the Fetal Membranes after Latrogenic PPROMCASE Studentship: Wesleigh DawsmithUK Preterm Birth Conference 2027 hosted at Queen Mary University of London from 18 and 19 January 2027. Sarah Brown, global health campaigner and Chair of the international children's charity Theirworld, will give a plenary address with Professor James Boardman, Scientific Director of the Jennifer Brown Research Laboratory, at the UK Preterm Birth Conference 2027, ... [more]
