Prof Conrad Bessant
Professor of Bioinformatics
School of Biological and Behavioural Sciences
Queen Mary University of London
Queen Mary University of London
Research
data science, computational biology, bioinformatics, artificial intelligence, drug discovery
Interests
Conrad Bessant has ~25 years’ experience of data science, tackling research questions in analytical chemistry, biomolecular science, and qualitative healthcare studies.His overarching research interest is the automation of scientific discovery in the biomedical domain. While some aspects of biomedical research such as data acquisition and routine analysis are already commonly automated, fundamental research activities such as hypothesis generation, identification of relevant datasets and interpretation of results still require extensive input from human experts. This is becoming increasingly intractable as available datasets grow in size and complexity – innovative solutions to automate the process are needed.
Technologies being used by Conrad’s research group to automate the scientific discovery process include machine learning, relational modelling, network science and Bayesian inference.
Conrad is based in QMUL’s Digital Environment Research Institute. He leads QMUL’s MSc Bioinformatics programme and is the academic lead of the UKRI AI for Drug Discovery Doctoral Training Programme.
Publications
2023
Branson N, Cutillas PR and Bessant C (2023). Comparison of multiple modalities for drug response prediction with learning curves using neural networks and XGBoost. Bioinformatics Advances, Oxford University Press (OUP) vol. 4 (1) 23-12-2023
Saihi H, Bessant C and Alazawi W (2023). Automated and reproducible cell identification in mass cytometry using neural networks. Briefings in Bioinformatics, Oxford University Press 02-11-2023
Elder GA and Bessant C (2023). Inferring Compensatory Kinase Networks in Yeast using Prolog. Electronic Proceedings in Theoretical Computer Science, Open Publishing Association vol. 385, 260-273. 12-09-2023
De Los Angeles Colomina Basanta C, Bazzi M, Hijazi M, Bessant C and Cutillas PR (2023). Community detection in empirical kinase networks identifies new potential members of signalling pathways. PLOS Computational Biology, Public Library of Science (PLoS) vol. 19 (6) 23-06-2023
Bessant C, Abdollahyan M and Smeraldi F (2023). CO51 Understanding the Lived Experience of Patients By Mining Online Health Boards. Value in Health, Elsevier vol. 26 (6), s23-s24. 01-06-2023
Byrom B, Bessant C, Smeraldi F, Abdollahyan M, Bridges Y, Chowdhury M and Tahsin A (2023). Deriving Meaningful Aspects of Health Related to Physical Activity in Chronic Disease: Concept Elicitation Using Machine Learning–Assisted Coding of Online Patient Conversations. Value in Health, Elsevier vol. 26 (7), 1057-1066. 16-02-2023
2022
Bessant C, Bridges Y, Chowdhury M, Tahsin A, Abdollahyan M, Smeraldi F and Byrom B (2022). PCR3 Assessing Concept Saturation and Sample Representativeness When Using Social Media Data to Inform Concept Elicitation Studies. Value in Health, Elsevier vol. 25 (12) 01-12-2022
Waller KJ, Saihi H, Li W, Brindley JH, De Jong A, Syn W-K, Bessant C and Alazawi W (2022). Single-cell phenotypes of peripheral blood immune cells in early and late stages of non-alcoholic fatty liver disease. Clinical and Molecular Hepatology, The Korean Association for the Study of the Liver vol. 29 (2), 417-432. 21-11-2022
Bridges Y, Chowdhury M, Tahsin A, Bessant C, Abdollahyan M, Smeraldi F and Byrom B (2022). POSB338 Identification of Meaningful Aspects of Physical Activity: Concept Elicitation By AI-Assisted Coding of Online Patient Conversations. Value in Health, Elsevier vol. 25 (1) 01-01-2022
2021
Patel R, Smeraldi F, Abdollahyan M, Irving J and Bessant C (2021). Analysis of mental and physical disorders associated with COVID-19 in online health forums: a natural language processing study. BMJ Open, BMJ vol. 11 (11) 01-11-2021
2020
Gomez EA, Colas RA, Souza PR, Hands R, Lewis MJ, Bessant C, Pitzalis C and Dalli J (2020). Blood pro-resolving mediators are linked with synovial pathology and are predictive of DMARD responsiveness in rheumatoid arthritis. Nature Communications, Springer Nature vol. 11 (1) 27-10-2020
Gadaleta E, Fourgoux P, Pirró S, Thorn GJ, Nelan R, Ironside A, Rajeeve V, Cutillas PR, Lobley AE, Wang J, Gea E, Ross-Adams H, Bessant C, Lemoine NR, Jones LJ and Chelala C (2020). Characterization of four subtypes in morphologically normal tissue excised proximal and distal to breast cancer. npj Breast Cancer, Nature Research (part of Springer Nature) vol. 6 (1) 21-08-2020
Gadaleta E, Fourgoux P, Pirró S, Thorn GJ, Nelan R, Ironside A, Rajeeve V, Cutillas PR, Lobley AE, Wang J, Gea E, Ross-Adams H, Bessant C, Lemoine NR, Jones LJ and Chelala C (2020). Characterization of four subtypes in morphologically normal tissue excised proximal and distal to breast cancer. NPJ Breast Cancer vol. 6 (1) 21-08-2020
Hijazi M, Smith R, Rajeeve V, Bessant C and Cutillas PR (2020). Reconstructing kinase network topologies from phosphoproteomics data reveals cancer-associated rewiring. Nature Biotechnology, Nature Research 20-01-2020
Abdollahyan M, Smeraldi F, Patel R and Bessant C (2020). Investigating Comorbidity of Mental and Physical Disorders in Online Health Forums. Proceedings of the 3rd International Conference on Applications of Intelligent Systems. 07-01-2020
2019
Cutillas PR, Hijazi M, Smith R, Bessant C and Britton D (2019). Abstract C088: Chemical phosphoproteomics systematically identifies circuitries of kinase networks in cancer cells and predicts their response to kinase inhibitors. 01-12-2019
2018
Ruiz-Romero C, Picchi F, Fernández-Puente P, González-Rodríguez L, Hands R, Calamia V, Camacho-Encina M, Bessant C, Pitzalis C and Blanco FJ (2018). THU0052 A circulating protein signature correlates with synovial pathotypes in rheumatoid arthritis patients. THURSDAY, 14 JUNE 2018. 01-06-2018
Ruiz-Romero C, Picchi F, González-Rodríguez L, Fernández-Puente P, Hands R, Calamia V, Camacho-Encina M, Bessant C, Pitzalis C and Blanco FJ (2018). SAT0074 Identification of a protein panel useful for the prediction of response to methotrexate in rheumatoid arthritis patients. Saturday, 16 JUNE 2018. 01-06-2018
Saha S, Matthews DA and Bessant C (2018). High throughput discovery of protein variants using proteomics informed by transcriptomics. Nucleic Acids Research, Oxford University Press (OUP) vol. 46 (10) 30-04-2018
Abdollahyan M, Mondragón RJ, Bessant C and Smeraldi F (2018). Visualising the topological structure of health-elated message board user networks. 01-01-2018
Ruiz-Romero C, Picchi F, Fernandez P, Gonzalez L, Hands R, Calamia V, Camacho M, Bessant C, Pitzalis C and Blanco FJ (2018). Identification of a Panel of Circulating Proteins Associated to Synovial Pathotypes in Early Rheumatoid Arthritis Patients. 01-01-2018
Ruiz-Romero C, Picchi F, Gonzalez L, Hands R, Calamia V, Fernandez P, Camacho M, Paz R, Bessant C, Pitzalis C and Blanco FJ (2018). Identification of a Protein Profile Useful to Predict Response to Methotrexate in Early Rheumatoid Arthritis Patients. 01-01-2018
2017
Pearce OMT, Delaine-Smith R, Maniati E, Nichols S, Wang J, Böhm S, Rajeeve V, Ullah D, Chakravarty P, Jones RR, Montfort A, Dowe T, Gribben J, Jones JL, Kocher HM, Serody JS, Vincent BG, Connelly J, Brenton JD, Chelala C, et al. (2017). Deconstruction of a metastatic tumor microenvironment reveals a common matrix response in human cancers. Cancer Discov 01-12-2017
SAHA S, Chatzimichali E, Matthews D and Bessant C (2017). PITDB: a database of translated genomic elements. Nucleic Acids Research, Oxford University Press 09-10-2017
Balkwill FR, Pearce OM, Delaine-Smith R, Maniati E, Nichols S, Wang J, Bessant C and Knight M (2017). Abstract 5558: Deconstruction of a human tumor microenvironment. 01-07-2017
Maringer K, Yousuf A, Heesom KJ, Fan J, Lee D, Fernandez-Sesma A, Bessant C, Matthews DA and Davidson AD (2017). Proteomics informed by transcriptomics for characterising active transposable elements and genome annotation in Aedes aegypti. BMC Genomics vol. 18 (1), 101-101. 19-01-2017
Bessant C (2017). Acknowledgements. New Developments in Mass Spectrometry vol. 2017-January (5) 01-01-2017
2016
Saha S, Matthews D and Bessant C (2016). Chapter 16 Proteomics Informed by Transcriptomics. Proteome Informatics 385-405. 15-11-2016
Bessant C (2016). Chapter 1 Introduction to Proteome Informatics. Proteome Informatics 1-14. 15-11-2016
Walton C, Montoya MPB, Fowler DP, Turner C, Jia W, Whitehead RN, Griffiths L, Waring RH, Ramsden DB, Cole JA, Cauchi M, Bessant C, Naylor SJ and Hunter JO (2016). Enteral feeding reduces metabolic activity of the intestinal microbiome in Crohn’s disease: an observational study. European Journal of Clinical Nutrition, Nature Publishing Group: Open Access Hybrid Model Option B vol. 70, 1052-1056. 11-05-2016
Cauchi M, Weber CM, Bolt BJ, Spratt PB, Bessant C, Turner DC, Willis CM, Britton LE, Turner C and Morgan G (2016). Evaluation of gas chromatography mass spectrometry and pattern recognition for the identification of bladder cancer from urine headspace. Analytical Methods, Royal Society of Chemistry (RSC) vol. 8 (20), 4037-4046. 01-01-2016
Mohareb F, Papadopoulou O, Panagou E, Nychas G-J and Bessant C (2016). Ensemble-based support vector machine classifiers as an efficient tool for quality assessment of beef fillets from electronic nose data. Analytical Methods, Royal Society of Chemistry (RSC) vol. 8 (18), 3711-3721. 01-01-2016
2015
Chatzimichali EA and Bessant C (2015). Novel application of heuristic optimisation enables the creation and thorough evaluation of robust support vector machine ensembles for machine learning applications. Metabolomics, Springer Nature vol. 12 (1) 21-11-2015
Qi D, Zhang H, Fan J, Perkins S, Pisconti A, Simpson DM, Bessant C, Hubbard S and Jones AR (2015). The mzqLibrary - An open source Java library supporting the HUPO-PSI quantitative proteomics standard. Proteomics vol. 15 (18), 3152-3162. 01-09-2015
Fan J, Saha S, Barker G, Heesom KJ, Ghali F, Jones AR, Matthews DA and Bessant C (2015). Galaxy Integrated Omics: Web-based Standards-Compliant Workflows for Proteomics Informed by Transcriptomics*[S]. Molecular & Cellular Proteomics, Elsevier vol. 14 (11), 3087-3093. 12-08-2015
Qi D, Zhang H, Fan J, Perkins S, Pisconti A, Simpson DM, Bessant C, Hubbard S and Jones AR (2015). The mzqLibrary – An open source Java library supporting the HUPO‐PSI quantitative proteomics standard. Proteomics, Wiley vol. 15 (18), 3152-3162. 14-07-2015
Cauchi M, Fowler DP, Walton C, Turner C, Waring RH, Ramsden DB, Hunter JO, Teale P, Cole JA and Bessant C (2015). Comparison of GC-MS, HPLC-MS and SIFT-MS in conjunction with multivariate classification for the diagnosis of Crohn's disease in urine. Analytical Methods, Royal Society of Chemistry (RSC) vol. 7 (19), 8379-8385. 01-01-2015
2014
Gonzalez-Galarza FF, Qi D, Fan J, Bessant C and Jones AR (2014). A tutorial for software development in quantitative proteomics using PSI standard formats. Biochim Biophys Acta vol. 1844 (1 Pt A), 88-97. 01-01-2014
Sattlecker M, Stone N and Bessant C (2014). Current trends in machine-learning methods applied to spectroscopic cancer diagnosis. TrAC Trends in Analytical Chemistry, Elsevier/Science Direct vol. 59, 17-25. 01-01-2014
Cauchi M, Fowler DP, Walton C, Turner C, Jia W, Whitehead RN, Griffiths L, Dawson C, Bai H, Waring RH and others (2014). Application of gas chromatography mass spectrometry (GC–MS) in conjunction with multivariate classification for the diagnosis of gastrointestinal diseases. Metabolomics, Springer US vol. 10 (6), 1113-1120. 01-01-2014
Bessant C, Oakley D and Shadforth I (2014). Building Bioinformatics Solutions 2nd Edition. 01-01-2014
Gonzalez-Galarza FF, Qi D, Fan J, Bessant C and Jones AR (2014). A tutorial for software development in quantitative proteomics using PSI standard formats. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS vol. 1844 (1), 88-97. 01-01-2014
2013
Walton C, Fowler DP, Turner C, Jia W, Whitehead RN, Griffiths L, Dawson C, Waring RH, Ramsden DB, Cole JA, Cauchi M, Bessant C and Hunter JO (2013). Analysis of volatile organic compounds of bacterial origin in chronic gastrointestinal diseases. Inflamm Bowel Dis vol. 19 (10), 2069-2078. 01-09-2013
Walzer M, Qi D, Mayer G, Uszkoreit J, Eisenacher M, Sachsenberg T, Gonzalez-Galarza FF, Fan J, Bessant C, Deutsch EW, Reisinger F, Vizcaíno JA, Medina-Aunon JA, Albar JP, Kohlbacher O and Jones AR (2013). The mzQuantML data standard for mass spectrometry-based quantitative studies in proteomics. Mol Cell Proteomics vol. 12 (8), 2332-2340. 01-08-2013
Bessant C and Fan J (2013). Computational approaches to selected reaction monitoring assay design. Methods Mol Biol vol. 1007, 219-235. 01-01-2013
Bessant C and Fan J (2013). Computational approaches to selected reaction monitoring assay design. Methods in Molecular Biology vol. 1007, 219-235. 01-01-2013
2012
Evans VC, Barker G, Heesom KJ, Fan J, Bessant C and Matthews DA (2012). De novo derivation of proteomes from transcriptomes for transcript and protein identification. Nat Methods vol. 9 (12), 1207-1211. 01-12-2012
Gonzalez-Galarza FF, Lawless C, Hubbard SJ, Fan J, Bessant C, Hermjakob H and Jones AR (2012). A critical appraisal of techniques, software packages, and standards for quantitative proteomic analysis. OMICS vol. 16 (9), 431-442. 01-09-2012
Fan J, Mohareb F, Bond NJ, Lilley KS and Bessant C (2012). MRMaid 2.0: mining PRIDE for evidence-based SRM transitions. OMICS vol. 16 (9), 483-488. 01-09-2012
Jia W, Whitehead RN, Griffiths L, Dawson C, Bai H, Waring RH, Ramsden DB, Hunter JO, Cauchi M, Bessant C, Fowler DP, Walton C, Turner C and Cole JA (2012). Diversity and distribution of sulphate-reducing bacteria in human faeces from healthy subjects and patients with inflammatory bowel disease. FEMS Immunol Med Microbiol vol. 65 (1), 55-68. 01-06-2012
Ikeno S, Sano K, Cauchi M, Takatsuji Y, Bessant C and Haruyama T (2012). Colorimetric analysis of agonistic/antagonistic actions on estrogen receptor using peptide-functionalized gold nanoparticle sensor. 17-05-2012
Fan J, Mohareb F, Jones AME and Bessant C (2012). MRMaid: The SRM Assay Design Tool for Arabidopsis and Other Species. Front Plant Sci vol. 3 01-01-2012
2011
Thiollet S, Bessant C and Morgan SL (2011). Application of multiple response optimization design to quantum dot-encoded microsphere bioconjugates hybridization assay. Anal Biochem vol. 414 (1), 23-30. 01-07-2011
Panagou EZ, Mohareb FR, Argyri AA, Bessant CM and Nychas G-JE (2011). A comparison of artificial neural networks and partial least squares modelling for the rapid detection of the microbial spoilage of beef fillets based on Fourier transform infrared spectral fingerprints. Food Microbiol vol. 28 (4), 782-790. 01-06-2011
Weber CM, Cauchi M, Patel M, Bessant C, Turner C, Britton LE and Willis CM (2011). Evaluation of a gas sensor array and pattern recognition for the identification of bladder cancer from urine headspace. Analyst vol. 136 (2), 359-364. 21-01-2011
Johnson PE, Baumgartner S, Aldick T, Bessant C, Giosafatto V, Heick J, Mamone G, O'Connor G, Poms R, Popping B, Reuter A, Ulberth F, Watson A, Monaci L and Mills ENC (2011). Current perspectives and recommendations for the development of mass spectrometry methods for the determination of allergens in foods. J AOAC Int vol. 94 (4), 1026-1033. 01-01-2011
Cauchi M, Bianco L and Bessant C (2011). The quantification of pollutants in drinking water by use of artificial neural networks. Nat. Comput. vol. 10, 77-90. 01-01-2011
Sattlecker M, Baker R, Stone N and Bessant C (2011). Support vector machine ensembles for breast cancer type prediction from mid-FTIR micro-calcification spectra. Chemometrics and Intelligent Laboratory Systems, Elsevier vol. 107, 363-370. 01-01-2011
Sattlecker M, Stone N, Smith J and Bessant C (2011). Assessment of robustness and transferability of classification models built for cancer diagnostics using Raman spectroscopy. Journal of Raman Spectroscopy, Wiley Online Library vol. 42, 897-903. 01-01-2011
Bessant C (2011). Data Mining for Genomics and Proteomics: Analysis of Gene and Protein Expression Data Darius M. Dziuda John Wiley and Sons, 2010, p. 327 ISBN: 978-0-470-16373-3. Proteomics, WILEY-VCH Verlag vol. 11, 3768-3768. 01-01-2011
2010
Kolk A, Hoelscher M, Maboko L, Jung J, Kuijper S, Cauchi M, Bessant C, van Beers S, Dutta R, Gibson T and Reither K (2010). Electronic-nose technology using sputum samples in diagnosis of patients with tuberculosis. J Clin Microbiol vol. 48 (11), 4235-4238. 01-11-2010
Sattlecker M, Bessant C, Smith J and Stone N (2010). Investigation of support vector machines and Raman spectroscopy for lymph node diagnostics. Analyst vol. 135 (5), 895-901. 01-05-2010
Cham Mead JA, Bianco L and Bessant C (2010). Free computational resources for designing selected reaction monitoring transitions. Proteomics vol. 10 (6), 1106-1126. 01-03-2010
Pagliarini R, Bianco L, Manca V and Bessant C (2010). Linking Bistable Dynamics to Metabolic P Systems. Eighth Brainstorming Week on Membrane Computing Universidad de Sevilla, Seville, Spain 1 Feb 2010 - 5 Feb 2010. 05-02-2010
Chem Mead JA, Bianco L and Bessant C (2010). Mining proteomic MS/MS data for MRM transitions. Methods Mol Biol vol. 604, 187-199. 01-01-2010
Cham JA, Bianco L, Barton C and Bessant C (2010). MRMaid-DB: a repository of published SRM transitions. J Proteome Res vol. 9 (1), 620-625. 01-01-2010
Tetsuya H (2010). Discerning data analysis methods to clarify agonistic/antagonistic actions on the ion flux assay of ligand-gated ionotropic glutamate receptor on engineered post-synapse model cells. Journal of Biosensors & Bioelectronics 01-01-2010
Tanoue C, Asakawa H, Cauchi M, Bessant C, Ikeno S and Haruyama T (2010). Tissular model/sensor seamless system for qualified analysis and its characterization. Biochemical Engineering Journal, Elsevier vol. 52, 110-115. 01-01-2010
Kolk A, Hoelscher M, Maboko L, Jung J, Kuijper S, Cauchi M, Bessant C, van Beers S, Dutta R, Gibson T and others (2010). Electronic-nose technology in diagnosis of TB patients using sputum samples. Journal of Clinical Microbiology, Am Soc Microbiol 01-01-2010
Jia W, Griffiths L, Whitehead B, Basser SJ, Dawson C, Turner C, Bessant C, Fowler D, Walton C, Ramsden D and others (2010). ABUNDANCE OF SULPHATE REDUCING BACTERIA IN INFLAMMATORY BOWEL DISEASE. 01-01-2010
2009
Spooner AD, Bessant C, Turner C, Knobloch H and Chambers M (2009). Evaluation of a combination of SIFT-MS and multivariate data analysis for the diagnosis of Mycobacterium bovis in wild badgers. Analyst vol. 134 (9), 1922-1927. 01-09-2009
Blanco L, Mead JA and Bessant C (2009). Comparison of novel decoy database designs for optimizing protein identification searches using ABRF sPRG2006 standard MS/MS data sets. J Proteome Res vol. 8 (4), 1782-1791. 01-04-2009
Babrah J, McCarthy K, Lush RJ, Rye AD, Bessant C and Stone N (2009). Fourier transform infrared spectroscopic studies of T-cell lymphoma, B-cell lymphoid and myeloid leukaemia cell lines. Analyst vol. 134 (4), 763-768. 01-04-2009
Mead JA, Bianco L, Ottone V, Barton C, Kay RG, Lilley KS, Bond NJ and Bessant C (2009). MRMaid, the web-based tool for designing multiple reaction monitoring (MRM) transitions. Mol Cell Proteomics vol. 8 (4), 696-705. 01-04-2009
Moczko E, Meglinski IV, Bessant C and Piletsky SA (2009). Dyes assay for measuring physicochemical parameters. Anal Chem vol. 81 (6), 2311-2316. 15-03-2009
Mead JA, Bianco L and Bessant C (2009). Recent developments in public proteomic MS repositories and pipelines. Proteomics vol. 9 (4), 861-881. 01-02-2009
Monteiro MB, Pintado ME, Malcata FX, Bessant C and Moreira PR (2009). Development of a Workflow for Protein Sequence Analysis Based on the Taverna Workbench Software., Editors: Omatu S, Rocha M, Bravo J, Riverola FF, Corchado E, Bustillo A and Corchado JM. 01-01-2009
Thanaraj T, Terry LA and Bessant C (2009). Chemometric profiling of pre-climacteric Sri Lankan mango fruit (< i> Mangifera indica L.). Food Chemistry, Elsevier vol. 112, 786-794. 01-01-2009
Tottey S, Robinson N, Waldron K, Firbank S and Bessant C (2009). Protein folding location determines binding of manganese versus copper. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, Pergamon vol. 153, S159-S159. 01-01-2009
2008
Robinson N, Waldron K, Tottey S and Bessant C (2008). Metalloprotein metal pools: identification and quantification by coupling native and non-native separations through principal component analysis. Protocol Exchange, Springer Nature 12-11-2008
Tottey S, Waldron KJ, Firbank SJ, Reale B, Bessant C, Sato K, Cheek TR, Gray J, Banfield MJ, Dennison C and Robinson NJ (2008). Protein-folding location can regulate manganese-binding versus copper- or zinc-binding. Nature vol. 455 (7216), 1138-1142. 23-10-2008
Stott W, Ryan A, Jacobs IJ, Menon U, Bessant C and Jones C (2008). OSPACS: Ultrasound image management system. Source Code Biol Med vol. 3 20-06-2008
Cauchi M, Bessant C and Setford S (2008). Simultaneous Quantitative Determination of Cadmium, Lead, and Copper on Carbon-Ink Screen-Printed Electrodes by Differential Pulse Anodic Stripping Voltammetry and Partial Least Squares Regression. Electroanalysis, Wiley Online Library vol. 20, 2571-2577. 01-01-2008
Mead J, Bianco L and Bessant C (2008). Using Bioinformatics to Increase Speed and Reduce Uncertainty in Protein Biomarker Discovery. Cranfield Multi-Strand Conference: Creating Wealth Through Research and Innovation vol. 6, 118-118. 01-01-2008
2007
Mead JA, Shadforth IP and Bessant C (2007). Public proteomic MS repositories and pipelines: available tools and biological applications. Proteomics vol. 7 (16), 2769-2786. 01-08-2007
Babrah J, McCarthy KP, Lush R, Rye AD, Bessant C and Stone N (2007). FT-infrared spectroscopic studies of lymphoma, lymphoid, and myeloid leukemia cell lines. Diagnostic Optical Spectroscopy in Biomedicine IV. 05-07-2007
Kumuthini J, Jouffe L and Bessant C (2007). A Novel Graph Optimisation Algorithm for the Extraction of Gene Regulatory Networks from Temporal Microarray Data., Editors: Hochreiter S and Wagner R. 01-01-2007
Goodacre R, Broadhurst D, Smilde AK, Kristal BS, Baker JD, Beger R, Bessant C, Connor S, Capuani G, Craig A and others (2007). Proposed minimum reporting standards for data analysis in metabolomics. Metabolomics, Springer US vol. 3, 231-241. 01-01-2007
Bessant C (2007). Microarray Analysis Software and its Applications. Handbook of Biosensors and Biochips, John Wiley & Sons, Ltd 01-01-2007
Babrah J, McCarthy KP, Lush R, Rye AD, Bessant C and Stone N (2007). FT-infrared spectroscopic studies of lymphoma, lymphoid, and myeloid leukemia cell lines [6628-28]. PROCEEDINGS-SPIE THE INTERNATIONAL SOCIETY FOR OPTICAL ENGINEERING, International Society for Optical Engineering; 1999 vol. 6628, 6628-6628. 01-01-2007
Babrah J, McCarthy KP, Lush R, Rye AD, Bessant C and Stone N (2007). FT-infrared spectroscopic studies of lymphoma, lymphoid, and myeloid leukemia cell lines. 01-01-2007
Kumuthini J, Bessant C, Wilson P and Crowther D (2007). Gene regulatory network of human adipocyte differentiation. BMC Systems Biology, BioMed Central Ltd vol. 1, P57-P57. 01-01-2007
Kumuthini J, Jouffe L and Bessant C (2007). Session 1-Microarray and Systems Biology I (Networks)-A Novel Graph Optimisation Algorithm for the Extraction of Gene Regulatory Networks from Temporal Microarray Data. Lecture Notes in Computer Science vol. 4414, 28-28. 01-01-2007
Babrah J, Lush R, Rye A, McCarthy K, Bessant C and Stone N (2007). Fourier transform infrared spectroscopic studies of lymphoma, lymphoid and myeloid leukaemia cell lines. 01-01-2007
2006
Shadforth I and Bessant C (2006). Genome annotating proteomics pipelines: available tools. Expert Rev Proteomics vol. 3 (6), 621-629. 01-12-2006
Shadforth I, Xu W, Crowther D and Bessant C (2006). GAPP: a fully automated software for the confident identification of human peptides from tandem mass spectra. J Proteome Res vol. 5 (10), 2849-2852. 01-10-2006
Ernst W, Trummer E, Mead J, Bessant C, Strelec H, Katinger H and Hesse F (2006). Evaluation of a genomics platform for cross-species transcriptome analysis of recombinant CHO cells. Biotechnol J vol. 1 (6), 639-650. 01-06-2006
Fend R, Kolk AHJ, Bessant C, Buijtels P, Klatser PR and Woodman AC (2006). Prospects for clinical application of electronic-nose technology to early detection of Mycobacterium tuberculosis in culture and sputum. J Clin Microbiol vol. 44 (6), 2039-2045. 01-06-2006
Dunkley TPJ, Hester S, Shadforth IP, Runions J, Weimar T, Hanton SL, Griffin JL, Bessant C, Brandizzi F, Hawes C, Watson RB, Dupree P and Lilley KS (2006). Mapping the Arabidopsis organelle proteome. Proc Natl Acad Sci U S A vol. 103 (17), 6518-6523. 25-04-2006
Saini S, Bessant C, Lee-davey J and Malecha MM (2006). VOLTAMMETRIC DETECTION OF METABOLITES IN PHYSIOLOGICAL FLUIDS. 22-03-2006
Sadowski PG, Dunkley TPJ, Shadforth IP, Dupree P, Bessant C, Griffin JL and Lilley KS (2006). Quantitative proteomic approach to study subcellular localization of membrane proteins. Nat Protoc vol. 1 (4), 1778-1789. 01-01-2006
Lilley KS, Hawes C, Hanton SL, Dunkley TPJ, Runions J, Hester S, Weimar T, Shadforth IP, Bessant C, Dupree P and others (2006). Mapping the Arabidopsis organelle proteome. Proceedings of the National Academy of Sciences of the United States of America, Editor no identificado, 6518-6523. 01-01-2006
2005
Shadforth I, Crowther D and Bessant C (2005). Protein and peptide identification algorithms using MS for use in high-throughput, automated pipelines. Proteomics vol. 5 (16), 4082-4095. 01-11-2005
Shadforth IP, Dunkley TPJ, Lilley KS and Bessant C (2005). i-Tracker: for quantitative proteomics using iTRAQ. BMC Genomics vol. 6 20-10-2005
Shadforth I, Todd K, Crowther D and Bessant C (2005). Determination of partial amino acid composition from tandem mass spectra for use in peptide identification strategies. Proteomics vol. 5 (7), 1787-1796. 01-05-2005
SAINI S, BESSANT C, LEE-DAVEY J, MALECHA M and others (2005). VOLTAMMETRIC DETECTION OF METABOLITES IN PHYSIOLOGICAL FLUIDS. 07-01-2005
Shadforth I, Dunkley T, Lilley K, Crowther D and Bessant C (2005). Confident protein identification using the average peptide score method coupled with search-specific, ab initio thresholds. Rapid Commun Mass Spectrom vol. 19 (22), 3363-3368. 01-01-2005
Mead JA, Bianco L and Bessant C (2005). the focus of attention in financial reporting. Abacus 01-01-2005
2004
Fend R, Bessant C, Williams AJ and Woodman AC (2004). Monitoring haemodialysis using electronic nose and chemometrics. Biosens Bioelectron vol. 19 (12), 1581-1590. 15-07-2004
Saini S, Bessant C, Lee-Davey J and Malecha MM (2004). Voltammetric detection of metabolites in physiological fluids. 28-06-2004
Richards E, Bessant C and Saini S (2004). Simultaneous quantification of analytes in quaternary mixtures using dual pulse staircase voltammetry and genetically optimised neural networks. Analyst vol. 129 (4), 355-358. 01-04-2004
Saini S, Bessant C, Liedtke C and Leiferkus J (2004). DIAGNOSIS BY SENSING VOLATILE COMPONENTS. 14-01-2004
Shadforth I, Crowther D and Bessant C (2004). Search-Space Reduction of a Non-Redundant Peptide Database. 01-01-2004
Oduguwa A, Tiwari A, Roy R and Bessant C (2004). An Overview of Soft Computing Techniques Used in the Drug Discovery Process., Editors: Abraham A, Baets BD, Köppen M and Nickolay B. 01-01-2004
2003
Malecha M, Bessant C and Saini S (2003). Identification of oil contaminants on polymer coated beverage cans using fluorescence spectroscopy. Appl Spectrosc vol. 57 (8), 1042-1048. 01-08-2003
Richards E, Bessant C and Saini S (2003). A liquid handling system for the automated acquisition of data for training, validating and testing calibration models. Sensors and Actuators B: Chemical, Elsevier vol. 88, 149-154. 01-01-2003
Bessant C and Richards E (2003). Neural networks for the calibration of voltammetric data. Nature-inspired methods in chemometrics: genetic algorithms and artificial neural networks: genetic algorithms and artificial neural networks, Elsevier vol. 23, 257-257. 01-01-2003
2002
SAINI S, BESSANT C, LIEDTKE C, LEIFERKUS J and others (2002). DIAGNOSIS BY SENSING VOLATILE COMPONENTS. 01-11-2002
Malecha M, Bessant C and Saini S (2002). Principal components analysis for the visualisation of multidimensional chemical data acquired by scanning Raman microspectroscopy. Analyst vol. 127 (9), 1261-1266. 01-09-2002
Saini S, Bessant C, Liedtke C and Leiferkus J (2002). Diagnosis by sensing volatile components. 19-04-2002
Richards E, Bessant C and Saini S (2002). Multivariate data analysis in electroanalytical chemistry. Electroanalysis, Wiley Online Library vol. 14, 1533-1542. 01-01-2002
Richards E, Bessant C and Saini S (2002). Optimisation of a neural network model for calibration of voltammetric data. Chemometrics and intelligent laboratory systems, Elsevier vol. 61, 35-49. 01-01-2002
Malecha M, Bessant C, Perry D and Saini S (2002). Identification of oil contaminants on polymer coated beverage cans using Raman spectroscopy. Analyst, Royal Society of Chemistry vol. 127, 297-303. 01-01-2002
2001
Brereton RG and Bessant C (2001). Simultaneous resolution of overlapping tailing peaks of Isomers using dual detector diode array liquid Chromatography electrospray mass spectrometry. Aegean Analytical Chemistry Conference. 31-12-2001
Saini S, Barr H and Bessant C (2001). Sniffing out disease using the artificial nose. Biologist (London) vol. 48 (5), 229-233. 01-10-2001
Bessant C, Ritchie L, Saini S, Pahlavanpour B and Wilson G (2001). Chemometric evaluation of synchronous scan fluorescence spectroscopy for the determination of regulatory conformance and usage history of insulation oils. Applied spectroscopy, Society for Applied Spectroscopy vol. 55, 840-846. 01-01-2001
2000
Ritchie LJ, Ferguson CP, Bessant C and Saini S (2000). A ten channel fibre-optic device for distributed sensing of underground hydrocarbon leakage. J Environ Monit vol. 2 (6), 670-673. 01-12-2000
Bessant C and Saini S (2000). A chemometric analysis of dual pulse staircase voltammograms obtained in mixtures of ethanol, fructose and glucose. Journal of electroanalytical chemistry, Elsevier vol. 489, 76-83. 01-01-2000
1999
Bessant C and Saini S (1999). Simultaneous determination of ethanol, fructose, and glucose at an unmodified platinum electrode using artificial neural networks. Analytical Chemistry, ACS Publications vol. 71, 2806-2813. 01-01-1999
Brereton R and others (1999). Integrated processing of triply coupled diode array liquid chromatography electrospray mass spectrometric signals by chemometric methods. Analyst, Royal Society of Chemistry vol. 124, 1733-1744. 01-01-1999
1997
Bessant C and Saini S (1997). An object oriented approach to electroanalytical technique implementation. Electroanalysis, Wiley Online Library vol. 9, 926-931. 01-01-1997
Grants
Grants of specific relevance to the Centre for Molecular Cell BiologyAI driven Omics Data Integration and Transfer Learning for Target and Biomarker IdentificationConrad Bessant
£127,935 BBSRC Biotechnology and Biological Sciences Research Council (01-10-2024 - 30-09-2028)
BBSRC AIDD CTP CASE Award: Syed Zayyan MasudConrad Bessant
£21,600 Nxera Pharma UK Ltd (01-10-2024 - 30-09-2028)
Mechanisms underlying preterm birth in women with HIV in rural ZimbabweAndrew Prendergast, Ruairi Robertson, Melanie Smuk, Claire Bourke, Nikolaos Donos, Robert Allaker, Abish Stephen, Conrad Bessant, Stefaan Verbruggen and Tina Chowdhury
£1,142,315 MRC Medical Research Council (01-05-2024 - 30-04-2027)
Martina Occhetta CTP Studentship - Exscientia FundedConrad Bessant and Emma Tjong
£8,600 EXSCIENTIA LIMITED (01-10-2023 - 30-09-2027)
TG: Target identification from multiomics data using systems biology and machine learning approachesConrad Bessant
£125,917 BBSRC Biotechnology and Biological Sciences Research Council (01-10-2023 - 30-09-2027)
CTP Training Grant: Lewis PalmerConrad Bessant
£123,829 BBSRC Biotechnology and Biological Sciences Research Council (01-10-2022 - 12-11-2026)
BBSRC AIDD CTP CASE Award: Lewis Palmer: “Prioritising Drug Targets in non-canonical pathways from multi-omic dataConrad Bessant
£10,400 Merck (26-09-2022 - 25-09-2026)
Survey and BIOinformatic review of fluid-tissue proteomics: novel biomarkers for ALSAndrea Malaspina and Conrad Bessant
£188,946 Barts and the London Charity (01-09-2020 - 31-08-2025)
Bid for MRC Industrial Strategy PhD Studentship 2018Conrad Bessant
£93,462 MRC Medical Research Council (01-10-2018 - 31-03-2022)