Dr Charalampos (Babis) Rallis
Reader in Genetics, Genomics and Fundamental Cell Biology
Director of Industrial Innovation
School of Biological and Behavioural Sciences
Queen Mary University of London
Queen Mary University of London
Research
Ageing, Metabolism, Fission yeast, Neurons, Senescence, Phenomics
Interests
We study gene and protein networks implicated in cellular fitness and metabolism, neurodegeneration, cancer and ageing with a focus on the nutrient-responsive signalling pathway Target of Rapamycin (TOR).Our aim is to elucidate the molecular mechanisms and principles behind senescence and lifespan and apply this knowledge for the amelioration of age-related diseases. In addition, the group performs quantitative fitness profiling of microbiomes and mycobiomes and explore the effects of nutrition on biome physiology and subsequent effects on human healthy ageing.
We use the fission yeast Schizosaccharomyces pombe and mammalian 2D and 3D tissue culture systems and utilise multi-omics approaches and network biology.
Publications
Publications of specific relevance to the Centre for Molecular Cell Biology2025
Rapalink-1 reveals TOR-dependent genes and an agmatinergic axis-based metabolic feedback regulating TOR activity and lifespan in fission yeast.Rallis C
Communications Biology, Nature Research vol. 8, 1364-1364.
29-09-2025
Dissecting the cell cycle regulation, DNA damage sensitivity and lifespan effects of caffeine in fission yeastAlao J-P Kumar J Stamataki D Rallis C
Microbial Cell, Shared Science Publishers Og vol. 12 (1)
24-06-2025
2023
Correction: Islam, R.A.; Rallis, C. Ribosomal Biogenesis and Heterogeneity in Development, Disease, and Aging. Epigenomes 2023, 7, 17Islam RA
Epigenomes, Mdpi vol. 7 (4)
26-10-2023
The longevity and reversibility of quiescence in Schizosaccharomyces pombe are dependent upon the HIRA histone chaperoneGal C Cochrane GA Morgan BA
Cell Cycle, Taylor & Francis vol. 22 (17), 1921-1936.
27-08-2023
Ribosomal Biogenesis and Heterogeneity in Development, Disease, and AgingIslam RA Rallis C
Epigenomes, Mdpi vol. 7 (3)
11-08-2023
Interplays of AMPK and TOR in Autophagy Regulation in YeastAlao J-P Legon L Dabrowska A Tricolici A-M
Cells, Mdpi vol. 12 (4)
04-02-2023
2022
Nutrient-Response Pathways in Healthspan and Lifespan RegulationDabrowska A Kumar J Rallis C
Cells, Mdpi vol. 11 (9)
06-05-2022
2021
Increased fidelity of protein synthesis extends lifespanMartinez-Miguel VE Lujan C Espie--Caullet T Martinez-Martinez D Moore S Gonzalez S Brown AEX Halic M et al.
Cell Metabolism, Elsevier vol. 33 (11), 2288-2300.e12.
14-09-2021
Genome-wide screens in yeast models towards understanding chronological lifespan regulationLegon L Rallis C
Briefings in Functional Genomics, Oxford University Press (OUP) vol. 21 (1), 4-12.
17-03-2021
Crosstalk between the mTOR and DNA Damage Response Pathways in Fission YeastAlao J-P Legon L
Cells, Mdpi vol. 10 (2)
02-02-2021
2020
Amino Acids Whose Intracellular Levels Change Most During Aging Alter Chronological Life Span of Fission YeastRallis C Mülleder M Smith G Au YZ
The Journals of Gerontology Series A, Oxford University Press (OUP) vol. 76 (2), 205-210.
03-11-2020
Caffeine Stabilises Fission Yeast Wee1 in a Rad24-Dependent Manner but Attenuates Its Expression in Response to DNA DamageAlao JP Johansson-Sjölander J Rallis C
Microorganisms, Mdpi vol. 8 (10)
30-09-2020
The Target of Rapamycin Signalling Pathway in Ageing and Lifespan RegulationBjedov I Rallis C
Genes, Mdpi vol. 11 (9)
03-09-2020
The GATA Transcription Factor Gaf1 Represses tRNAs, Inhibits Growth, and Extends Chronological Lifespan Downstream of Fission Yeast TORC1Rodríguez-López M Gonzalez S Hillson O Tunnacliffe E Codlin S
Cell Reports, Elsevier vol. 30 (10), 3240-3249.e4.
01-03-2020
2019
An essential role for dNTP homeostasis following CDK-induced replication stressPai C-C Hsu K-F Durley SC Keszthelyi A Kearsey SE Rallis C Folkes LK Deegan R et al.
Journal of Cell Science, The Company of Biologists vol. 132 (6)
15-03-2019
2018
Prospects of Pharmacological Interventions to Organismal AgingHillson O Gonzalez S Rallis C
Biomolecular Concepts, De Gruyter vol. 9 (1), 200-215.
31-12-2018
Long noncoding RNA repertoire and targeting by nuclear exosome, cytoplasmic exonuclease, and RNAi in fission yeastAtkinson SR Marguerat S Bitton DA Rodríguez-López M Rallis C Lemay J-F Malecki M Smialowski P et al.
Rna, Cold Spring Harbor Laboratory vol. 24 (9), 1195-1213.
18-06-2018
Uncovering Natural Longevity Alleles from Intercrossed Pools of Aging Fission Yeast CellsEllis DA Mustonen V Rodríguez-López M Rallis C Bähler J
Genetics, Oxford University Press (OUP) vol. 210 (2), 733-744.
08-02-2018
2017
RNA metabolism is the primary target of formamide in vivoHoyos-Manchado R Reyes-Martín F Rallis C Gamero-Estévez E Rodríguez-Gómez P Quintero-Blanco J
Scientific Reports, Springer Nature vol. 7 (1)
21-11-2017
Erratum: Corrigendum: Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processesRallis C Townsend S Bähler J
Scientific Reports, Springer Nature vol. 7 (1)
10-07-2017
Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processesRallis C Bähler J
Scientific Reports, Springer Nature vol. 7 (1)
10-03-2017
Transient structural variations have strong effects on quantitative traits and reproductive isolation in fission yeastJeffares DC Jolly C Hoti M Speed D Shaw L Rallis C Bähler J
Nature Communications, Springer Nature vol. 8 (1)
24-01-2017
2016
Functional and regulatory profiling of energy metabolism in fission yeastMalecki M Bitton DA Rodríguez-López M Rallis C Calavia NG Smith GC
Genome Biology, Springer Nature vol. 17 (1)
25-11-2016
Php4 Is a Key Player for Iron Economy in Meiotic and Sporulating CellsBrault A Rallis C Normant V Garant J-M
G3: Genes, Genomes, Genetics, Oxford University Press (OUP) vol. 6 (10), 3077-3095.
01-10-2016
Spotsizer: High-throughput quantitative analysis of microbial growthBischof L Pevorovsk M Rallis C Jeffares DC
Biotechniques, Taylor & Francis vol. 61 (4), 191-201.
01-10-2016
Identification of nuclear genes affecting 2-Deoxyglucose resistance in Schizosaccharomyces pombeVishwanatha A Rallis C Subramanyaswamy SB Bähler J
Fems Yeast Research, Oxford University Press (OUP) vol. 16 (6)
31-07-2016
Increasing extracellular H2O2 produces a bi-phasic response in intracellular H2O2, with peroxiredoxin hyperoxidation only triggered once the cellular H2O2-buffering capacity is overwhelmedTomalin LE Day AM Underwood ZE Smith GR Pezze PD Rallis C Dickinson BC Bähler J et al.
Free Radical Biology and Medicine, Elsevier vol. 95, 333-348.
02-03-2016
2015
A central role for TOR signalling in a yeast model for juvenile CLN3 diseaseBond ME Brown R Rallis C Bähler J
Microbial Cell, Shared Science Publishers Og vol. 2 (12)
07-12-2015
Cell-based screens and phenomics with fission yeastRallis C Bähler J
Critical Reviews in Biochemistry and Molecular Biology, Taylor & Francis vol. 51 (2), 86-95.
02-11-2015
Widespread exon skipping triggers degradation by nuclear RNA surveillance in fission yeastBitton DA Atkinson SR Rallis C Ellis DA Chen YYC Malecki M Codlin S Cotobal C et al.
Genome Research, Cold Spring Harbor Laboratory vol. 25 (6), 884-896.
16-04-2015
The genomic and phenotypic diversity of Schizosaccharomyces pombeJeffares DC Rallis C Rieux A Speed D Převorovský M Mourier T Marsellach FX Iqbal Z et al.
Nature Genetics, Springer Nature vol. 47 (3), 235-241.
09-02-2015
Parallel Profiling of Fission Yeast Deletion Mutants for Proliferation and for Lifespan During Long-Term QuiescenceSideri T Rallis C Lages BM Suo F Rodríguez-López M
G3: Genes, Genomes, Genetics, Oxford University Press (OUP) vol. 5 (1), 145-155.
01-01-2015
2014
Lithium suppresses Aβ pathology by inhibiting translation in an adult Drosophila model of Alzheimer's diseaseSofola-Adesakin O Castillo-Quan JI Rallis C Bjedov I Rogers I Li L Martinez P Khericha M
Frontiers in Aging Neuroscience, Frontiers vol. 6
30-07-2014
LaSSO, a strategy for genome-wide mapping of intronic lariats and branch points using RNA-seqBitton DA Rallis C Jeffares DC Smith GC Codlin S Marguerat S
Genome Research, Cold Spring Harbor Laboratory vol. 24 (7), 1169-1179.
07-04-2014
Systematic screen for mutants resistant to TORC1 inhibition in fission yeast reveals genes involved in cellular ageing and growthRallis C López-Maury L Georgescu T Bähler J
Biology Open, The Company of Biologists vol. 3 (2), 161-171.
17-01-2014
2013
Inhibition of TORC1 signaling and increased lifespan: gained in translation?Rallis C Bähler J
Aging, Impact Journals vol. 5 (5), 335-336.
21-05-2013
TORC1 signaling inhibition by rapamycin and caffeine affect lifespan, global gene expression, and cell proliferation of fission yeastRallis C Bähler J
Aging Cell, Wiley vol. 12 (4), 563-573.
02-05-2013
2012
Predicting the Fission Yeast Protein Interaction NetworkPancaldi V Saraç ÖS Rallis C McLean JR Převorovský M
G3: Genes, Genomes, Genetics, Oxford University Press (OUP) vol. 2 (4), 453-467.
01-04-2012
2011
Bright days for yeast researchPřevorovský M
Genome Biology. vol. 12 (5)
01-01-2011
2010
Cell-autonomous integrin control of Wnt and Notch signalling during somitogenesisRallis C Pinchin SM Ish-Horowicz D
Development, The Company of Biologists vol. 137 (21), 3591-3601.
28-09-2010
Integrin-Linked Kinase Is a Functional Mn2+-Dependent Protein Kinase that Regulates Glycogen Synthase Kinase-3β (GSK-3β) PhosphorylationMaydan M McDonald PC Sanghera J Yan J Rallis C Pinchin S Hannigan GE
Plos One, Public Library of Science (Plos) vol. 5 (8)
23-08-2010
2009
New tricks for an old-favorite modelRallis C
Genome Biology. vol. 10 (9)
01-01-2009
2008
Elucidating developmental gene networksHanisch A Vezzaro A Rallis C
Genome Biology. vol. 9 (6)
01-01-2008
2007
Cell signaling and cancerBazigou E Rallis C
Genome Biology. vol. 8 (7)
01-01-2007
Chickens get their place in the sunRallis C
Genome Biology. vol. 8 (5)
01-01-2007
2006
Developmental genomics reaches new heightsRallis C
Genome Biology. vol. 7 (10)
01-01-2006
2005
Tbx3 can alter limb position along the rostrocaudal axis of the developing embryoRallis C Del Buono J
Development, The Company of Biologists vol. 132 (8), 1961-1970.
15-04-2005
2003
Tbx5 is required for forelimb bud formation and continued outgrowthRallis C Bruneau BG Del Buono J Seidman CE Seidman JG Logan MPO
Development, The Company of Biologists vol. 130 (12), 2741-2751.
15-06-2003
2001
Isolation of the avian homologue of the homeobox gene Mox2 and analysis of its expression pattern in developing somites and limbsRallis C Stamataki D Pontikakis S
Cells and Development, Elsevier vol. 104 (1-2), 121-124.
01-06-2001
Rapalink-1 reveals novel mTOR-dependent genes and an agmatinergic axis-based metabolic feedback regulating mTOR activity and lifespanKumar J Rallis C
In Biorxiv
Dissecting the cell cycle regulation, DNA damage sensitivity and lifespan effects of caffeine in fission yeastAlao J-P Kumar J Stamataki D Rallis C
In Biorxiv
Amino acids whose intracellular levels change most during aging alter chronological lifespan of fission yeastRallis C Mülleder M Smith G Au YZ Ralser M Bähler J
In Biorxiv
Caffeine stabilises fission yeast Wee1 in a Rad24-dependent manner but attenuates its expression in response to DNA damage identifying a putative role for TORC1 in mediating its effects on cell cycle progressionAlao JP Johansson-Sjölander J Rallis C Sunnerhagen P
In Biorxiv
The GATA transcription factor Gaf1 represses tRNA genes, inhibits growth, and extends chronological lifespan downstream of fission yeast TORC1Rodríguez-López M Gonzalez S Hillson O Tunnacliffe E Codlin S Tallada VA Bähler J Rallis C
In Biorxiv
An essential role for dNTP homeostasis following CDK-induced replication stressPai C-C Hsu K-F Durley SC Keszthelyi A Kearsey SE Rallis C Folkes LK Deegan R et al.
In Biorxiv
Uncovering Natural Longevity Alleles from Intercrossed Pools of Aging Fission Yeast CellsEllis DA Mustonen V Rodríguez-López M Rallis C Malecki M Jeffares DC Bähler J
In Biorxiv
Long non-coding RNA repertoire and regulation by nuclear exosome, cytoplasmic exonuclease and RNAi in fission yeastAtkinson SR Marguerat S Bitton DA Rodríguez-López M Rallis C Lemay J-F Cotobal C Malecki M et al.
In Biorxiv
Functional and Regulatory Profiling of Energy Metabolism in Fission YeastMalecki M Bitton DA Rodriguez-Lopez M Rallis C Cavalia NG Smith GC Bahler J
In Preprints.Org
Transient structural variations have strong effects on quantitative traits and reproductive isolation in fission yeastJeffares DC Jolly C Hoti M Speed D Shaw L Rallis C Balloux F Dessimoz C et al.
In Biorxiv
Skip and bin: pervasive alternative splicing triggers degradation by nuclear RNA surveillance in fission yeastBitton DA Atkinson SR Rallis C Smith GC Ellis DA Jeffares DC Chen YYC Malecki M et al.
In Biorxiv
The TOR Signaling Pathway in Spatial and Temporal Control of Cell Size and GrowthGonzalez S Rallis C
Grants
Grants of specific relevance to the Centre for Molecular Cell BiologyIntegrating cellular space and time: inteplays between subcellular organisation and lifespan-GRANT TRANSFERCharalampos (Babis) Rallis
£269,451 BBSRC Biotechnology and Biological Sciences Research Council
01-09-2023 - 14-04-2026
Mechanisms of uncoupling cellular growth from mTOR pathway activity - GRANT TRANSFERCharalampos (Babis) Rallis
£292,263 MRC Medical Research Council
01-09-2023 - 13-02-2025
Research Group
PhD Students
- Irlanda Del Angel Miranda
Genetic Basis of Mtor Inhibitors and Drug Repurposing Through High-Throughput Phenotyping in Fission Yeast. - Jhonatan Salgado-Garduño
Decoding Antibiotic Resistance: Cell Death, Phenotypic Responses, and Cell Wall Dynamics - Natalia Twardowska
Uncovering Mechanisms of Mtor Inhibition Resistance Through - Olga Xintarakou
Investigating Mtor Activity Effects on Cellular Metabolism and Cytoarchitecture
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