Dr Elena Torlai Triglia
Lecturer in Genetics, Genomics & Fundamental Cell Biology
Theme Lead for Genomics of Disease and Ageing
School of Biological and Behavioural Sciences
Queen Mary University of London
Research
Gene regulation, Single-cell genomics, Cancer biology, Epigenetics
Interests
I am a computational and molecular biologist, interested in understanding how genetic and epigenetic alterations shape cell behaviour during disease development, particularly in cancer.
I have a PhD in Molecular Biology from the Humboldt University of Berlin, which I earned from working in the group Ana Pombo at the Berlin Institute for Medical Systems Biology (part of the Max Delbruck Center for Molecular Medicine). After that, I was a postdoctoral researcher in the labs of Aviv Regev and Brad Bernstein at Broad Institute of MIT and Harvard/ Dana Farber Cancer Institute (Boston, MA, US). I joined QMUL in Feb 2024.
See more information about my research interests at:
ettlab.science/
Publications
Publications of specific relevance to the Centre for Molecular Cell Biology
2025
Direct genetic transformation bypasses tumor-associated DNA methylation alterationsHetzel S Hodis E Torlai Triglia E Kovacsovics A Steinmann K Gnirke A Cui M McQuaid D et al.
Genome Biology,
Bmc vol. 26 (212)
17-07-2025Author Correction: B-cell-specific checkpoint molecules that regulate anti-tumour immunityBod L Kye Y-C Shi J Torlai Triglia E Schnell A Fessler J Ostrowski SM Von-Franque MY et al.
Nature,
Springer Nature vol. 640 (8057), e1-e1.
17-03-2025 2023
B-cell-specific checkpoint molecules that regulate anti-tumour immunityBod L Kye Y-C Shi J Torlai Triglia E Schnell A Fessler J Ostrowski SM Von-Franque MY et al.
Nature,
Springer Nature vol. 619 (7969), 348-356.
21-06-2023 2022
Stepwise-edited, human melanoma models reveal mutations’ effect on tumor and microenvironmentHodis E Torlai Triglia E Kwon JYH Biancalani T Zakka LR Parkar S Hütter J-C Buffoni L et al.
Science,
American Association For The Advancement of Science (Aaas) vol. 376 (6592), eabi8175-eabi8175.
29-04-2022 2021
Cell-type specialization is encoded by specific chromatin topologiesWinick-Ng W Kukalev A Harabula I Zea-Redondo L Szabó D Meijer M Serebreni L Zhang Y et al.
Nature,
Springer Nature vol. 599 (7886), 684-691.
17-11-2021 Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographicsMuus C Luecken MD Eraslan G Sikkema L Waghray A Heimberg G Kobayashi Y Vaishnav ED et al.
Nature Medicine,
Springer Nature vol. 27 (3), 546-559.
02-03-2021 Skin-resident innate lymphoid cells converge on a pathogenic effector stateBielecki P Riesenfeld SJ Hütter J-C Torlai Triglia E Kowalczyk MS Ricardo-Gonzalez RR Lian M Amezcua Vesely MC et al.
Nature,
Springer Nature vol. 592 (7852), 128-132.
03-02-2021 2019
R-Loops Enhance Polycomb Repression at a Subset of Developmental Regulator GenesSkourti-Stathaki K Torlai Triglia E Warburton M Voigt P
Molecular Cell,
Elsevier vol. 73 (5), 930-945.e4.
29-01-2019 2017
RNA polymerase II primes Polycomb‐repressed developmental genes throughout terminal neuronal differentiationFerrai C Torlai Triglia E Risner‐Janiczek JR Rito T Rackham OJL Santiago I Kukalev A
Molecular Systems Biology,
Springer Nature vol. 13 (10), 946-946.
01-10-2017 Flipping between Polycomb repressed and active transcriptional states introduces noise in gene expression.Kar G Kim JK Kolodziejczyk AA Natarajan KN Torlai Triglia E Mifsud B Elderkin S
Nat Commun,
Macmillan Publishers Limited, Part of Springer Nature vol. 8 (1), 36-36.
26-06-2017 Keep Them Close: PRC2 Poises Enhancer-Promoter Interactions at Anterior Neuronal GenesCaglio G Torlai Triglia E Pombo A
01-05-2017 Active and poised promoter states drive folding of the extended HoxB locus in mouse embryonic stem cellsBarbieri M Xie SQ Torlai Triglia E Chiariello AM Bianco S de Santiago I Branco MR Rueda D
Nature Structural & Molecular Biology,
Springer Nature vol. 24 (6), 515-524.
24-04-2017 A Finer Print Than TADs: PRC1-Mediated DomainsTorlai Triglia E Rito T
01-02-2017 2015
Methylation of RNA polymerase II non-consensus Lysine residues marks early transcription in mammalian cellsDias JD Rito T Torlai Triglia E Kukalev A Ferrai C Chotalia M Kimura H
Elife,
Elife vol. 4, e11215-e11215.
19-12-2015 Active and poised promoter states drive folding of the extended HoxB locus in mouse embryonic stem cellsBarbieri M Xie SQ Torlai Triglia E de Santiago I Branco MR Rueda D Nicodemi M Pombo A
In
Biorxiv TIM-4 Identifies Effector B Cells Expressing An IL-23-Driven Proinflammatory Cytokine Module That Promotes Immune ResponsesDing Q Wu Y Torlai Triglia E Gommerman JL Subramanian A Kuchroo VK Rothstein DM
In
Biorxiv
Research Group
PhD Students
- Tanzila Harun
Understanding The Genetic and Epigenetic Regulation of Cell Behaviours in Melanoma
