Professor Michelle West
Head of School of Biological and Behavioural Sciences, Professor of Tumour Virology
School of Biological and Behavioural Sciences
Queen Mary University of London
Research
Epstein-Barr Virus, Transcription, epigenetics, cancer, structural biology, drug discovery
Interests
Mechanisms of Epstein-Barr Virus B cell transformation and its role in cancer development. Transcriptional regulation by the EBV transcription factors, EBNA2, 3A, 3B and 3C. Enhancer-promoter interactions and 3D chromatin reorganisation. Impact of sequence variation on the structure and function of EBV proteins, including the latent replication factor EBNA 1. Structure-led drug discovery of inhibitors of EBNA1 for the development of new therapeutics.
Publications
Publications of specific relevance to the Centre for Molecular Cell Biology
2025
Repression of CADM1 transcription by HPV type 18 is mediated by three-dimensional rearrangement of promoter-enhancer interactions Plos Pathogens,
Public Library of Science (Plos) vol. 21 (1)
27-01-20252024
A Shared Receptor Suggests a Common Ancestry between an Insecticidal Bacillus thuringiensis Cry Protein and an Anti-Cancer Parasporin Biomolecules,
Mdpi vol. 14 (7)
04-07-2024 2022
Regulation of B cell receptor signalling by Epstein–Barr virus nuclear antigens Biochemical Journal,
Portland Press vol. 479 (23), 2395-2417.
07-12-2022 Dissecting the impact of bromodomain inhibitors on the Interferon Regulatory Factor 4‐MYC oncogenic axis in multiple myelomaAgnarelli A Mitchell S Caalim G Wood CD Milton‐Harris L Chevassut T West MJ Mancini EJ
Hematological Oncology,
Wiley vol. 40 (3), 417-429.
18-05-2022 Probing the Mechanism of Action of Cry41Aa on HepG2 through the Establishment of a Resistant Subline Toxins,
Mdpi vol. 14 (5)
29-04-2022 2019
Differential proteolytic activation of the Bacillus thuringiensis Cry41Aa parasporin modulates its anticancer effect. Biochemical Journal,
Portland Press vol. 476 (24), 3805-3816.
23-12-2019 Increased association between Epstein-Barr virus EBNA2 from type 2 strains and the transcriptional repressor BS69 restricts EBNA2 activity Plos Pathogens,
Public Library of Science (Plos) vol. 15 (7)
08-07-2019 The role of membrane-bound metal ions in toxicity of a human cancer cell-active pore-forming toxin Cry41Aa from Bacillus thuringiensis Toxicon,
Elsevier vol. 167, 123-133.
07-06-2019 2018
Disruption of CTCF-YY1–dependent looping of the human papillomavirus genome activates differentiation-induced viral oncogene transcription Plos Biology,
Public Library of Science (Plos) vol. 16 (10)
25-10-2018 Enhancer Control of MicroRNA miR-155 Expression in Epstein-Barr Virus-Infected B Cells Journal of Virology,
American Society For Microbiology vol. 92 (19), 10.1128/jvi.00716-10.1128/jvi.00718.
12-09-2018 Pumilio directs deadenylation-associated translational repression of the cyclin-dependent kinase 1 activator RGC-32 Nucleic Acids Research,
Oxford University Press (OUP) vol. 46 (7)
27-01-2018 2016
MYC activation and BCL2L11 silencing by a tumour virus through the large-scale reconfiguration of enhancer-promoter hubs Elife,
Elife vol. 5
04-08-2016 1994
Precipitation of the Epstein—Barr virus protein EBNA 2 by an EBNA 3c-specific monoclonal antibody Journal of General Virology,
Microbiology Society vol. 75 (4), 769-778.
01-04-1994
Research Group
