Dr Paul J. Hurd
Reader in Genome Regulation and Epigenetics
School of Biological and Behavioural Sciences
Queen Mary University of London
Queen Mary University of London
Research
Honey bee, Functional Genomics, Epigenetics, Chromatin, Phenotypic plasticity
Publications
Publications of specific relevance to the Centre for Molecular Cell Biology2025
A dynamic histone-based chromatin regulatory toolkit underpins genome and developmental evolution in an invertebrate cladeMartín-Zamora FM Cole J Donnellan RD Guynes K Carrillo-Baltodano AM Dickman MJ Hurd PJ Martín-Durán JM
Genome Biology, Springer Nature vol. 26 (1)
10-06-2025
2024
Annelid methylomes reveal ancestral developmental and aging-associated epigenetic erosion across BilateriaGuynes K Sarre LA Carrillo-Baltodano AM Davies BE Xu L Liang Y Martín-Zamora FM Hurd PJ et al.
Genome Biology, Springer Nature vol. 25 (1), 204-204.
01-08-2024
2023
The PWWP domain and the evolution of unique DNA methylation toolkits in HymenopteraKucharski R Ellis N Maleszka R
Iscience, Cell Press vol. 26 (11)
17-11-2023
2022
Chromatin accessibility-based characterisation of brain gene regulatory networks in three distinct honey bee polyphenisms.Lowe R Wojciechowski M
Nucleic Acids Research, Oxford University Press
04-11-2022
2021
Novel structure in the nuclei of honey bee brain neurons revealed by immunostainingHurd PJ Grübel K Wojciechowski M Maleszka R
Scientific Reports, Nature Publishing Group vol. 11 (1)
01-12-2021
Dataset of the next-generation sequencing of variable 16S rRNA from bacteria and ITS2 regions from fungi and plants derived from honeybees kept under anthropogenic landscapesGancarz M Hurd PJ Latoch P Polaszek A Michalska-Madej J Grochowalski Ł Strapagiel D Gnat S et al.
Data in Brief, Elsevier vol. 36
02-04-2021
Amplicon Sequencing of Variable 16S rRNA from Bacteria and ITS2 Regions from Fungi and Plants, Reveals Honeybee Susceptibility to Diseases Results from Their Forage Availability under Anthropogenic LandscapesPtaszyńska AA Latoch P Hurd PJ Polaszek A Michalska-Madej J Strapagiel D Gnat S Załuski D et al.
Pathogens, Mdpi vol. 10 (3)
22-03-2021
2020
Phenotypic responses to temperature in the ciliate Tetrahymena thermophilaWeber de Melo V Lowe R Hurd PJ Petchey OL
Ecology and Evolution, Wiley
01-07-2020
2019
Acute social isolation alters neurogenomic state in songbird forebrain.George JM Bell ZW Condliffe D Dohrer K Abaurrea T Spencer K Gahr M Hurd PJ
Proc Natl Acad Sci U S A
22-07-2019
2018
Phenotypically distinct female castes in honey bees are defined by alternative chromatin states during larval developmentWOJCIECHOWSKI M LOWE R Maleszka J CONN D
Genome Research, Cold Spring Harbor Laboratory Press
22-08-2018
Changes in the bioelement content of summer and winter western honeybees (Apis mellifera) induced by Nosema ceranae infectionPtaszyńska AA Gancarz M Borsuk G Wiącek D Nawrocka A Strachecka A
Plos One, Public Library of Science (Plos) vol. 13 (7)
25-07-2018
2015
Binding loci of RelA-containing nuclear factor-kappaB dimers in promoter regions of PHM1-31 myometrial smooth muscle cells.Cookson VJ Waite SL Hurd PJ Chapman NR
Mol Hum Reprod vol. 21 (11), 865-883.
01-11-2015
Arginine methylation and citrullination of splicing factor proline- and glutamine-rich (SFPQ/PSF) regulates its association with mRNA.Snijders AP Hautbergue GM Bloom A Williamson JC Minshull TC Phillips HL Mihaylov SR Gjerde DT et al.
Rna vol. 21 (3), 347-359.
01-03-2015
2014
S6 kinase 2 is bound to chromatin-nuclear matrix cellular fractions and is able to phosphorylate histone H3 at threonine 45 in vitro and in vivo.Ismail HMS Hurd PJ Khalil MIM Kouzarides T Bannister A
J Cell Biochem vol. 115 (6), 1048-1062.
01-06-2014
2013
Epigenetic mechanisms in development and disease.Murrell A Hurd PJ
Biochem Soc Trans vol. 41 (3), 697-699.
01-06-2013
Inactive or moderately active human promoters are enriched for inter-individual epialleles.Gemma C Ramagopalan SV Down TA Beyan H Hawa MI Hurd PJ Giovannoni G Leslie RD
Genome Biol vol. 14 (5)
25-05-2013
Extensive histone post-translational modification in honey bees.Dickman MJ Kucharski R Hurd PJ
Insect Biochem Mol Biol vol. 43 (2), 125-137.
01-02-2013
2012
Meeting previewMurrell A Hurd P Wood I
The Biochemist, Portland Press vol. 34 (5)
01-10-2012
2010
The era of epigenetics.Hurd PJ
Brief Funct Genomics vol. 9 (5-6), 425-428.
01-12-2010
Systems biology for ecology. From molecules to ecosystemsPurdy KJ Hurd PJ Trimmer M Woodward G
30-11-2010
Systems Biology for Ecology: From Molecules to EcosystemsPurdy KJ Hurd PJ Moya-Larano J Trimmer M Woodward G
Adv Ecol Res vol. 43, 87-149.
01-01-2010
Chapter 3 Systems Biology for Ecology From Molecules to EcosystemsPurdy KJ Hurd PJ Moya-Laraño J Trimmer M Oakley BB
In Integrative Ecology: From Molecules to Ecosystems, Elsevier 87-149.
01-01-2010
2009
Phosphorylation of histone H3 Thr-45 is linked to apoptosis.Hurd PJ Bannister AJ Halls K Dawson MA Vermeulen M Olsen JV Somers J Owen-Hughes T
J Biol Chem vol. 284 (24), 16575-16583.
12-06-2009
Advantages of next-generation sequencing versus the microarray in epigenetic research.Hurd PJ Nelson CJ
Brief Funct Genomic Proteomic vol. 8 (3), 174-183.
01-05-2009
2008
Heritable gene repression through the action of a directed DNA methyltransferase at a chromosomal locusSmith AE Hurd PJ Bannister AJ
J Biol Chem vol. 283 (15), 9878-9885.
11-04-2008
DNMT1 interacts with the developmental transcriptional repressor HESX1.Sajedi E Gaston-Massuet C Andoniadou CL Signore M Hurd PJ Dattani M
Biochim Biophys Acta vol. 1783 (1), 131-143.
01-01-2008
2007
Directed de novo DNA methylation of a genomic locus leads to heritable transcriptional repressionFord KG Hurd PJ Bannister AJ
BLOOD. vol. 110 (11), 108A-108A.
16-11-2007
2006
Dynamic distribution of the replacement histone variant H3.3 in the mouse oocyte and preimplantation embryosTorres-Padilla ME Bannister AJ Hurd PJ Zernicka-Goetz M
Int J Dev Biol vol. 50 (5), 455-461.
01-01-2006
2003
The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase.Fuks F Deplus R
Nucleic Acids Res vol. 31 (9), 2305-2312.
01-05-2003
The Methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylationFuks F Hurd PJ Wolf D Nan XS
J Biol Chem vol. 278 (6), 4035-4040.
07-02-2003
2002
Characterisation of site-biased DNA methyltransferases: specificity, affinity and subsite relationshipsMcNamara AR Hurd PJ Smith AEF Ford KG
Nucleic Acids Res vol. 30 (17), 3818-3830.
01-09-2002
Zebularine: a novel DNA methylation inhibitor that forms a covalent complex with DNA methyltransferases.Zhou L Cheng X Dickman MJ Hurd PJ
J Mol Biol vol. 321 (4), 591-599.
23-08-2002
1999
Mechanism-based inhibition of C5-cytosine DNA methyltransferases by 2-H pyrimidinone.HURD PJ Whitmarsh AJ Baldwin GS Waltho JP Price NC Hornby DP
Journal of Molecular Biology vol. 286 (2), 389-401.
01-01-1999
The evolution and developmental dynamics of histone-based chromatin regulation in AnnelidaMartín-Zamora FM Cole J Donnellan RD Guynes K Carrillo-Baltodano AM Dickman MJ Hurd PJ Martín-Durán JM
In Biorxiv
Amplicon sequencing of variable 16S rRNA and ITS2 regions reveal honeybee susceptibility to diseases resulted of their dietary preferences under anthropogenic landformsPtaszyńska AA Latoch P Hurd PJ Polaszek A Michalska-Madej J Grochowalski Ł Strapagiel D Gnat S et al.
In Biorxiv
Systemic mutational rescue in Escherichia coli elicited by a valency dependent, high affinity protein DNA interactionHurd PJ Al-Swailem AM Bin Dukhyil AAA Sheikh QI Al-Ghanim AA Alfageih L Matin M Lu YT et al.
In Biorxiv
Annelid methylomes reveal ancestral developmental and ageing-associated epigenetic erosion across BilateriaGuynes K Sarre LA Carrillo-Baltodano AM Davies BE Xu L Liang Y Martín-Zamora FM Hurd PJ et al.
In Biorxiv
Grants
Grants of specific relevance to the Centre for Molecular Cell BiologyThe Role of Nutrition as an Epigenetic Modulator of Phenotypic Plasticity during Honeybee DevelopmentPaul J. Hurd
£672,317 BBSRC Biotechnology and Biological Sciences Research Council
01-05-2022 - 30-04-2026
Genomic experiments and data generation for UoMunsterPaul J. Hurd
£10,188 University of Munster
01-02-2021 - 31-10-2023
Research Group
Research Staff
PhD Students
- Nicole Forrester
Regulation of Stem Cell Differentiation and Organismal Development by Royal Jelly - Yeahji Jeong
High Resolution Molecular Diagnostics to Improve Pollinator Health - Zoe O'Neill
Epigenetic Determination of Phenotypic Plasticity in The Honey Bee - Peng Zhou
Characterization of The Evolution of DNA Methylation Readers Across Eukaryotes
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