Dr Claire Villette
Lecturer in Computational Bioengineering
School of Engineering and Materials Science
Queen Mary University of London
Research
Bone metastasis, Computational models, In vitro models, Mechanobiology, Biomechanics
Interests
With the B-MECA lab, I focus on the interactions between cancerous metastases and bone intrinsic remodelling processes, with a particular interest in dormancy and the influence of mechanical loading. I use both in silico and in vitro approaches, harnessing the synergy between mechanistic computational modelling and experimental tissue engineering.
Publications

Publications of specific relevance to the Centre for Bioengineering
2025
Targeting uPARAP Modifies Lymphatic Vessel Architecture and Attenuates Lymphedema Circulation,
Lippincott Williams & Wilkins vol. 151 (19), 1412-1429.
13-05-2025
Semi-mechanistic efficacy model for PARP plus ATR inhibitors-application to rucaparib and talazoparib in combination with gartisertib in breast cancer PDXs British Journal of Cancer,
Springernature vol. 132 (5), 481-491.
23-03-20252024
Influence of a change in activity regime on femoral bone architecture and failure behaviour Plos One,
Public Library of Science (Plos) 29-04-20242023
Should personalised dosing have a role in cancer treatment? Frontiers in Oncology,
Frontiers Media Sa vol. 13 (ARTN 1154493)
05-05-2023
Therapeutic effect of mechanical loading on bone metastasis: an hca modelling framework 01-01-20232022
Hybrid cellular automaton representation of the influence of mechanical stimulation on the development of bone metastases 10-10-20222021
A precision dosing application for patients treated with docetaxel and G-CSF. 01-07-2021
A precision dosing application for prostate cancer patients treated with docetaxel and G-CSF. 01-05-20212020
Multitechnology Biofabrication: A New Approach for the Manufacturing of Functional Tissue Structures? Trends in Biotechnology,
Elsevier vol. 38 (12), 1316-1328.
01-01-20202019
Influence of femoral external shape on internal architecture and fracture risk Biomechanics and Modeling in Mechanobiology,
Springer Heidelberg vol. 19 (4), 1251-1261.
08-11-2019
Developing a head and neck cancer model to assess the effect of radiotherapy on tumour growth inhibition and regrowth 01-01-2019
A precision dosing application for prostate cancer chemotherapy 01-01-20192018
Rate and age-dependent damage elasticity formulation for efficient hip fracture simulations Medical Engineering & Physics,
Elsevier vol. 61, 1-12.
01-01-2018
Optimised heterogeneous scaffolds for bone tissue engineering: towards tailored mechanical stimulation 01-01-2018
Heterogeneous design optimisation of tissue engineering scaffolds: in-vitro assessment of a digital design framework 01-01-2018
Computational design optimisation for local control over mechanical properties in heterogeneous scaffolds 01-01-20182017
Microscale poroelastic metamodel for efficient mesoscale bone remodelling simulations Biomechanics and Modeling in Mechanobiology,
Springer Heidelberg vol. 16 (6), 2077-2091.
01-12-2017
Optimised heterogeneous scaffolds for bone tissue engineering: towards tailored bone mechanotransduction 01-01-2017
Optimisation of heterogeneous bone tissue engineering scaffolds: proof of concept for a digital design tool 01-01-20172016
Surrogate poroelastic microscale representation of bone remodelling to inform an ef?cient structural mesoscale bone adaptation model 01-01-2016
Microscale poroelastic metamodel for efficient mesoscale bone remodelling simulations 01-01-2016
Informing phenomenological structural bone remodelling with a mechanistic poroelastic model Biomechanics and Modeling in Mechanobiology,
Springer (Part of Springer Nature) vol. 15 (1), 69-82.
01-01-20162015
Rate and age-dependent damage elasticity formulation for efficient hip fracture simulations 01-01-2015
Frangible optimised lower limb surrogate for assessing injury caused by underbelly blast 01-01-2015
Femoral bone mesoscale structural architecture prediction using musculoskeletal and finite element modelling International Biomechanics,
Taylor & Francis Group vol. 2 (1), 43-61.
01-01-20152014
Towards a patient-specific combined musculoskeletal and finite element model of bone structure 01-01-2014
Combined predictive structural finite element and musculoskeletal modelling of bone structure for study of fracture under solid blast condition 01-01-2014
Combined musculoskeletal and finite element predictive modelling of bone structure for study of solid blast injury 01-01-2014
Combined musculoskeletal and finite element predictive modelling of bone structure and simple fracture analysis 01-01-2014
Combined finite element and musculoskeletal predictive structural modelling of the femur: Potential mechanobiology applications 01-01-20142013
The influence of extreme speeds on scapula kinematics and the importance of controlling the plane of elevation Clinical Biomechanics,
Elsevier vol. 28 (9-10), 973-980.
01-01-2013
Combined Musculoskeletal and Finite Element Modelling of the Femur 01-01-2013
Research Group