Dr Claire Villette

Lecturer in Computational Bioengineering
School of Engineering and Materials Science
Queen Mary University of London
Queen Mary University of London
Research
Bone metastasis, Computational models, In vitro models, Mechanobiology, Biomechanics
Interests
With the B-MECA lab, I focus on the interactions between cancerous metastases and bone intrinsic remodelling processes, with a particular interest in dormancy and the influence of mechanical loading. I use both in silico and in vitro approaches, harnessing the synergy between mechanistic computational modelling and experimental tissue engineering.Publications
Publications of specific relevance to the Centre for Bioengineering2025
Development of an In Vitro Bone Metastasis Model Mimicking Cellular Crosstalk in the Bone MicroenvironmentVillette C Champion A
Congress of the European Society Of Biomaterials Turin 7 Sep 2025 - 11 Sep 2025.
07-09-2025
Targeting uPARAP Modifies Lymphatic Vessel Architecture and Attenuates LymphedemaGucciardo F Lebeau A Pirson S Buntinx F Ivanova E Blacher S Brouillard P Deroye J et al.
Circulation, Wolters Kluwer vol. 151 (19), 1412-1429.
04-03-2025
Semi-mechanistic efficacy model for PARP + ATR inhibitors—application to rucaparib and talazoparib in combination with gartisertib in breast cancer PDXsVillette CC Dupuy N Brightman FA Zimmermann A Lignet F Zenke FT Terranova N Bolleddula J et al.
British Journal of Cancer, Springer Nature vol. 132 (5), 481-491.
28-01-2025
2024
Influence of a change in activity regime on femoral bone architecture and failure behaviourVillette C Phillips ATM
Plos One, Public Library of Science (Plos)
29-04-2024
2023
Should personalised dosing have a role in cancer treatment?Villette CC Orrell D Millen J Chassagnole C
Frontiers in Oncology, Frontiers vol. 13
05-05-2023
Therapeutic effect of mechanical loading on bone metastasis: an hca modelling frameworkVillette C Geris L
01-01-2023
2022
Hybrid cellular automaton representation of the influence of mechanical stimulation on the development of bone metastasesVillette C Geris L
10-10-2022
2021
A precision dosing application for patients treated with docetaxel and G-CSF.Hurry C Villette C Mistry H Millen J Chassagnole C
01-07-2021
A precision dosing application for prostate cancer patients treated with docetaxel and G-CSF.Villette C Hurry C Mistry H Millen J Chassagnole C
20-05-2021
2020
Multitechnology Biofabrication: A New Approach for the Manufacturing of Functional Tissue Structures?Castilho M de Ruijter M Beirne S Villette CC Ito K Wallace GG Malda J
Trends in Biotechnology, Elsevier vol. 38 (12), 1316-1328.
25-05-2020
2019
Influence of femoral external shape on internal architecture and fracture riskVillette CC Zhang J Phillips ATM
Biomechanics and Modeling in Mechanobiology, Springer Nature vol. 19 (4), 1251-1261.
08-11-2019
Developing a head and neck cancer model to assess the effect of radiotherapy on tumour growth inhibition and regrowthOrtega F Orell D Villette C Mistry H Brightman F Millen J Chassagnole C
01-01-2019
A precision dosing application for prostate cancer chemotherapyVillette C Mistry H Ortega FG Orrell D Brightman FA Millen J Chassagnole C
01-01-2019
2018
Rate and age-dependent damage elasticity formulation for efficient hip fracture simulationsVillette CC Phillips ATM
Medical Engineering & Physics, Iop Publishing vol. 61 (1), 1-12.
08-09-2018
Optimised heterogeneous scaffolds for bone tissue engineering: towards tailored mechanical stimulationVillette C
01-01-2018
Heterogeneous design optimisation of tissue engineering scaffolds: in-vitro assessment of a digital design frameworkVillette CC Castilho M Malda J Phillips A
01-01-2018
Computational design optimisation for local control over mechanical properties in heterogeneous scaffoldsVillette CC Castilho M Malda J Phillips A
01-01-2018
2017
Microscale poroelastic metamodel for efficient mesoscale bone remodelling simulationsVillette CC Phillips ATM
Biomechanics and Modeling in Mechanobiology, Springer Nature vol. 16 (6), 2077-2091.
09-08-2017
Optimised heterogeneous scaffolds for bone tissue engineering: towards tailored bone mechanotransductionVillette C Castilho M Malda J Phillips A
01-01-2017
Optimisation of heterogeneous bone tissue engineering scaffolds: proof of concept for a digital design toolVillette C Castilho M Malda J Phillips A
01-01-2017
2016
Surrogate poroelastic microscale representation of bone remodelling to inform an ef?cient structural mesoscale bone adaptation modelVillette C Phillips A
01-01-2016
Microscale poroelastic metamodel for efficient mesoscale bone remodelling simulationsVillette C Phillips A
01-01-2016
2015
Informing phenomenological structural bone remodelling with a mechanistic poroelastic modelVillette CC Phillips ATM
Biomechanics and Modeling in Mechanobiology, Springer Nature vol. 15 (1), 69-82.
03-11-2015
Rate and age-dependent damage elasticity formulation for efficient hip fracture simulationsVillette C Phillips A
01-01-2015
Frangible optimised lower limb surrogate for assessing injury caused by underbelly blastVillette C Zaharie D Phillips A
01-01-2015
Femoral bone mesoscale structural architecture prediction using musculoskeletal and finite element modellingPhillips ATM Villette CC Modenese L
International Biomechanics, Taylor & Francis vol. 2 (1), 43-61.
01-01-2015
2014
Towards a patient-specific combined musculoskeletal and finite element model of bone structureVillette C Phillips A
01-01-2014
Combined predictive structural finite element and musculoskeletal modelling of bone structure for study of fracture under solid blast conditionVillette C Phillips A
01-01-2014
Combined musculoskeletal and finite element predictive modelling of bone structure for study of solid blast injuryVillette C Phillips A
01-01-2014
Combined musculoskeletal and finite element predictive modelling of bone structure and simple fracture analysisVillette C Phillips A Modenese L
01-01-2014
Combined finite element and musculoskeletal predictive structural modelling of the femur: Potential mechanobiology applicationsVillette C Modenese L Phillips A
01-01-2014
2013
The influence of extreme speeds on scapula kinematics and the importance of controlling the plane of elevationPrinold JAI Villette CC Bull AMJ
Clinical Biomechanics, Elsevier vol. 28 (9-10), 973-980.
17-10-2013
Combined Musculoskeletal and Finite Element Modelling of the FemurVillette C Thibon A Modenese L Phillips A
01-01-2013
Research Group
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