Dr Josephine Wu
PhD
Academic Fellow in Tissue Engineering & Regenerative Medicine
School of Engineering and Materials Science
Queen Mary University of London
Research
tissue engineering, regenerative medicine, stem cells, cartilage, optogenetics, bioprinting
Interests
Our research focus is on tissue engineering of cartilage and bone. In particular, we are interested in leveraging cellular self-assembly (spheroids) while applying bioengineering strategies (e.g. bioprinting, optogenetics) to define local identity and structure, leading to spatially organized tissues with enhanced functionality. Ultimately, these advanced human tissue models will help us to better understand joint disease, develop associated treatments, and accelerate the clinical translation of regenerative implants.
Publications
Publications of specific relevance to the Centre for Bioengineering
2023
Directed differentiation of human iPSCs into mesenchymal lineages by optogenetic control of TGF-β signalingWu JY Yeager K Tavakol DN Morsink M Wang B Soni RK Hung CT Vunjak-Novakovic G
Cell Reports,
Elsevier vol. 42 (5)
01-05-20232022
Bioengineering Human Cartilage-Bone Tissues for Modeling of Osteoarthritis.Wu JY Vunjak-Novakovic G
Stem Cells Dev vol. 31 (15-16), 399-405.
01-08-2022 2020
Tissue engineered autologous cartilage-bone grafts for temporomandibular joint regenerationChen D Wu JY Kennedy KM Yeager K Bernhard JC Ng JJ Zimmerman BK Robinson S et al.
Science Translational Medicine,
American Association For The Advancement of Science (Aaas) vol. 12 (565)
14-10-2020 2019
Long-Acting IL-33 Mobilizes High-Quality Hematopoietic Stem and Progenitor Cells More Efficiently Than Granulocyte Colony-Stimulating Factor or AMD3100Alt C Yuan S Wu F Stankovich B Calaoagan J Schopies S Wu JY Shen J et al.
Transplantation and Cellular Therapy,
Elsevier vol. 25 (8), 1475-1485.
01-06-2019
Grants
Grants of specific relevance to the Centre for Bioengineering
Engineering functional tissues by spatiotemporal patterning: 3D bioprinting and optogenetics for directing the organization of cell spheroid building blocks (OPTO-BIOPRINTING)Josephine Wu£685,186
Wellcome Trust 
15-08-2025 - 14-08-2030
Research Group
