Dr Marco Pensalfini
Lecturer in Mechanical and Biomedical Engineering
School of Engineering and Materials Science
Queen Mary University of London
Research
Bioengineering, Experimental Biomechanics, Multiscale Computational Modelling, Fibrous Biomaterials, Wound Healing, Bioinspired Design
Interests
My expertise is at the interface of mechanical and biomedical engineering, with a focus on the multiscale mechanics of soft fibrous biomaterials. A central theme is the development of novel experimental approaches combining mechanics and imaging techniques to unravel mechanisms of load redistribution across tissue lengthscales and address their mechanobiological relevance. I also have broad experience in establishing two-way links between experiments and corresponding computational models with predictive or interpretative function, including inverse FEA and hierarchical Bayesian inverse analysis. My work is intrinsically multidisciplinary, and over the years I have initiated multiple collaborations with clinical and industrial partners.
Publications

Publications of specific relevance to the Centre for Bioengineering
2025
Decoding Multiscale Mechanisms in Facial Sagging: Impact of Soft Tissue Deformability, Growth, and Dermal Anchoring on Jowl FormationPensalfini M Bielicki A Shaiek A Dal Belo SE Santoprete R
Journal of Investigative Dermatology,
Elsevier 01-10-20252023
Nonaffine Mechanics of Entangled Networks Inspired by Intermediate FilamentsPensalfini M Golde T Arroyo M
Physical Review Letters,
American Physical Society (Aps) vol. 131 (5)
04-08-2023
Mechano-biological and bio-mechanical pathways in cutaneous wound healingPensalfini M Tepole AB
Plos Computational Biology,
Public Library of Science (Plos) vol. 19 (3)
09-03-20232020
How cosmetic tightening products modulate the biomechanics and morphology of human skinPensalfini M Rotach M Hopf R Bielicki A
Acta Biomaterialia,
Elsevier vol. 115, 299-316.
25-08-2020
Activin-mediated alterations of the fibroblast transcriptome and matrisome control the biomechanical properties of skin woundsWietecha MS Pensalfini M Cangkrama M Müller B Jin J Werner S
Nature Communications,
Springer Nature vol. 11 (1)
25-05-20202019
Publisher Correction: Tear resistance of soft collagenous tissuesBircher K Zündel M Pensalfini M Ehret AE Mazza E
Nature Communications,
Springer Nature vol. 10 (1)
30-05-2019
On the compressibility and poroelasticity of human and murine skinWahlsten A Pensalfini M Stracuzzi A Hopf R
Biomechanics and Modeling in Mechanobiology,
Springer Nature vol. 18 (4), 1079-1093.
26-02-2019
Tear resistance of soft collagenous tissuesBircher K Zündel M Pensalfini M Ehret AE
Nature Communications,
Springer Nature vol. 10 (1)
15-02-20192018
Development of a Novel Human Cell-Derived Tissue-Engineered Heart Valve for Transcatheter Aortic Valve Replacement: an In Vitro and In Vivo Feasibility StudyLintas V Fioretta ES Motta SE Dijkman PE Pensalfini M Mazza E Rodriguez H Lipiski M et al.
Journal of Cardiovascular Translational Research,
Springer Nature vol. 11 (6), 470-482.
13-08-2018
A novel ultra-light suction device for mechanical characterization of skinMüller B Elrod J Pensalfini M Hopf R Schiestl C
Plos One,
Public Library of Science (Plos) vol. 13 (8)
08-08-20182017
Location-specific mechanical response and morphology of facial soft tissuesPensalfini M Weickenmeier J Rominger M Santoprete R Distler O
Journal of The Mechanical Behavior of Biomedical Materials,
Elsevier vol. 78, 108-115.
14-11-2017
The mechanical fingerprint of murine excisional woundsPensalfini M Haertel E Wietecha M
Acta Biomaterialia,
Elsevier vol. 65, 226-236.
12-10-2017
The suture retention test, revisited and revisedPensalfini M Meneghello S Lintas V Bircher K Ehret AE
Journal of The Mechanical Behavior of Biomedical Materials,
Elsevier vol. 77, 711-717.
24-08-20172016
Factors affecting the mechanical behavior of collagen hydrogels for skin tissue engineeringPensalfini M Ehret AE Stüdeli S Marino D Kaech A Reichmann E
Journal of The Mechanical Behavior of Biomedical Materials,
Elsevier vol. 69, 85-97.
09-12-2016
Guidelines for standardization of bioprinting: a systematic study of process parameters and their effect on bioprinted structuresKesti M Fisch P Pensalfini M
Bionanomaterials,
De Gruyter vol. 17 (3-4), 193-204.
19-05-20162015
Challenging the in-vivo assessment of biomechanical properties of the uterine cervix: A critical analysis of ultrasound based quasi-static proceduresMaurer MM Badir S Pensalfini M Bajka M Mazza E
Journal of Biomechanics,
Elsevier vol. 48 (9), 1541-1548.
26-02-20152014
Evaluation of Global Load Sharing and Shear-Lag Models to Describe Mechanical Behavior in Partially Lacerated TendonsPensalfini M Duenwald-Kuehl S Kondratko-Mittnacht J
Journal of Biomechanical Engineering,
Asme International vol. 136 (9)
15-07-2014
A keratin bundling transition uncages the nucleus in stretched epitheliaGolde T Pensalfini M Chahare N Roca-Cusachs P Wiche G Charras GT Arroyo M Trepat X
In
Biorxiv
Grants

Grants of specific relevance to the Centre for Bioengineering
Full-field Biomechanical Characterization Of Oral Wounds In Physiological ConditionsMarco Pensalfini£29,620
Royal Society31-03-2025 - 31-05-2026
Research Group
PhD Students
- Johnson Lee
Engineered Recombinant Strategies to Organo-Hydrogel Design With Applications From Plant-Based Foods to Tissue Engineering - Sara Piccirillo
Biomechanics of Scarless Wound Healing - Hasitha Senevirathne
Coact Cdt Training Programme