Dr Ian Sealy
Postdoctoral Research Assistant
School of Biological and Behavioural Sciences
Queen Mary University of London
Queen Mary University of London
Member of Dr Elisabeth Busch-Nentwich's Research Group
| Funder: | National Institutes of Health - USA |
| Project: | NIH: Zebrafish addiction screen |
Publications
Publications of specific relevance to the Centre for Evolutionary and Functional Genomics2024
Digenic inheritance involving a muscle-specific protein kinase and the giant titin protein causes a skeletal muscle myopathyTöpf A, Cox D, Zaharieva IT, Di Leo V, Sarparanta J, Jonson PH, Sealy IM, Smolnikov A, White RJ, Vihola A, Savarese M, Merteroglu M, Wali N, Laricchia KM, Venturini C, Vroling B, Stenton SL, Cummings BB, Harris E, Marini-Bettolo C, et al.
Nature Genetics, Springer Nature vol. 56 (3), 395-407.
01-03-2024
Transcriptional profiling of zebrafish identifies host factors controlling susceptibility to Shigella flexneriTorraca V, White RJ, Sealy IM, Mazon-Moya M, Duggan G, Willis A, Busch-Nentwich EM and Mostowy S
Disease Models & Mechanisms, The Company of Biologists vol. 17 (1)
01-01-2024
2022
VP.81 In vivo modulation of novel genetic modifiers for LAMA2-RDPini V, Weisburd B, Merteroglu M, Sealy I, White R, Busch-Nentwich E and Muntoni F
Neuromuscular Disorders, Elsevier vol. 32, s124-s125.
01-10-2022
Loss of slc39a14 causes simultaneous manganese hypersensitivity and deficiency in zebrafishTuschl K, White RJ, Trivedi C, Valdivia LE, Niklaus S, Bianco IH, Dadswell C, González-Méndez R, Sealy IM, Neuhauss SCF, Houart C, Rihel J, Wilson SW and Busch-Nentwich EM
Disease Models and Mechanisms, The Company of Biologists vol. 15 (6)
15-06-2022
Translational relevance of forward genetic screens in animal models for the study of psychiatric diseaseSheardown E, Mech AM, Petrazzini MEM, Leggieri A, Gidziela A, Hosseinian S, Sealy IM, Torres-Perez JV, Busch-Nentwich EM, Malanchini M and Brennan CH
Neuroscience and Biobehavioral Reviews, Elsevier vol. 135
04-02-2022
Behavioral and Gene Regulatory Responses to Developmental Drug Exposures in ZebrafishMech AM, Merteroglu M, Sealy IM, Teh M-T, White RJ, Havelange W, Brennan CH and Busch-Nentwich EM
Frontiers in Psychiatry, Frontiers vol. 12
10-01-2022
2019
Common and distinct transcriptional signatures of mammalian embryonic lethalityCollins JE, White RJ, Staudt N, Sealy IM, Packham I, Wali N, Tudor C, Mazzeo C, Green A, Siragher E, Ryder E, White JK, Papatheodoru I, Tang A, Füllgrabe A, Billis K, Geyer SH, Weninger WJ, Galli A, Hemberger M, et al.
Nature Communications, Springer Nature vol. 10 (1)
26-06-2019
The gene regulatory basis of genetic compensation during neural crest inductionDooley CM, Wali N, Sealy IM, White RJ, Stemple DL, Collins JE and Busch-Nentwich EM
Plos Genetics, Public Library of Science (Plos) vol. 15 (6)
14-06-2019
Compensatory growth renders Tcf7l1a dispensable for eye formation despite its requirement in eye field specificationYoung RM, Hawkins TA, Cavodeassi F, Stickney HL, Schwarz Q, Lawrence LM, Wierzbicki C, Cheng BY, Luo J, Ambrosio EM, Klosner A, Sealy IM, Rowell J, Trivedi CA, Bianco IH, Allende ML, Busch-Nentwich EM, Gestri G and Wilson SW
Elife, Elife vol. 8
19-02-2019
2018
The age of heterozygous telomerase mutant parents influences the adult phenotype of their offspring irrespective of genotype in zebrafishScahill CM, Digby Z, Sealy IM, White RJ, Wali N, Collins JE, Stemple DL and Busch-Nentwich EM
Wellcome Open Research, F1000research vol. 2
22-02-2018
CAPZB: A Potential Novel Key Player in Cardiac Development and Congenital Heart DefectsRadloff A, Breckpot J, Hoff K, Kramer HH, Panáková D, Mercks A, Devriendt K, Gewillig M, Sealy I, Collins J, Busch-Nentwich E, Kahlert AK and Hitz MP
50th Annual Meeting of the German Society for Pediatric Cardiology (DGPK). vol. 66, s111-s138.
01-01-2018
2017
A high-resolution mRNA expression time course of embryonic development in zebrafishWhite RJ, Collins JE, Sealy IM, Wali N, Dooley CM, Digby Z, Stemple DL, Murphy DN, Billis K, Hourlier T, Füllgrabe A, Davis MP, Enright AJ and Busch-Nentwich EM
Elife, Elife vol. 6
16-11-2017
Loss of the chromatin modifier Kdm2aa causes BrafV600E-independent spontaneous melanoma in zebrafishScahill CM, Digby Z, Sealy IM, Wojciechowska S, White RJ, Collins JE, Stemple DL, Bartke T, Mathers ME, Patton EE and Busch-Nentwich EM
Plos Genetics, Public Library of Science (Plos) vol. 13 (8)
14-08-2017
2016
gEVAL — a web-based browser for evaluating genome assembliesChow W, Brugger K, Caccamo M, Sealy I, Torrance J and Howe K
Bioinformatics, Oxford University Press (OUP) vol. 32 (16), 2508-2510.
07-04-2016
2015
Genome-wide mapping of Hif-1α binding sites in zebrafishGreenald D, Jeyakani J, Pelster B, Sealy I, Mathavan S and van Eeden FJ
Bmc Genomics, Springer Nature vol. 16 (1)
11-11-2015
G.P.239 Zebrafish models of inherited skeletal muscle disordersPatrick J, Wali N, Sealy I, Collins J, Busch-Nentwich E and Stemple D
Neuromuscular Disorders, Elsevier vol. 25
01-10-2015
High-throughput and quantitative genome-wide messenger RNA sequencing for molecular phenotypingCollins JE, Wali N, Sealy IM, Morris JA, White RJ, Leonard SR, Jackson DK, Jones MC, Smerdon NC, Zamora J, Dooley CM, Carruthers SN, Barrett JC, Stemple DL and Busch-Nentwich EM
Bmc Genomics, Springer Nature vol. 16 (1)
05-08-2015
Identification of a plant isoflavonoid that causes biliary atresiaLorent K, Gong W, Koo KA, Waisbourd-Zinman O, Karjoo S, Zhao X, Sealy I, Kettleborough RN, Stemple DL, Windsor PA, Whittaker SJ, Porter JR, Wells RG and Pack M
Science Translational Medicine, American Association For The Advancement of Science (Aaas) vol. 7 (286)
06-05-2015
2013
Correction: Corrigendum: The zebrafish reference genome sequence and its relationship to the human genomeHowe K, Clark MD, Torroja CF, Torrance J, Berthelot C, Muffato M, Collins JE, Humphray S, McLaren K, Matthews L, McLaren S, Sealy I, Caccamo M, Churcher C, Scott C, Barrett JC, Koch R, Rauch G-J, White S, Chow W, et al.
Nature, Springer Nature vol. 505 (7482), 248-248.
11-12-2013
Identification of the zebrafish maternal and paternal transcriptomesHarvey SA, Sealy I, Kettleborough R, Fenyes F, White R, Stemple D and Smith JC
Development, The Company of Biologists vol. 140 (13), 2703-2710.
29-05-2013
The zebrafish reference genome sequence and its relationship to the human genomeHowe K, Clark MD, Torroja CF, Torrance J, Berthelot C, Muffato M, Collins JE, Humphray S, McLaren K, Matthews L, McLaren S, Sealy I, Caccamo M, Churcher C, Scott C, Barrett JC, Koch R, Rauch G-J, White S, Chow W, et al.
Nature, Springer Nature vol. 496 (7446), 498-503.
01-04-2013
A systematic genome-wide analysis of zebrafish protein-coding gene functionKettleborough RNW, Busch-Nentwich EM, Harvey SA, Dooley CM, de Bruijn E, van Eeden F, Sealy I, White RJ, Herd C, Nijman IJ, Fényes F, Mehroke S, Scahill C, Gibbons R, Wali N, Carruthers S, Hall A, Yen J, Cuppen E and Stemple DL
Nature, Springer Nature vol. 496 (7446), 494-497.
01-04-2013
2007
Ensembl 2008Flicek P, Aken BL, Beal K, Ballester B, Caccamo M, Chen Y, Clarke L, Coates G, Cunningham F, Cutts T, Down T, Dyer SC, Eyre T, Fitzgerald S, Fernandez-Banet J, Gräf S, Haider S, Hammond M, Holland R, Howe KL, et al.
Nucleic Acids Research, Oxford University Press (OUP) vol. 36 (suppl_1), d707-d714.
23-12-2007
Genomic regulatory blocks encompass multiple neighboring genes and maintain conserved synteny in vertebratesKikuta H, Laplante M, Navratilova P, Komisarczuk AZ, Engström PG, Fredman D, Akalin A, Caccamo M, Sealy I, Howe K, Ghislain J, Pezeron G, Mourrain P, Ellingsen S, Oates AC, Thisse C, Thisse B, Foucher I, Adolf B, Geling A, et al.
Genome Research, Cold Spring Harbor Laboratory vol. 17 (5), 545-555.
26-03-2007
2006
Ensembl 2007Hubbard TJP, Aken BL, Beal K, Ballester B, Caccamo M, Chen Y, Clarke L, Coates G, Cunningham F, Cutts T, Down T, Dyer SC, Fitzgerald S, Fernandez-Banet J, Graf S, Haider S, Hammond M, Herrero J, Holland R, Howe K, et al.
Nucleic Acids Research, Oxford University Press (OUP) vol. 35 (suppl_1), d610-d617.
05-12-2006
Ensembl 2006Birney E, Andrews D, Caccamo M, Chen Y, Clarke L, Coates G, Cox T, Cunningham F, Curwen V, Cutts T, Down T, Durbin R, Fernandez-Suarez XM, Flicek P, Gräf S, Hammond M, Herrero J, Howe K, Iyer V, Jekosch K, et al.
Nucleic Acids Research, Oxford University Press (OUP) vol. 34 (suppl_1), d556-d561.
01-01-2006