Dr Aravindan Ilangovan

Aravindan Ilangovan

Reader in Structural Biology

School of Biological and Behavioural Sciences
Queen Mary University of London

Research

Protein-nucleic acid complexes, Helicases, Cryogenic Electron Microscopy

Interests

Further details can be found in our lab website; www.ilangovan-lab.com

Publications

solid heart iconPublications of specific relevance to the Centre for Molecular Cell Biology

2024

Relevant PublicationFecht S, Paracuellos P, Subramoni S, Tan CAZ, Ilangovan A, Costa TRD and Filloux A (2024). Functionality of chimeric TssA proteins in the type VI secretion system reveals sheath docking specificity within their N-terminal domains. Nature Communications, Springer Nature vol. 15 (1) 
20-05-2024

2023

Relevant PublicationPelliciari S, Bodet-Lefèvre S, Fenyk S, Stevens D, Winterhalter C, Schramm FD, Pintar S, Burnham DR, Merces G, Richardson TT, Tashiro Y, Hubbard J, Yardimci H, Ilangovan A and Murray H (2023). The bacterial replication origin BUS promotes nucleobase capture. Nature Communications, Springer Nature vol. 14 (1) 
14-12-2023
bullet iconNajmudin S, Pan X-S, Beavil AJ, Cronin NB, Ilangovan A, Fisher LM and Sanderson MR (2023). Higher-order cryo-EM structures of the full tetrameric type II topoisomerase with bound 18mer dsDNA. Acta Crystallographica Section A: Foundations and advances, International Union of Crystallography (IUCr) vol. 79 (a2), c702-c702.  
22-08-2023
Relevant PublicationWinterhalter C, Pelliciari S, Stevens D, Fenyk S, Marchand E, Cronin NB, Soultanas P, Costa TRD, Ilangovan A and Murray H (2023). The DNA replication initiation protein DnaD recognises a specific strand of the Bacillus subtilis chromosome origin. Nucleic Acids Research, Oxford University Press vol. 51 (9), 4322-4340.  
22-05-2023

2022

Relevant PublicationWinterhalter C, Stevens D, Fenyk S, Pelliciari S, Marchand E, Soultanas P, Ilangovan A and Murray H (2022). SirA inhibits the essential DnaA:DnaD interaction to block helicase recruitment during Bacillus subtilis sporulation. Nucleic Acids Research, Oxford University Press vol. 51 (9), 4302-4321.  
23-11-2022

2021

Relevant PublicationAmin H, Ilangovan A and Costa TRD (2021). Architecture of the outer-membrane core complex from a conjugative type IV secretion system. Nature Communications, Nature Research vol. 12 (1) 
25-11-2021
bullet iconZheng W, Peña A, Ilangovan A, Clark JN-B, Frankel G, Egelman EH and Costa TRD (2021). Cryoelectron-microscopy structure of the enteropathogenic Escherichia coli type III secretion system EspA filament. Proc Natl Acad Sci U S A vol. 118 (2) 
12-01-2021

2017

bullet iconIlangovan A, Kay CWM, Roier S, Mkami HE, Salvadori E, Zechner EL, Zanetti G and Waksman G (2017). Cryo-EM Structure of a Relaxase Reveals the Molecular Basis of DNA Unwinding during Bacterial Conjugation. Cell, Elsevier vol. 169 (4), 708-721.e12.  
27-04-2017

2016

bullet iconCosta TRD, Ilangovan A, Ukleja M, Redzej A, Santini JM, Smith TK, Egelman EH and Waksman G (2016). Structure of the Bacterial Sex F Pilus Reveals an Assembly of a Stoichiometric Protein-Phospholipid Complex. Cell, Elsevier vol. 166 (6), 1436-1444.e10.  
01-09-2016

2015

bullet iconIlangovan A, Connery S and Waksman G (2015). Structural biology of the Gram-negative bacterial conjugation systems. Trends in Microbiology, Elsevier vol. 23 (5), 301-310.  
27-03-2015

2013

bullet iconRedzej A, Ilangovan A, Lang S, Gruber CJ, Topf M, Zangger K, Zechner EL and Waksman G (2013). Structure of a translocation signal domain mediating conjugative transfer by type IV secretion systems. Molecular Microbiology, Wiley vol. 89 (2), 324-333.  
14-06-2013
bullet iconIlangovan A, Fletcher M, Rampioni G, Pustelny C, Rumbaugh K, Heeb S, Cámara M, Truman A, Chhabra SR, Emsley J and Williams P (2013). Structural Basis for Native Agonist and Synthetic Inhibitor Recognition by the Pseudomonas aeruginosa Quorum Sensing Regulator PqsR (MvfR). PLOS Pathogens, Public Library of Science (PLoS) vol. 9 (7) 
01-01-2013

Grants

solid heart iconGrants of specific relevance to the Centre for Molecular Cell Biology
solid heart iconRegulation of linear ubiquitin signaling in innate immunity
Benjamin Stieglitz and Aravindan Ilangovan
£661,348 MRC Medical Research Council (01-03-2024 - 28-02-2027)
solid heart iconMolecular mechanism of DNA processing for antibiotic resistance gene transfer in bacteria
Aravindan Ilangovan
£517,030 BBSRC Biotechnology and Biological Sciences Research Council (01-11-2023 - 31-10-2026)
solid heart iconMolecular mechanisms for loading the bacterial replicative helicase
Aravindan Ilangovan
£1,329,649 Wellcome Trust (01-01-2023 - 31-12-2030)


solid heart iconUnderstanding the molecular mechanism of antibiotic resistance gene transfer in bacteria
Aravindan Ilangovan
£99,467 AMS Academy of Medical Sciences (01-06-2022 - 30-11-2024)