Dr Aravindan Ilangovan

Aravindan Ilangovan

Reader in Structural Biology

School of Biological and Behavioural Sciences
Queen Mary University of London

Research

Protein-nucleic acid complexes, Helicases, Cryogenic Electron Microscopy

Interests

Further details can be found in our lab website; www.ilangovan-lab.com

Publications

Relevant PublicationPublications of specific relevance to the Centre for Molecular Cell Biology

2023

Relevant PublicationPelliciari S, Bodet-Lefèvre S, Fenyk S, Stevens D, Winterhalter C, Schramm FD, Pintar S, Burnham DR, Merces G, Richardson TT, Tashiro Y, Hubbard J, Yardimci H, Ilangovan A and Murray H (2023). The bacterial replication origin BUS promotes nucleobase capture. Nature Communications, Springer Nature vol. 14 (1) 
14-12-2023
Relevant PublicationWinterhalter C, Pelliciari S, Stevens D, Fenyk S, Marchand E, Cronin NB, Soultanas P, Costa TRD, Ilangovan A and Murray H (2023). The DNA replication initiation protein DnaD recognises a specific strand of the Bacillus subtilis chromosome origin. Nucleic Acids Research, Oxford University Press vol. 51 (9), 4322-4340.  
22-05-2023

2022

bullet iconAmin H, Ilangovan A and Costa TRD (2022). Publisher Correction: Architecture of the outer-membrane core complex from a conjugative type IV secretion system (Nature Communications, (2021), 12, 1, (6834), 10.1038/s41467-021-27178-8). Nature Communications vol. 13 (1) 
01-12-2022
Relevant PublicationWinterhalter C, Stevens D, Fenyk S, Pelliciari S, Marchand E, Soultanas P, Ilangovan A and Murray H (2022). SirA inhibits the essential DnaA:DnaD interaction to block helicase recruitment during Bacillus subtilis sporulation. Nucleic Acids Research, Oxford University Press vol. 51 (9), 4302-4321.  
23-11-2022
bullet iconNajmudin S, Pan XS, Beavil AJ, Cronin NB, Ilangovan A, Fisher LM and Sanderson MR (2022). High-resolution cryo-EM structure of a type II topoisomerase cleavage core complex with bound 18mer dsDNA. Acta Crystallographica Section A: Foundations and advances, International Union of Crystallography (IUCr) vol. 78 (a2), e46-e46.  
23-08-2022

2021

Relevant PublicationAmin H, Ilangovan A and Costa TRD (2021). Architecture of the outer-membrane core complex from a conjugative type IV secretion system. Nature Communications, Nature Research vol. 12 (1) 
25-11-2021
bullet iconZheng W, Peña A, Ilangovan A, Clark JN-B, Frankel G, Egelman EH and Costa TRD (2021). Cryoelectron-microscopy structure of the enteropathogenic Escherichia coli type III secretion system EspA filament. Proc Natl Acad Sci U S A vol. 118 (2) 
12-01-2021

2017

bullet iconIlangovan A, Kay CWM, Roier S, Mkami HE, Salvadori E, Zechner EL, Zanetti G and Waksman G (2017). Cryo-EM Structure of a Relaxase Reveals the Molecular Basis of DNA Unwinding during Bacterial Conjugation. Cell, Elsevier vol. 169 (4), 708-721.e12.  
27-04-2017

2016

bullet iconCosta TRD, Ilangovan A, Ukleja M, Redzej A, Santini JM, Smith TK, Egelman EH and Waksman G (2016). Structure of the Bacterial Sex F Pilus Reveals an Assembly of a Stoichiometric Protein-Phospholipid Complex. Cell, Elsevier vol. 166 (6), 1436-1444.e10.  
01-09-2016

2015

bullet iconIlangovan A, Connery S and Waksman G (2015). Structural biology of the Gram-negative bacterial conjugation systems. Trends in Microbiology, Elsevier vol. 23 (5), 301-310.  
27-03-2015

2013

bullet iconRedzej A, Ilangovan A, Lang S, Gruber CJ, Topf M, Zangger K, Zechner EL and Waksman G (2013). Structure of the TraI translocation signal domain. Molecular Microbiology, Wiley vol. 89 (2), 324-333.  
14-06-2013
bullet iconIlangovan A, Fletcher M, Rampioni G, Pustelny C, Rumbaugh K, Heeb S, Cámara M, Truman A, Chhabra SR, Emsley J and Williams P (2013). Structural Basis for Native Agonist and Synthetic Inhibitor Recognition by the Pseudomonas aeruginosa Quorum Sensing Regulator PqsR (MvfR). PLOS Pathogens, Public Library of Science (PLoS) vol. 9 (7) 
01-01-2013

Grants

solid heart iconGrants of specific relevance to the Centre for Molecular Cell Biology
solid heart iconMolecular mechanisms for loading the bacterial replicative helicase
Aravindan Ilangovan
£1,329,649 Wellcome Trust (01-01-2023 - 31-12-2030)
solid heart iconRegulation of linear ubiquitin signaling in innate immunity
Benjamin Stieglitz and Aravindan Ilangovan
£661,348 MRC Medical Research Council (01-03-2024 - 28-02-2027)
solid heart iconMolecular mechanism of DNA processing for antibiotic resistance gene transfer in bacteria
Aravindan Ilangovan
£517,030 BBSRC Biotechnology and Biological Sciences Research Council (01-11-2023 - 31-10-2026)
solid heart iconUnderstanding the molecular mechanism of antibiotic resistance gene transfer in bacteria
Aravindan Ilangovan
£99,467 AMS Academy of Medical Sciences (01-06-2022 - 31-05-2024)