Dr Benjamin Stieglitz
Senior Lecturer in Biochemistry
School of Biological and Behavioural Sciences
Queen Mary University of London
Queen Mary University of London
Research
Ubiquitin, Innate Immunity, Inflammation, Enzymology, Host-pathogen interaction, Structural biology
Publications
Publications of specific relevance to the Centre for Molecular Cell Biology
2024
Kliza KW, Song W, Pinzuti I, Schaubeck S, Kunzelmann S, Kuntin D, Fornili A, Pandini A, Hofmann K, Garnett JA, Stieglitz B and Husnjak K (2024). N4BP1 functions as a dimerization-dependent linear ubiquitin reader which regulates TNF signalling. Cell Death Discovery, Springer Nature vol. 10 (1)
20-04-2024
20-04-2024
2023
Wu Q, Koliopoulos MG, Rittinger K and Stieglitz B (2023). Structural basis for ubiquitylation by HOIL-1. Frontiers in Molecular Biosciences, Frontiers vol. 9
06-01-2023
06-01-2023
2022
Stieglitz B (2022). HHARI in motion reveals an unexpected substrate recognition site for RBR ligases. Structure, Elsevier vol. 30 (9), 1221-1223.
01-09-2022
01-09-2022
2020
Green JL, Wu Y and Stieglitz B (2020). Ubiquitin activation is essential for schizont maturation in Plasmodium falciparum blood-stage development. PLoS Pathogens, Public Library of Science (PLoS) vol. 16 (6), e1008640-e1008640.
22-06-2020
22-06-2020
2019
Burlina F, Abdel-Aal A-BM, Raz R, Pinzuti I, Papageorgiou G, Li J, Antrobus R, Martin SR, Kunzelmann S, Stieglitz B and Offer J (2019). Auxiliary-assisted chemical ubiquitylation of NEMO and linear extension by HOIP. Communications Chemistry, Springer Science and Business Media LLC vol. 2 (1)
19-09-2019
19-09-2019
2017
Kliza K, Taumer C, Pinzuti I, Franz-Wachtel M, Kunzelmann S, STIEGLITZ B, Macek B and Husnjak K (2017). Internally Tagged Ubiquitin: a Tool to Identify Linear Polyubiquitin-modified Proteins by Mass Spectrometry. Nature Methods, Nature Publishing Group
20-03-2017
20-03-2017
Oregioni A, STIEGLITZ B, Kelly G, Rittinger K and Frenkiel T (2017). Determination of the pKa of
the N-terminal amino group of
ubiquitin by NMR. Scientific Reports, Nature Publishing Group, 1-8.
02-03-2017
02-03-2017
2016
Dove KK, Stieglitz B, Duncan ED, Rittinger K and Klevit RE (2016). Molecular insights into RBR E3 ligase ubiquitin transfer mechanisms. EMBO Reports, EMBO Press
16-06-2016
16-06-2016
2013
Stieglitz B, Rana RR, Koliopoulos MG, Morris-Davies AC, Schaeffer V, Christodoulou E, Howell S, Brown NR, Dikic I and Rittinger K (2013). Structural basis for ligase-specific conjugation of linear ubiquitin chains by HOIP. Nature, Springer Nature vol. 503 (7476), 422-426.
20-10-2013
20-10-2013
2012
Stieglitz B, Morris‐Davies AC, Koliopoulos MG, Christodoulou E and Rittinger K (2012). LUBAC synthesizes linear ubiquitin chains via a thioester intermediate. EMBO Reports, Springer Nature vol. 13 (9), 840-846.
13-07-2012
13-07-2012
Stieglitz B, Rittinger K and Haire LF (2012). Crystallization of SHARPIN using an automated two‐dimensional grid screen for optimization. Acta Crystallographica Section F: Structural Biology Communications, International Union of Crystallography (IUCr) vol. 68 (7), 816-819.
28-06-2012
28-06-2012
Stieglitz B, Haire LF, Dikic I and Rittinger K (2012). Structural Analysis of SHARPIN, a Subunit of a Large Multi-protein E3 Ubiquitin Ligase, Reveals a Novel Dimerization Function for the Pleckstrin Homology Superfold*. Journal of Biological Chemistry, Elsevier vol. 287 (25), 20823-20829.
01-05-2012
01-05-2012
2011
Wilhelm C, Hirota K, Stieglitz B, Van Snick J, Tolaini M, Lahl K, Sparwasser T, Helmby H and Stockinger B (2011). An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation. Nature Immunology, Springer Nature vol. 12 (11), 1071-1077.
09-10-2011
09-10-2011
Ikeda F, Deribe YL, Skånland SS, Stieglitz B, Grabbe C, Franz-Wachtel M, van Wijk SJL, Goswami P, Nagy V, Terzic J, Tokunaga F, Androulidaki A, Nakagawa T, Pasparakis M, Iwai K, Sundberg JP, Schaefer L, Rittinger K, Macek B and Dikic I (2011). SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis. Nature, Springer Nature vol. 471 (7340), 637-641.
01-03-2011
01-03-2011
Wilhelm C, Hirota K, Stieglitz B, Van Snick J, Tolaini M, Lahl K, Sparwasser T, Helmby H and Stockinger B (2011). Novel sources of IL-9 in lung inflammation.
01-01-2011
01-01-2011
2010
Bee C, Moshnikova A, Mellor CD, Molloy JE, Koryakina Y, Stieglitz B, Khokhlatchev A and Herrmann C (2010). Growth and Tumor Suppressor NORE1A Is a Regulatory Node between Ras Signaling and Microtubule Nucleation*. Journal of Biological Chemistry, Elsevier vol. 285 (21), 16258-16266.
25-03-2010
25-03-2010
2008
Stieglitz B, Bee C, Schwarz D, Yildiz Ö, Moshnikova A, Khokhlatchev A and Herrmann C (2008). Novel type of Ras effector interaction established between tumour suppressor NORE1A and Ras switch II. The EMBO Journal, Springer Nature vol. 27 (14), 1995-2005.
03-07-2008
03-07-2008
Vogelsgesang M, Stieglitz B, Herrmann C, Pautsch A and Aktories K (2008). Crystal structure of the Clostridium limosum C3 exoenzyme. FEBS Letters, Wiley vol. 582 (7), 1032-1036.
04-03-2008
04-03-2008
2007
Herrmann C and Stieglitz B (2007). Ras/Nore1 interaction: mechanism of apoptotic signaling.
22-08-2007
22-08-2007
Grants
Grants of specific relevance to the Centre for Molecular Cell Biology
Regulation of linear ubiquitin signaling in innate immunity
Benjamin Stieglitz and Aravindan Ilangovan
£661,348 MRC Medical Research Council (01-03-2024 - 28-02-2027)
Benjamin Stieglitz and Aravindan Ilangovan
£661,348 MRC Medical Research Council (01-03-2024 - 28-02-2027)