Dr Benjamin Stieglitz
Senior Lecturer in Biochemistry
School of Biological and Behavioural Sciences
Queen Mary University of London
Queen Mary University of London
Research
Ubiquitin, Innate Immunity, Inflammation, Enzymology, Host-pathogen interaction, Structural biology
Publications
Publications of specific relevance to the Centre for Molecular Cell Biology
2023
Wu Q, Koliopoulos MG, Rittinger K and Stieglitz B (2023). Structural basis for ubiquitylation by HOIL-1. Frontiers in Molecular Biosciences, Frontiers vol. 9
06-01-2023
06-01-2023
2022
Stieglitz B (2022). HHARI in motion reveals an unexpected substrate recognition site for RBR ligases. Structure, Elsevier vol. 30 (9), 1221-1223.
01-09-2022
01-09-2022
2020
Green JL, Wu Y and Stieglitz B (2020). Ubiquitin activation is essential for schizont maturation in Plasmodium falciparum blood-stage development. PLoS Pathogens, Public Library of Science (PLoS) vol. 16 (6), e1008640-e1008640.
22-06-2020
22-06-2020
2019
Burlina F, Abdel-Aal A-BM, Raz R, Pinzuti I, Papageorgiou G, Li J, Antrobus R, Martin SR, Kunzelmann S, Stieglitz B and Offer J (2019). Auxiliary-assisted chemical ubiquitylation of NEMO and linear extension by HOIP. Communications Chemistry, Springer Science and Business Media LLC vol. 2 (1)
19-09-2019
19-09-2019
2017
Kliza K, Taumer C, Pinzuti I, Franz-Wachtel M, Kunzelmann S, STIEGLITZ B, Macek B and Husnjak K (2017). Internally Tagged Ubiquitin: a Tool to Identify Linear Polyubiquitin-modified Proteins by Mass Spectrometry. Nature Methods, Nature Publishing Group
20-03-2017
20-03-2017
Oregioni A, STIEGLITZ B, Kelly G, Rittinger K and Frenkiel T (2017). Determination of the pKa of
the N-terminal amino group of
ubiquitin by NMR. Scientific Reports, Nature Publishing Group, 1-8.
02-03-2017
02-03-2017
2016
Dove KK, Stieglitz B, Duncan ED, Rittinger K and Klevit RE (2016). Molecular insights into RBR E3 ligase ubiquitin transfer mechanisms. EMBO Reports, EMBO Press
16-06-2016
16-06-2016
2013
Stieglitz B, Rana RR, Koliopoulos MG, Morris-Davies AC, Schaeffer V, Christodoulou E, Howell S, Brown NR, Dikic I and Rittinger K (2013). Structural basis for ligase-specific conjugation of linear ubiquitin chains by HOIP. Nature, Springer Nature vol. 503 (7476), 422-426.
20-10-2013
20-10-2013
2012
Stieglitz B, Morris-Davies AC, Koliopoulos MG, Christodoulou E and Rittinger K (2012). LUBAC synthesizes linear ubiquitin chains via a thioester intermediate. EMBO Reports, Springer Nature vol. 13 (9), 840-846.
13-07-2012
13-07-2012
Stieglitz B, Rittinger K and Haire LF (2012). Crystallization of SHARPIN using an automated two‐dimensional grid screen for optimization. Acta Crystallographica Section F: Structural Biology Communications, International Union of Crystallography (IUCr) vol. 68 (7), 816-819.
28-06-2012
28-06-2012
Stieglitz B, Haire LF, Dikic I and Rittinger K (2012). Structural Analysis of SHARPIN, a Subunit of a Large Multi-protein E3 Ubiquitin Ligase, Reveals a Novel Dimerization Function for the Pleckstrin Homology Superfold*. Journal of Biological Chemistry, Elsevier vol. 287 (25), 20823-20829.
01-05-2012
01-05-2012
2011
Wilhelm C, Hirota K, Stieglitz B, Van Snick J, Tolaini M, Lahl K, Sparwasser T, Helmby H and Stockinger B (2011). An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation. Nature Immunology, Springer Nature vol. 12 (11), 1071-1077.
09-10-2011
09-10-2011
Ikeda F, Deribe YL, Skånland SS, Stieglitz B, Grabbe C, Franz-Wachtel M, van Wijk SJL, Goswami P, Nagy V, Terzic J, Tokunaga F, Androulidaki A, Nakagawa T, Pasparakis M, Iwai K, Sundberg JP, Schaefer L, Rittinger K, Macek B and Dikic I (2011). SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis. Nature, Springer Nature vol. 471 (7340), 637-641.
01-03-2011
01-03-2011
Wilhelm C, Hirota K, Stieglitz B, Van Snick J, Tolaini M, Lahl K, Sparwasser T, Helmby H and Stockinger B (2011). Novel sources of IL-9 in lung inflammation.
01-01-2011
01-01-2011
2010
Bee C, Moshnikova A, Mellor CD, Molloy JE, Koryakina Y, Stieglitz B, Khokhlatchev A and Herrmann C (2010). Growth and Tumor Suppressor NORE1A Is a Regulatory Node between Ras Signaling and Microtubule Nucleation*. Journal of Biological Chemistry, Elsevier vol. 285 (21), 16258-16266.
25-03-2010
25-03-2010
2008
Stieglitz B, Bee C, Schwarz D, Yildiz Ö, Moshnikova A, Khokhlatchev A and Herrmann C (2008). Novel type of Ras effector interaction established between tumour suppressor NORE1A and Ras switch II. The EMBO Journal, Springer Nature vol. 27 (14), 1995-2005.
03-07-2008
03-07-2008
Vogelsgesang M, Stieglitz B, Herrmann C, Pautsch A and Aktories K (2008). Crystal structure of the Clostridium limosum C3 exoenzyme. FEBS Letters, Wiley vol. 582 (7), 1032-1036.
04-03-2008
04-03-2008
Grants
Grants of specific relevance to the Centre for Molecular Cell Biology
Regulation of linear ubiquitin signaling in innate immunity
Benjamin Stieglitz and Aravindan Ilangovan
£661,348 MRC Medical Research Council (01-03-2024 - 28-02-2027)
Benjamin Stieglitz and Aravindan Ilangovan
£661,348 MRC Medical Research Council (01-03-2024 - 28-02-2027)