Dr Benjamin Stieglitz

Benjamin Stieglitz

Senior Lecturer in Biochemistry

School of Biological and Behavioural Sciences
Queen Mary University of London
ORCID

Research

Ubiquitin, Innate Immunity, Inflammation, Enzymology, Host-pathogen interaction, Structural biology

Publications

solid heart iconPublications of specific relevance to the Centre for Molecular Cell Biology

2024

bullet iconKliza KW, Song W, Pinzuti I, Schaubeck S, Kunzelmann S, Kuntin D, Fornili A, Pandini A, Hofmann K, Garnett JA, Stieglitz B and Husnjak K (2024). N4BP1 functions as a dimerization-dependent linear ubiquitin reader which regulates TNF signalling. Cell Death Discovery, Springer Nature vol. 10 (1) 
20-04-2024

2023

Relevant PublicationWu Q, Koliopoulos MG, Rittinger K and Stieglitz B (2023). Structural basis for ubiquitylation by HOIL-1. Frontiers in Molecular Biosciences, Frontiers vol. 9 
06-01-2023

2022

bullet iconStieglitz B (2022). HHARI in motion reveals an unexpected substrate recognition site for RBR ligases. Structure, Elsevier vol. 30 (9), 1221-1223.  
01-09-2022

2020

bullet iconGreen JL, Wu Y and Stieglitz B (2020). Ubiquitin activation is essential for schizont maturation in Plasmodium falciparum blood-stage development. PLoS Pathogens, Public Library of Science (PLoS) vol. 16 (6), e1008640-e1008640.  
22-06-2020

2019

bullet iconBurlina F, Abdel-Aal A-BM, Raz R, Pinzuti I, Papageorgiou G, Li J, Antrobus R, Martin SR, Kunzelmann S, Stieglitz B and Offer J (2019). Auxiliary-assisted chemical ubiquitylation of NEMO and linear extension by HOIP. Communications Chemistry, Springer Science and Business Media LLC vol. 2 (1) 
19-09-2019

2017

bullet iconKliza K, Taumer C, Pinzuti I, Franz-Wachtel M, Kunzelmann S, STIEGLITZ B, Macek B and Husnjak K (2017). Internally Tagged Ubiquitin: a Tool to Identify Linear Polyubiquitin-modified Proteins by Mass Spectrometry. Nature Methods, Nature Publishing Group 
20-03-2017
bullet iconOregioni A, STIEGLITZ B, Kelly G, Rittinger K and Frenkiel T (2017). Determination of the pKa of the N-terminal amino group of ubiquitin by NMR. Scientific Reports, Nature Publishing Group, 1-8.  
02-03-2017

2016

bullet iconDove KK, Stieglitz B, Duncan ED, Rittinger K and Klevit RE (2016). Molecular insights into RBR E3 ligase ubiquitin transfer mechanisms. EMBO Reports, EMBO Press 
16-06-2016

2013

bullet iconStieglitz B, Rana RR, Koliopoulos MG, Morris-Davies AC, Schaeffer V, Christodoulou E, Howell S, Brown NR, Dikic I and Rittinger K (2013). Structural basis for ligase-specific conjugation of linear ubiquitin chains by HOIP. Nature, Springer Nature vol. 503 (7476), 422-426.  
20-10-2013

2012

bullet iconStieglitz B, Morris‐Davies AC, Koliopoulos MG, Christodoulou E and Rittinger K (2012). LUBAC synthesizes linear ubiquitin chains via a thioester intermediate. EMBO Reports, Springer Nature vol. 13 (9), 840-846.  
13-07-2012
bullet iconStieglitz B, Rittinger K and Haire LF (2012). Crystallization of SHARPIN using an automated two‐dimensional grid screen for optimization. Acta Crystallographica Section F: Structural Biology Communications, International Union of Crystallography (IUCr) vol. 68 (7), 816-819.  
28-06-2012
bullet iconStieglitz B, Haire LF, Dikic I and Rittinger K (2012). Structural Analysis of SHARPIN, a Subunit of a Large Multi-protein E3 Ubiquitin Ligase, Reveals a Novel Dimerization Function for the Pleckstrin Homology Superfold*. Journal of Biological Chemistry, Elsevier vol. 287 (25), 20823-20829.  
01-05-2012

2011

bullet iconWilhelm C, Hirota K, Stieglitz B, Van Snick J, Tolaini M, Lahl K, Sparwasser T, Helmby H and Stockinger B (2011). An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation. Nature Immunology, Springer Nature vol. 12 (11), 1071-1077.  
09-10-2011
bullet iconIkeda F, Deribe YL, Skånland SS, Stieglitz B, Grabbe C, Franz-Wachtel M, van Wijk SJL, Goswami P, Nagy V, Terzic J, Tokunaga F, Androulidaki A, Nakagawa T, Pasparakis M, Iwai K, Sundberg JP, Schaefer L, Rittinger K, Macek B and Dikic I (2011). SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis. Nature, Springer Nature vol. 471 (7340), 637-641.  
01-03-2011
bullet iconWilhelm C, Hirota K, Stieglitz B, Van Snick J, Tolaini M, Lahl K, Sparwasser T, Helmby H and Stockinger B (2011). Novel sources of IL-9 in lung inflammation. 
01-01-2011

2010

bullet iconBee C, Moshnikova A, Mellor CD, Molloy JE, Koryakina Y, Stieglitz B, Khokhlatchev A and Herrmann C (2010). Growth and Tumor Suppressor NORE1A Is a Regulatory Node between Ras Signaling and Microtubule Nucleation*. Journal of Biological Chemistry, Elsevier vol. 285 (21), 16258-16266.  
25-03-2010

2008

bullet iconStieglitz B, Bee C, Schwarz D, Yildiz Ö, Moshnikova A, Khokhlatchev A and Herrmann C (2008). Novel type of Ras effector interaction established between tumour suppressor NORE1A and Ras switch II. The EMBO Journal, Springer Nature vol. 27 (14), 1995-2005.  
03-07-2008
bullet iconVogelsgesang M, Stieglitz B, Herrmann C, Pautsch A and Aktories K (2008). Crystal structure of the Clostridium limosum C3 exoenzyme. FEBS Letters, Wiley vol. 582 (7), 1032-1036.  
04-03-2008

2007

bullet iconHerrmann C and Stieglitz B (2007). Ras/Nore1 interaction: mechanism of apoptotic signaling. 
22-08-2007

Grants

solid heart iconGrants of specific relevance to the Centre for Molecular Cell Biology
solid heart iconRegulation of linear ubiquitin signaling in innate immunity
Benjamin Stieglitz and Aravindan Ilangovan
£661,348 MRC Medical Research Council (01-03-2024 - 28-02-2027)