Professor of Evolutionary Genetics
Population Genetics, Evolutionary Genomics, Bayesian Analysis, Conservation, Range Expansion, Invasive Species
Publications of specific relevance to the Centre for Evolutionary and Functional GenomicsRapid polygenic adaptation in a wild population of ash trees under a novel fungal epidemicQuantitative measurement of phenotype dynamics during cancer drug resistance evolution using genetic barcodingCan genomic analysis actually estimate past population size?Nitrogen and phosphorus interactions at a 21 nitrogen:1 phosphorus Redfield‐like ratio impact growth and seed yield in wheat (Triticum aestivum L.)Maintenance and expansion of genetic and trait variation following domestication in a clonal cropAssembly‐free quantification of vagrant DNA insertsNon-Lethal Detection of Frog Virus 3-Like (RUK13) and Common Midwife Toad Virus-Like (PDE18) Ranaviruses in Two UK-Native Amphibian SpeciesWhi3 mnemon association with endoplasmic reticulum membranes confines the memory of deceptive courtship to the yeast mother cellCyto-nuclear incompatibilities across a bluebell hybrid zone in northern Spain do not prevent genome-wide introgression of neutral markersEvidence for the Widespread Occurrence of Bacteria Implicated in Acute Oak Decline from Incidental Genetic SamplingSpatially clustered count data provide more efficient search strategies in invasion biology and disease control.Correction: Genomic architecture and evolutionary antagonism drive allelic expression bias in the social supergene of red fire ants.Whi3 Mnemon Association with Endoplasmic Reticulum Membranes Confines the Memory of Deceptive Courtship to the Yeast Mother CellGenomic basis of European ash tree resistance to ash dieback fungusGenomic assessment of local adaptation in dwarf birch to inform assisted gene flowModelling Ranavirus Transmission in Populations of Common Frogs (Rana temporaria) in the United KingdomEffects of historic and projected climate change on the range and impacts of an emerging wildlife diseaseGenome-wide haplotype analysis improves trait predictions in Brassica napus hybridsGenetic diversity maintained among fragmented populations of a tree undergoing range contraction.The fire ant social chromosome supergene variant Sb shows low diversity but high divergence from SBGenetic linkage to explain genetic variationReconstructing the emergence of a lethal infectious disease of wildlife supports a key role for spread through translocations by humans.Estimating the Number of Subpopulations (K) in Structured PopulationsDocumentation for MAVERICK software: Version 1.0File s1: Derivation of evidence estimators and model comparison statisticsUnidirectional diploid-tetraploid introgression among British birch trees with shifting ranges shown by RAD markersGenome size and ploidy influence angiosperm species’ biomass under nitrogen and phosphorus limitationGenomic Prediction of Testcross Performance in Canola (Brassica napus)Analysis of the giant genomes of Fritillaria (Liliaceae) indicates that a lack of DNA removal characterizes extreme expansions in genome sizeRates of Vaccine Evolution Show Strong Effects of Latency: Implications for Varicella Zoster Virus EpidemiologyDetection of a frog virus 3-like ranavirus in native and introduced amphibians in the United Kingdom in 2007 and 2008Experimental evidence in support of single host maintenance of a multihost pathogenCollapse of Amphibian Communities Due to an Introduced RanavirusWhat is genetic differentiation, and how should we measure it--GST, D, neither or both?Molecular footprints of the Holocene retreat of dwarf birch in Britain.Inside the Melanoplinae: new molecular evidence for the evolutionary history of the Eurasian Podismini (Orthoptera: Acrididae).Spatial targeting of infectious disease control: Identifying multiple, unknown sourcesPurifying selection in deeply conserved human enhancers is more consistent than in coding sequences.Testing single-sample estimators of effective population size in genetically structured populationsMolecular footprints of the Holocene retreat of dwarf birch in BritainConservation Genetic Resources for Effective Species Survival (ConGRESS): Bridging the divide between conservation research and practiceInvestigations into the life history stages of the common frog (Rana temporaria) affected by an amphibian ranavirus in the United KingdomDeep Sequencing of Viral Genomes Provides Insight into the Evolution and Pathogenesis of Varicella Zoster Virus and Its Vaccine in HumansDiploidization and genome size change in allopolyploids is associated with differential dynamics of low- and high-copy sequences.Diploidization and genome size change in allopolyploids is associated with differential dynamics of low- and high-copy sequencesGodfrey M Hewitt (1940-2013): highlights in Heredity from a career in evolutionary genetics.Hybridization and speciationNext generation sequencing analysis reveals a relationship between rDNA unit diversity and locus number in Nicotiana diploidsBringing genetic diversity to the forefront of conservation policy and managementConservation Genetic Resources for Effective Species Survival (ConGRESS): Bridging the divide between conservation research and practiceSample Planning Optimization Tool for conservation and population Genetics (SPOTG): a software for choosing the appropriate number of markers and samplesIndependent, rapid and targeted loss of highly repetitive DNA in natural and synthetic allopolyploids of Nicotiana tabacum.Next generation sequencing reveals genome downsizing in allotetraploid Nicotiana tabacum, predominantly through the elimination of paternally derived repetitive DNAs.Predictions of single-nucleotide polymorphism differentiation between two populations in terms of mutual information.Stops making sense: translational trade-offs and stop codon reassignment.Population diversity in batches of the varicella Oka vaccineHousehold size is critical to varicella-zoster virus transmission in the tropics despite lower viral infectivity.Induced dispersal in wildlife management: experimental evaluation of the risk of hybrid breakdown and the benefit of hybrid vigor in the F1 generationPhylogenetic relationships in Pterodroma petrels are obscured by recent secondary contact and hybridization.Range expansion and hybridization in Round Island petrels (Pterodroma spp.): evidence from microsatellite genotypes.Population genetic patterns suggest a behavioural change in wild common frogs (Rana temporaria) following disease outbreaks (Ranavirus)Geographically localised bursts of ribosomal DNA mobility in the grasshopper Podisma pedestris.European phylogeography of the common frog (Rana temporaria): routes of postglacial colonization into the British Isles, and evidence for an Irish glacial refugium.Evidence for directional selection at a novel major histocompatibility class I marker in wild common frogs (Rana temporaria) exposed to a viral pathogen (Ranavirus).The inexorable spread of a newly arisen neo-Y chromosome.A method for quantifying differentiation between populations at multi-allelic loci and its implications for investigating identity and paternity (vol 96, pg 3, 1995)The frequency of rDNA variants within individuals provides evidence of population history and gene flow across a grasshopper hybrid zone.The role of vicariance vs. dispersal in shaping genetic patterns in ocellated lizard species in the western MediterraneanLandscape, habitat characteristics and the genetic population structure of two caddisfliesDNA sequence variability in Oka vaccine isolatesDates from the molecular clock: how wrong can we be?Transition-transversion bias is not universal: a counter example from grasshopper pseudogenes.Natural selection for rash-forming genotypes of the varicella-zoster vaccine virus detected within immunized human hostsGenome-wide characterisation of Hepatitis B mutations involved in clinical outcomeRibosomal DNA in the grasshopper Podisma pedestris: escape from concerted evolution.Morphological differentiation following experimental bottlenecks in the butterfly Bicyclus anynana (Nymphalidae)Natural selection of rash-forming genotypes of the varicella vaccine virus within humansVaccine Oka varicella-zoster virus genotypes are monomorphic in single vesicles and polymorphic in respiratory tract secretionsA novel approach to characterise pathogen candidate genetic polymorphisms involved in clinical outcomeHepatitis B virus mutations involved in clinical outcomeRecruitment, kin and the spatial genetic structure of a caddisfly Plectrocnemia conspersa in a southern English streamQuantitative genetics focus issueGenetic and Evolutionary Impacts of Climate ChangeThe origin and evolution of geminivirus-related DNA sequences in Nicotiana.Molecular phylogeny and morphological change in the Psittacula parakeets.Using molecular markers with high mutation rates to obtain estimates of relative population size and to distinguish the effects of gene flow and mutation: a demonstration using data from endemic Mauritian skinks.An analysis of consanguinity and social structure within the UK Asian population using microsatellite data.Genetic population structure and neighbourhood population size estimates of the caddisfly Plectrocnemia conspersaApplication of DNA microarrays to study the evolutionary genomics of Yersinia pestis and Yersinia pseudotuberculosis.A molecular phylogeny of African kestrels with reference to divergence across the Indian OceanY genetic data support the Neolithic demic diffusion modelThe effect of reproductive compensation on recessive disorders within consanguineous human populations.Using nested clade analysis to assess the history of colonization and the persistence of populations of an Iberian LizardPatterns of colonization in a metapopulation of grey sealsPhylogenetic analysis of varicella-zoster virus: Evidence of intercontinental spread of genotypes and recombinationA molecular phylogeny of African kestrels with reference to divergence across the Indian OceanThe double origin of Iberian peninsular chameleonsCulex pipiens in London Underground tunnels: differentiation between surface and subterranean populationsMicrosatellites for the net-spinning caddisfly Plectrocnemia conspersa (Polycentropodidae)A method for distinguishing consanguinity and population substructure using multilocus genotype dataThe persistence of Pliocene populations through the Pleistocene climatic cycles: evidence from the phylogeography of an Iberian lizardGene trees and species trees are not the same.Genetic differentiation of a European caddisfly: past and present gene flow among fragmented larval habitats.Mating patterns, relatedness and the basis of natal philopatry in the brown long-eared bat, Plecotus auritusEvaluating the severity of the population bottleneck in the Mauritius kestrel Falco punctatus from ringing records using MCMC estimationEffects of bottlenecks on quantitative genetic variation in the butterfly Bicyclus anynanaSustaining genetic variation in a small population: evidence from the Mauritius kestrelMinisatellite mutational processes reduce F-st estimatesInbreeding of bottlenecked butterfly populations: Estimation using the likelihood of changes in marker allele frequenciesCulex pipiens in London Underground tunnels: differentiation between surface and subterranean populations.The introduction of molecular genetic techniques into forensic scienceGenetic differentiation between and within strains of the saw-toothed grain beetle, Oryzaephilus surinamensis (Coleoptera: Silvanidae) at RAPD loci.Significant genetic correlations among Caucasians at forensic DNA loci.Population structure and insecticidal control of the sawtoothed grain beetle (Coleoptera: Silvanidae) under simulated field conditionsEvaluating loci for use in the genetic analysis of population structureSevere inbreeding depression and rapid fitness rebound in the butterfly Bicyclus anynana (Satyridae)Spatial patterns of genetic variation generated by different forms of dispersal during range expansionIs it ancient or modern history that we can read in the genes?Assessing relatedness and evolutionary divergence: why the genetic evidence alone is not enough.Population genetics of STR loci in Caucasians.A METHOD FOR QUANTIFYING DIFFERENTIATION BETWEEN POPULATIONS AT MULTI-ALLELIC LOCI AND ITS IMPLICATIONS FOR INVESTIGATING IDENTITY AND PATERNITYPHILOPATRY IN THE ALPINE GRASSHOPPER, PODISMA-PEDESTRIS - A NOVEL EXPERIMENTAL AND ANALYTICAL METHODA method for quantifying differentiation between populations at multi-allelic loci and its implications for investigating identity and paternity.A method for quantifying differentiation between populations at multi-allelic loci and its implications for investigating identity and paternitySOME CAUSES FOR CONCERN ABOUT DNA PROFILES - COMMENTTHE GENETIC CONSEQUENCES OF LONG-DISTANCE DISPERSAL DURING COLONIZATIONDNA profile match probability calculation: how to allow for population stratification, relatedness, database selection and single bands.Comment: Some causes for concern about DNA profilesDetecting gene conversion: primate visual pigment genes.SEXUAL PREFERENCE AND GENETIC CORRELATIONSEffects of population structure on DNA fingerprint analysis in forensic science.THE FRAGMENTATION OF TENSION ZONES IN SPARSELY POPULATED AREASMITOCHONDRIAL-DNA CLUES TO GOPHER TORTOISE DISPERSALSPERM PRECEDENCE AND HOMOGAMY ACROSS A HYBRID ZONE IN THE ALPINE GRASSHOPPER PODISMA-PEDESTRISDOES RUNAWAY SEXUAL SELECTION WORK IN FINITE POPULATIONSECOLOGICAL GENETICS - 1868 AND ALL THAT FOR MAGICICADAEVOLUTION AT A SNAILS PACEGENETIC AND ECOLOGICAL DIFFERENTIATION ACROSS A HYBRID ZONEHOMOGAMY IN A HYBRID ZONE IN THE ALPINE GRASSHOPPER PODISMA-PEDESTRISPOPULATION-STRUCTURE AND THE SHAPE OF A CHROMOSOMAL CLINE BETWEEN 2 RACES OF PODISMA-PEDESTRIS (ORTHOPTERA, ACRIDIDAE)HETEROCHROMATIN READJUSTING CHIASMA DISTRIBUTION IN 2 SPECIES OF THE GENUS ARCYPTERA - THE EFFECT AMONG INDIVIDUALS AND POPULATIONSCombined phylogenetic and geographic data can predict plant-pest interactions with high accuracyRecurrent evolution of cryptic triploids in cultivated enset increases yieldQuantitative measurement of phenotype dynamics during cancer drug resistance evolution using genetic barcodingEuropean ash pangenome reveals widespread structural variation and a diverse genetic basis for low ash dieback susceptibilityInteractions between plant genome size, nutrients and herbivory by rabbits, molluscs and insects on a temperate grasslandConservation biology - ‘Ghost’ alleles of the Mauritius kestrelGenomic architecture and evolutionary antagonism drive allelic expression bias in the social supergene of red fire antsGenomic assessment of local adaptation in dwarf birch to inform assisted gene flowGenomic basis of European ash tree resistance to ash dieback fungusEvidence for the Widespread Occurrence of Bacteria Implicated in Acute Oak Decline from Incidental Genetic SamplingA mechanism to prevent transformation of the Whi3 mnemon into a prionGenomic architecture and evolutionary conflict drive allele-specific expression in the social supergene of the red fire antMitochondrial sequences or Numts – By-catch differs between sequencing methodsTemperature is a key driver of a wildlife epidemic and future warming will increase impactsRapid polygenic adaptation in a wild population of ash trees under a novel fungal epidemicAssembly-free quantification of vagrant DNA insertsIdentification of Novel Endogenous Retroviruses in AnuraGrants of specific relevance to the Centre for Evolutionary and Functional GenomicsADB513: Genomic basis of ash health after five and thirteen years’ exposure to ash dieback CFP25_A56Predicting risk to non-native trees species from potential threats in the UKPhD studentship - Assessing the risk to plant health in the UK from future Agrilus invasionsA high-throughput platform for assembling genome data: the SaphyrNERC DTP CASE Award - Charlotte Ford studentship top upGCRF Ethiopian project with KewResearch (published in Science) led by Profs Richard Nichols and Richard Buggs has uncovered early-stage signs of natural resistance to ash dieback—a fungal disease expected to kill half of the UK's 80 million ash trees. By comparing the DNA of older trees, present before the fungus arrived in 2012, with younger ... [more]
