Dr. rer. nat., MRSC
Research
Photoelectrochemical imaging, Light-addressable potentiometric sensors, Light-activated electrochemistry, Biosensors, Live-cell imaging
Interests
My research focuses on the development of chemical and biological sensors and electrochemical imaging.
Light-Addressable Potentiometric Sensors (LAPS) and Scanning Photo-induced Impedance Microscopy (SPIM) are imaging techniques based on photocurrent measurements at electrolyte/insulator/silicon (EIS) field-effect structures. They are capable of measuring local changes in the surface potential (LAPS), which can be used to image ion concentrations, and of measuring the local impedance (SPIM). Recent highlights of our research are the achievement of submicron resolution of photocurrent measurements at silicon-on-sapphire substrates using a two-photon effect, the increase in the sensitivity of SPIM using organic, self-assembled monolayers as insulators, the use of SPIM for the interrogation of biosensor arrays for the detection of charged molecules such as DNA, quantitative impedance imaging of polyelectrolyte microcapsules with high resolution and the measurement of cell surface charge and cell impedance.
Recent development of photoelectrochemical imaging with semiconducting metal oxide substrates such as indium tin oxide and hematite allows detection of redox active molecules and hence a much broader range of analytes than with traditional EIS structures. Combined with a recently developed fast imaging setup, the technique has shown great potential for continuous functional electrochemical imaging of the attachment area of cells, providing information such as ion concentration, action potentials and cell membrane permeability. Photoelectrochemical imaging is particularly attractive for label-free in-situ monitoring in in-vitro models.
Publications
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Publications of specific relevance to the Centre for Bioengineering
2023
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Gorecki J and
Krause S (2023).
Numerical investigation of a graphene-on-semiconductor device for optical monitoring of cell electrophysiology. iScience,
Elsevier vol. 27 (1)
24-11-20232022
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Jacques R, Zhou B, Marhuenda E, Gorecki J, Das A,
Iskratsch T and
Krause S (2022).
Photoelectrochemical imaging of single cardiomyocytes and monitoring of their action potentials through contact force manipulation of organoids. Biosensors and Bioelectronics,
Elsevier 21-12-2022![Relevant Publication](/common/publications/images/fav.png)
Zhou B, Jiang Y, Guo Q, Das A,
Jorge Sobrido A,
Hing K, Zayats A and
Krause S (2022).
Photoelectrochemical Detection of Calcium Ions Based on Hematite Nanorod Sensors. ACS Applied Nano Materials,
American Chemical Society 10-11-2022![Relevant Publication](/common/publications/images/fav.png)
Meng Y, Chen F, Wu C,
Krause S, Wang J and Zhang DW (2022).
Light-Addressable Electrochemical Sensors toward Spatially Resolved Biosensing and Imaging Applications. ACS Sensors,
American Chemical Society 28-06-20222021
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Wan K, Liu Y, Santagiuliana G, Barandun G, Taroni Junior P, Güder F, Bastiaansen CWM, Baxendale M,
Fenwick O,
Papageorgiou DG,
Krause S,
Zhang H and Bilotti E (2021).
Self-powered ultrasensitive and highly stretchable temperature–strain sensing composite yarns. Materials Horizons 12-07-2021![Relevant Publication](/common/publications/images/fav.png)
Zhou B, Das A, Zhong M, Guo Q, Zhang D-W,
Hing KA, Sobrido AJ, Titirici M-M and
Krause S (2021).
Photoelectrochemical imaging system with high spatiotemporal resolution for visualizing dynamic cellular responses. Biosensors and Bioelectronics,
Elsevier vol. 180
02-03-20212020
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Tu Y, Kyle C, Luo H, Zhang DW, Das A,
Briscoe J, Dunn S, Titirici MM and
Krause S (2020).
Ammonia Gas Sensor Response of a Vertical Zinc Oxide Nanorod-Gold Junction Diode at Room Temperature. ACS Sensors vol. 5 (11), 3568-3575.
25-11-20202019
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Zhou B, Das A, Kappers M, Oliver R,
Humphreys C and
Krause S (2019).
InGaN as a substrate for AC photoelectrochemical imaging. Sensors,
MDPI 11-10-2019![Relevant Publication](/common/publications/images/fav.png)
Wang J, Yang Z, Chen W, Du L, Jiao B,
Krause S, Wang P, Wei Q, Zhang D-W and Wu C (2019).
Modulated light-activated electrochemistry at silicon functionalized with metal-organic frameworks towards addressable DNA chips. Biosensors and Bioelectronics,
Elsevier vol. 146, 111750-111750.
03-10-2019![bullet icon](/common/publications/images/bullet24.png)
Wan K, Taroni PJ, Liu Z, Liu Y, Tu Y, Santagiuliana G, Hsia I,
Zhang H,
Fenwick O,
Krause S, Baxendale M, Schroeder BC and Bilotti E (2019).
Flexible and Stretchable Self‐Powered Multi‐Sensors Based on the N‐Type Thermoelectric Response of Polyurethane/Na
x
(Ni‐ett)
n
Composites. Advanced Electronic Materials,
Wiley, 1900582-1900582.
15-09-2019![Relevant Publication](/common/publications/images/fav.png)
Ahmad N, Colak B, Gibbs MJ, Zhang D-W,
Gautrot JE, Watkinson M, Becer CR and
Krause S (2019).
Peptide Cross-Linked Poly(2-oxazoline) as a Sensor Material for the Detection of Proteases with a Quartz Crystal Microbalance. Biomacromolecules vol. 20 (7), 2506-2514.
07-06-2019![Relevant Publication](/common/publications/images/fav.png)
Wu F, Zhou B, Wang J, Zhong M, Das A, Watkinson M,
Hing K, Zhang D-W and
Krause S (2019).
Photoelectrochemical Imaging System for the Mapping of Cell Surface Charges. Anal Chem 15-04-2019![Relevant Publication](/common/publications/images/fav.png)
Ahmad N, Colak B, Zhang D-W, Gibbs MJ, Watkinson M, Becer CR,
Gautrot JE and
Krause S (2019).
Peptide Cross-Linked Poly (Ethylene Glycol) Hydrogel Films as Biosensor Coatings for the Detection of Collagenase. Sensors,
MDPI vol. 19 (7)
08-04-20192018
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Zhang D, Papaioannou N, Titirici M-M and
Krause S (2018).
Photoelectrochemical Imaging Using Carbon Dots (CDs) Derived from Chitosan. Proceedings,
MDPI vol. 2 (13)
10-12-2018![Relevant Publication](/common/publications/images/fav.png)
Ahmad N, Colak B, Gibbs MJ, Zhang D-W, Becer CR, Watkinson M,
Gautrot JE and
Krause S (2018).
Collagenase Biosensor Based on the Degradation of Peptide Cross-Linked Poly(Ethylene Glycol) Hydrogel Films. 30-11-2018![bullet icon](/common/publications/images/bullet24.png)
Tu Y, Li J, Zhang D-W,
Briscoe J and
Krause S (2018).
The Effect of Semiconductor Morphology on the Spatial Resolution of ZnO Based Light-Addressable Potentiometric Sensors. EUROSENSORS 2018.
27-11-2018![Relevant Publication](/common/publications/images/fav.png)
TU Y, AHMAD N,
BRISCOE J, ZHANG D and
KRAUSE S (2018).
Light-Addressable Potentiometric Sensors using ZnO Nanorods as the Sensor Substrate for Bioanalytical Applications. Analytical Chemistry,
American Chemical Society 22-06-2018![bullet icon](/common/publications/images/bullet24.png)
Wang J, Du L,
Krause S, Wu C and Wang P (2018).
Surface modification and construction of LAPS towards biosensing applications. Sensors and Actuators, B: Chemical vol. 265, 161-173.
08-03-2018![bullet icon](/common/publications/images/bullet24.png)
ZHANG D, PAPAIOANNOU N, David NM, LUO H, GAO H, Tanase LC, Degousee T, Samori P,
SAPELKIN A,
FENWICK O, TITIRICI M and
KRAUSE SK (2018).
Photoelectrochemical response of carbon dots (CDs) derived from chitosan and their use in electrochemical imaging. Materials Horizons,
Rsc 12-02-2018![bullet icon](/common/publications/images/bullet24.png)
TU Y, CHEN S, LI X, GORBACIOVA J,
GILLIN WP,
KRAUSE S and
BRISCOE J (2018).
Control of oxygen vacancies in ZnO nanorods by annealing and their influence on ZnO/PEDOT:PSS diode behaviour. Journal of Materials Chemistry C,
Royal Society of Chemistry 02-02-2018![Relevant Publication](/common/publications/images/fav.png)
Schöning MJ, Wagner T, Poghossian A, Miyamoto K-I, Werner CF,
Krause S and Yoshinobu T (2018).
Light-Addressable Potentiometric Sensors for (Bio-)chemical Sensing and Imaging. Encyclopedia of Interfacial Chemistry 295-308.
01-01-2018![Relevant Publication](/common/publications/images/fav.png)
Yoshinobu T,
Krause S, Miyamoto K-I, Werner CF, Poghossian A, Wagner T and Schöning MJ (2018).
(Bio-)chemical Sensing and Imaging by LAPS and SPIM. Label-Free Biosensing 103-132.
01-01-20182017
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Zhang D, Wu F and
KRAUSE SK (2017).
LAPS and SPIM imaging using ITO coated glass as the substrate material. Analytical Chemistry,
American Chemical Society 05-07-2017![Relevant Publication](/common/publications/images/fav.png)
Wu F, Campos I, Zhang D and
KRAUSE SK (2017).
Biological imaging using light-addressable potentiometric sensors and scanning photo-induced impedance microscopy. Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences,
Royal Society, The 03-05-2017![bullet icon](/common/publications/images/bullet24.png)
Zhang D and
Krause S (2017).
Image Detection of Yeast Saccharomyces Cerevisiae By Light-Addressable Potentiometric Sensors (LAPS). ECS Meeting Abstracts,
The Electrochemical Society vol. MA2017-01 (38), 1770-1770.
15-04-2017![bullet icon](/common/publications/images/bullet24.png)
Wu F, Watkinson M and
Krause S (2017).
Electrochemical Imaging of Copper Contamination on Self-Assembled Organic Monolayer Modified Silicon Surfaces Following a ‘Click’ Reaction with Light-Addressable Potentiometric Sensors and Scanning Photo-Induced Impedance Microscopy. ECS Meeting Abstracts,
The Electrochemical Society vol. MA2017-01 (38), 1769-1769.
15-04-2017![bullet icon](/common/publications/images/bullet24.png)
Wu F, Zhang DW, Wang J, Watkinson M and
Krause S (2017).
Copper Contamination of Self-Assembled Organic Monolayer Modified Silicon Surfaces Following a “Click” Reaction Characterized with LAPS and SPIM. Langmuir vol. 33 (13), 3170-3177.
04-04-2017
Krause S (2017).
High-resolution impedance and potential imaging using light-addressable potentiometric sensors for bio-imaging applications. 01-03-20172016
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Zhang DW, Wu F, Wang J, Watkinson M and
KRAUSE SK (2016).
Image detection of yeast Saccharomyces cerevisiae by light-addressable potentiometric sensors (LAPS). Electrochemistry Communications vol. 72, 41-45.
24-08-2016![bullet icon](/common/publications/images/bullet24.png)
Wang J, Campos I, Wu F, Zhu J,
Sukhorukov GB,
Palma M, Watkinson M and
Krause S (2016).
The effect of gold nanoparticles on the impedance of microcapsules visualized by scanning photo-induced impedance microscopy. Electrochimica Acta vol. 208, 39-46.
04-05-20162015
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Wang J, Wu F, Watkinson M, Zhu J and
Krause S (2015).
click Patterning of Self-Assembled Monolayers on Hydrogen-Terminated Silicon Surfaces and Their Characterization Using Light-Addressable Potentiometric Sensors. Langmuir vol. 31 (35), 9646-9654.
08-09-2015![Relevant Publication](/common/publications/images/fav.png)
Gibbs MJ, Biela A and
Krause S (2015).
α-Amylase sensor based on the degradation of oligosaccharide hydrogel films monitored with a quartz crystal sensor. Biosens Bioelectron vol. 67, 540-545.
15-05-2015![bullet icon](/common/publications/images/bullet24.png)
Zhang H, Yilmaz P, Ansari JO, Khan FF, Binions R,
Krause S and Dunn S (2015).
Incorporation of Ag nanowires in CuWO4 for improved visible light-induced photoanode performance. Journal of Materials Chemistry A vol. 3 (18), 9638-9644.
26-03-2015![Relevant Publication](/common/publications/images/fav.png)
Biela A, Watkinson M, Meier UC, Baker D, Giovannoni G, Becer CR and
Krause S (2015).
Disposable MMP-9 sensor based on the degradation of peptide cross-linked hydrogel films using electrochemical impedance spectroscopy. Biosensors and Bioelectronics vol. 68, 660-667.
27-01-20152014
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Wang J, Zhou Y, Watkinson M,
Gautrot J and
Krause S (2014).
High-sensitivity light-addressable potentiometric sensors using silicon on sapphire functionalized with self-assembled organic monolayers. Sensors and Actuators B: Chemical,
Elsevier vol. 209, 230-236.
26-11-20142013
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Dzaraini K, Norizan A,
Krause S, Hunter C and Milanesi L (2013).
Degradation behaviour of thin polymer films of poly (amide ester) hydrogel using quartz crystal microbalance. Advanced Materials Research vol. 812, 38-45.
29-10-20132012
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Zhang DW, Zhang FT, Cui YR, Deng QP,
Krause S, Zhou YL and Zhang XX (2012).
A label-free aptasensor for the sensitive and specific detection of cocaine using supramolecular aptamer fragments/target complex by electrochemical impedance spectroscopy. Talanta vol. 92, 65-71.
15-04-20122011
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Zheng X, Cook JP, Watkinson M, Yang S, Douglas I, Rawlinson A and
Krause S (2011).
Generic protease detection technology for monitoring periodontal disease. Faraday Discussions vol. 149, 37-47.
17-01-20112010
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Chen L, Zhou Y, Jiang S, Kunze J, Schmuki P and
Krause S (2010).
High resolution LAPS and SPIM. Electrochemistry Communications vol. 12 (6), 758-760.
01-06-20102009
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Kamarun D, Zheng XW, Milanesi L, Hunter CA and
Krause S (2009).
A peptide cross-linked polyacrylamide hydrogel for the detection of human neutrophil elastase. ELECTROCHIMICA ACTA vol. 54 (22), 4985-4990.
01-09-2009![Relevant Publication](/common/publications/images/fav.png)
Stair JL, Watkinson M and
Krause S (2009).
Sensor materials for the detection of proteases. Biosensors and Bioelectronics vol. 24 (7), 2113-2118.
15-03-2009![bullet icon](/common/publications/images/bullet24.png)
Sweeney SJ and
Krause S (2009).
Selected Papers from the Second International Conference on Optical, Optoelectronic and Photonic Materials and Applications, 2007. J MATER SCI-MATER EL vol. 20, 1-2.
01-01-2009![bullet icon](/common/publications/images/bullet24.png)
Sweeney SJ and
Krause S (2009).
Editorial: Selected papers from the second international conference on optical, optoelectronic and photonic materials and applications, 2007. Journal of Materials Science: Materials in Electronics vol. 20 (SUPPL. 1)
01-01-20092008
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Chen L, Zhou Y,
Krause S, Munoz AG, Kunze J and Schmuki P (2008).
Repair of thin thermally grown silicon dioxide by anodic oxidation. Electrochimica Acta vol. 53 (8), 3395-3402.
10-03-20082007
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Zhou Y, Jiang S,
Krause S and Chazalviel J-N (2007).
Biosensor arrays based on the degradation of thin polymer films interrogated by scanning photoinduced impedance microscopy. Anal Chem vol. 79 (23), 8974-8978.
01-12-2007![bullet icon](/common/publications/images/bullet24.png)
Zhou Y, Chen L,
Krause S and Chazalviel J-N (2007).
Scanning photoinduced impedance microscopy using amorphous silicon photodiode structures. Anal Chem vol. 79 (16), 6208-6214.
15-08-20072006
Krause S, Moritz W, Talabani H, Xu M, Sabot A and Ensell G (2006).
Scanning Photo-Induced Impedance Microscopy - Resolution studies and polymer characterization. ELECTROCHIMICA ACTA vol. 51 (8-9), 1423-1430.
20-01-2006![Relevant Publication](/common/publications/images/fav.png)
Zhou YL,
Krause S, Chazalviel JN and McNeil CJ (2006).
Biosensor arrays based on the degradation of thin polymer films interrogated by Scanning Photo-induced Impedance Microscopy. 01-01-2006
KRAUSE SK, Fernandez-Sanchez C and McNeil CJ (2006).
Sensors based on thin film degradation. Encyclopedia of Sensors 289-306.
01-01-20062004
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Moritz W, Yoshinobu T, Finger F,
Krause S, Martin-Fernandez M and Schoning MJ (2004).
High resolution LAPS using amorphous silicon as the semiconductor material. SENSORS AND ACTUATORS B-CHEMICAL vol. 103 (1-2), 436-441.
29-09-20042003
KRAUSE SK (2003).
Impedance methods. Encyclopedia of Electrochemistry, Volume 3, Instrumentation and Electroanalytical Chemistry 196-229.
01-01-20032002
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Sabot A and
Krause S (2002).
Simultaneous quartz crystal microbalance impedance and electrochemical impedance measurements. Investigation into the degradation of thin polymer films. Anal Chem vol. 74 (14), 3304-3311.
15-07-2002
Krause S, Talabani H, Xu M, Moritz W and Griffiths J (2002).
Scanning photo-induced impedance microscopy - an impedance based imaging technique. ELECTROCHIMICA ACTA vol. 47 (13-14), 2143-2148.
25-05-20022001
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Sumner C,
Krause S, Sabot A, Turner K and McNeil CJ (2001).
Biosensor based on enzyme-catalysed degradation of thin polymer films. BIOSENSORS & BIOELECTRONICS vol. 16 (9-12), 709-714.
01-12-2001![bullet icon](/common/publications/images/bullet24.png)
Moritz W,
Krause S, Roth U, Klimm D and Lippitz A (2001).
Re-activation of an all solid state oxygen sensor. ANAL CHIM ACTA vol. 437 (2), 183-190.
27-06-2001
KRAUSE SK, Sabot A and Sumner C (2001).
Combined QCM and electrochemical impedance measurements for biosensor applications. Chemical and Biological Sensors and Analytical Methods II, ECS Conference, San Francisco.
01-01-2001![bullet icon](/common/publications/images/bullet24.png)
Wilkop T,
Krause S, Nabok A, Ray AK and Yates R (2001).
The detection of organic pollutants in water with calixarene coated electrodes., Editors: Moebius D and Miller R.
01-01-20012000
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Sumner C, Sabot A, Turner K and
Krause S (2000).
A transducer based on enzyme-induced degradation of thin polymer films monitored by surface plasmon resonance. Anal Chem vol. 72 (21), 5225-5232.
01-11-2000![bullet icon](/common/publications/images/bullet24.png)
Moritz W, Gerhardt I, Roden D, Xu M and
Krause S (2000).
Photocurrent measurements for laterally resolved interface characterization. FRESENIUS JOURNAL OF ANALYTICAL CHEMISTRY vol. 367 (4), 329-333.
01-06-20001999
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Ho WO,
Krause S, McNeil CJ, Pritchard JA, Armstrong RD, Athey D and Rawson K (1999).
Electrochemical sensor for measurement of urea and creatinine in serum based on ac impedance measurement of enzyme-catalyzed polymer transformation. ANAL CHEM vol. 71 (10), 1940-1946.
15-05-19991998
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Moritz W,
Krause S, Bartholomäus L, Gabusjan T, Vasiliev AA, Godovski DY and Malyshev VV (1998).
Silicon-Based Sensor for Flourine Gas. ACS Symposium Series vol. 690, 119-129.
01-01-19981995
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McNeil CJ, Athey D, Ball M, Ho WO,
Krause S, Armstrong RD, Des Wright J and Rawson K (1995).
Electrochemical Sensors Based on Impedance Measurement of Enzyme-Catalyzed Polymer Dissolution: Theory and Applications. Analytical Chemistry,
American Chemical Society (ACS) vol. 67 (21), 3928-3935.
01-11-1995![bullet icon](/common/publications/images/bullet24.png)
Moritz W,
Krause S, Vasiliev AA, Godovski DY and Malyshev VV (1995).
Monitoring of HF and F2 using a field-effect sensor. Sensors and Actuators B Chemical,
Elsevier vol. 24 (1-3), 194-196.
01-03-19951994
Krause S, Moritz W and Grohmann I (1994).
Improved long-term stability for an LaF3 based oxygen sensor. Sensors and Actuators B Chemical,
Elsevier vol. 18 (1-3), 148-154.
01-03-19941992
Krause S, Moritz W and Grohmann I (1992).
A low-temperature oxygen sensor based on the Si/LaF3/Pt capacitive structure. Sensors and Actuators B Chemical,
Elsevier vol. 9 (3), 191-196.
01-10-19921991
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Bobrov PV, Tarantov YA,
Krause S and Moritz W (1991).
Chemical sensitivity of an ISFET with Ta2O5 membrane in strong acid and alkaline solutions. Sensors and Actuators B Chemical,
Elsevier vol. 3 (1), 75-81.
01-01-1991