Prof Julien Gautrot
Professor of Biomaterials and Biointerfaces
School of Engineering and Materials Science
Queen Mary University of London
Queen Mary University of London
Research
Hydrogels, Polymer brush, Stem cells, Cell therapy, Gene delivery
Interests
The reconstruction of artificial micro-environment for tissue engineering and regenerative medicine requires the design of novel biomaterials with controlled chemistry, biochemisty, mechanical properties and geometry, at different length scales. In addition, these platforms should be dynamic in order to allow remodelling events that are necessary to processes such as wound healing, angiogenesis and tissue regeneration.Cell behaviours such as spreading, motility, proliferation, death and differentiation are tightly regulated by the cell micro-environment. Biochemical properties but also its geometric and mechanical properties of this micro-environment control cell phenotype. For regenerative medicine applications, novel biomaterials and patterning tools are required, with controlled chemistry and biochemistry, as well as mechanical and geometric properties at different length scales.
Publications
Publications of specific relevance to the Centre for Bioengineering2024
Murphy JF, Lavelle M, Asciak L, Burdis R, Levis HJ, Ligorio C, McGuire J, Polleres M, Smith PO, Tullie L, Uribe-Gomez J, Chen B, Dawson JI, Gautrot JE, Hooper NM, Kelly DJ, Li VSW, Mata A, Pandit A, Phillips JB, et al. (2024). Biofabrication and biomanufacturing in Ireland and the UK. Bio-Design and Manufacturing, Springer Nature, 1-32. 23-10-2024
Zhang J, Marciano D, Wang L, Wang W, Gossen M, Yang M, Peng T, Gautrot J, Xu X and Ma N (2024). Bioinspired Hyaluronic Acid‐Based Hydrogel Fuels Bi‐Directional Lung Organoid Maturation via PIEZO1 and ITGB1 Mediated Mechanosensation. Advanced Materials Interfaces, Wiley 03-09-2024
Joy JD, Malacrida B, Laforêts F, Kotantaki P, Maniati E, Manchanda R, Annibaldi A, Hopkins S, Garrobo-Calleja I, Gautrot J and Balkwill FR (2024). Human 3D Ovarian Cancer Models Reveal Malignant Cell-Intrinsic and -Extrinsic Factors That Influence CAR T-cell Activity. Cancer Res vol. 84 (15), 2432-2449. 01-08-2024
Marchena MH, Lambert E, Bogdanović B, Quadir F, Neri-Cruz CE, Luo J, Nadal C, Migliorini E and Gautrot JE (2024). BMP-Binding Polysulfonate Brushes to Control Growth Factor Presentation and Regulate Matrix Remodelling. ACS Applied Materials & Interfaces, American Chemical Society (ACS) vol. 16 (31), 40455-40468. 29-07-2024
Mojares E, Nadal C, Hayler D, Kanso H, Chrysanthou A, Cruz CEN and Gautrot JE (2024). Strong Elastic Protein Nanosheets Enable the Culture and Differentiation of Induced Pluripotent Stem Cells on Microdroplets. Advanced Materials, Wiley vol. 36 (38) 22-07-2024
Chrysanthou A, Bosch-Fortea M, Nadal C, Zarbakhsh A and Gautrot JE (2024). Interfacial mechanics of β-casein and albumin mixed protein assemblies at liquid-liquid interfaces. Journal of Colloid and Interface Science, Elsevier vol. 674, 379-391. 15-06-2024
Summan S, Mayes A, Gunn D, Madapura P, Gautrot J, Caley M and O’Toole E (2024). O08 Exploring the effect of skin ageing-related basement membrane collagen loss on nuclear mechanics. British Journal of Dermatology, Oxford University Press (OUP) vol. 190 (6), e71-e72. 17-05-2024
Joy JD, Malacrida B, Laforets F, Kotantaki P, Maniati E, Manchanda R, Hopkins S, Garrobo-Calleja I, Annibaldi A, Gautrot J and Balkwill FR (2024). Abstract B079: Human 3D ovarian cancer models reveal malignant cell intrinsic and extrinsic factors that influence CAR-T cell activity. Cancer Research, American Association for Cancer Research (AACR) vol. 84 (5_Supplement_2), b079-b079. 04-03-2024
Di Cio S, Marhuenda E, Haddrick M and Gautrot JE (2024). Vascularised cardiac spheroids-on-a-chip for testing the toxicity of therapeutics. Scientific Reports, Springer Nature vol. 14 (1) 09-02-2024
Scemama A, Lunetto S, Tailor A, Di Cio S, Dibble M, Gautrot J and Biddle A (2024). Development of an in vitro microfluidic model to study the role of microenvironmental cells in oral cancer metastasis. F1000Research, F1000Research vol. 12 15-01-2024
2023
Summan SK, Mayes A, Gunn D, Gautrot J, Caley M and O’Toole E (2023). P16 How does skin ageing-related basement membrane collagen loss affect the nucleus? British Journal of Dermatology, Oxford University Press (OUP) vol. 189 (1), e20-e20. 07-07-2023
Neri-Cruz CE, Teixeira FME and Gautrot JE (2023). A guide to functionalisation and bioconjugation strategies to surface-initiated polymer brushes. Chemical Communications, Royal Society of Chemistry vol. 59 (49), 7534-7558. 09-05-2023
Summan SK, Mayes A, Gunn DA, Gautrot J, Caley M and O'Toole E (2023). 741 The effect of skin ageing-related basement membrane collagen loss on the nucleus. Journal of Investigative Dermatology, Elsevier vol. 143 (5), s127-s127. 01-05-2023
Scemama A, Tailor A, Di Cio S, Dibble M, Gautrot J and Biddle A (2023). Development of an in vitro microfluidic model to study the role of microenvironmental cells in oral cancer metastasis. F1000Research, Taylor and Francis vol. 12, 439-439. 25-04-2023
Cervantes-Salguero K, Gutiérrez Fosado YA, Megone W, Gautrot JE and Palma M (2023). Programmed Self-Assembly of DNA Nanosheets with Discrete Single-Molecule Thickness and Interfacial Mechanics: Design, Simulation, and Characterization. Molecules, MDPI vol. 28 (9) 24-04-2023
Dibble M, Di Cio’ S, Luo P, Balkwill F and Gautrot JE (2023). The impact of pericytes on the stability of microvascular networks in response to nanoparticles. Scientific Reports, Springer Nature vol. 13 (1) 07-04-2023
Joy JD, Malacrida B, Laforêts F, Kotantaki P, Maniati E, Hopkins S, Garrobo-Calleja I, Gautrot J and Balkwill F (2023). Abstract 4576: 3D in vitro models uncover malignant cell intrinsic and extrinsic mechanisms of CAR-T cell resistance in high grade serous ovarian cancer. Cancer Research, American Association for Cancer Research (AACR) vol. 83 (7_Supplement), 4576-4576. 04-04-2023
Peng L, Nadal C and Gautrot JE (2023). Growth of mesenchymal stem cells at the surface of silicone, mineral and plant-based oils. Biomedical Materials, IOP Publishing vol. 18 (3) 17-03-2023
Peng L, Matellan C, Bosch‐Fortea M, Gonzalez‐Molina J, Frigerio M, Salentinig S, del Rio Hernandez A and Gautrot JE (2023). Mesenchymal Stem Cells Sense the Toughness of Nanomaterials and Interfaces. Advanced Healthcare Materials, Wiley vol. 12 (13) 21-02-2023
Nguyen KDQ, Dejean S, Nottelet B and Gautrot JE (2023). Mechanical Evaluation of Hydrogel–Elastomer Interfaces Generated through Thiol–Ene Coupling. ACS Applied Polymer Materials, American Chemical Society (ACS) vol. 5 (2), 1364-1373. 30-01-2023
Chrysanthou A, Bosch-Fortea M and Gautrot JE (2023). Co-Surfactant-Free Bioactive Protein Nanosheets for the Stabilization of Bioemulsions Enabling Adherent Cell Expansion. Biomacromolecules, American Chemical Society (ACS) vol. 24 (10), 4465-4477. 23-01-2023
Chrysanthou A, Kanso H, Zhong W, Shang L and Gautrot JE (2023). Supercharged Protein Nanosheets for Cell Expansion on Bioemulsions. ACS Applied Materials & Interfaces, American Chemical Society (ACS) vol. 15 (2), 2760-2770. 04-01-2023
Kaur A, Gautrot JE, Akutagawa K, Watson D, Bickley A and Busfield JJC (2023). Thiyl radical induced cis / trans isomerism in double bond containing elastomers. RSC Advances, Royal Society of Chemistry (RSC) vol. 13 (34), 23967-23975. 01-01-2023
2022
Kaur A, Gautrot JE, Cavalli G, Watson D, Bickley A, Akutagawa K and Busfield JJC (2022). Kinetic analysis of thiol-ene based cross-linking reaction of polychloroprene rubber. Constitutive Models for Rubber XII 223-229. 28-11-2022
Gautrot JE, Chang L, Alexis C, Gutfreund P and Zarbakhsh A (2022). The Architecture of Oligonucleotide-Polycationic Brush Complexes – A Neutron Reflectometry Study. Advanced Materials Interfaces, Wiley 13-10-2022
Jones CFE, Di Cio S, Connelly JT and Gautrot JE (2022). Design of an Integrated Microvascularized Human Skin-on-a-Chip Tissue Equivalent Model. Frontiers in Bioengineering and Biotechnology, Frontiers Media vol. 10 19-07-2022
Sarmin AM, Moussaid NE, Suntornnond R, Tyler EJ, Kim Y-H, Di Cio S, Megone WV, Pearce O, Gautrot JE, Dawson J and Connelly JT (2022). Multi-Scale Analysis of the Composition, Structure, and Function of Decellularized Extracellular Matrix for Human Skin and Wound Healing Models. Biomolecules, MDPI vol. 12 (6) 16-06-2022
Ghorbani S, Shahrokhtash A, Gautrot JE and Sutherland DS (2022). Protein Ligand Nanopattern Size Selects for Cellular Adhesion via Hemidesmosomes over Focal Adhesions. Small Methods, Wiley vol. 6 (6) 22-04-2022
Kong D, Peng L, Bosch-Fortea M, Chrysanthou A, Alexis CVJM, Matellan C, Zarbakhsh A, Mastroianni G, del Rio Hernandez A and Gautrot JE (2022). Impact of the multiscale viscoelasticity of quasi-2D self-assembled protein networks on stem cell expansion at liquid interfaces. Biomaterials, Elsevier vol. 284 06-04-2022
Nguyen NT, Jennings J, Milani AH, Martino CDS, Nguyen LTB, Wu S, Mokhtar MZ, Saunders JM, Gautrot JE, Armes SP and Saunders BR (2022). Highly Stretchable Conductive Covalent Coacervate Gels for Electronic Skin. Biomacromolecules, American Chemical Society (ACS) vol. 23 (3), 1423-1432. 21-02-2022
2021
Peng L and Gautrot JE (2021). Long term expansion profile of mesenchymal stromal cells at protein nanosheet-stabilised bioemulsions for next generation cell culture microcarriers. Materials Today Bio, Elsevier vol. 12, 100159-100159. 16-11-2021
Raynold AAM, Li D, Chang L and Gautrot JE (2021). Competitive binding and molecular crowding regulate the cytoplasmic interactome of non-viral polymeric gene delivery vectors. Nature Communications, Springer Nature vol. 12 (1) 08-11-2021
Nguyen KDQ, Crespo-Ribadeneyra M, Picot O, Colak B and Gautrot JE (2021). Ultrafast Photo-Crosslinking of Thiol–Norbornene Opaque Silicone Elastomer Nanocomposites in Air. ACS Applied Polymer Materials, American Chemical Society 19-10-2021
Kaur A, Gautrot JE, Cavalli G, Watson D, Bickley A, Akutagawa K and Busfield JJC (2021). Novel Crosslinking System for Poly-Chloroprene Rubber to Enable Recyclability and Introduce Self-Healing. Polymers, MDPI vol. 13 (19) 29-09-2021
Megone W, Tang P, Roohpour N and Gautrot JE (2021). Impact of the molecular structure of cationic binders on the rheological and adhesive properties of carboxymethyl cellulose-based coacervate hydrogels. Arkivoc, ARKAT USA vol. 2021 (6), 101-119. 21-07-2021
Chang L, Yan H, Chang J and Gautrot JE (2021). Cationic Polymer Brush-Coated Bioglass Nanoparticles for the Design of Bioresorbable RNA Delivery Vectors. European Polymer Journal, Elsevier, 110593-110593. 13-06-2021
Pang X, Li W, Chang L, Gautrot JE, Wang W and Azevedo HS (2021). Hyaluronan (HA) Immobilized on Surfaces via Self-Assembled Monolayers of HA-Binding Peptide Modulates Endothelial Cell Spreading and Migration through Focal Adhesion. ACS Applied Materials and Interfaces, American Chemical Society vol. 13 (22), 25792-25804. 26-05-2021
Megone W, Kong D, Peng L and Gautrot JE (2021). Extreme reversal in mechanical anisotropy in liquid-liquid interfaces reinforced with self-assembled protein nanosheets. Journal of Colloid and Interface Science, Elsevier vol. 594, 650-657. 17-03-2021
Qu F, Ma X and Gautrot JE (2021). Precise positioning of enzymes within hierarchical polymer nanostructures for switchable bioelectrocatalysis. Biosensors and Bioelectronics, Elsevier vol. 179, 113045-113045. 18-02-2021
Cozens EJ, Roohpour N and Gautrot JE (2021). Comparative Adhesion of Chemically and Physically Crosslinked Poly(Acrylic Acid)-Based Hydrogels to Soft Tissues. European Polymer Journal, Elsevier, 110250-110250. 18-01-2021
Qu F, Raynold AM and Gautrot JE (2021). Chapter 11 Recent Advances in the Design of Surface-initiated Polymer Brushes for Biomedical Applications. Soft Matter for Biomedical Applications 264-300. 01-01-2021
2020
Zhang X, Shi X, Gautrot JE and Peijs T (2020). Nanoengineered electrospun fibers and their biomedical applications: a review. Nanocomposites, Taylor & Francis vol. 7 (1), 1-34. 29-12-2020
Suzuki K and Gautrot J (2020). Engineered Cell-Degradable Poly(2-alkyl-2-oxazoline) Hydrogels Improve Epicardial Placement of Mesenchymal Stromal Cells by Stimulating Paracrine Signaling for Cardiac Repair. Biomaterials, Elsevier 19-09-2020
You Y, Kobayashi K, Colak B, Luo P, Cozen E, Fields L, Suzuki K and Gautrot J (2020). Engineered cell-degradable poly(2-alkyl-2-oxazoline) hydrogel for epicardial placement of mesenchymal stem cells for myocardial repair. Biomaterials, Elsevier, 120356-120356. 19-09-2020
Li D, Xu L, Wang J and Gautrot JE (2020). Responsive Polymer Brush Design and Emerging Applications for Nanotheranostics. Advanced Healthcare Materials, Wiley 06-09-2020
Wu L, Di Cio S, Azevedo HS and Gautrot JE (2020). Photoconfigurable, Cell-Remodelable Disulfide Cross-linked Hyaluronic Acid Hydrogels. Biomacromolecules, American Chemical Society 24-08-2020
Colak B, Wu L, Cozens EJ and Gautrot JE (2020). Modulation of Thiol-Ene Coupling by the Molecular Environment of Polymer Backbones for Hydrogel Formation and Cell Encapsulation. ACS Applied Bio Materials, American Chemical Society 24-08-2020
Zhang X, Megone W, Peijs T and Gautrot JE (2020). Functionalization of electrospun PLA fibers using amphiphilic block copolymers for use in carboxy-methyl-cellulose hydrogel composites. Nanocomposites, Taylor & Francis Group 26-06-2020
2019
Di Cio S, Iskratsch T, Connelly JT and Gautrot JE (2019). Contractile myosin rings and cofilin-mediated actin disassembly orchestrate ECM nanotopography sensing. Biomaterials, Elsevier vol. 232 16-12-2019
Cozens EJ, Kong D, Roohpour N and Gautrot JE (2019). The physico-chemistry of adhesions of protein resistant and weak polyelectrolyte brushes to cells and tissues. Soft Matter, Royal Society of Chemistry vol. 16 (2), 505-522. 05-12-2019
Li D, Wu L, Qu F, Ribadeneyra MC, Tu G and Gautrot J (2019). Core-independent approach for polymer brush-functionalised nanomaterials with a fluorescent tag for RNA delivery. Chemical Communications, Royal Society of Chemistry vol. 55 (94), 14166-14169. 21-10-2019
Ahmad N, Colak B, Gibbs MJ, Zhang D-W, Gautrot JE, Watkinson M, Becer CR and Krause S (2019). Peptide Cross-Linked Poly(2-oxazoline) as a Sensor Material for the Detection of Proteases with a Quartz Crystal Microbalance. Biomacromolecules vol. 20 (7), 2506-2514. 07-06-2019
Crespo M, Santagiuliana G, Picot O, Portale G, Bilotti E and Gautrot JE (2019). Photo‐Responsive Graphene: A Photoaddressable Liquid Crystalline Phase Transition in Graphene Oxide Nanocomposites (Adv. Funct. Mater. 24/2019). Advanced Functional Materials, Wiley vol. 29 (24) 01-06-2019
Qu F, Li D, Ma X, Chen F and Gautrot JE (2019). A Kinetic Model of Oligonucleotide–Brush Interactions for the Rational Design of Gene Delivery Vectors. Biomacromolecules, American Chemical Society (ACS) vol. 20 (6), 2218-2229. 24-04-2019
Crespo M, Santagiuliana G, Picot O, Portale G, Bilotti E and Gautrot JE (2019). A Photoaddressable Liquid Crystalline Phase Transition in Graphene Oxide Nanocomposites. Advanced Functional Materials, Wiley vol. 29 (24) 14-04-2019
Ahmad N, Colak B, Zhang D-W, Gibbs MJ, Watkinson M, Becer CR, Gautrot JE and Krause S (2019). Peptide Cross-Linked Poly (Ethylene Glycol) Hydrogel Films as Biosensor Coatings for the Detection of Collagenase. Sensors, MDPI vol. 19 (7) 08-04-2019
GAUTROT JEE (2019). Conformational Dynamics and Responsiveness of Weak and Strong Polyelectrolyte Brushes: Atomistic Simulations of PDMAEMA and PMETAC. Langmuir, American Chemical Society 14-03-2019
GAUTROT JEE (2019). Modes of adsorption of polyelectrolytes to model substrates of hydroxyapatite. Journal of Colloid and Interface Science, Elsevier vol. 543, 237-237. 20-02-2019
2018
Ahmad N, Colak B, Gibbs MJ, Zhang D-W, Becer CR, Watkinson M, Gautrot JE and Krause S (2018). Collagenase Biosensor Based on the Degradation of Peptide Cross-Linked Poly(Ethylene Glycol) Hydrogel Films. 30-11-2018
Kong D, Peng L, Di Cio S, Novak P and Gautrot JE (2018). Stem Cell Expansion and Fate Decision on Liquid Substrates Are Regulated by Self-Assembled Nanosheets. ACS Nano vol. 12 (9), 9206-9213. 25-09-2018
Zhang X, Geven MA, Wang X, Qin L, Grijpma DW, Peijs T, Eglin D, Guillaume O and Gautrot JE (2018). A drug eluting poly(trimethylene carbonate)/poly(lactic acid)-reinforced nanocomposite for the functional delivery of osteogenic molecules. International Journal of Nanomedicine, Taylor & Francis vol. 13, 5701-5718. 01-09-2018
Tang P, di Cio S, Wang W and E Gautrot J (2018). Surface-Initiated Poly(oligo(2-alkyl-2-oxazoline)methacrylate) Brushes. Langmuir vol. 34 (34), 10019-10027. 28-08-2018
Zhang F, An Y, Roohpour N, Barber AH and Gautrot JE (2018). Hydration dependent mechanical performance of denture adhesive hydrogels. Dental Materials, Elsevier vol. 34 (10), 1440-1448. 28-06-2018
Pandey P, Hawkes W, Hu J, Megone WV, Gautrot J, Anilkumar N, Zhang M, Hirvonen L, Cox S, Ehler E, Hone J, Sheetz M and Iskratsch T (2018). Cardiomyocytes Sense Matrix Rigidity through a Combination of Muscle and Non-muscle Myosin Contractions. Developmental Cell, Elsevier vol. 45 (5) 01-06-2018
Megone W, Roohpour N and Gautrot JE (2018). Impact of surface adhesion and sample heterogeneity on the multiscale mechanical characterisation of soft biomaterials. Sci Rep vol. 8 (1), 6780-6780. 30-04-2018
Mata A, Azevedo HS, Connelly J and Gautrot J (2018). Bioengineering Complexity and Tuneability in Hydrogels. Hydrogels 301-323. 28-02-2018
Kong D, Megone W, Nguyen KDQ, Di Cio S, Ramstedt M and Gautrot JE (2018). Protein Nanosheet Mechanics Controls Cell Adhesion and Expansion on Low-Viscosity Liquids. Nano Lett 07-02-2018
Pandey P, Hawkes W, Hu J, Megone WV, Gautrot J, Anilkumar N, Zhang M, Hirvonen L, Cox S, Ehler E, Hone J, Sheetz M and Iskratsch T (2018). Cardiomyocytes Sense Matrix Rigidity through a Combination of Muscle and Non-muscle Myosin Contractions. Dev Cell vol. 44 (3), 326-336.e3. 05-02-2018
Li D, Sharili AS, Connelly J and Gautrot JE (2018). Highly Stable RNA Capture by Dense Cationic Polymer Brushes for the Design of Cytocompatible, Serum-Stable SiRNA Delivery Vectors. Biomacromolecules 31-01-2018
Gill SK, Roohpour N, An Y, Gautrot JE, Topham PD and Tighe BJ (2018). Hydrophobic and hydrophilic effects on water structuring and adhesion in denture adhesives. Journal of Biomedical Materials Research Part A, Wiley vol. 106 (5), 1355-1362. 13-01-2018
Colak B, Di Cio S and Gautrot JE (2018). Biofunctionalised Patterned Polymer Brushes via Thiol-Ene Coupling for the Control of Cell Adhesion and the Formation of Cell Arrays. Biomacromolecules 02-01-2018
2017
Li D and Gautrot JE (2017). Design of Polymer Brushes for Cell Culture and Cellular Delivery. Polymer and Biopolymer Brushes 557-603. 04-12-2017
Krishnamoorthy M, Li D, Sharili AS, Gulin-Sarfraz T, Rosenholm JM and Gautrot JE (2017). The Solution Conformation of Polymer Brushes Determines their Interactions with DNA and Transfection Efficiency. Biomacromolecules 11-10-2017
Darshan GH, Kong D, Gautrot J and Vootla S (2017). Physico-chemical characterization of Antheraea mylitta silk mats for wound healing applications. Scientific Reports, Springer Nature vol. 7 (1) 04-09-2017
Zhang X, Geven MA, Grijpma D, Peijs T and Gautrot JE (2017). Tunable and processable shape memory composites based on degradable polymers. Polymer 27-06-2017
Kong D, Nguyen KDQ, Megone W, Peng L and Gautrot JE (2017). The culture of HaCaT cells on liquid substrates is mediated by a mechanically strong liquid–liquid interface. Faraday Discuss. vol. 204, 367-381. 06-04-2017
Di Cio S, Bøggild TML, Connelly J, Sutherland DS and Gautrot JE (2017). Differential integrin expression regulates cell sensing of the matrix nanoscale geometry. Acta Biomaterialia vol. 50, 280-292. 01-03-2017
Gh D, Kong D, Gautrot J and Vootla SK (2017). Fabrication and Characterization of Conductive Conjugated Polymer-Coated Antheraea mylitta Silk Fibroin Fibers for Biomedical Applications. Macromol Biosci vol. 17 (7) 27-02-2017
Amabilino D, Bâldea I, Barykina O, Batteas J, Besenius P, Beton P, Bilbao N, Buck M, Chi L, Clarke S, Costantini G, Davidson J, Davies P, De Feyter S, Diaz Fernandez Y, Dwivedi D, Ernst K-H, Flood A, Gautrot J, Jabbarzadeh A, et al. (2017). Preparing macromolecular systems on surfaces: general discussion. Faraday Discussions, Royal Society of Chemistry (RSC) vol. 204, 395-418. 01-01-2017
2016
Gautrot JE (2016). Cell Sensing of the Physical Properties of the Microenvironment at Multiple Scales. Mechanobiology 297-329. 23-12-2016
Attwood SJ, Cortes E, Haining AW, Robinson B, Li D, Gautrot J and Del Río Hernández A (2016). Adhesive ligand tether length affects the size and length of focal adhesions and influences cell spreading and attachment. Sci Rep vol. 6, 34334-34334. 30-09-2016
Colak B, Da Silva JCS, Soares TA and Gautrot JE (2016). Impact of the Molecular Environment on Thiol-Ene Coupling For Biofunctionalization and Conjugation. Bioconjugate Chemistry, American Chemical Society vol. 27 (9), 2111-2123. 21-09-2016
Nguyen KDQ, Megone WV, Kong D and Gautrot JE (2016). Ultrafast diffusion-controlled thiol-ene based crosslinking of silicone elastomers with tailored mechanical properties for biomedical applications. Polymer Chemistry vol. 7 (33), 5281-5293. 02-08-2016
Zhang X, Geven MA, Grijpma DW, Gautrot JE and Peijs T (2016). “Polymer-polymer composites for the design of strong and tough degradable biomaterials”. Materials Today Communications vol. 8, 53-63. 02-06-2016
An Y, Li D, Roohpour N, Gautrot JE and Barber AH (2016). Failure mechanisms in denture adhesives. Dental Materials, Elsevier vol. 32 (5), 615-623. 01-05-2016
Di Cio S and Gautrot JE (2016). Cell sensing of physical properties at the nanoscale: Mechanisms and control of cell adhesion and phenotype. Acta Biomaterialia vol. 30, 26-48. 15-01-2016
Tan KY, Ramstedt M, Colak B, Huck WTS and Gautrot JE (2016). Study of thiol–ene chemistry on polymer brushes and application to surface patterning and protein adsorption. Polymer Chemistry, Royal Society of Chemistry (RSC) vol. 7 (4), 979-990. 01-01-2016
Jia Y, Wang K, Le Devedec F, Strandman S, Gauthier MA, Gautrot JE and Zhu J (2016). Biomedical applications of polymers made from natural compounds. 01-01-2016
2015
Di Cio S and Gautrot JE (2015). Cell sensing of physical properties at the nanoscale: Mechanisms and control of cell adhesion and phenotype. Acta Biomaterialia, Elsevier vol. 30, 26-48. 17-11-2015
Eglin D, Alini M, de Bruijn J, Gautrot J, Grijpma DW, Kamer L, Lai Y, Lu S, Peijs T, Peng J, Tang TT, Wang X, Richards RG and Qin L (2015). The RAPIDOS project-European and Chinese collaborative research on biomaterials. J Orthop Translat vol. 3 (2), 78-84. 20-03-2015
Hackett AJ, Malmström J, Molino PJ, Gautrot JE, Zhang H, Higgins MJ, Wallace GG, Williams DE and Travas-Sejdic J (2015). Conductive surfaces with dynamic switching in response to temperature and salt. Journal of Materials Chemistry B, Royal Society of Chemistry (RSC) vol. 3 (48), 9285-9294. 01-01-2015
2014
Wang J, Zhou Y, Watkinson M, Gautrot J and Krause S (2014). High-sensitivity light-addressable potentiometric sensors using silicon on sapphire functionalized with self-assembled organic monolayers. Sensors and Actuators B: Chemical, Elsevier vol. 209, 230-236. 26-11-2014
Krishnamoorthy M, Hakobyan S, Ramstedt M and GAUTROT JEE (2014). Surface initiated polymer brushes in the biomedical field: Applications in membrane science, biosensing, cell culture, regenerative medicine and antibacterial coatings. Chemical Reviews, American Chemical Society vol. 114 (21), 10976-11026. 29-10-2014
Deo DI, Gautrot JE, Sukhorukov GB and Wang W (2014). Biofunctionalization of PEGylated microcapsules for exclusive binding to protein substrates. Biomacromolecules vol. 15 (7), 2555-2562. 14-07-2014
Gautrot JE, Malmström J, Sundh M, Margadant C, Sonnenberg A and Sutherland DS (2014). The nanoscale geometrical maturation of focal adhesions controls stem cell differentiation and mechanotransduction. Nano Letters vol. 14 (7), 3945-3952. 09-07-2014
Costa P, Gautrot JE and Connelly JT (2014). Directing cell migration using micropatterned and dynamically adhesive polymer brushes. Acta Biomater vol. 10 (6), 2415-2422. 01-06-2014
2013
Tan KY, Lin H, Ramstedt M, Watt FM, Huck WTS and Gautrot JE (2013). Decoupling geometrical and chemical cues directing epidermal stem cell fate on polymer brush-based cell micro-patterns. Integr Biol (Camb) vol. 5 (6), 899-910. 01-06-2013
GAUTROT JEE, Rzhepishevska O, Hakobyan S, Ruhal R, Barbero D and Ramstedt M (2013). The surface charge of anti-bacterial coatings alters motility and biofilm architecture. Journal of Biomaterials Science: Polymer Edition vol. 1 (6), 589-602. 01-01-2013
2012
Gautrot JE, Wang C, Liu X, Goldie SJ, Trappmann B, Huck WTS and Watt FM (2012). Mimicking normal tissue architecture and perturbation in cancer with engineered micro-epidermis. Biomaterials vol. 33 (21), 5221-5229. 01-07-2012
Trappmann B, Gautrot JE, Connelly JT, Strange DGT, Li Y, Oyen ML, Cohen Stuart MA, Boehm H, Li B, Vogel V, Spatz JP, Watt FM and Huck WTS (2012). Extracellular-matrix tethering regulates stem-cell fate. Nature Materials 01-01-2012
2011
Rodriguez-Emmenegger C, Brynda E, Riedel T, Houska M, Šubr V, Alles AB, Hasan E, Gautrot JE and Huck WTS (2011). Polymer brushes showing non-fouling in blood plasma challenge the currently accepted design of protein resistant surfaces. Macromol Rapid Commun vol. 32 (13), 952-957. 01-07-2011
Tan KY, Gautrot JE and Huck WTS (2011). Formation of pickering emulsions using ion-specific responsive colloids. Langmuir vol. 27 (4), 1251-1259. 15-02-2011
Connelly JT, Mishra A, Gautrot JE and Watt FM (2011). Shape-induced terminal differentiation of human epidermal stem cells requires p38 and is regulated by histone acetylation. PLoS One vol. 6 (11) 01-01-2011
Tan KY, Gautrot JE and Huck WTS (2011). Island brushes to control adhesion of water in oil droplets on planar surfaces. SOFT MATTER vol. 7 (15), 7013-7020. 01-01-2011
Strandman S, Gautrot JE and Zhu XX (2011). Recent advances in entropy-driven ring-opening polymerizations. POLYMER CHEMISTRY vol. 2 (4), 791-799. 01-01-2011
2010
Connelly JT, Gautrot JE, Trappmann B, Tan DWM, Donati G, Huck WTS and Watt FM (2010). Actin and serum response factor transduce physical cues from the microenvironment to regulate epidermal stem cell fate decisions. Nature Cell Biology vol. 12 (7), 711-718. 01-07-2010
Gautrot JE, Trappmann B, Oceguera-Yanez F, Connelly J, He X, Watt FM and Huck WTS (2010). Exploiting the superior protein resistance of polymer brushes to control single cell adhesion and polarisation at the micron scale. Biomaterials vol. 31 (18), 5030-5041. 01-06-2010
Gautrot JE, Huck WTS, Welch M and Ramstedt M (2010). Protein-resistant NTA-functionalized polymer brushes for selective and stable immobilization of histidine-tagged proteins. ACS Appl Mater Interfaces vol. 2 (1), 193-202. 01-01-2010
Therien-Aubin H, Gautrot JE, Shao Y, Zhang J and Zhu XX (2010). Shape memory properties of main chain bile acids polymers. POLYMER vol. 51 (1), 22-25. 01-01-2010
2009
Gautrot JE and Zhu XX (2009). Shape memory polymers based on naturally-occurring bile acids. Macromolecules vol. 42 (19), 7324-7331. 13-10-2009
Trmcic-Cvitas J, Hasan E, Ramstedt M, Li X, Cooper MA, Abell C, Huck WTS and Gautrot JE (2009). Biofunctionalized protein resistant oligo(ethylene glycol)-derived polymer brushes as selective immobilization and sensing platforms. Biomacromolecules vol. 10 (10), 2885-2894. 12-10-2009
Gautrot JE and Zhu XX (2009). Macrocyclic bile acids: from molecular recognition to degradable biomaterial building blocks. JOURNAL OF MATERIALS CHEMISTRY vol. 19 (32), 5705-5716. 01-01-2009
Huck WTS, Gautrot J and Watt F (2009). The effects of surface chemistry on epidermal stem cell differentiation. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY vol. 237 01-01-2009
Hodge P and Gautrot JE (2009). Polymers containing in-chain quinone moieties: synthesis and properties. POLYMER INTERNATIONAL vol. 58 (3), 261-266. 01-01-2009
Gautrot JE, Zhang J, Shao Y and Zhu XX (2009). New degradable polymers made from natural compounds bile acids by ROMP. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY vol. 237 01-01-2009
Gautrot JE, Hodge P, Helliwell M, Raftery J and Cupertino D (2009). Synthesis of electron-accepting polymers containing phenanthra-9,10-quinone units. JOURNAL OF MATERIALS CHEMISTRY vol. 19 (24), 4148-4156. 01-01-2009
2008
Gautrot JE and Zhu XX (2008). High molecular weight bile acid and ricinoleic acid-based copolyesters via entropy-driven ring-opening metathesis polymerisation. Chem Commun (Camb) (14), 1674-1676. 14-04-2008
2007
Nguyen BT, Gautrot JE, Nguyen MT and Zhu XX (2007). Silver nanoparticles stabilized by nitrocellulose as low conversion temperature precursors for inkjet-printed electronic circuits. 2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Technical Proceedings vol. 2, 68-71. 23-08-2007
Charbonneau C, Gautrot JE, Hébert M-J, Zhu XX and Lerouge S (2007). Chondroitin-4-sulfate: a bioactive macromolecule to foster vascular healing around stent-grafts after endovascular aneurysm repair. Macromol Biosci vol. 7 (5), 746-752. 10-05-2007
Chen Y, Gautrot JE and Zhu XX (2007). Synthesis and characterization of core-shell microspheres with double thermosensitivity. Langmuir vol. 23 (3), 1047-1051. 30-01-2007
Gautrot JE and Zhu XX (2007). Molar mass of main-chain bile acid-based oligo-esters measured by SEC, MALDI-TOF spectrometry and NMR spectroscopy: a comparative study. Anal Chim Acta vol. 581 (2), 281-286. 09-01-2007
Gautrot JE, Hodge P, Cupertino D and Helliwell M (2007). 2,6-Diaryl-9,10-anthraquinones as models for electron-accepting polymers. NEW JOURNAL OF CHEMISTRY vol. 31 (9), 1585-1593. 01-01-2007
Chen Y, Gautrot JE and Zhu XX (2007). Synthesis and characterization of core-shell microspheres with double thermosensitivity. LANGMUIR vol. 23 (3), 1047-1051. 01-01-2007
Chen Y, Gautrot JE, Li Z and Zhu XX (2007). Preparation and thermo-responsive light diffraction behaviors of soft polymerized crystalline colloidal arrays. SOFT MATTER vol. 3 (5), 571-579. 01-01-2007
Nguyen BT, Gautrot JE, Nguyen MT and Zhu XX (2007). Nitrocellulose-stabilized silver nanoparticles as low conversion temperature precursors useful for inkjet printed electronics. JOURNAL OF MATERIALS CHEMISTRY vol. 17 (17), 1725-1730. 01-01-2007
Gautrot JE and Hodge P (2007). Poly(dibenzo[a,c]phenazine-2,7-diyl)s -: Synthesis and characterisation of a new family of electron-accepting conjugated polymers. POLYMER vol. 48 (24), 7065-7077. 01-01-2007
2006
Gautrot JE and Zhu XX (2006). Main-chain bile acid based degradable elastomers synthesized by entropy-driven ring-opening metathesis polymerization. Angew Chem Int Ed Engl vol. 45 (41), 6872-6874. 20-10-2006
Gautrot JE and Zhu XX (2006). Main‐Chain Bile Acid Based Degradable Elastomers Synthesized by Entropy‐Driven Ring‐Opening Metathesis Polymerization. Angewandte Chemie, Wiley vol. 118 (41), 7026-7028. 17-10-2006
Nguyen BT, Gautrot JE, Ji C, Brunner P-L, Nguyen MT and Zhu XX (2006). Enhancing the photoluminescence intensity of conjugated polycationic polymers by using quantum dots as antiaggregation reagents. Langmuir vol. 22 (10), 4799-4803. 09-05-2006
Gautrot JE and Zhu XX (2006). Biodegradable polymers based on bile acids and potential biomedical applications. JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION vol. 17 (10), 1123-1139. 01-01-2006
Gautrot JE, Hodge P, Cupertino D and Helliwell M (2006). Experimental evidence for carbonyl-π electron cloud interactions. NEW JOURNAL OF CHEMISTRY vol. 30 (12), 1801-1807. 01-01-2006
2005
Schroeder R, Majewski LA, Grell M, Maunoury J, Gautrot J, Hodge P and Turner M (2005). Electrode specific electropolymerization of ethylenedioxythiophene: Injection enhancement in organic transistors. APPLIED PHYSICS LETTERS vol. 87 (11) 01-01-2005
Grants
Grants of specific relevance to the Centre for BioengineeringAPP13387: Micro-manufacturing of tissue patterned organ-chips for accelerated deployment of new medicinesMartin Knight, Hazel Screen, Julien Gautrot, Timothy Hopkins, John Connelly, Liisa Blowes and Xavier Griffin
£1,787,725 EPSRC Engineering and Physical Sciences Research Council (01-10-2024 - 30-09-2027)
Unravelling mechanisms of drug-induced myocarditis using immune-responsive human cardiovascular chipYung-Yao Lin and Julien Gautrot
£121,420 MRC Medical Research Council (01-10-2024 - 30-09-2028)
ProNaGen: Engineering of Recombinant Protein Nanosheet-Based Bioemulsions for Next Generation Bioprocessing and BiomanufacturingJulien Gautrot
£127,041 EPSRC - EU Scheme (01-11-2023 - 30-04-2025)
Targeting epigenetic gene regulation in epidermolysis bullosa simplexJohn Connelly, Julien Gautrot and David Kelsell
£199,751 Action Medical Research (01-06-2023 - 31-05-2026)
On-Demand Targeted RNA Delivery Nanotheranostics for Glioblastoma TreatmentSilvia Marino and Julien Gautrot
£184,106 Barts and the London Charity (01-03-2023 - 01-04-2026)
Engineered Recombinant Strategies to Organogel Design for Food Product FormulationsJulien Gautrot
£31,688 Motif Food Works Inc (01-09-2022 - 31-08-2026)
How does ageing related loss of basement membrane collagen regulate epidermal barrier homeostasisEdel O'Toole, Julien Gautrot and Matthew Caley
£64,000 Unilever UK Ltd (01-10-2021 - 30-11-2025)
How does ageing related loss of basement membrane collagen regulate epidermal barrier homeostasisEdel O'Toole, Julien Gautrot and Matthew Caley
£116,803 BBSRC Biotechnology and Biological Sciences Research Council (27-09-2021 - 26-09-2025)
Costing of MoBioC mini-CDT studentship for bit.bio, 3M, Sphere Fluidics, RB, Unilever, Photocentric and Manchester BiogelJulien Gautrot
£70,000 Bit.Bio Ltd (01-09-2021 - 01-09-2025)
A 3Rs approach to tumour metastasis: investigating the role of cancer stem cells in metastasis using an in vitro microfluidic modelAdrian Biddle and Julien Gautrot
£90,000 NC3Rs National Center for the Replacement, Refinement and Reduction of Animals in Research (01-10-2019 - 30-12-2022)
A Biophysical Model of Gum Reintegration on enamelJulien Gautrot
£32,000 GSK GlaxoSmithKline UK Ltd (01-10-2019 - 30-09-2023)
Engineered Protein Nanosheets at Liquid-Liquid Interfaces for Stem Cell Expansion, Sorting and Tissue Engineering (PROLICELL)Julien Gautrot
£1,499,542 EU Commission - Horizon 2020 (01-09-2018 - 31-08-2024)