Dr Benjamin Stieglitz
Senior Lecturer in Biochemistry
School of Biological and Behavioural Sciences
Queen Mary University of London
Queen Mary University of London
Research
Ubiquitin, Innate Immunity, Inflammation, Enzymology, Host-pathogen interaction, Structural biology
Publications
Publications of specific relevance to the Centre for Molecular Cell Biology2024
N4BP1 functions as a dimerization-dependent linear ubiquitin reader which regulates TNF signallingKliza KW Song W Pinzuti I Schaubeck S Kunzelmann S Kuntin D Fornili A Hofmann K
Cell Death Discovery, Springer Nature vol. 10 (1)
20-04-2024
2023
Structural basis for ubiquitylation by HOIL-1Wu Q Koliopoulos MG Stieglitz B
Frontiers in Molecular Biosciences, Frontiers vol. 9
06-01-2023
2022
HHARI in motion reveals an unexpected substrate recognition site for RBR ligasesStieglitz B
Structure, Elsevier vol. 30 (9), 1221-1223.
01-09-2022
2020
Ubiquitin activation is essential for schizont maturation in Plasmodium falciparum blood-stage developmentGreen JL Wu Y
Plos Pathogens, Public Library of Science (Plos) vol. 16 (6), e1008640-e1008640.
22-06-2020
2019
Auxiliary-assisted chemical ubiquitylation of NEMO and linear extension by HOIPBurlina F Abdel-Aal A-BM Raz R Pinzuti I Papageorgiou G Li J Antrobus R Kunzelmann S
Communications Chemistry, Springer Science and Business Media Llc vol. 2 (1)
19-09-2019
2017
Internally Tagged Ubiquitin: a Tool to Identify Linear Polyubiquitin-modified Proteins by Mass SpectrometryKliza K Taumer C Pinzuti I Kunzelmann S STIEGLITZ B Husnjak K
Nature Methods, Nature Publishing Group
20-03-2017
Determination of the pKa of
the N-terminal amino group of
ubiquitin by NMROregioni A STIEGLITZ B Rittinger K
Scientific Reports, Nature Publishing Group, 1-8.
02-03-2017
2016
Molecular insights into RBR E3 ligase ubiquitin transfer mechanismsDove KK Stieglitz B Duncan ED
Embo Reports, Embo Press
16-06-2016
2013
Structural basis for ligase-specific conjugation of linear ubiquitin chains by HOIPStieglitz B Rana RR Koliopoulos MG Morris-Davies AC Schaeffer V Christodoulou E Howell S Dikic I
Nature, Springer Nature vol. 503 (7476), 422-426.
20-10-2013
2012
LUBAC synthesizes linear ubiquitin chains via a thioester intermediateStieglitz B Koliopoulos MG Christodoulou E
Embo Reports, Springer Nature vol. 13 (9), 840-846.
13-07-2012
Crystallization of SHARPIN using an automated two-dimensional grid screen for optimizationStieglitz B Rittinger K
Acta Crystallographica Section F: Structural Biology Communications, International Union of Crystallography (Iucr) vol. 68 (7), 816-819.
28-06-2012
Structural Analysis of SHARPIN, a Subunit of a Large Multi-protein E3 Ubiquitin Ligase, Reveals a Novel Dimerization Function for the Pleckstrin Homology Superfold*Stieglitz B Haire LF Dikic I
Journal of Biological Chemistry, Elsevier vol. 287 (25), 20823-20829.
01-05-2012
2011
An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammationWilhelm C Hirota K Stieglitz B Tolaini M Lahl K Sparwasser T
Nature Immunology, Springer Nature vol. 12 (11), 1071-1077.
09-10-2011
SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosisIkeda F Deribe YL Skånland SS Stieglitz B Grabbe C Franz-Wachtel M Goswami P Nagy V et al.
Nature, Springer Nature vol. 471 (7340), 637-641.
01-03-2011
Novel sources of IL-9 in lung inflammationWilhelm C Hirota K Stieglitz B Tolaini M Lahl K Sparwasser T Helmby H
IMMUNOLOGY. vol. 135, 128-128.
01-01-2011
2010
Growth and Tumor Suppressor NORE1A Is a Regulatory Node between Ras Signaling and Microtubule Nucleation*Bee C Moshnikova A Mellor CD Molloy JE Koryakina Y Khokhlatchev A
Journal of Biological Chemistry, Elsevier vol. 285 (21), 16258-16266.
25-03-2010
2008
Novel type of Ras effector interaction established between tumour suppressor NORE1A and Ras switch IIStieglitz B Bee C Schwarz D Moshnikova A Khokhlatchev A
The Embo Journal, Springer Nature vol. 27 (14), 1995-2005.
03-07-2008
Crystal structure of the Clostridium limosum C3 exoenzymeVogelsgesang M Stieglitz B Herrmann C Pautsch A
Febs Letters, Wiley vol. 582 (7), 1032-1036.
04-03-2008
2007
Ras/Nore1 interaction: mechanism of apoptotic signalingHerrmann C Stieglitz B
Acta Crystallographica Section A: Foundations and advances. vol. 63 (a1), s16-s16.
22-08-2007
The acidic N-terminus of HHARI and neddylation are essential for the activation and maintenance of RIG-I-mediated type I interferon responseKontra I Ward H Vinluan F Lau R Rajeeve V Cutillas P Stieglitz B Lewis MJ
In Biorxiv
N4BP1 is dimerization-dependent linear ubiquitin reader regulating TNFR1 signalling through linear ubiquitin binding and Caspase-8-mediated processingKliza K Song W Pinzuti I Schaubeck S Kunzelmann S Kuntin D Fornili A Pandini A et al.
In Biorxiv
Protein ubiquitylation is essential for the schizont to merozoite transition in Plasmodium falciparum blood-stage developmentWu Y Encheva V Green JL Lasonder E Prommaban A Kunzelmann S Christodoulou E Grainger M et al.
In Biorxiv
Structural basis for ubiquitylation by HOIL-1Wu Q Koliopoulos MG Rittinger K Stieglitz B
In Biorxiv
Grants of specific relevance to the Centre for Molecular Cell Biology
Grants of specific relevance to the Centre for Molecular Cell BiologyRegulation of linear ubiquitin signaling in innate immunityBenjamin Stieglitz and Aravindan Ilangovan
£661,348 MRC Medical Research Council
01-03-2024 - 28-02-2027
Research Group
Research Staff
PhD Students
- Ibtehal Albursan
Structural and Functional Investigation of Polyubiquitin Chain Formation Catalyzed by Novel E3 Ligases (Nel) in Bacterial Type III Secretion System - Boyu Li
Understanding Ubiquitin Conjugation in Immunity and Inflamma - Nasrin Sultana
In Vitro Reconstitution of Lubac: Regulation and Control of Linear Ubiquitin Chain Synthesis Activity - Kexin Wang
Engineering Ubiquitin Ligases For Targeted Protein Degradation of Cancer-Associated Proteins
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