Dr Vladimir Volkov
Lecturer in Physiology
School of Biological and Behavioural Sciences
Queen Mary University of London
Queen Mary University of London
Research
cell division, mitosis, kinetochore, microtubules, cytoskeleton
Interests
Microtubules are dynamic biopolymers exerting forces when they grow or shorten. These forces are important in various contexts in living cells, such as during cell division, when microtubule ends attach to chromosomes and help them segregate to daughter cells. Microtubule ends transmit forces to cellular structures using teams of coupling protein molecules. Our research is focused on molecular and mechanical mechanisms by which these protein teams assemble and transmit the forces to cellular structures.Publications of specific relevance to the Centre for Molecular Cell Biology
2023
Polley S, Müschenborn H, Terbeck M, De Antoni A, Vetter IR, Dogterom M, Musacchio A, Volkov VA and Veld PJHIT (2023). Stable kinetochore‐microtubule attachment requires loop‐dependent Ndc80‐Ndc80 binding. The EMBO Journal, Springer Nature vol. 42 (13) 19-05-2023
Maan R, Reese L, Volkov VA, King MR, van der Sluis EO, Andrea N, Evers WH, Jakobi AJ and Dogterom M (2023). Author Correction: Multivalent interactions facilitate motor-dependent protein accumulation at growing microtubule plus-ends. Nature Cell Biology, Springer Nature vol. 25 (4), 626-626. 15-03-2023
2022
Nick Maleki A, Huis In 't Veld PJ, Akhmanova A, Dogterom M and Volkov VA (2022). Estimation of microtubule-generated forces using a DNA origami nanospring. Journal of Cell Science, The Company of Biologists vol. 136 (5) 05-10-2022
2018
Volkov VA, Veld PJHIT, Dogterom M and Musacchio A (2018). Multivalency of NDC80 in the outer kinetochore is essential to track shortening microtubules and generate forces. eLife, eLife vol. 7 09-04-2018
Grants
Grants of specific relevance to the Centre for Molecular Cell BiologyAmyloids and Oligomers. Curvilinear and annular structures and their interation with exosomes and whole cellsJohn Viles, Ivan Kadurin, Vladimir Volkov and Vidya Darbari
£485,209 BBSRC Biotechnology and Biological Sciences Research Council (01-12-2023 - 30-11-2026)
Cooperativity and forces in molecular interactions governing chromosome stabilityVladimir Volkov and Viji Draviam Sastry
£717,413 BBSRC Biotechnology and Biological Sciences Research Council (20-11-2023 - 19-11-2026)