Publications
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Publications of specific relevance to the Centre for Molecular Cell Biology
2024
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Islam A, Manjarrez-González JC, Song X, Gore T and
Draviam VM (2024).
Search for chromosomal instability aiding variants reveal naturally occurring kinetochore gene variants that perturb chromosome segregation. iScience,
Elsevier vol. 27 (3)
26-01-20242023
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Chai B, Efstathiou C, Yue H and
Draviam VM (2023).
Opportunities and challenges for deep learning in cell dynamics research. Trends in Cell Biology,
Elsevier 01-11-2023![bullet icon](/common/publications/images/bullet24.png)
Dang D, Efstathiou C, Sun D, Yue H, Sastry NR and
Draviam VM (2023).
Deep learning techniques and mathematical modeling allow 3D analysis of mitotic spindle dynamics. Journal of Cell Biology,
Rockefeller University Press vol. 222 (5)
02-03-20232021
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Song X, Conti D, Shrestha RL, Braun D and
Draviam VM (2021).
Counteraction between Astrin-PP1 and Cyclin-B-CDK1 pathways protects chromosome-microtubule attachments independent of biorientation. Nature Communications,
Springer Nature vol. 12 (1)
01-12-2021![bullet icon](/common/publications/images/bullet24.png)
Efstathiou C and
Draviam VM (2021).
Electrically tunable lenses - Eliminating mechanical axial movements during high-speed 3D live imaging. Journal of Cell Science,
Company of Biologists vol. 134 (16)
01-08-2021![bullet icon](/common/publications/images/bullet24.png)
Hart M, Adams SD and
Draviam VM (2021).
Multinucleation associated DNA damage blocks proliferation in p53-compromised cells. Communications Biology,
Springer Nature vol. 4 (1)
09-04-20212019
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Conti D, Gul P, Islam A, Martín-Durán JM,
Pickersgill RW and
Draviam VM (2019).
Kinetochores attached to microtubule-ends are stabilised by astrin bound pp1 to ensure proper chromosome segregation. eLife,
eLife Sciences Publications Ltd vol. 8
24-12-2019![bullet icon](/common/publications/images/bullet24.png)
Hart M, Zulkipli I, Shrestha RL, Dang D, Conti D, Gul P, Kujawiak I and
Draviam VM (2019).
MARK2/Par1b kinase present at centrosomes and retraction fibres corrects spindle off-centring induced by actin disassembly. Open Biology,
The Royal Society vol. 9 (6)
26-06-20192018
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Zulkipli I, Clark J, HART M, Shrestha R, GUL P, DANG D, Kasichiwin T, Kujawiak I, SASTRY N and
DRAVIAM VM (2018).
Spindle rotation in human cells is reliant on a MARK2-mediated equatorial spindle centering mechanism. Journal of Cell Biology,
Rockefeller University Press 25-06-20182017
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Zulkipli I, Shrestha RL, Clark J and
Draviam VM (2017).
Proper rotation of the mitotic spindle requires an equatorial spindle centering mechanism in human cells. ASCB.
15-12-2017![bullet icon](/common/publications/images/bullet24.png)
Shrestha RL, Conti D, Tamura N, Braun D, Ramalingam RA, Cieslinski K, Ries J and
Draviam VM (2017).
Aurora-B kinase pathway controls the lateral to end-on conversion of kinetochore-microtubule attachments in human cells. Nat Commun,
Macmillan Publishers Limited, part of Springer Nature. vol. 8 (1), 150-150.
28-07-2017![bullet icon](/common/publications/images/bullet24.png)
Conti D, Hart M, Tamura N, Shrestha R, Islam A and
Draviam VM (2017).
How are Dynamic Microtubules Stably Tethered to Human Chromosomes? Cytoskeleton - Structure, Dynamics, Function and Disease 17-05-2017![bullet icon](/common/publications/images/bullet24.png)
Conti D, Cieslinski KA, Ries J and
Draviam VM (2017).
Outer kinetochore phosphatases-PP2A-B56 and PP1-differently contribute to the establishment of chromosome-microtubule attachments. 01-01-20172016
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Patel H, Stavrou I, Shrestha RL,
Draviam V, Frame MC and Brunton VG (2016).
Kindlin1 regulates microtubule function to ensure normal mitosis. Journal of Molecular Cell Biology,
Oxford University Press (OUP) vol. 8 (4), 338-348.
19-08-2016![bullet icon](/common/publications/images/bullet24.png)
Hiroi N,
Draviam VM and Funahashi A (2016).
Editorial: Quantitative Biology: Dynamics of Living Systems. Front Physiol,
Frontiers Media SA vol. 7
02-06-20162015
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Iorio F, Shrestha RL, Levin N, Boilot V, Garnett MJ, Saez-Rodriguez J and
Draviam VM (2015).
A Semi-Supervised Approach for Refining Transcriptional Signatures of Drug Response and Repositioning Predictions. PLOS ONE,
Public Library of Science (PLoS) vol. 10 (10)
09-10-2015![bullet icon](/common/publications/images/bullet24.png)
Corrigan AM, Shrestha R,
Draviam VM and Donald AM (2015).
Modeling of Noisy Spindle Dynamics Reveals Separable Contributions to Achieving Correct Orientation. Biophysical Journal,
Elsevier vol. 109 (7), 1398-1409.
01-10-2015![bullet icon](/common/publications/images/bullet24.png)
Tamura N, Simon JE, Nayak A, Shenoy R, Hiroi N, Boilot V, Funahashi A and
Draviam VM (2015).
A proteomic study of mitotic phase-specific interactors of EB1 reveals a role for SXIP-mediated protein interactions in anaphase onset. Biology Open,
The Company of Biologists vol. 4 (2), 155-169.
16-01-2015![bullet icon](/common/publications/images/bullet24.png)
Ochi T, Blackford AN, Coates J, Jhujh S, Mehmood S, Tamura N, Travers J, Wu Q,
Draviam VM, Robinson CV, Blundell TL and Jackson SP (2015).
PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair. Science,
American Association for the Advancement of Science (AAAS) vol. 347 (6218), 185-188.
09-01-2015![bullet icon](/common/publications/images/bullet24.png)
Nakai Y, Ozeki M, Hiraiwa T, Tanimoto R, Funahashi A, Hiroi N, Taniguchi A, Nonaka S, Boilot V, Shrestha R, Clark J, Tamura N,
Draviam VM and Oku H (2015).
High-speed microscopy with an electrically tunable lens to image the dynamics of in vivo molecular complexes. Review of Scientific Instruments,
AIP Publishing vol. 86 (1)
01-01-20152014
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Chin HMS, Nandra K, Clark J and
Draviam VM (2014).
Need for multi-scale systems to identify spindle orientation regulators relevant to tissue disorganization in solid cancers. Frontiers in Physiology,
Frontiers vol. 5
25-07-2014![bullet icon](/common/publications/images/bullet24.png)
Shrestha RL, Tamura N, Fries A, Levin N, Clark J and
Draviam VM (2014).
TAO1 kinase maintains chromosomal stability by facilitating proper congression of chromosomes. Open Biology,
The Royal Society vol. 4 (6)
01-06-2014![bullet icon](/common/publications/images/bullet24.png)
Shrestha RL and
Draviam VM (2014).
Lateral to End-on Conversion of Chromosome-Microtubule Attachment Requires Kinesins CENP-E and MCAK. 01-01-2014![bullet icon](/common/publications/images/bullet24.png)
Conti D and
Draviam VM (2014).
Role of phosphatases in chromosome segregation. 01-01-20142013
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Shrestha RL and
Draviam VM (2013).
Lateral to End-on Conversion of Chromosome-Microtubule Attachment Requires Kinesins CENP-E and MCAK. Current Biology,
Elsevier vol. 23 (23), 2440-2441.
01-12-2013![bullet icon](/common/publications/images/bullet24.png)
Corrigan AM, Shrestha RL, Zulkipli I, Hiroi N, Liu Y, Tamura N, Yang B, Patel J, Funahashi A, Donald A and
Draviam VM (2013).
Automated tracking of mitotic spindle pole positions shows that LGN is required for spindle rotation but not orientation maintenance. Cell Cycle,
Taylor & Francis vol. 12 (16), 2643-2655.
15-08-2013![bullet icon](/common/publications/images/bullet24.png)
Shrestha RL and
Draviam VM (2013).
Lateral to End-on Conversion of Chromosome-Microtubule Attachment Requires Kinesins CENP-E and MCAK. Current Biology,
Elsevier vol. 23 (16), 1514-1526.
25-07-2013
Draviam VM, Funahashi A, Hiroi N, Kimura A and Kobayashi TJ (2013).
Meeting report of the International Workshop on Quantitative Biology 2012: mesoscopic and microscopic worlds meet. Frontiers in Physiology,
Frontiers vol. 3
01-01-20132012
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Tamura N and
Draviam VM (2012).
Microtubule plus-ends within a mitotic cell are ‘moving platforms’ with anchoring, signalling and force-coupling roles. Open Biology,
The Royal Society vol. 2 (11)
01-11-2012![bullet icon](/common/publications/images/bullet24.png)
Tamura N, Shrestha RL and
Draviam VM (2012).
Microtubule-end bound complexes power chromosome movement during chromosome segregation. 01-01-2012![bullet icon](/common/publications/images/bullet24.png)
Shrestha RL and
Draviam VM (2012).
TAO1 maintains genome integrity by mediating the timely maturation of chromosome attachments made to lateral walls of microtubules. 01-01-20122011
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Shrestha RL, Tamura N, Zulkipli I and
Draviam VM (2011).
A mechanism linking microtubule destabilisation to maturation of chromosome-microtubule attachments. 01-01-20112009
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Pagliuca C,
Draviam VM, Marco E, Sorger PK and De Wulf P (2009).
Roles for the Conserved Spc105p/Kre28p Complex in Kinetochore-Microtubule Binding and the Spindle Assembly Checkpoint. PLOS ONE,
Public Library of Science (PLoS) vol. 4 (10)
28-10-2009![bullet icon](/common/publications/images/bullet24.png)
McAinsh AD, Meraldi P,
Draviam VM, Toso A and Sorger PK (2009).
The human kinetochore proteins Nnf1R and Mcm21R are required for accurate chromosome segregation. The EMBO Journal,
Springer Nature vol. 28 (9), 1374-1374.
06-05-20092008
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Foijer F,
Draviam VM and Sorger PK (2008).
Studying chromosome instability in the mouse. Biochimica et Biophysica Acta,
Elsevier vol. 1786 (1), 73-82.
26-07-20082007
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Stegmeier F, Rape M,
Draviam VM, Nalepa G, Sowa ME, Ang XL, McDonald ER, Li MZ, Hannon GJ, Sorger PK, Kirschner MW, Harper JW and Elledge SJ (2007).
Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. Nature vol. 447 (7141), 876-881.
10-05-2007
Draviam VM, Stegmeier F, Nalepa G, Sowa ME, Chen J, Liang A, Hannon GJ, Sorger PK, Harper JW and Elledge SJ (2007).
A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling. Nature Cell Biology,
Springer Nature vol. 9 (5), 556-564.
08-04-2007![bullet icon](/common/publications/images/bullet24.png)
Stegmeier F, Rape M,
Draviam VM, Nalepa G, Sowa ME, Ang XL, McDonald III ER, Li MZ, Hannon GJ, Sorger PK, Kirschner MW, Harper JW and Elledge SJ (2007).
Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. Nature,
Springer Nature vol. 446 (7138), 876-881.
01-04-2007![bullet icon](/common/publications/images/bullet24.png)
Basto R, Gergely F,
Draviam VM, Ohkura H, Liley K and Raff JW (2007).
Hsp90 is required to localise cyclin B and Msps/ch-TOG to the mitotic spindle in Drosophila and humans. Journal of Cell Science,
The Company of Biologists vol. 120 (7), 1278-1287.
01-04-20072006
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McAinsh AD, Meraldi P,
Draviam VM, Toso A and Sorger PK (2006).
The human kinetochore proteins Nnf1R and Mcm21R are required for accurate chromosome segregation. The EMBO Journal,
Springer Nature vol. 25 (17), 4033-4049.
24-08-2006
Draviam VM, Shapiro I, Aldridge B and Sorger PK (2006).
Misorientation and reduced stretching of aligned sister kinetochores promote chromosome missegregation in EB1‐ or APC‐depleted cells. The EMBO Journal,
Springer Nature vol. 25 (12), 2814-2827.
08-06-2006
Draviam VM, Stegmeier F, Nalepa G, Sowa M, Hannon G, Harper W, Elledge S and Sorger P (2006).
Functional Genomic Screen Reveals the Role of a Novel Checkpoint Kinase, TAO1 in Mitosis and Cell Cycle Progression. 01-01-20062004
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Meraldi P,
Draviam VM and Sorger PK (2004).
Timing and Checkpoints in the Regulation of Mitotic Progression. Developmental Cell,
Elsevier vol. 7 (1), 45-60.
01-07-2004
Draviam VM, Xie S and Sorger PK (2004).
Chromosome segregation and genomic stability. Current Opinion in Genetics & Development,
Elsevier vol. 14 (2), 120-125.
01-04-20042003
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Gergely F,
Draviam VM and Raff JW (2003).
The ch-TOG/XMAP215 protein is essential for spindle pole organization in human somatic cells. Genes & Development,
Cold Spring Harbor Laboratory vol. 17 (3), 336-341.
01-02-20032001
Draviam VM, Orrechia S, Lowe M, Pardi R and Pines J (2001).
The Localization of Human Cyclins B1 and B2 Determines Cdk1 Substrate Specificity and Neither Enzyme Requires Mek to Disassemble the Golgi Apparatus. Journal of Cell Biology,
Rockefeller University Press vol. 152 (5), 945-958.
05-03-2001