Prof Maurice Elphick

Research

Neuropeptide, Evolution, Neurobiology, Echinoderm, Physiology

Interests

Neuropeptides and peptide hormones have fundamental roles in controlling, regulating and integrating physiological and behavioural processes in humans and other animals. I am interested in reconstructing the evolutionary history of neuropeptide signalling systems and investigating how neuropeptides are utilised to co-ordinate physiological processes and behaviour in animals. The primary focus of my neuropeptide research is on echinoderms (e.g. starfish, sea urchins), which are of special interest for a number of reasons. As deuterostomes, echinoderms are more closely related to vertebrates than the majority of invertebrates, and therefore research on echinoderms can shed light on the evolutionary origins of vertebrate neuropeptides. Echinoderms also have many remarkable morphological and physiological characteristics – they are typically five-sided and have a unique ability to rapidly change (under neural control) the stiffness of their body wall collagenous tissue; they also have amazing powers of regeneration, which makes them of great interest from a medical perspective. Facilitated by the recent advances in transcriptome and genome sequencing and using the common European starfish Asterias rubens and other echinoderms as experimental animals, our research is providing “missing links” in our understanding of neuropeptide biology, bridging the huge evolutionary gap between protostome invertebrates (e.g. Drosophila, C. elegans) and the vertebrates. For example, our paper published recently in PNAS has provided important new insights into the evolutionary history of somatostatin, a hormone that regulates growth in humans.

Publications of specific relevance to the Centre for Molecular Cell Biology

2014

2005

Grants