Dr Isabel M Palacios
Lecturer of Cell Biology
Deputy Director of Research Nanchang
School of Biological and Behavioural Sciences
Queen Mary University of London
Queen Mary University of London
Research
Drosophila, human organoids, human iPSCs, organogenesis, cell biophysics, cytoskeleton
Publications
Publications of specific relevance to the Centre for Molecular Cell Biology2024
Palacios IM and Palacios De Castro MI (2024). Essential conserved neuronal motors kinesin-1 and kinesin-3 regulate Aβ42 toxicity in vivo., Editors: biorxiv team . bioRxiv journal 24-04-2024
2023
López EM, Kabanova A, Winkel A, Franze K, Palacios IM and Martín-Bermudo MD (2023). Constriction imposed by basement membrane regulates developmental cell migration. PLoS Biology, Public Library of Science vol. 21 (6) 28-06-2023
2020
(2020). The humble fruit fly is helping the African science community to thrive. Nature Reviews Molecular Cell Biology, Springer Nature vol. 21 (10), 558-559. 17-08-2020
Santa-Cruz Mateos C, Valencia-Expósito A, Palacios IM and Martín-Bermudo MD (2020). Integrins regulate epithelial cell shape by controlling the architecture and mechanical properties of basal actomyosin networks. PLOS Genetics, Public Library of Science (PLoS) vol. 16 (6), e1008717-e1008717. 01-06-2020
Drechsler M, Lang LF, Al-Khatib L, Dirks H, Burger M, Schönlieb C-B and Palacios IM (2020). Optical flow analysis reveals that Kinesin-mediated advection impacts on the orientation of microtubules in the Drosophila oocyte. Molecular Biology of the Cell, American Society for Cell Biology, mbcE19080440-mbcE19080440. 08-04-2020
2019
Francis D, Chanana B, Fernandez B, Gordon B, Mak T and Palacios IM (2019). YAP/Yorkie in the germline modulates the age-related decline of germline stem cells and niche cells. PLOS ONE, Public Library of Science (PLoS) vol. 14 (4) 03-04-2019
2017
PALACIOS IM (2017). Active diffusion and advection in Drosophila oocytes result from the interplay of actin and microtubules. Nature Communications, Nature Publishing Group vol. 8 15-11-2017
Martín-Bermudo MD, Gebel L and Palacios IM (2017). DrosAfrica: Building an African biomedical research community using Drosophila. Seminars in Cell & Developmental Biology, Elsevier BV vol. 70, 58-64. 30-08-2017
2016
Ng BF, Selvaraj GK, Santa-Cruz Mateos C, Grosheva I, Alvarez-Garcia I, Martín-Bermudo MD and Palacios IM (2016). α-Spectrin and integrins act together to regulate actomyosin and columnarization, and to maintain a monolayered follicular epithelium. Journal of Cell Science, The Company of Biologists vol. 129 (9), e1.2-e1.2. 01-05-2016
Vicente‐Crespo M, Muñoz‐Descalzo S, Weil T, Martín‐Bermudo MD and Palacios I (2016). Workshop‐Based Training for Capacity Building: Using Drosophila to Bring Research Skills to Africa. 01-04-2016
Ng BF, Selvaraj GK, Santa-Cruz Mateos C, Grosheva I, Alvarez-Garcia I, Martín-Bermudo MD and Palacios IM (2016). α-Spectrin and integrins act together to regulate actomyosin and columnarization, and to maintain a monolayered follicular epithelium. Development, The Company of Biologists vol. 143 (8), 1388-1399. 07-03-2016
Saavedra P, Brittle A, Palacios IM, Strutt D, Casal J and Lawrence PA (2016). Planar cell polarity: the Dachsous/Fat system contributes differently to the embryonic and larval stages of Drosophila. Biology Open, The Company of Biologists vol. 5 (4), 397-408. 02-03-2016
2015
Palacios IM, Drechsler M and Ganguly S (2015). A complex relationship between motor activity, cytoplasmic flows and the organisation of the actin and microtubule cytoskeletons. 01-01-2015
Palacios IM and Martin-Bermudo M (2015). Alpha-spectrin is essential for septate junction formation and columnarization, but not for proliferation control, in the follicular epithelium. 01-01-2015
Palacios IM, Drechsler M and Ganguly S (2015). A complex relationship between motor activity, cytoplasmic flows and the organisation of the actin and microtubule cytoskeletons. 01-01-2015
2014
Palacios IM (2014). Hop-on hop-off: Polysomes take a tour of the cell on endosomes. Journal of Cell Biology, Rockefeller University Press vol. 204 (3), 287-289. 03-02-2014
Saavedra P, Vincent J-P, Palacios IM, Lawrence PA and Casal J (2014). Plasticity of both planar cell polarity and cell identity during the development of Drosophila. eLife, eLife vol. 3 01-01-2014
Gómez-Lamarca MJ, Cobreros-Reguera L, Ibáñez-Jiménez B, Palacios IM and Martín-Bermudo MD (2014). Integrins regulate epithelial cell differentiation by modulating Notch activity. Journal of Cell Science, The Company of Biologists vol. 127 (21), 4667-4678. 01-01-2014
Braun AL, Chanana B and Palacios IM (2014). Epithelia patterning and body plan mapping in the Drosophila egg chamber: cell fate specific screen. 01-01-2014
Drechsler M, Goldstein R and Palacios IM (2014). A combined cell biological and biophysical strategy to analyze actin/microtubule crosstalk and its relation to cytoplasmic streaming. 01-01-2014
Williams LS, Ganguly S, Loiseau P, Ng BF and Palacios IM (2014). The auto-inhibitory domain and ATP-independent microtubulebinding region of Kinesin heavy chain are major functional domains for transport in the Drosophila germline. Journal of Cell Science, The Company of Biologists vol. 127 (1), e1-e1. 01-01-2014
2013
Roca-Varela ML and Palacios IM (2013). How are spoken skills assessed in proficiency tests of general English as a Foreign Language? A preliminary survey. International Journal of English Studies, Servicio de Publicaciones de la Universidad de Murcia vol. 13 (2), 53-68. 01-12-2013
Williams LS, Ganguly S, Loiseau P, Ng BF and Palacios IM (2013). The auto-inhibitory domain and ATP-independent microtubule-binding region of Kinesin heavy chain are major functional domains for transport in the Drosophila germline. Development, The Company of Biologists vol. 141 (1), 176-186. 20-11-2013
2012
Palacios IM (2012). Nonsense-mediated mRNA decay: from mechanistic insights to impacts on human health. Briefings in Functional Genomics, Oxford University Press (OUP) vol. 12 (1), 25-36. 11-11-2012
Ganguly S, Williams LS, Palacios IM and Goldstein RE (2012). Cytoplasmic streaming in Drosophila oocytes varies with kinesin activity and correlates with the microtubule cytoskeleton architecture. Proceedings of the National Academy of Sciences of the United States of America, Proceedings of the National Academy of Sciences vol. 109 (38), 15109-15114. 04-09-2012
Baden T, Palacios I, Vicente M, Martin Bermudo MD, Yusuf S and Godino LP (2012). HIGHER EDUCATION IN THE DEVELOPING WORLD: DROSOPHILA NEUROGENETICS, UGANDA. 01-01-2012
2011
Avery P, Vicente-Crespo M, Francis D, Nashchekina O, Alonso CR and Palacios IM (2011). Drosophila Upf1 and Upf2 loss of function inhibits cell growth and causes animal death in a Upf3-independent manner. RNA, Cold Spring Harbor Laboratory vol. 17 (4), 624-638. 11-02-2011
Vicente-Crespo M and Palacios IM (2011). Nonsense-mediated mRNA decay and development: shoot the messenger to survive? Biochemical Society Transactions, Portland Press vol. 39 (1), 411-411. 19-01-2011
2010
Vicente-Crespo M and Palacios IM (2010). Nonsense-mediated mRNA decay and development: shoot the messenger to survive? Biochemical Society Transactions, Portland Press vol. 38 (6), 1500-1505. 24-11-2010
Loiseau P, Davies T, Williams LS, Mishima M and Palacios IM (2010). Drosophila PAT1 is required for Kinesin-1 to transport cargo and to maximize its motility. Journal of Cell Science, The Company of Biologists vol. 123 (16), e1-e1. 15-08-2010
2007
Meignin C, Alvarez-Garcia I, Davis I and Palacios IM (2007). The Salvador-Warts-Hippo Pathway Is Required for Epithelial Proliferation and Axis Specification in Drosophila. Current Biology, Elsevier vol. 17 (21), 1871-1878. 25-10-2007
Palacios IM (2007). How does an mRNA find its way? Intracellular localisation of transcripts. Seminars in Cell and Developmental Biology, Elsevier vol. 18 (2), 163-170. 26-01-2007
2004
Palacios IM, Gatfield D, St Johnston D and Izaurralde E (2004). An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay. Nature, Springer Nature vol. 427 (6976), 753-757. 01-02-2004
2003
Macchi P, Kroening S, Palacios IM, Baldassa S, Grunewald B, Ambrosino C, Goetze B, Lupas A, St. Johnston D and Kiebler M (2003). Barentsz, a New Component of the Staufen-Containing Ribonucleoprotein Particles in Mammalian Cells, Interacts with Staufen in an RNA-Dependent Manner. Journal of Neuroscience, Society for Neuroscience vol. 23 (13), 5778-5788. 02-07-2003
2002
Palacios IM and St Johnston D (2002). Kinesin light chain-independent function of the Kinesin heavy chain in cytoplasmic streaming and posterior localisation in theDrosophila oocyte. Development, The Company of Biologists vol. 129 (23), 5473-5485. 01-12-2002
Benton R, Palacios IM and St Johnston D (2002). Drosophila 14-3-3/PAR-5 Is an Essential Mediator of PAR-1 Function in Axis Formation. Developmental Cell, Elsevier vol. 3 (5), 659-671. 01-11-2002
Palacios IM (2002). RNA Processing: Splicing and the Cytoplasmic Localisation of mRNA. Current Biology, Elsevier vol. 12 (2), r50-r52. 01-01-2002
2001
Palacios IM and Johnston DS (2001). GETTING THE MESSAGE ACROSS: The Intracellular Localization of mRNAs in Higher Eukaryotes. Annual Review of Cell and Developmental Biology, Annual Reviews vol. 17 (1), 569-614. 01-11-2001
Wagner C, Palacios I, Jaeger L, St Johnston D, Ehresmann B, Ehresmann C and Brunel C (2001). Dimerization of the 3′UTR of bicoid mRNA involves a two-step mechanism11Edited by J. Doudna. Journal of Molecular Biology, Elsevier vol. 313 (3), 511-524. 01-10-2001
van Eeden FJM, Palacios IM, Petronczki M, Weston MJD and St Johnston D (2001). Barentsz is essential for the posterior localization of oskar mRNA and colocalizes with it to the posterior pole. Journal of Cell Biology, Rockefeller University Press vol. 154 (3), 511-524. 30-07-2001
Palacios I and Izaurralde E (2001). RNA Intracellular Transport. Encyclopedia of Life Sciences 19-04-2001
1997
Palacios I, Hetzer M, Adam SA and Mattaj IW (1997). Nuclear import of U snRNPs requires importin β. The EMBO Journal, Springer Nature vol. 16 (22), 6783-6792. 15-11-1997
Palacios I and Izaurralde E (1997). An immersion in nucleocytoplasmic transport at the Garda lake. 01-02-1997
Dingwall C and Palacios I (1997). Chapter 23 In Vitro Systems for the Reconstitution of snRNP and Protein Nuclear Import. Methods in Cell Biology, Elsevier vol. 53, 517-543. 01-01-1997
1996
Palacios I, Weis K, Klebe C, Mattaj IW and Dingwall C (1996). RAN/TC4 mutants identify a common requirement for snRNP and protein import into the nucleus. Journal of Cell Biology, Rockefeller University Press vol. 133 (3), 485-494. 01-05-1996
Perales B, de la Luna S, Palacios I and Ortín J (1996). Mutational analysis identifies functional domains in the influenza A virus PB2 polymerase subunit. Journal of Virology, American Society for Microbiology vol. 70 (3), 1678-1686. 01-03-1996
1995
Boelens WC, Palacios I and Mattaj IW (1995). Nuclear retention of RNA as a mechanism for localization. RNA vol. 1 (3), 273-283. 01-05-1995
Grants
Grants of specific relevance to the Centre for Molecular Cell BiologyHighthroughput Light Sheet Microscopy: Imaging Across ScalesViji Draviam Sastry, Caroline Brennan, Vidya Darbari, Jose Martin Duran, Ivan Kadurin, Maria Isabel Palacios De Castro, Richard Pickersgill, Sarah McClelland, Tyson Sharp and Martin Knight
£386,205 MRC Medical Research Council (01-10-2022 - 31-03-2023)
A confocal microscope for multidisciplinary dynamic studies of complex biological systemsConrad Mullineaux, Caroline Brennan, Alexandre De Mendoza Soler, Viji Draviam Sastry, Maurice Elphick, Christoph Engl, Maria Isabel Palacios De Castro, Matteo Palma, Marina Resmini, Alexander Ruban, Peter Thorpe, Angelika Stollewerk, Jose Martin Duran, Paulo Baptista Ribeiro, Susana Alves Godinho, Richard Grose, Stephanie Kermorgant, Peter McCormick and Tyson Sharp
£390,834 BBSRC Biotechnology and Biological Sciences Research Council (01-08-2022 - 31-07-2023)