Dr Isabel M Palacios

Isabel M Palacios
Lecturer of Cell Biology

Lecturer of Cell Biology
Deputy Director of Research Nanchang

School of Biological and Behavioural Sciences
Queen Mary University of London
ORCID

Research

Drosophila, human organoids, human iPSCs, organogenesis, cell biophysics, cytoskeleton

Publications

solid heart iconPublications of specific relevance to the Centre for Molecular Cell Biology

2024

Relevant PublicationPalacios IM and Palacios De Castro MI (2024). Essential conserved neuronal motors kinesin-1 and kinesin-3 regulate Aβ42 toxicity in vivo., Editors: biorxiv team . bioRxiv journal 
24-04-2024

2023

Relevant PublicationLópez EM, Kabanova A, Winkel A, Franze K, Palacios IM and Martín-Bermudo MD (2023). Constriction imposed by basement membrane regulates developmental cell migration. PLoS Biology, Public Library of Science vol. 21 (6) 
28-06-2023

2020

Relevant Publication (2020). The humble fruit fly is helping the African science community to thrive. Nature Reviews Molecular Cell Biology, Springer Nature vol. 21 (10), 558-559.  
17-08-2020
Relevant PublicationSanta-Cruz Mateos C, Valencia-Expósito A, Palacios IM and Martín-Bermudo MD (2020). Integrins regulate epithelial cell shape by controlling the architecture and mechanical properties of basal actomyosin networks. PLOS Genetics, Public Library of Science (PLoS) vol. 16 (6), e1008717-e1008717.  
01-06-2020
Relevant PublicationDrechsler M, Lang LF, Al-Khatib L, Dirks H, Burger M, Schönlieb C-B and Palacios IM (2020). Optical flow analysis reveals that Kinesin-mediated advection impacts on the orientation of microtubules in the Drosophila oocyte. Molecular Biology of the Cell, American Society for Cell Biology, mbcE19080440-mbcE19080440.  
08-04-2020

2019

Relevant PublicationFrancis D, Chanana B, Fernandez B, Gordon B, Mak T and Palacios IM (2019). YAP/Yorkie in the germline modulates the age-related decline of germline stem cells and niche cells. PLOS ONE, Public Library of Science (PLoS) vol. 14 (4) 
03-04-2019

2017

Relevant PublicationPALACIOS IM (2017). Active diffusion and advection in Drosophila oocytes result from the interplay of actin and microtubules. Nature Communications, Nature Publishing Group vol. 8 
15-11-2017
Relevant PublicationMartín-Bermudo MD, Gebel L and Palacios IM (2017). DrosAfrica: Building an African biomedical research community using Drosophila. Seminars in Cell & Developmental Biology, Elsevier BV vol. 70, 58-64.  
30-08-2017

2016

Relevant PublicationNg BF, Selvaraj GK, Santa-Cruz Mateos C, Grosheva I, Alvarez-Garcia I, Martín-Bermudo MD and Palacios IM (2016). α-Spectrin and integrins act together to regulate actomyosin and columnarization, and to maintain a monolayered follicular epithelium. Journal of Cell Science, The Company of Biologists vol. 129 (9), e1.2-e1.2.  
01-05-2016
Relevant PublicationVicente‐Crespo M, Muñoz‐Descalzo S, Weil T, Martín‐Bermudo MD and Palacios I (2016). Workshop‐Based Training for Capacity Building: Using Drosophila to Bring Research Skills to Africa. 
01-04-2016
Relevant PublicationNg BF, Selvaraj GK, Santa-Cruz Mateos C, Grosheva I, Alvarez-Garcia I, Martín-Bermudo MD and Palacios IM (2016). α-Spectrin and integrins act together to regulate actomyosin and columnarization, and to maintain a monolayered follicular epithelium. Development, The Company of Biologists vol. 143 (8), 1388-1399.  
07-03-2016
Relevant PublicationSaavedra P, Brittle A, Palacios IM, Strutt D, Casal J and Lawrence PA (2016). Planar cell polarity: the Dachsous/Fat system contributes differently to the embryonic and larval stages of Drosophila. Biology Open, The Company of Biologists vol. 5 (4), 397-408.  
02-03-2016

2015

Relevant PublicationPalacios IM, Drechsler M and Ganguly S (2015). A complex relationship between motor activity, cytoplasmic flows and the organisation of the actin and microtubule cytoskeletons. 
01-01-2015
Relevant PublicationPalacios IM and Martin-Bermudo M (2015). Alpha-spectrin is essential for septate junction formation and columnarization, but not for proliferation control, in the follicular epithelium. 
01-01-2015
Relevant PublicationPalacios IM, Drechsler M and Ganguly S (2015). A complex relationship between motor activity, cytoplasmic flows and the organisation of the actin and microtubule cytoskeletons. 
01-01-2015

2014

Relevant PublicationPalacios IM (2014). Hop-on hop-off: Polysomes take a tour of the cell on endosomes. Journal of Cell Biology, Rockefeller University Press vol. 204 (3), 287-289.  
03-02-2014
Relevant PublicationSaavedra P, Vincent J-P, Palacios IM, Lawrence PA and Casal J (2014). Plasticity of both planar cell polarity and cell identity during the development of Drosophila. eLife, eLife vol. 3 
01-01-2014
Relevant PublicationGómez-Lamarca MJ, Cobreros-Reguera L, Ibáñez-Jiménez B, Palacios IM and Martín-Bermudo MD (2014). Integrins regulate epithelial cell differentiation by modulating Notch activity. Journal of Cell Science, The Company of Biologists vol. 127 (21), 4667-4678.  
01-01-2014
Relevant PublicationBraun AL, Chanana B and Palacios IM (2014). Epithelia patterning and body plan mapping in the Drosophila egg chamber: cell fate specific screen. 
01-01-2014
Relevant PublicationDrechsler M, Goldstein R and Palacios IM (2014). A combined cell biological and biophysical strategy to analyze actin/microtubule crosstalk and its relation to cytoplasmic streaming. 
01-01-2014
Relevant PublicationWilliams LS, Ganguly S, Loiseau P, Ng BF and Palacios IM (2014). The auto-inhibitory domain and ATP-independent microtubulebinding region of Kinesin heavy chain are major functional domains for transport in the Drosophila germline. Journal of Cell Science, The Company of Biologists vol. 127 (1), e1-e1.  
01-01-2014

2013

Relevant PublicationRoca-Varela ML and Palacios IM (2013). How are spoken skills assessed in proficiency tests of general English as a Foreign Language? A preliminary survey. International Journal of English Studies, Servicio de Publicaciones de la Universidad de Murcia vol. 13 (2), 53-68.  
01-12-2013
Relevant PublicationWilliams LS, Ganguly S, Loiseau P, Ng BF and Palacios IM (2013). The auto-inhibitory domain and ATP-independent microtubule-binding region of Kinesin heavy chain are major functional domains for transport in the Drosophila germline. Development, The Company of Biologists vol. 141 (1), 176-186.  
20-11-2013

2012

Relevant PublicationPalacios IM (2012). Nonsense-mediated mRNA decay: from mechanistic insights to impacts on human health. Briefings in Functional Genomics, Oxford University Press (OUP) vol. 12 (1), 25-36.  
11-11-2012
Relevant PublicationGanguly S, Williams LS, Palacios IM and Goldstein RE (2012). Cytoplasmic streaming in Drosophila oocytes varies with kinesin activity and correlates with the microtubule cytoskeleton architecture. Proceedings of the National Academy of Sciences of the United States of America, Proceedings of the National Academy of Sciences vol. 109 (38), 15109-15114.  
04-09-2012
Relevant PublicationBaden T, Palacios I, Vicente M, Martin Bermudo MD, Yusuf S and Godino LP (2012). HIGHER EDUCATION IN THE DEVELOPING WORLD: DROSOPHILA NEUROGENETICS, UGANDA. 
01-01-2012

2011

Relevant PublicationAvery P, Vicente-Crespo M, Francis D, Nashchekina O, Alonso CR and Palacios IM (2011). Drosophila Upf1 and Upf2 loss of function inhibits cell growth and causes animal death in a Upf3-independent manner. RNA, Cold Spring Harbor Laboratory vol. 17 (4), 624-638.  
11-02-2011
Relevant PublicationVicente-Crespo M and Palacios IM (2011). Nonsense-mediated mRNA decay and development: shoot the messenger to survive? Biochemical Society Transactions, Portland Press vol. 39 (1), 411-411.  
19-01-2011

2010

bullet iconVicente-Crespo M and Palacios IM (2010). Nonsense-mediated mRNA decay and development: shoot the messenger to survive? Biochemical Society Transactions, Portland Press vol. 38 (6), 1500-1505.  
24-11-2010
bullet iconLoiseau P, Davies T, Williams LS, Mishima M and Palacios IM (2010). Drosophila PAT1 is required for Kinesin-1 to transport cargo and to maximize its motility. Journal of Cell Science, The Company of Biologists vol. 123 (16), e1-e1.  
15-08-2010

2007

bullet iconMeignin C, Alvarez-Garcia I, Davis I and Palacios IM (2007). The Salvador-Warts-Hippo Pathway Is Required for Epithelial Proliferation and Axis Specification in Drosophila. Current Biology, Elsevier vol. 17 (21), 1871-1878.  
25-10-2007
bullet iconPalacios IM (2007). How does an mRNA find its way? Intracellular localisation of transcripts. Seminars in Cell and Developmental Biology, Elsevier vol. 18 (2), 163-170.  
26-01-2007

2004

bullet iconPalacios IM, Gatfield D, St Johnston D and Izaurralde E (2004). An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay. Nature, Springer Nature vol. 427 (6976), 753-757.  
01-02-2004

2003

bullet iconMacchi P, Kroening S, Palacios IM, Baldassa S, Grunewald B, Ambrosino C, Goetze B, Lupas A, St. Johnston D and Kiebler M (2003). Barentsz, a New Component of the Staufen-Containing Ribonucleoprotein Particles in Mammalian Cells, Interacts with Staufen in an RNA-Dependent Manner. Journal of Neuroscience, Society for Neuroscience vol. 23 (13), 5778-5788.  
02-07-2003

2002

bullet iconPalacios IM and St Johnston D (2002). Kinesin light chain-independent function of the Kinesin heavy chain in cytoplasmic streaming and posterior localisation in theDrosophila oocyte. Development, The Company of Biologists vol. 129 (23), 5473-5485.  
01-12-2002
bullet iconBenton R, Palacios IM and St Johnston D (2002). Drosophila 14-3-3/PAR-5 Is an Essential Mediator of PAR-1 Function in Axis Formation. Developmental Cell, Elsevier vol. 3 (5), 659-671.  
01-11-2002
bullet iconPalacios IM (2002). RNA Processing: Splicing and the Cytoplasmic Localisation of mRNA. Current Biology, Elsevier vol. 12 (2), r50-r52.  
01-01-2002

2001

bullet iconPalacios IM and Johnston DS (2001). GETTING THE MESSAGE ACROSS: The Intracellular Localization of mRNAs in Higher Eukaryotes. Annual Review of Cell and Developmental Biology, Annual Reviews vol. 17 (1), 569-614.  
01-11-2001
bullet iconWagner C, Palacios I, Jaeger L, St Johnston D, Ehresmann B, Ehresmann C and Brunel C (2001). Dimerization of the 3′UTR of bicoid mRNA involves a two-step mechanism11Edited by J. Doudna. Journal of Molecular Biology, Elsevier vol. 313 (3), 511-524.  
01-10-2001
bullet iconvan Eeden FJM, Palacios IM, Petronczki M, Weston MJD and St Johnston D (2001). Barentsz is essential for the posterior localization of oskar mRNA and colocalizes with it to the posterior pole. Journal of Cell Biology, Rockefeller University Press vol. 154 (3), 511-524.  
30-07-2001
bullet iconPalacios I and Izaurralde E (2001). RNA Intracellular Transport. Encyclopedia of Life Sciences  
19-04-2001

1997

bullet iconPalacios I, Hetzer M, Adam SA and Mattaj IW (1997). Nuclear import of U snRNPs requires importin β. The EMBO Journal, Springer Nature vol. 16 (22), 6783-6792.  
15-11-1997
bullet iconPalacios I and Izaurralde E (1997). An immersion in nucleocytoplasmic transport at the Garda lake. 
01-02-1997
bullet iconDingwall C and Palacios I (1997). Chapter 23 In Vitro Systems for the Reconstitution of snRNP and Protein Nuclear Import. Methods in Cell Biology, Elsevier vol. 53, 517-543.  
01-01-1997

1996

bullet iconPalacios I, Weis K, Klebe C, Mattaj IW and Dingwall C (1996). RAN/TC4 mutants identify a common requirement for snRNP and protein import into the nucleus. Journal of Cell Biology, Rockefeller University Press vol. 133 (3), 485-494.  
01-05-1996
bullet iconPerales B, de la Luna S, Palacios I and Ortín J (1996). Mutational analysis identifies functional domains in the influenza A virus PB2 polymerase subunit. Journal of Virology, American Society for Microbiology vol. 70 (3), 1678-1686.  
01-03-1996

1995

bullet iconBoelens WC, Palacios I and Mattaj IW (1995). Nuclear retention of RNA as a mechanism for localization. RNA vol. 1 (3), 273-283.  
01-05-1995

Grants

solid heart iconGrants of specific relevance to the Centre for Molecular Cell Biology
bullet iconHighthroughput Light Sheet Microscopy: Imaging Across Scales
Viji Draviam Sastry, Caroline Brennan, Vidya Darbari, Jose Martin Duran, Ivan Kadurin, Maria Isabel Palacios De Castro, Richard Pickersgill, Sarah McClelland, Tyson Sharp and Martin Knight
£386,205 MRC Medical Research Council (01-10-2022 - 31-03-2023)
solid heart iconA confocal microscope for multidisciplinary dynamic studies of complex biological systems
Conrad Mullineaux, Caroline Brennan, Alexandre De Mendoza Soler, Viji Draviam Sastry, Maurice Elphick, Christoph Engl, Maria Isabel Palacios De Castro, Matteo Palma, Marina Resmini, Alexander Ruban, Peter Thorpe, Angelika Stollewerk, Jose Martin Duran, Paulo Baptista Ribeiro, Susana Alves Godinho, Richard Grose, Stephanie Kermorgant, Peter McCormick and Tyson Sharp
£390,834 BBSRC Biotechnology and Biological Sciences Research Council (01-08-2022 - 31-07-2023)