Dr Ann-Marie de Lange

Research

Brain imaging (MRI), Genetics, Population Health, Women's Health, Machine Learning

Publications

Publications of specific relevance to the Centre for Brain and Behaviour

2026

Longitudinal Associations Between Physical Activity Behavior and Structural Brain MRI Features After Stroke: A Sub-Study From the Nor-COAST Project.
Neurorehabilitation and Neural Repair, Sage Publications 

DOI 10.1177/15459683251399125

09-01-2026

2025

No causal links between estradiol and female’s brain and mental health using Mendelian randomization
Oppenheimer H van der Meer D Schindler LS Crestol A Shadrin A Andreassen OA Westlye LT de Lange A-MG et al.
Nature Communications, Springer Nature vol. 16 (1) 

DOI 10.1038/s41467-025-65878-7

05-12-2025

Author Response: Sex-Dependent Effects of Cardiometabolic Health and APOE4 on Brain Age
Subramaniapillai S Cole JH de Lange A-MG
Neurology, Wolters Kluwer vol. 105 (9) 

DOI 10.1212/wnl.0000000000210221

17-10-2025

Investigating Shared Cardiovascular Factors and Genetic Overlap of Pregnancy-Related Disorders, Major Depressive Disorder, and Alzheimer’s Disease
Oppenheimer H Shadrin A Andersen JØ Schindler LS Crestol A Andreassen OA Westlye LT de Lange A-MG et al.
Biological Psychiatry, Elsevier 

DOI 10.1016/j.biopsych.2025.09.018

01-10-2025

A Bayesian analysis of diagnostic timelines across Alzheimer's disease, frontotemporal dementia, and other neurodegenerative conditions
Ambikairajah A Foxe D de Lange AG Carrick J Cheung SC Srikanth VK Hwang YT Ahmed RM et al.
Alzheimer's & Dementia Diagnosis Assessment & Disease Monitoring, Wiley vol. 17 (3) 

DOI 10.1002/dad2.70184

01-07-2025

Menopausal hormone therapy and the female brain: Leveraging neuroimaging and prescription registry data from the UK Biobank cohort
Barth C Galea LA Jacobs EG Lee BH Westlye LT de Lange A-MG
Elife, Elife vol. 13 

DOI 10.7554/elife.99538

29-05-2025

Mediation Analyses Link Cardiometabolic Factors and Liver Fat With White Matter Hyperintensities and Cognitive Performance: A UK Biobank Study
Askeland-Gjerde DE Westlye LT Andersson P Korbmacher M de Lange A-M van der Meer D Smeland OB Halvorsen S et al.
Biological Psychiatry Global Open Science, Elsevier vol. 5 (4) 

DOI 10.1016/j.bpsgos.2025.100488

20-03-2025

2024

Sex-Dependent Effects of Cardiometabolic Health and APOE4 on Brain Age
Subramaniapillai S Schindler LS Redmond P Bastin ME Wardlaw JM Valdés Hernández M Maniega SM Aribisala B et al.
Neurology, Wolters Kluwer vol. 103 (6) 

DOI 10.1212/wnl.0000000000209744

22-08-2024

Dimensions of Early-Life Adversity Are Differentially Associated With Patterns of Delayed and Accelerated Brain Maturation
Beck D Whitmore L MacSweeney N Brieant A Karl V de Lange A-MG Westlye LT Mills KL et al.
Biological Psychiatry, Elsevier vol. 97 (1), 64-72.  

DOI 10.1016/j.biopsych.2024.07.019

29-07-2024

Linking menopause-related factors, history of depression, APOE ε4, and proxies of biological aging in the UK biobank cohort
Crestol A de Lange A-MG Schindler L Subramaniapillai S Nerland S Oppenheimer H Westlye LT Andreassen OA et al.
Hormones and Behavior, Elsevier vol. 164 

DOI 10.1016/j.yhbeh.2024.105596

29-06-2024

An evolutionary timeline of the oxytocin signaling pathway
Sartorius AM Rokicki J Birkeland S Bettella F Barth C de Lange A-MG Haram M Shadrin A et al.
Communications Biology, Springer Nature vol. 7 (1) 

DOI 10.1038/s42003-024-06094-9

17-04-2024

Dissecting unique and common variance across body and brain health indicators using age prediction
Beck D de Lange AG Gurholt TP Voldsbekk I Maximov II Subramaniapillai S Schindler L Hindley G et al.
Human Brain Mapping, Wiley vol. 45 (6) 

DOI 10.1002/hbm.26685

15-04-2024

Advancing the neuroscience of human pregnancy
Martínez-García M Jacobs EG de Lange A-MG Carmona S
Nature Neuroscience, Springer Nature vol. 27 (5), 805-807.  

DOI 10.1038/s41593-024-01629-z

10-04-2024

Parental status and markers of brain and cellular age: A 3D convolutional network and classification study
de Lange A-MG Leonardsen EH Barth C Schindler LS Crestol A Holm MC Subramaniapillai S Hill D et al.
Psychoneuroendocrinology, Elsevier vol. 165 

DOI 10.1016/j.psyneuen.2024.107040

02-04-2024

Investigating the synergistic effects of hormone replacement therapy, apolipoprotein E and age on brain health in the UK Biobank
Ambikairajah A Khondoker M Morris E de Lange AG Saleh RNM Minihane AM Hornberger M
Human Brain Mapping, Wiley vol. 45 (2) 

DOI 10.1002/hbm.26612

01-02-2024

Brain asymmetries from mid- to late life and hemispheric brain age
Korbmacher M van der Meer D Beck D de Lange A-MG Eikefjord E Lundervold A Andreassen OA Westlye LT et al.
Nature Communications, Springer Nature vol. 15 (1) 

DOI 10.1038/s41467-024-45282-3

01-02-2024

2023

Recommendations for a Better Understanding of Sex and Gender in the Neuroscience of Mental Health
Wierenga LM Ruigrok A Aksnes ER Barth C Beck D Burke S Crestol A van Drunen L et al.
Biological Psychiatry Global Open Science, Elsevier vol. 4 (2) 

DOI 10.1016/j.bpsgos.2023.100283

30-12-2023

Cardiometabolic health across menopausal years is linked to white matter hyperintensities up to a decade later
Schindler LS Subramaniapillai S Ambikairajah A Barth C Crestol A Voldsbekk I Beck D Gurholt TP et al.
Frontiers in Global Women's Health, Frontiers vol. 4 

DOI 10.3389/fgwh.2023.1320640

21-12-2023

Sex and gender in health research: Intersectionality matters
Subramaniapillai S Am Galea L Einstein G de Lange A-M
Frontiers in Neuroendocrinology, Elsevier vol. 72 

DOI 10.1016/j.yfrne.2023.101104

28-10-2023

Sex steroids and the female brain across the lifespan: insights into risk of depression and Alzheimer's disease
Barth C Crestol A de Lange A-MG Galea LAM
The Lancet Diabetes & Endocrinology, Elsevier vol. 11 (12), 926-941.  

DOI 10.1016/s2213-8587(23)00224-3

18-10-2023

Sex and gender in infection and immunity: addressing the bottlenecks from basic science to public health and clinical applications
Pasin C Consiglio CR Huisman JS de Lange A-MG Peckham H Vallejo-Yagüe E Abela IA Islander U et al.
Royal Society Open Science, The Royal Society vol. 10 (7) 

DOI 10.1098/rsos.221628

01-07-2023

Development and validation of a dementia risk score in the UK Biobank and Whitehall II cohorts
Anatürk M Patel R Ebmeier KP Georgiopoulos G Newby D Topiwala A de Lange A-MG Cole JH et al.
Bmj Mental Health, Bmj vol. 26 (1) 

DOI 10.1136/bmjment-2023-300719

01-07-2023

Bio-psycho-social factors’ associations with brain age: a large-scale UK Biobank diffusion study of 35,749 participants
Korbmacher M Gurholt TP de Lange A-MG van der Meer D Beck D Eikefjord E Lundervold A Andreassen OA et al.
Frontiers in Psychology, Frontiers vol. 14 

DOI 10.3389/fpsyg.2023.1117732

09-06-2023

Brain‐wide associations between white matter and age highlight the role of fornix microstructure in brain ageing
Korbmacher M de Lange AM van der Meer D Beck D Eikefjord E Lundervold A Andreassen OA Westlye LT et al.
Human Brain Mapping, Wiley vol. 44 (10), 4101-4119.  

DOI 10.1002/hbm.26333

17-05-2023

Genetic architecture of brain age and its causal relations with brain and mental disorders
Leonardsen EH Vidal-Piñeiro D Roe JM Frei O Shadrin AA Iakunchykova O de Lange A-MG Kaufmann T et al.
Molecular Psychiatry, Springer Nature vol. 28 (7), 3111-3120.  

DOI 10.1038/s41380-023-02087-y

10-05-2023

Topography of associations between cardiovascular risk factors and myelin loss in the ageing human brain
Trofimova O Latypova A DiDomenicantonio G Lutti A de Lange A-MG Kliegel M Stringhini S Marques-Vidal P et al.
Communications Biology, Springer Nature vol. 6 (1) 

DOI 10.1038/s42003-023-04741-1

10-04-2023

Linking brain maturation and puberty during early adolescence using longitudinal brain age prediction in the ABCD cohort
Holm MC Leonardsen EH Beck D Dahl A Kjelkenes R de Lange A-MG Westlye LT
Developmental Cognitive Neuroscience, Elsevier vol. 60 

DOI 10.1016/j.dcn.2023.101220

22-02-2023

Shared pattern of impaired social communication and cognitive ability in the youth brain across diagnostic boundaries
Voldsbekk I Kjelkenes R Wolfers T Dahl A Lund MJ Kaufmann T Fernandez-Cabello S de Lange A-MG et al.
Developmental Cognitive Neuroscience, Elsevier vol. 60 

DOI 10.1016/j.dcn.2023.101219

18-02-2023

Visual processing deficits in patients with schizophrenia spectrum and bipolar disorders and associations with psychotic symptoms, and intellectual abilities
Løchen AR Kolskår KK de Lange A-MG Sneve MH Haatveit B Lagerberg TV Ueland T Melle I et al.
Heliyon, Elsevier vol. 9 (2) 

DOI 10.1016/j.heliyon.2023.e13354

01-02-2023

Associations between reproductive history, hormone use, APOE ε4 genotype and cognition in middle- to older-aged women from the UK Biobank
Lindseth LRS de Lange A-MG van der Meer D Agartz I Westlye LT Tamnes CK Barth C
Frontiers in Aging Neuroscience, Frontiers vol. 14 

DOI 10.3389/fnagi.2022.1014605

19-01-2023

2022

The link between liver fat and cardiometabolic diseases is highlighted by genome-wide association study of MRI-derived measures of body composition
van der Meer D Gurholt TP Sønderby IE Shadrin AA Hindley G Rahman Z de Lange A-MG Frei O et al.
Communications Biology, Springer Nature vol. 5 (1) 

DOI 10.1038/s42003-022-04237-4

19-11-2022

Longitudinal brain age prediction and cognitive function after stroke
Aamodt EB Alnæs D de Lange A-MG Aam S Schellhorn T Saltvedt I Beyer MK Westlye LT
Neurobiology of Aging, Elsevier vol. 122, 55-64.  

DOI 10.1016/j.neurobiolaging.2022.10.007

29-10-2022

Cognitive and hippocampal changes weeks and years after memory training
Bråthen ACS Sørensen Ø de Lange A-MG Mowinckel AM Fjell AM Walhovd KB
Scientific Reports, Springer Nature vol. 12 (1) 

DOI 10.1038/s41598-022-11636-4

12-05-2022

Sex‐ and age‐specific associations between cardiometabolic risk and white matter brain age in the UK Biobank cohort
Subramaniapillai S Suri S Barth C Maximov II Voldsbekk I van der Meer D Gurholt TP Beck D et al.
Human Brain Mapping, Wiley vol. 43 (12), 3759-3774.  

DOI 10.1002/hbm.25882

23-04-2022

Oxytocin receptor expression patterns in the human brain across development
Rokicki J Kaufmann T de Lange A-MG van der Meer D Bahrami S Sartorius AM Haukvik UK Steen NE et al.
Neuropsychopharmacology, Springer Nature vol. 47 (8), 1550-1560.  

DOI 10.1038/s41386-022-01305-5

28-03-2022

Mind the gap: Performance metric evaluation in brain‐age prediction
de Lange AG Anatürk M Rokicki J Han LKM Franke K Alnæs D Ebmeier KP Draganski B et al.
Human Brain Mapping, Wiley vol. 43 (10), 3113-3129.  

DOI 10.1002/hbm.25837

21-03-2022

Adipose tissue distribution from body MRI is associated with cross-sectional and longitudinal brain age in adults
Beck D de Lange A-MG Alnæs D Maximov II Pedersen ML Leinhard OD Linge J Simon R et al.
Neuroimage Clinical, Elsevier vol. 33 

DOI 10.1016/j.nicl.2022.102949

01-01-2022

Associations between abdominal adipose tissue, reproductive span, and brain characteristics in post-menopausal women
Schindler LS Subramaniapillai S Barth C van der Meer D Pedersen ML Kaufmann T Maximov II Linge J et al.
Neuroimage Clinical, Elsevier vol. 36 

DOI 10.1016/j.nicl.2022.103239

01-01-2022

2021

Brain age prediction using fMRI network coupling in youths and associations with psychiatric symptoms
Lund MJ Alnæs D de Lange A-MG Andreassen OA Westlye LT Kaufmann T
Neuroimage Clinical, Elsevier vol. 33 

DOI 10.1016/j.nicl.2021.102921

20-12-2021

Oxytocin-pathway polygenic scores for severe mental disorders and metabolic phenotypes in the UK Biobank
Winterton A Bettella F de Lange A-MG Haram M Steen NE Westlye LT Andreassen OA Quintana DS
Translational Psychiatry, Springer Nature vol. 11 (1) 

DOI 10.1038/s41398-021-01725-9

25-11-2021

Cardiometabolic risk factors associated with brain age and accelerated brain ageing
Beck D de Lange AG Pedersen ML Alnæs D Maximov II Voldsbekk I Richard G Sanders A et al.
Human Brain Mapping, Wiley vol. 43 (2), 700-720.  

DOI 10.1002/hbm.25680

09-10-2021

Prominent health problems, socioeconomic deprivation, and higher brain age in lonely and isolated individuals: A population-based study
de Lange A-MG Kaufmann T Quintana DS Winterton A Andreassen OA Westlye LT Ebmeier KP
Behavioural Brain Research, Elsevier vol. 414 

DOI 10.1016/j.bbr.2021.113510

04-08-2021

A history of previous childbirths is linked to women's white matter brain age in midlife and older age
Voldsbekk I Barth C Maximov II Kaufmann T Beck D Richard G Moberget T Westlye LT et al.
Human Brain Mapping, Wiley vol. 42 (13), 4372-4386.  

DOI 10.1002/hbm.25553

12-06-2021

Fast qualitY conTrol meThod foR derIved diffUsion Metrics (YTTRIUM) in big data analysis: U.K. Biobank 18,608 example
Maximov II van der Meer D de Lange AG Kaufmann T Shadrin A Frei O Wolfers T Westlye LT
Human Brain Mapping, Wiley vol. 42 (10), 3141-3155.  

DOI 10.1002/hbm.25424

31-03-2021

Apolipoprotein ɛ4 Status and Brain Structure 12 Months after Mild Traumatic Injury: Brain Age Prediction Using Brain Morphometry and Diffusion Tensor Imaging
Hellstrøm T Andelic N de Lange A-MG Helseth E Eiklid K Westlye LT
Journal of Clinical Medicine, Mdpi vol. 10 (3) 

DOI 10.3390/jcm10030418

22-01-2021

In Vivo Amygdala Nuclei Volumes in Schizophrenia and Bipolar Disorders
Barth C Nerland S de Lange A-MG Wortinger LA Hilland E Andreassen OA Jørgensen KN Agartz I
Schizophrenia Bulletin, Oxford University Press (OUP) vol. 47 (5), 1431-1441.  

DOI 10.1093/schbul/sbaa192

22-01-2021

Linking objective measures of physical activity and capability with brain structure in healthy community dwelling older adults
Sanders A-M Richard G Kolskår K Ulrichsen KM Kaufmann T Alnæs D Beck D Dørum ES et al.
Neuroimage Clinical, Elsevier vol. 31 

DOI 10.1016/j.nicl.2021.102767

01-01-2021

2020

The scientific body of knowledge: Whose body does it serve? A spotlight on women’s brain health
de Lange A-MG Jacobs EG Galea LAM
Frontiers in Neuroendocrinology, Elsevier vol. 60 

DOI 10.1016/j.yfrne.2020.100898

28-12-2020

Multimodal imaging improves brain age prediction and reveals distinct abnormalities in patients with psychiatric and neurological disorders
Rokicki J Wolfers T Nordhøy W Tesli N Quintana DS Alnæs D Richard G de Lange AG et al.
Human Brain Mapping, Wiley vol. 42 (6), 1714-1726.  

DOI 10.1002/hbm.25323

19-12-2020

Prediction of brain age and cognitive age: Quantifying brain and cognitive maintenance in aging
Anatürk M Kaufmann T Cole JH Suri S Griffanti L Zsoldos E Filippini N Singh‐Manoux A et al.
Human Brain Mapping, Wiley vol. 42 (6), 1626-1640.  

DOI 10.1002/hbm.25316

14-12-2020

Within-session verbal learning slope is predictive of lifespan delayed recall, hippocampal volume, and memory training benefit, and is heritable
Walhovd KB Bråthen ACS Panizzon MS Mowinckel AM Sørensen Ø de Lange A-MG Krogsrud SK Håberg A et al.
Scientific Reports, Springer Nature vol. 10 (1) 

DOI 10.1038/s41598-020-78225-1

03-12-2020

White matter microstructure across the adult lifespan: A mixed longitudinal and cross-sectional study using advanced diffusion models and brain-age prediction
Beck D de Lange A-MG Maximov II Richard G Andreassen OA Nordvik JE Westlye LT
Neuroimage, Elsevier vol. 224 

DOI 10.1016/j.neuroimage.2020.117441

09-10-2020

Women's brain aging: Effects of sex‐hormone exposure, pregnancies, and genetic risk for Alzheimer's disease
de Lange AG Barth C Kaufmann T Maximov II van der Meer D Agartz I Westlye LT
Human Brain Mapping, Wiley vol. 41 (18), 5141-5150.  

DOI 10.1002/hbm.25180

28-08-2020

Multimodal brain-age prediction and cardiovascular risk: The Whitehall II MRI sub-study
de Lange A-MG Anatürk M Suri S Kaufmann T Cole JH Griffanti L Zsoldos E Jensen DEA et al.
Neuroimage, Elsevier vol. 222 

DOI 10.1016/j.neuroimage.2020.117292

21-08-2020

The maternal brain: Region‐specific patterns of brain aging are traceable decades after childbirth
de Lange AG Barth C Kaufmann T Anatürk M Suri S Ebmeier KP Westlye LT
Human Brain Mapping, Wiley vol. 41 (16), 4718-4729.  

DOI 10.1002/hbm.25152

07-08-2020

Brain Age Prediction Reveals Aberrant Brain White Matter in Schizophrenia and Bipolar Disorder: A Multisample Diffusion Tensor Imaging Study
Tønnesen S Kaufmann T de Lange A-MG Richard G Doan NT Alnæs D van der Meer D Rokicki J et al.
Biological Psychiatry Cognitive Neuroscience and Neuroimaging, Elsevier vol. 5 (12), 1095-1103.  

DOI 10.1016/j.bpsc.2020.06.014

08-07-2020

Towards an understanding of women’s brain aging: the immunology of pregnancy and menopause
Barth C de Lange A-MG
Frontiers in Neuroendocrinology, Elsevier vol. 58 

DOI 10.1016/j.yfrne.2020.100850

03-06-2020

Risk- and protective factors for memory plasticity in aging
Bråthen ACS De Lange A-MG Fjell AM Walhovd KB
Aging Neuropsychology and Cognition, Taylor & Francis vol. 28 (2), 201-217.  

DOI 10.1080/13825585.2020.1727834

25-02-2020

Commentary: Correction procedures in brain-age prediction
de Lange A-MG Cole JH
Neuroimage Clinical, Elsevier vol. 26 

DOI 10.1016/j.nicl.2020.102229

01-01-2020

2019

Self-reported Sleep Problems Related to Amyloid Deposition in Cortical Regions with High HOMER1 Gene Expression
Fjell AM Sederevicius D Sneve MH de Lange A-MG Bråthen AC Idland A-V Watne LO Wang Y et al.
Cerebral Cortex, Oxford University Press (OUP) vol. 30 (4), 2144-2156.  

DOI 10.1093/cercor/bhz228

11-11-2019

Population-based neuroimaging reveals traces of childbirth in the maternal brain
de Lange A-MG Kaufmann T van der Meer D Maglanoc LA Alnæs D Moberget T Douaud G Andreassen OA et al.
Proceedings of The National Academy of Sciences of The United States of America, Proceedings of The National Academy of Sciences vol. 116 (44), 22341-22346.  

DOI 10.1073/pnas.1910666116

15-10-2019

2018

Multimodal cortical and hippocampal prediction of episodic‐memory plasticity in young and older adults
Bråthen ACS de Lange AG Rohani DA Sneve MH Fjell AM Walhovd KB
Human Brain Mapping, Wiley vol. 39 (11), 4480-4492.  

DOI 10.1002/hbm.24287

13-07-2018

The Temporal Dynamics of Brain Plasticity in Aging
de Lange A-MG Bråthen ACS Rohani DA Fjell AM Walhovd KB
Cerebral Cortex, Oxford University Press (OUP) vol. 28 (5), 1857-1865.  

DOI 10.1093/cercor/bhy003

27-02-2018

2017

The effects of memory training on behavioral and microstructural plasticity in young and older adults
de Lange AG Bråthen ACS Rohani DA Grydeland H Fjell AM Walhovd KB
Human Brain Mapping, Wiley vol. 38 (11), 5666-5680.  

DOI 10.1002/hbm.23756

07-08-2017

2016

White matter integrity as a marker for cognitive plasticity in aging
de Lange A-MG Bråthen ACS Grydeland H Sexton C Johansen-Berg H Andersson JLR Rohani DA Nyberg L et al.
Neurobiology of Aging, Elsevier vol. 47, 74-82.  

DOI 10.1016/j.neurobiolaging.2016.07.007

15-07-2016

2015

Premises of plasticity — And the loneliness of the medial temporal lobe
Walhovd KB Westerhausen R de Lange A-MG Bråthen ACS Grydeland H Engvig A Fjell AM
Neuroimage, Elsevier vol. 131, 48-54.  

DOI 10.1016/j.neuroimage.2015.10.060

24-10-2015

Functional connectivity change across multiple cortical networks relates to episodic memory changes in aging
Fjell AM Sneve MH Grydeland H Storsve AB de Lange A-MG Amlien IK Røgeberg OJ Walhovd KB
Neurobiology of Aging, Elsevier vol. 36 (12), 3255-3268.  

DOI 10.1016/j.neurobiolaging.2015.08.020

24-08-2015

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