Dr Ann-Marie de Lange
Lecturer in Population Neuroscience & Applied Machine Learning
School of Biological and Behavioural Sciences
Queen Mary University of London
Queen Mary University of London
Research
Brain imaging (MRI), Genetics, Population Health, Women's Health, Machine Learning
Interests
My research combines neuroimaging (structural MRI), clinical, genetic, and psychosocial data to study brain health and disease risk, with a particular focus on women's brain health across the lifespan. Topics of interest include:• Hormonal transition phases (puberty, pregnancy, menopause)
• Brain ageing, cognitive decline, and dementia
• Genetic risk and epigenetic ageing
• Cardiometabolic health
• Mental health, stress and trauma
• Socioeconomic factors and intersectionality
I work with both population-based and clinical cohorts, and have expertise in machine learning and advanced statistical modelling of large-scale neuroimaging and health data.
Publications
Publications of specific relevance to the Centre for Brain and Behaviour2026
Linking obesity with white matter microstructure highlights the importance of brainstem tracts and sex differencesGurholt TP Beck D Voldsbekk I Parker N Askeland-Gjerde DE de Lange A-MG van der Meer D Tamnes CK et al.
Brain Communications, Oxford University Press (OUP) vol. 8 (1)
02-01-2026
Longitudinal Associations Between Physical Activity Behavior and Structural Brain MRI Features After Stroke: A Sub-Study From the Nor-COAST ProjectLuzum G Aamodt EB Allore H Alnæs D Beyer MK de Lange A-MG Saltvedt I Schellhorn T et al.
Neurorehabilitation and Neural Repair, Sage Publications vol. 40 (1), 75-87.
01-01-2026
Menopausal hormone therapy and risk of neuropsychiatric disease: a drug target Mendelian randomisation studySchindler LS Gill D Oppenheimer H Barth C Andreassen OA Draganski B Westlye LT Topiwala A et al.
Npj Women's Health, Springer Nature vol. 4 (1)
01-01-2026
Mapping sex differences in brain and cognition in relation to APOE ε4 and amyloid burden: A longitudinal normative modelling studySubramaniapillai S Verdi S Keuss S Lu K James S Coath W Cash DM Barkhof F et al.
Alzheimer's & Dementia: Translational Research & Clinical Interventions, Wiley vol. 12 (1)
01-01-2026
2025
No causal links between estradiol and female’s brain and mental health using Mendelian randomizationOppenheimer H van der Meer D Schindler LS Crestol A Shadrin A Andreassen OA Westlye LT de Lange A-MG et al.
Nature Communications, Springer Nature vol. 16 (1)
05-12-2025
Author Response: Sex-Dependent Effects of Cardiometabolic Health and APOE4 on Brain AgeSubramaniapillai S Cole JH de Lange A-MG
Neurology, Wolters Kluwer vol. 105 (9)
17-10-2025
Investigating Shared Cardiovascular Factors and Genetic Overlap of Pregnancy-Related Disorders, Major Depressive Disorder, and Alzheimer’s DiseaseOppenheimer H Shadrin A Andersen JØ Schindler LS Crestol A Andreassen OA Westlye LT de Lange A-MG et al.
Biological Psychiatry, Elsevier
01-10-2025
A Bayesian analysis of diagnostic timelines across Alzheimer's disease, frontotemporal dementia, and other neurodegenerative conditionsAmbikairajah A Foxe D de Lange AG Carrick J Cheung SC Srikanth VK Hwang YT Ahmed RM et al.
Alzheimer's & Dementia Diagnosis Assessment & Disease Monitoring, Wiley vol. 17 (3)
01-07-2025
Menopausal hormone therapy and the female brain: Leveraging neuroimaging and prescription registry data from the UK Biobank cohortBarth C Galea LA Jacobs EG Lee BH Westlye LT de Lange A-MG
Elife, Elife vol. 13
29-05-2025
Mediation Analyses Link Cardiometabolic Factors and Liver Fat With White Matter Hyperintensities and Cognitive Performance: A UK Biobank StudyAskeland-Gjerde DE Westlye LT Andersson P Korbmacher M de Lange A-M van der Meer D Smeland OB Halvorsen S et al.
Biological Psychiatry Global Open Science, Elsevier vol. 5 (4)
20-03-2025
2024
Sex-Dependent Effects of Cardiometabolic Health and APOE4 on Brain AgeSubramaniapillai S Schindler LS Redmond P Bastin ME Wardlaw JM Valdés Hernández M Maniega SM Aribisala B et al.
Neurology, Wolters Kluwer vol. 103 (6)
22-08-2024
Dimensions of Early-Life Adversity Are Differentially Associated With Patterns of Delayed and Accelerated Brain MaturationBeck D Whitmore L MacSweeney N Brieant A Karl V de Lange A-MG Westlye LT Mills KL et al.
Biological Psychiatry, Elsevier vol. 97 (1), 64-72.
29-07-2024
Linking menopause-related factors, history of depression, APOE ε4, and proxies of biological aging in the UK biobank cohortCrestol A de Lange A-MG Schindler L Subramaniapillai S Nerland S Oppenheimer H Westlye LT Andreassen OA et al.
Hormones and Behavior, Elsevier vol. 164
29-06-2024
An evolutionary timeline of the oxytocin signaling pathwaySartorius AM Rokicki J Birkeland S Bettella F Barth C de Lange A-MG Haram M Shadrin A et al.
Communications Biology, Springer Nature vol. 7 (1)
17-04-2024
Dissecting unique and common variance across body and brain health indicators using age predictionBeck D de Lange AG Gurholt TP Voldsbekk I Maximov II Subramaniapillai S Schindler L Hindley G et al.
Human Brain Mapping, Wiley vol. 45 (6)
15-04-2024
Advancing the neuroscience of human pregnancyMartínez-García M Jacobs EG de Lange A-MG Carmona S
Nature Neuroscience, Springer Nature vol. 27 (5), 805-807.
10-04-2024
Parental status and markers of brain and cellular age: A 3D convolutional network and classification studyde Lange A-MG Leonardsen EH Barth C Schindler LS Crestol A Holm MC Subramaniapillai S Hill D et al.
Psychoneuroendocrinology, Elsevier vol. 165
02-04-2024
Investigating the synergistic effects of hormone replacement therapy, apolipoprotein E and age on brain health in the UK BiobankAmbikairajah A Khondoker M Morris E de Lange AG Saleh RNM Minihane AM Hornberger M
Human Brain Mapping, Wiley vol. 45 (2)
01-02-2024
Brain asymmetries from mid- to late life and hemispheric brain ageKorbmacher M van der Meer D Beck D de Lange A-MG Eikefjord E Lundervold A Andreassen OA Westlye LT et al.
Nature Communications, Springer Nature vol. 15 (1)
01-02-2024
2023
Recommendations for a Better Understanding of Sex and Gender in the Neuroscience of Mental HealthWierenga LM Ruigrok A Aksnes ER Barth C Beck D Burke S Crestol A van Drunen L et al.
Biological Psychiatry Global Open Science, Elsevier vol. 4 (2)
30-12-2023
Cardiometabolic health across menopausal years is linked to white matter hyperintensities up to a decade laterSchindler LS Subramaniapillai S Ambikairajah A Barth C Crestol A Voldsbekk I Beck D Gurholt TP et al.
Frontiers in Global Women's Health, Frontiers vol. 4
21-12-2023
Sex and gender in health research: Intersectionality mattersSubramaniapillai S Am Galea L Einstein G de Lange A-M
Frontiers in Neuroendocrinology, Elsevier vol. 72
28-10-2023
Sex steroids and the female brain across the lifespan: insights into risk of depression and Alzheimer's diseaseBarth C Crestol A de Lange A-MG Galea LAM
The Lancet Diabetes & Endocrinology, Elsevier vol. 11 (12), 926-941.
18-10-2023
Sex and gender in infection and immunity: addressing the bottlenecks from basic science to public health and clinical applicationsPasin C Consiglio CR Huisman JS de Lange A-MG Peckham H Vallejo-Yagüe E Abela IA Islander U et al.
Royal Society Open Science, The Royal Society vol. 10 (7)
01-07-2023
Development and validation of a dementia risk score in the UK Biobank and Whitehall II cohortsAnatürk M Patel R Ebmeier KP Georgiopoulos G Newby D Topiwala A de Lange A-MG Cole JH et al.
Bmj Mental Health, Bmj vol. 26 (1)
01-07-2023
Bio-psycho-social factors’ associations with brain age: a large-scale UK Biobank diffusion study of 35,749 participantsKorbmacher M Gurholt TP de Lange A-MG van der Meer D Beck D Eikefjord E Lundervold A Andreassen OA et al.
Frontiers in Psychology, Frontiers vol. 14
09-06-2023
Brain‐wide associations between white matter and age highlight the role of fornix microstructure in brain ageingKorbmacher M de Lange AM van der Meer D Beck D Eikefjord E Lundervold A Andreassen OA Westlye LT et al.
Human Brain Mapping, Wiley vol. 44 (10), 4101-4119.
17-05-2023
Genetic architecture of brain age and its causal relations with brain and mental disordersLeonardsen EH Vidal-Piñeiro D Roe JM Frei O Shadrin AA Iakunchykova O de Lange A-MG Kaufmann T et al.
Molecular Psychiatry, Springer Nature vol. 28 (7), 3111-3120.
10-05-2023
Topography of associations between cardiovascular risk factors and myelin loss in the ageing human brainTrofimova O Latypova A DiDomenicantonio G Lutti A de Lange A-MG Kliegel M Stringhini S Marques-Vidal P et al.
Communications Biology, Springer Nature vol. 6 (1)
10-04-2023
Linking brain maturation and puberty during early adolescence using longitudinal brain age prediction in the ABCD cohortHolm MC Leonardsen EH Beck D Dahl A Kjelkenes R de Lange A-MG Westlye LT
Developmental Cognitive Neuroscience, Elsevier vol. 60
22-02-2023
Shared pattern of impaired social communication and cognitive ability in the youth brain across diagnostic boundariesVoldsbekk I Kjelkenes R Wolfers T Dahl A Lund MJ Kaufmann T Fernandez-Cabello S de Lange A-MG et al.
Developmental Cognitive Neuroscience, Elsevier vol. 60
18-02-2023
Visual processing deficits in patients with schizophrenia spectrum and bipolar disorders and associations with psychotic symptoms, and intellectual abilitiesLøchen AR Kolskår KK de Lange A-MG Sneve MH Haatveit B Lagerberg TV Ueland T Melle I et al.
Heliyon, Elsevier vol. 9 (2)
01-02-2023
Associations between reproductive history, hormone use, APOE ε4 genotype and cognition in middle- to older-aged women from the UK BiobankLindseth LRS de Lange A-MG van der Meer D Agartz I Westlye LT Tamnes CK Barth C
Frontiers in Aging Neuroscience, Frontiers vol. 14
19-01-2023
2022
The link between liver fat and cardiometabolic diseases is highlighted by genome-wide association study of MRI-derived measures of body compositionvan der Meer D Gurholt TP Sønderby IE Shadrin AA Hindley G Rahman Z de Lange A-MG Frei O et al.
Communications Biology, Springer Nature vol. 5 (1)
19-11-2022
Longitudinal brain age prediction and cognitive function after strokeAamodt EB Alnæs D de Lange A-MG Aam S Schellhorn T Saltvedt I Beyer MK Westlye LT
Neurobiology of Aging, Elsevier vol. 122, 55-64.
29-10-2022
Cognitive and hippocampal changes weeks and years after memory trainingBråthen ACS Sørensen Ø de Lange A-MG Mowinckel AM Fjell AM Walhovd KB
Scientific Reports, Springer Nature vol. 12 (1)
12-05-2022
Sex‐ and age‐specific associations between cardiometabolic risk and white matter brain age in the UK Biobank cohortSubramaniapillai S Suri S Barth C Maximov II Voldsbekk I van der Meer D Gurholt TP Beck D et al.
Human Brain Mapping, Wiley vol. 43 (12), 3759-3774.
23-04-2022
Oxytocin receptor expression patterns in the human brain across developmentRokicki J Kaufmann T de Lange A-MG van der Meer D Bahrami S Sartorius AM Haukvik UK Steen NE et al.
Neuropsychopharmacology, Springer Nature vol. 47 (8), 1550-1560.
28-03-2022
Mind the gap: Performance metric evaluation in brain‐age predictionde Lange AG Anatürk M Rokicki J Han LKM Franke K Alnæs D Ebmeier KP Draganski B et al.
Human Brain Mapping, Wiley vol. 43 (10), 3113-3129.
21-03-2022
Adipose tissue distribution from body MRI is associated with cross-sectional and longitudinal brain age in adultsBeck D de Lange A-MG Alnæs D Maximov II Pedersen ML Leinhard OD Linge J Simon R et al.
Neuroimage Clinical, Elsevier vol. 33
01-01-2022
Associations between abdominal adipose tissue, reproductive span, and brain characteristics in post-menopausal womenSchindler LS Subramaniapillai S Barth C van der Meer D Pedersen ML Kaufmann T Maximov II Linge J et al.
Neuroimage Clinical, Elsevier vol. 36
01-01-2022
2021
Brain age prediction using fMRI network coupling in youths and associations with psychiatric symptomsLund MJ Alnæs D de Lange A-MG Andreassen OA Westlye LT Kaufmann T
Neuroimage Clinical, Elsevier vol. 33
20-12-2021
Oxytocin-pathway polygenic scores for severe mental disorders and metabolic phenotypes in the UK BiobankWinterton A Bettella F de Lange A-MG Haram M Steen NE Westlye LT Andreassen OA Quintana DS
Translational Psychiatry, Springer Nature vol. 11 (1)
25-11-2021
Cardiometabolic risk factors associated with brain age and accelerated brain ageingBeck D de Lange AG Pedersen ML Alnæs D Maximov II Voldsbekk I Richard G Sanders A et al.
Human Brain Mapping, Wiley vol. 43 (2), 700-720.
09-10-2021
Prominent health problems, socioeconomic deprivation, and higher brain age in lonely and isolated individuals: A population-based studyde Lange A-MG Kaufmann T Quintana DS Winterton A Andreassen OA Westlye LT Ebmeier KP
Behavioural Brain Research, Elsevier vol. 414
04-08-2021
A history of previous childbirths is linked to women's white matter brain age in midlife and older ageVoldsbekk I Barth C Maximov II Kaufmann T Beck D Richard G Moberget T Westlye LT et al.
Human Brain Mapping, Wiley vol. 42 (13), 4372-4386.
12-06-2021
Fast qualitY conTrol meThod foR derIved diffUsion Metrics (YTTRIUM) in big data analysis: U.K. Biobank 18,608 exampleMaximov II van der Meer D de Lange AG Kaufmann T Shadrin A Frei O Wolfers T Westlye LT
Human Brain Mapping, Wiley vol. 42 (10), 3141-3155.
31-03-2021
Apolipoprotein ɛ4 Status and Brain Structure 12 Months after Mild Traumatic Injury: Brain Age Prediction Using Brain Morphometry and Diffusion Tensor ImagingHellstrøm T Andelic N de Lange A-MG Helseth E Eiklid K Westlye LT
Journal of Clinical Medicine, Mdpi vol. 10 (3)
22-01-2021
In Vivo Amygdala Nuclei Volumes in Schizophrenia and Bipolar DisordersBarth C Nerland S de Lange A-MG Wortinger LA Hilland E Andreassen OA Jørgensen KN Agartz I
Schizophrenia Bulletin, Oxford University Press (OUP) vol. 47 (5), 1431-1441.
22-01-2021
Linking objective measures of physical activity and capability with brain structure in healthy community dwelling older adultsSanders A-M Richard G Kolskår K Ulrichsen KM Kaufmann T Alnæs D Beck D Dørum ES et al.
Neuroimage Clinical, Elsevier vol. 31
01-01-2021
2020
The scientific body of knowledge: Whose body does it serve? A spotlight on women’s brain healthde Lange A-MG Jacobs EG Galea LAM
Frontiers in Neuroendocrinology, Elsevier vol. 60
28-12-2020
Multimodal imaging improves brain age prediction and reveals distinct abnormalities in patients with psychiatric and neurological disordersRokicki J Wolfers T Nordhøy W Tesli N Quintana DS Alnæs D Richard G de Lange AG et al.
Human Brain Mapping, Wiley vol. 42 (6), 1714-1726.
19-12-2020
Prediction of brain age and cognitive age: Quantifying brain and cognitive maintenance in agingAnatürk M Kaufmann T Cole JH Suri S Griffanti L Zsoldos E Filippini N Singh‐Manoux A et al.
Human Brain Mapping, Wiley vol. 42 (6), 1626-1640.
14-12-2020
Within-session verbal learning slope is predictive of lifespan delayed recall, hippocampal volume, and memory training benefit, and is heritableWalhovd KB Bråthen ACS Panizzon MS Mowinckel AM Sørensen Ø de Lange A-MG Krogsrud SK Håberg A et al.
Scientific Reports, Springer Nature vol. 10 (1)
03-12-2020
White matter microstructure across the adult lifespan: A mixed longitudinal and cross-sectional study using advanced diffusion models and brain-age predictionBeck D de Lange A-MG Maximov II Richard G Andreassen OA Nordvik JE Westlye LT
Neuroimage, Elsevier vol. 224
09-10-2020
Women's brain aging: Effects of sex‐hormone exposure, pregnancies, and genetic risk for Alzheimer's diseasede Lange AG Barth C Kaufmann T Maximov II van der Meer D Agartz I Westlye LT
Human Brain Mapping, Wiley vol. 41 (18), 5141-5150.
28-08-2020
Multimodal brain-age prediction and cardiovascular risk: The Whitehall II MRI sub-studyde Lange A-MG Anatürk M Suri S Kaufmann T Cole JH Griffanti L Zsoldos E Jensen DEA et al.
Neuroimage, Elsevier vol. 222
21-08-2020
The maternal brain: Region‐specific patterns of brain aging are traceable decades after childbirthde Lange AG Barth C Kaufmann T Anatürk M Suri S Ebmeier KP Westlye LT
Human Brain Mapping, Wiley vol. 41 (16), 4718-4729.
07-08-2020
Brain Age Prediction Reveals Aberrant Brain White Matter in Schizophrenia and Bipolar Disorder: A Multisample Diffusion Tensor Imaging StudyTønnesen S Kaufmann T de Lange A-MG Richard G Doan NT Alnæs D van der Meer D Rokicki J et al.
Biological Psychiatry Cognitive Neuroscience and Neuroimaging, Elsevier vol. 5 (12), 1095-1103.
08-07-2020
Towards an understanding of women’s brain aging: the immunology of pregnancy and menopauseBarth C de Lange A-MG
Frontiers in Neuroendocrinology, Elsevier vol. 58
03-06-2020
Risk- and protective factors for memory plasticity in agingBråthen ACS De Lange A-MG Fjell AM Walhovd KB
Aging Neuropsychology and Cognition, Taylor & Francis vol. 28 (2), 201-217.
25-02-2020
Commentary: Correction procedures in brain-age predictionde Lange A-MG Cole JH
Neuroimage Clinical, Elsevier vol. 26
01-01-2020
2019
Self-reported Sleep Problems Related to Amyloid Deposition in Cortical Regions with High HOMER1 Gene ExpressionFjell AM Sederevicius D Sneve MH de Lange A-MG Bråthen AC Idland A-V Watne LO Wang Y et al.
Cerebral Cortex, Oxford University Press (OUP) vol. 30 (4), 2144-2156.
11-11-2019
Population-based neuroimaging reveals traces of childbirth in the maternal brainde Lange A-MG Kaufmann T van der Meer D Maglanoc LA Alnæs D Moberget T Douaud G Andreassen OA et al.
Proceedings of The National Academy of Sciences of The United States of America, Proceedings of The National Academy of Sciences vol. 116 (44), 22341-22346.
15-10-2019
2018
Multimodal cortical and hippocampal prediction of episodic‐memory plasticity in young and older adultsBråthen ACS de Lange AG Rohani DA Sneve MH Fjell AM Walhovd KB
Human Brain Mapping, Wiley vol. 39 (11), 4480-4492.
13-07-2018
The Temporal Dynamics of Brain Plasticity in Agingde Lange A-MG Bråthen ACS Rohani DA Fjell AM Walhovd KB
Cerebral Cortex, Oxford University Press (OUP) vol. 28 (5), 1857-1865.
27-02-2018
2017
The effects of memory training on behavioral and microstructural plasticity in young and older adultsde Lange AG Bråthen ACS Rohani DA Grydeland H Fjell AM Walhovd KB
Human Brain Mapping, Wiley vol. 38 (11), 5666-5680.
07-08-2017
2016
White matter integrity as a marker for cognitive plasticity in agingde Lange A-MG Bråthen ACS Grydeland H Sexton C Johansen-Berg H Andersson JLR Rohani DA Nyberg L et al.
Neurobiology of Aging, Elsevier vol. 47, 74-82.
15-07-2016
2015
Premises of plasticity — And the loneliness of the medial temporal lobeWalhovd KB Westerhausen R de Lange A-MG Bråthen ACS Grydeland H Engvig A Fjell AM
Neuroimage, Elsevier vol. 131, 48-54.
24-10-2015
Functional connectivity change across multiple cortical networks relates to episodic memory changes in agingFjell AM Sneve MH Grydeland H Storsve AB de Lange A-MG Amlien IK Røgeberg OJ Walhovd KB
Neurobiology of Aging, Elsevier vol. 36 (12), 3255-3268.
24-08-2015
Learning diverse and generic representations of the brain with large-scale multi-task pretrainingLeonardsen EH Dahl A Holm MC de Lange A-M Grødem EOS Marquand AF Sørensen Ø Schwarz E et al.
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