Dr Elisabeth Busch-Nentwich
Senior Lecturer in Organismal Biology
Deputy Head for the Centre for Evolutionary and Functional Genomics
School of Biological and Behavioural Sciences
Queen Mary University of London
Research
Functional Genomics, Disease Modelling, Developmental Biology
Interests
Embryonic development is an intricate process governed by gene-regulatory interactions that occur with spatial and temporal precision. Given the complexity, it can seem surprising how reliable this process is even when gene function is lost. Our research uses zebrafish and functional genomics approaches to study the underpinnings of phenotypic robustness during embryonic development. We are interested in understanding paralog interactions and gene expression plasticity.
We also use our large mutant collection to uncover disease mechanisms. One of our current projects investigates a newly identified neurodevelopmental disorder caused by de novo variants in a chromatin modifier.
For more information go to buschlab.org
Publications
Publications of specific relevance to the Centre for Brain and Behaviour
2024
Zebrafish are resilient to the loss of major diacylglycerol acyltransferase enzymesWilson MH Hensley MR Shen M-C Lu H-Y Quinlivan VH
Journal of Biological Chemistry,
Elsevier Bv, 107973-107973.
05-11-2024Pla2g12b drives expansion of triglyceride-rich lipoproteinsThierer JH Foresti O Yadav PK Wilson MH Moll TOC Shen M-C Busch-Nentwich EM Morash M et al.
Nature Communications,
Springer Nature vol. 15 (1), 2095-2095.
07-03-2024 Digenic inheritance involving a muscle-specific protein kinase and the giant titin protein causes a skeletal muscle myopathyTöpf A Cox D Zaharieva IT Di Leo V Sarparanta J Jonson PH Sealy IM Smolnikov A et al.
Nature Genetics,
Springer Nature vol. 56 (3), 395-407.
01-03-2024 Transcriptional profiling of zebrafish identifies host factors controlling susceptibility to Shigella flexneriTorraca V White RJ Sealy IM Mazon-Moya M Duggan G
Disease Models & Mechanisms,
The Company of Biologists vol. 17 (1)
01-01-2024 2023
Selenoprotein deficiency disorder predisposes to aortic aneurysm formationSchoenmakers E Marelli F Jørgensen HF Visser WE Moran C Groeneweg S Avalos C Jurgens SJ et al.
Nature Communications,
Springer Nature vol. 14 (1), 7994-7994.
02-12-2023 Gaucher disease protects against tuberculosisFan J Hale VL Lelieveld LT Whitworth LJ Busch-Nentwich EM Troll M Edelstein PH Roca FJ et al.
Proceedings of The National Academy of Sciences of The United States of America,
Proceedings of The National Academy of Sciences vol. 120 (7), e2217673120-e2217673120.
06-02-2023 P38 Mediates Tumor Suppression through Reduced Autophagy and Actin Cytoskeleton Changes in NRAS-Mutant MelanomaBanik I Ghosh A Beebe E Burja B Frank Bertoncelj M Dooley CM Markkanen E
Cancers,
Mdpi vol. 15 (3), 877-877.
31-01-2023 2022
Conserved roles for Hnf4 family transcription factors in zebrafish development and intestinal functionHeppert JK Lickwar CR Tillman MC Davis BR Lu H-Y Chen W
Genetics,
Oxford University Press (OUP) vol. 222 (4), iyac133-iyac133.
11-10-2022 mTOR-regulated mitochondrial metabolism limits mycobacterium-induced cytotoxicityPagán AJ Lee LJ Edwards-Hicks J Moens CB Busch-Nentwich EM Ramakrishnan L
Cell,
Elsevier vol. 185 (20), 3720-3738.e13.
01-09-2022 Loss of slc39a14 causes simultaneous manganese hypersensitivity and deficiency in zebrafishTuschl K White RJ Trivedi C Valdivia LE Niklaus S Dadswell C González-Méndez R Sealy IM
Disease Models and Mechanisms,
The Company of Biologists vol. 15 (6)
15-06-2022 Allele-specific gene expression can underlie altered transcript abundance in zebrafish mutantsWhite RJ Mackay E Wilson SW Busch-Nentwich EM
Elife,
Elife vol. 11
17-02-2022 Ankk1 Loss of Function Disrupts Dopaminergic Pathways in ZebrafishLeggieri A García-González J Torres-Perez JV Havelange W Hosseinian S Mech AM Keatinge M Busch-Nentwich EM et al.
Frontiers in Neuroscience,
Frontiers vol. 16
08-02-2022 Translational relevance of forward genetic screens in animal models for the study of psychiatric diseaseSheardown E Mech AM Petrazzini MEM Leggieri A Gidziela A Hosseinian S Sealy IM Torres-Perez JV et al.
Neuroscience and Biobehavioral Reviews,
Elsevier vol. 135
04-02-2022 Behavioral and Gene Regulatory Responses to Developmental Drug Exposures in ZebrafishMech AM Merteroglu M Sealy IM Teh M-T White RJ Havelange W Brennan CH Busch-Nentwich EM
Frontiers in Psychiatry,
Frontiers vol. 12
10-01-2022 Total Nucleic Acid Extraction from Single Zebrafish Embryos for Genotyping and RNA-seq.Wali N Merteroglu M White RJ Busch-Nentwich EM
Bio-Protocol,
Bio-Protocol vol. 12 (1)
01-01-2022
Research Group
PhD Students
- Srishti Arya
Transforming Meiofaunal Molecular Systematics and Community Ecology Through Nanopore-Based Transcriptomics. - Luisa Fernanda Cerda Osnaya
Molecular Genetic Mechanisms of Fibromyalgia - Yeahji Jeong
High Resolution Molecular Diagnostics to Improve Pollinator Health - Kite Jones
Functional Characterisation of Neuropeptides That Act as Ligands For Secretin-Type Receptors in An Echinoderm. - Pavol Kramár
Investigating Mechanisms of Functional Compensation Between Paralogous Genes in Embryonic Development - Joe Minus
Integrating Fossils and Genomes to Unravel The Pattern of Mammalian Diversification Through Time. - Zoe O'Neill
Epigenetic Determination of Phenotypic Plasticity in The Honey Bee - Tian Qiu
The Role of The Chromatin Modifier Kdm2aa in Melanoma Formation - Roudin Sarama
Human Genetic Adaptation to Pathogens During The Holocene as Unveiled by Ancient DNA and Machine Learning - Jingcheng Wei
The Evolution and Control of Early Spiral Cleavage - Haoran Zhang
The Role of Chromatin Instability Induced by Kdm2aa Mutations in Oogenesis and Tissue Regeneration
