Research
Cognition, Motivation, Neural Circuits, Functional Connectivity, Appetite, Memory
Interests
A good memory system is key to effective foraging. When searching for food animals are best served by remembering the location of different food sources (spatial memory), their nutritional content (appetitive memory) and the motor repertoire for securing and consuming a meal (motor memory) - all the while cautiously on the lookout for potential dangers that may have been previously experienced (fear memory). Foraging therefore is a key behaviour to gain insights into rodent cognition.
My research builds on the premise that cognition has evolved to meet the competitive demand for resources and that by investigating different memory systems one can shed light on the interplay between these systems for understanding decision-making. To do so we use advanced recording and manipulation tools in transgenic rodents to monitor and interrogate distinct neural circuits related to food seeking and memory. Our research takes a bottom-up approach where brain anatomy informs potential pathways for investigating function using advanced recording and neural manipulation techniques in behaving animals.
Publications

Publications of specific relevance to the Centre for Brain and Behaviour
2025
Dietary protein restriction in rats leads to a rapid within-session preference for proteinChiacchierini G Naneix F McCutcheon JE
Physiology & Behavior,
Elsevier vol. 295
01-04-20252023
Involvement of A13 dopaminergic neurons in prehensile movements but not reward in the ratGarau C Hayes J Chiacchierini G
Current Biology,
Elsevier vol. 33 (22), 4786-4797.e4.
09-10-20232022
Restriction of dietary protein in rats increases progressive-ratio motivation for proteinChiacchierini G Naneix F Apergis-Schoute J
Physiology & Behavior,
Elsevier vol. 254
11-06-20222021
Predictive and motivational factors influencing anticipatory contrast: A comparison of contextual and gustatory predictors in food restricted and free-fed ratsHayes J Garau C Chiacchierini G McCutcheon JE
Physiology & Behavior,
Elsevier vol. 242
23-09-2021
Protein appetite drives macronutrient-related differences in ventral tegmental area neural activityChiacchierini G Naneix F Peters KZ Apergis-Schoute J Snoeren EMS
Journal of Neuroscience,
Society For Neuroscience vol. 41 (23)
29-04-20212019
Editorial: Neuronal Co-transmissionApergis-Schoute J Burnstock G Nusbaum MP Morales MA
Frontiers in Neural Circuits,
Frontiers vol. 13
26-03-2019
General Principles of Neuronal Co-transmission: Insights From Multiple Model SystemsSvensson E Apergis-Schoute J Burnstock G Nusbaum MP
Frontiers in Neural Circuits,
Frontiers vol. 12
21-01-20192018
Basal Forebrain and Brainstem Cholinergic Neurons Differentially Impact Amygdala Circuits and Learning-Related BehaviorAitta-aho T Hay YA Saksida LM Bussey TJ Paulsen O Apergis-Schoute J
Current Biology,
Elsevier vol. 28 (16), 2557-2569.e4.
01-08-20182017
Cell Class-Dependent Intracortical Connectivity and Output Dynamics of Layer 6 Projection Neurons of the Rat Primary Visual CortexCotel F Fletcher LN Croft SK-D Apergis-Schoute J
Cerebral Cortex,
Oxford University Press (OUP) vol. 28 (7), 2340-2350.
07-06-2017
Accumbal Cholinergic Interneurons Differentially Influence Motivation Related to Satiety SignalingAitta-aho T Phillips BU Pappa E Harnischfeger F Heath CJ Saksida LM
Eneuro,
Society For Neuroscience vol. 4 (2), eneuro.0328-eneu16.2017.
01-03-20172016
Cellular activation of hypothalamic hypocretin/orexin neurons facilitates short-term spatial memory in miceAitta-aho T Pappa E Burdakov D
Neurobiology of Learning and Memory,
Elsevier vol. 136, 183-188.
13-10-2016
Sex difference in physical activity, energy expenditure and obesity driven by a subpopulation of hypothalamic POMC neuronsBurke LK Doslikova B D'Agostino G Greenwald-Yarnell M Georgescu T Chianese R Ogunnowo-Bada E Cansell C et al.
Molecular Metabolism,
Elsevier vol. 5 (3), 245-252.
22-01-20162015
Nicotinic α4 Receptor-Mediated Cholinergic Influences on Food Intake and Activity Patterns in Hypothalamic CircuitsGarcía AP Aitta-aho T Schaaf L Heuschmid L Apergis-Schoute J
Plos One,
Public Library of Science (Plos) vol. 10 (8)
06-08-2015
Optogenetic Evidence for Inhibitory Signaling from Orexin to MCH Neurons via Local MicrocircuitsApergis-Schoute J Iordanidou P Faure C Jego S Aitta-Aho T Adamantidis A
Journal of Neuroscience,
Society For Neuroscience vol. 35 (14), 5435-5441.
08-04-20152014
Left–right dissociation of hippocampal memory processes in miceShipton OA El-Gaby M Apergis-Schoute J Deisseroth K Kohl MM
Proceedings of The National Academy of Sciences of The United States of America,
Proceedings of The National Academy of Sciences vol. 111 (42), 15238-15243.
22-09-2014
Coreleased Orexin and Glutamate Evoke Nonredundant Spike Outputs and Computations in Histamine NeuronsSchöne C Apergis-Schoute J Sakurai T
Cell Reports,
Elsevier vol. 7 (3), 697-704.
24-04-20142012
Optogenetic Probing of Fast Glutamatergic Transmission from Hypocretin/Orexin to Histamine Neurons In SituSchöne C Cao ZFH Apergis-Schoute J Adamantidis A Burdakov D
Journal of Neuroscience,
Society For Neuroscience vol. 32 (36), 12437-12443.
05-09-20122011
Activation of Central Orexin/Hypocretin Neurons by Dietary Amino AcidsKarnani MM Apergis-Schoute J Adamantidis A Jensen LT de Lecea L Burdakov D
Neuron,
Elsevier vol. 72 (4), 616-629.
01-11-2011
Associative Properties of the Perirhinal NetworkUnal G Apergis-Schoute J Paré D
Cerebral Cortex,
Oxford University Press (OUP) vol. 22 (6), 1318-1332.
12-08-20112010
Methods for predicting cortical UP and DOWN states from the phase of deep layer local field potentialsSaleem AB Chadderton P Apergis-Schoute J
Journal of Computational Neuroscience,
Springer Nature vol. 29 (1-2), 49-62.
12-03-20102009
Maximum entropy decoding of multivariate neural spike trainsSeiler H Zhang Y Saleem AB Bream P
Bmc Neuroscience,
Springer Nature vol. 10 (Suppl 1)
13-07-20092008
Amygdala intercalated neurons are required for expression of fear extinctionLikhtik E Popa D Apergis-Schoute J Fidacaro GA
Nature,
Springer Nature vol. 454 (7204), 642-645.
01-07-20082007
Muscarinic Control of Long-Range GABAergic Inhibition within the Rhinal CorticesApergis-Schoute J Pinto A
Journal of Neuroscience,
Society For Neuroscience vol. 27 (15), 4061-4071.
11-04-20072006
Ultrastructural organization of medial prefrontal inputs to the rhinal corticesApergis‐Schoute J Pinto A Paré D
European Journal of Neuroscience,
Wiley vol. 24 (1), 135-144.
01-07-20062005
Interaction Between Amygdala and Neocortical Inputs in the Perirhinal CortexPelletier JG Apergis-Schoute J Paré D
Journal of Neurophysiology,
American Physiological Society vol. 94 (3), 1837-1848.
01-09-20052004
Low-Probability Transmission of Neocortical and Entorhinal Impulses Through the Perirhinal CortexPelletier JG Apergis J Paré D
Journal of Neurophysiology,
American Physiological Society vol. 91 (5), 2079-2089.
01-05-2004
Lesions in the bed nucleus of the stria terminalis disrupt corticosterone and freezing responses elicited by a contextual but not by a specific cue-conditioned fear stimulusSullivan GM Apergis J Bush DEA Johnson LR
Neuroscience,
Elsevier vol. 128 (1), 7-14.
01-01-20042003
Rodent doxapram model of panic: behavioral effects and c-Fos immunoreactivity in the amygdalaSullivan GM Apergis J Gorman JM
Biological Psychiatry,
Elsevier vol. 53 (10), 863-870.
01-05-20032001
Two different lateral amygdala cell populations contribute to the initiation and storage of memoryRepa JC Muller J Apergis J Desrochers TM
Nature Neuroscience,
Springer Nature vol. 4 (7), 724-731.
01-07-2001
Dietary protein restriction in rats leads to a rapid within-session preference for proteinChiacchierini G Naneix F Apergis-Schoute J McCutcheon JE
In
Biorxiv
Restriction of dietary protein in rats increases progressive-ratio motivation for proteinChiacchierini G Naneix F Apergis-Schoute J McCutcheon JE
In
Biorxiv
Basal forebrain and brainstem cholinergic neurons differentially impact amygdala circuits and learning-related behaviorAitta-aho T Hay YA Phillips BU Saksida LM Bussey TJ Paulsen O Apergis-Schoute J
In
Biorxiv
Predictive and motivational factors influencing anticipatory contrast: A comparison of contextual and gustatory predictors in food restricted and free-fed ratsHayes J Garau C Chiacchierini G Urcelay GP McCutcheon JE Apergis-Schoute J
In
Biorxiv
Protein appetite drives macronutrient-related differences in ventral tegmental area neural activityChiacchierini G Naneix F Peters KZ Apergis-Schoute J Snoeren EMS McCutcheon JE
In
Biorxiv
Electrophysiological characterization and MCH/orexin neuronal distribution in the lateral hypothalamus of naked mole-rats (Heterocephalus glaber)Husson Z Apergis-Schoute J Smith ESJ
In
Biorxiv