Dr Christopher Jones

Christopher Jones

Senior Lecturer

School of Physical and Chemical Sciences
Queen Mary University of London
ResearcherID ORCID Google Scholar LinkedIn X


Organic chemistry, Methodology development, Heterocyclic synthesis, Reactive intermediates (arynes), Functionalised carbon nanomaterials


We are interested in developing new synthetic organic methodology that has the potential to impact upon contemporary socioeconomic issues such as new drug discovery and the need to find more sustainable chemical feedstocks. As such, we aim to harness the high levels of reactivity of arynes, carbenes and radicals (“reactive intermediates”), as they afford unique and powerful opportunities to control challenging new chemical and biological processes. In our group we are particularly focused on exploiting aryne reactivity for the development of new synthetic strategies, in addition to exploring related applications in functional carbon nanomaterial preparation. Overall, we strive to facilitate the employment of cheap and abundant hydrocarbon sources within chemical processes and therefore reduce our reliance upon more limited and heavily functionalised starting materials.


Relevant PublicationPublications of specific relevance to the Centre for Chemical Research


Relevant PublicationLi Q, Xu Y, Pedersen A, Wang M, Zhang M, Feng J, Luo H, Titirici M and Jones CR (2023). Investigating the Role of Fe‐Pyrrolic N4 Configuration in the Oxygen Reduction Reaction via Covalently Bound Porphyrin Functionalized Carbon Nanotubes. Advanced Functional Materials, Wiley 
Relevant PublicationXu Y, Xie R, Li Q, Feng J, Luo H, Ye Q, Guo Z, Cao Y, Palma M, Chai G, Titirici MM and Jones CR (2023). Pyridine Functionalized Carbon Nanotubes: Unveiling the Role of External Pyridinic Nitrogen Sites for Oxygen Reduction Reaction. Small, Wiley 
Relevant PublicationIdiris FIM and Jones CR (2023). Rarely used strained molecules step up for organic synthesis. Nature, Springer Nature vol. 618 (7966), 683-685.  
Relevant PublicationSun W, Uttendorfer M, Idiris FIM, Werling AYR, Siddiq K and Jones CR (2023). Selective access to dihydrophenanthridines and phenanthridinones via cyclisation of aryl amines onto N -tethered arynes. Chemical Communications, Royal Society of Chemistry (RSC) vol. 59 (79), 11823-11826.  


bullet iconCao Y, Xu Y, Li Q, Rose R-S, Abrahams I, Jones CR and Sheriff TS (2022). Corrosion Inhibition and Disinfection of Heating and Cooling Water Systems Using In Situ Generated Hydrogen Peroxide. New Journal of Chemistry, Royal Society of Chemistry 
bullet iconYang Y and Jones CR (2022). The Aryne Ene Reaction. Synthesis, Thieme vol. 54 (22), 5042-5054.  


bullet iconFang L, Crespo-Otero R, Jones CR and Watkinson M (2021). Protect to detect: A Golgi apparatus targeted probe to image mobile zinc through the use of a lipophilic cell-labile protecting group strategy. Sensors and Actuators B: Chemical: international journal devoted to research and development of physical and chemical transducers, Elsevier vol. 338 
bullet iconNeal EA, Werling AYR and Jones CR (2021). A simple Hückel model-driven strategy to overcome electronic barriers to retro-Brook silylation relevant to aryne and bisaryne precursor synthesis. Chem Commun (Camb) 


bullet iconFang L, Trigiante G, Crespo-Otero R, Philpott MP, Jones CR and Watkinson M (2019). An alternative modular 'click-SNAr-click' approach to develop subcellular localised fluorescent probes to image mobile Zn2+ . Organic and Biomolecular Chemistry, Royal Society of Chemistry 
bullet iconFang L, Trigiante G, Crespo-Otero R, Hawes CS, Philpott M, Jones CR and Watkinson M (2019). Endoplasmic reticulum targeting fluorescent probes to image mobile Zn2+. Chemical Science, Royal Society of Chemistry (RSC) 
bullet iconYang Y, Xu Y and Jones C (2019). A Ring Expansion Route to Benzofused N-Heterocycles via Aryne Insertion into 1,3-Diaza-heterocycles. European Journal of Organic Chemistry, Wiley 
Relevant PublicationClement P, Trinchera P, Cervantes-Salguero K, Ye Q, Jones CR and Palma M (2019). One‐step chemical strategy for the formation of carbon nanotube junctions in aqueous solution: The Reaction of DNA‐WrappedCarbon Nanotubes with Diazonium Salts. ChemPlusChem, Wiley 


bullet iconJONES CR, TRINCHERA P, SUN W, kurdi N, Crespo-Otero R, Palomas D, Javid F and Saeed A (2018). Aryne-Mediated Arylation of Hantzsch Esters: Access to Highly Substituted Aryl-dihydropyridines, Aryl-tetrahydropyridines and Spiro[benzocyclobutene-1,1′-(3′,4′-dihydropyridines)]. SYNTHESIS, Thieme Publishing vol. 50 (23) 
bullet iconJONES CR, IDIRIS F, Majesté C and Craven G (2018). Intramolecular hydride transfer onto arynes: redox-neutral and transition metal-free C(sp3)-H functionalization of amines. Chemical Science, Royal Society of Chemistry 


bullet iconJONES CR and Idiris FIM (2017). Recent advances in fluoride-free aryne generation from arene precursors., Editors: Yu J-Q. Organic & Biomolecular Chemistry, Royal Society of Chemistry 
bullet iconJONES CR, Trinchera P, Sun W, Smith JE, Palomas D and Crespo-Otero R (2017). Intermolecular Aryne Ene Reaction of Hantzsch Esters: Stable Co-valent Ene Adducts from a 1,4-Dihydropyridine Reaction., Editors: Molander G. Organic Letters, American Chemical Society 


bullet iconFerguson MD, Donohoe TJ and Jones CR (2014). Lithium 4,4′‐Di‐tert‐butylbiphenylide. Encyclopedia of Reagents for Organic Synthesis  1-11.  
bullet iconDonohoe TJ, Jones CR, Kornahrens AF, Barbosa LCA, Walport LJ, Tatton MR, O'Hagan M, Rathi AH and Baker DB (2014). ChemInform Abstract: Total Synthesis of the Antitumor Antibiotic (.+‐.)‐Streptonigrin: First‐ and Second‐Generation Routes for de Novo Pyridine Formation Using Ring‐Closing Metathesis. ChemInform, Wiley vol. 45 (21), no-no.  
bullet iconDonohoe TJ, Jones CR and Winter C (2014). 8.22 Partial and Complete Reduction of Pyrroles, Furans, Thiophenes, and their Benzo Analogs, Heterocycles Containing More Than One Heteroatom. Comprehensive Organic Synthesis II  794-837.  


bullet iconDonohoe TJ, Jones CR, Kornahrens AF, Barbosa LCA, Walport LJ, Tatton MR, O'Hagan M, Rathi AH and Baker DB (2013). Total synthesis of the antitumor antibiotic (±)-streptonigrin: first- and second-generation routes for de novo pyridine formation using ring-closing metathesis. J Org Chem vol. 78 (24), 12338-12350.  


bullet iconDonohoe TJ, O’Riordan TJC, Peifer M, Jones CR and Miles TJ (2012). Asymmetric Synthesis of the Fully Elaborated Pyrrolidinone Core of Oxazolomycin A. Organic Letters, American Chemical Society (ACS) vol. 14 (21), 5460-5463.  
bullet iconJones CR, Baruah PK, Thompson AL, Scheiner S and Smith MD (2012). Can a C-H•••O interaction be a determinant of conformation? Journal of the American Chemical Society vol. 134 (29), 12064-12071.  
bullet iconNeier R, Journot G, R. Jones C and Blangy V (2012). The Hydrogenation of Heterocyclic Calix[4]arenes, a Transformation Leading to Novel Macrocyclic Ligands. Heterocycles, The Japan Institute of Heterocyclic Chemistry vol. 85 (4) 


bullet iconDonohoe TJ, Jones CR and Barbosa LCA (2011). Total Synthesis of (±)-Streptonigrin: De Novo Construction of a Pentasubstituted Pyridine using Ring-Closing Metathesis. Journal of the American Chemical Society, American Chemical Society (ACS) vol. 133 (41), 16418-16421.  


bullet iconJones CR, Dan Panto G, Morrison AJ and Smith MD (2009). Plagiarizing proteins: enhancing efficiency in asymmetric hydrogenbonding catalysis through positive cooperativity. Angewandte Chemie - International Edition vol. 48 (40), 7391-7394.  
bullet iconJones CR, Pantoş GD, Morrison AJ and Smith MD (2009). Plagiarizing Proteins: Enhancing Efficiency in Asymmetric Hydrogen‐Bonding Catalysis through Positive Cooperativity. Angewandte Chemie, Wiley vol. 121 (40), 7527-7530.  


bullet iconJones CR, Qureshi MKN, Truscott FR, Hsu STD, Morrison AJ and Smith MD (2008). A nonpeptidic reverse turn that promotes parallel sheet structure stabilized by C-H⋯O hydrogen bonds in a cyclopropane γ-peptide. Angewandte Chemie - International Edition vol. 47 (37), 7099-7102.  
bullet iconJones CR, Qureshi MKN, Truscott FR, Hsu SD, Morrison AJ and Smith MD (2008). A Nonpeptidic Reverse Turn that Promotes Parallel Sheet Structure Stabilized by CH⋅⋅⋅O Hydrogen Bonds in a Cyclopropane γ‐Peptide. Angewandte Chemie, Wiley vol. 120 (37), 7207-7210.  


solid heart iconGrants of specific relevance to the Centre for Chemical Research
solid heart iconInnovations in ADC linker design - PhD studentship (AstraZeneca)
Christopher Jones and Stellios Arseniyadis
£60,000 AZ AstraZeneca UK Limited (18-09-2023 - 17-09-2027)
solid heart iconPAK UK Education Gateway Mobility Partnership for Faculty
Alan Drew, Maria Crespo Ribadeneyra, Annalisa Bruno, Devis Di Tommaso, Edo Boek, Mahdieh Sadabadi, Paul Balcombe and Christopher Jones
£26,500 British Council (01-04-2023 - 30-06-2024)