Prof Maurice Elphick

Maurice Elphick

Professor of Animal Physiology and Neuroscience

School of Biological and Behavioural Sciences
Queen Mary University of London
www.qmul.ac.uk/sbbs/staff/mauriceelphick.html
Centre for Evolutionary and Functional Genomics
Centre for Biodiversity and Sustainability
Centre for Brain and Behaviour
Centre for Molecular Cell Biology
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Research

Neuropeptide, Evolution, Neurobiology, Echinoderm, Physiology

Interests

Neuropeptides and peptide hormones have fundamental roles in controlling, regulating and integrating physiological and behavioural processes in humans and other animals. I am interested in reconstructing the evolutionary history of neuropeptide signalling systems and investigating how neuropeptides are utilised to co-ordinate physiological processes and behaviour in animals. The primary focus of my neuropeptide research is on echinoderms (e.g. starfish, sea urchins), which are of special interest for a number of reasons. As deuterostomes, echinoderms are more closely related to vertebrates than the majority of invertebrates, and therefore research on echinoderms can shed light on the evolutionary origins of vertebrate neuropeptides. Echinoderms also have many remarkable morphological and physiological characteristics – they are typically five-sided and have a unique ability to rapidly change (under neural control) the stiffness of their body wall collagenous tissue; they also have amazing powers of regeneration, which makes them of great interest from a medical perspective. Facilitated by the recent advances in transcriptome and genome sequencing and using the common European starfish Asterias rubens and other echinoderms as experimental animals, our research is providing “missing links” in our understanding of neuropeptide biology, bridging the huge evolutionary gap between protostome invertebrates (e.g. Drosophila, C. elegans) and the vertebrates. For example, our paper published recently in PNAS provided important new insights into the evolution and physiological roles of bombesin-type neuropeptide signalling (doi.org/10.1073/pnas.2420966122).