Dr Aravindan Ilangovan
Reader in Structural Biology
School of Biological and Behavioural Sciences
Queen Mary University of London
Queen Mary University of London
Research
Protein-nucleic acid complexes, Helicases, Cryogenic Electron Microscopy
Interests
Further details can be found in our lab website; www.ilangovan-lab.comPublications
Publications of specific relevance to the Centre for Molecular Cell Biology2025
Cryo-EM Structure of the relaxosome, a complex essential for bacterial mating and the spread of antibiotic resistance genesWilliams SM Raffl S Kienesberger S Ilangovan A Zechner EL Waksman G
Nature Communications, Springer Nature vol. 16 (1)
27-05-2025
2024
Functionality of chimeric TssA proteins in the type VI secretion system reveals sheath docking specificity within their N-terminal domainsFecht S Paracuellos P Subramoni S Tan CAZ Ilangovan A Costa TRD Filloux A
Nature Communications, Springer Nature vol. 15 (1)
20-05-2024
2023
The bacterial replication origin BUS promotes nucleobase capturePelliciari S Bodet-Lefèvre S Fenyk S Stevens D Winterhalter C Schramm FD Pintar S Burnham DR et al.
Nature Communications, Springer Nature vol. 14 (1)
14-12-2023
Higher-order cryo-EM structures of the full tetrameric type II topoisomerase with bound 18mer dsDNANajmudin S Pan X-S Beavil AJ Cronin NB Ilangovan A Fisher LM Sanderson MR
Acta Crystallographica Section a: Foundations and Advances, International Union of Crystallography (Iucr) vol. 79 (a2), c702-c702.
22-08-2023
The DNA replication initiation protein DnaD recognises a specific strand of the Bacillus subtilis chromosome originWinterhalter C Pelliciari S Stevens D Fenyk S Marchand E Cronin NB Soultanas P Costa TRD et al.
Nucleic Acids Research, Oxford University Press vol. 51 (9), 4322-4340.
22-05-2023
2022
SirA inhibits the essential DnaA:DnaD interaction to block helicase recruitment during Bacillus subtilis sporulationWinterhalter C Stevens D Fenyk S Pelliciari S Marchand E Soultanas P Ilangovan A Murray H
Nucleic Acids Research, Oxford University Press vol. 51 (9), 4302-4321.
23-11-2022
2021
Architecture of the outer-membrane core complex from a conjugative type IV secretion systemAmin H Ilangovan A Costa TRD
Nature Communications, Nature Research vol. 12 (1)
25-11-2021
Cryoelectron-microscopy structure of the enteropathogenic Escherichia coli type III secretion system EspA filament.Zheng W Peña A Ilangovan A Clark JN-B Frankel G Egelman EH Costa TRD
Proc Natl Acad Sci U S A vol. 118 (2)
12-01-2021
2017
Cryo-EM Structure of a Relaxase Reveals the Molecular Basis of DNA Unwinding during Bacterial ConjugationIlangovan A Kay CWM Roier S Mkami HE Salvadori E Zechner EL Zanetti G Waksman G
Cell, Elsevier vol. 169 (4), 708-721.e12.
27-04-2017
2016
Structure of the Bacterial Sex F Pilus Reveals an Assembly of a Stoichiometric Protein-Phospholipid ComplexCosta TRD Ilangovan A Ukleja M Redzej A Santini JM Smith TK Egelman EH Waksman G
Cell, Elsevier vol. 166 (6), 1436-1444.e10.
01-09-2016
2015
Structural biology of the Gram-negative bacterial conjugation systemsIlangovan A Connery S Waksman G
Trends in Microbiology, Elsevier vol. 23 (5), 301-310.
27-03-2015
2013
Structure of a translocation signal domain mediating conjugative transfer by type IV secretion systemsRedzej A Ilangovan A Lang S Gruber CJ Topf M Zangger K Zechner EL Waksman G
Molecular Microbiology, Wiley vol. 89 (2), 324-333.
14-06-2013
Structural Basis for Native Agonist and Synthetic Inhibitor Recognition by the Pseudomonas aeruginosa Quorum Sensing Regulator PqsR (MvfR)Ilangovan A Fletcher M Rampioni G Pustelny C Rumbaugh K Heeb S Cámara M Truman A et al.
Plos Pathogens, Public Library of Science (Plos) vol. 9 (7)
01-01-2013
Cryo-EM Structure of the relaxosome, a complex essential for bacterial mating and the spread of antibiotic resistance genesWilliams SM Raffl S Kienesberger S Ilangovan A Zechner EL Waksman G
In Biorxiv
Positive and negative control of helicase recruitment at a bacterial chromosome originWinterhalter C Stevens D Fenyk S Pelliciari S Marchand E Cronin NB Soultanas P Costa TRD et al.
In Biorxiv
SirA inhibits the essential DnaA:DnaD interaction to block helicase recruitment during Bacillus subtilis sporulationWinterhalter C Stevens D Fenyk S Pelliciari S Marchand E Soultanas P Ilangovan A Murray H
In Biorxiv
The DNA replication initiation protein DnaD is recruited to a specific strand of the Bacillus subtilis chromosome originWinterhalter C Pelliciari S Stevens D Fenyk S Marchand E Cronin NB Soultanas P Costa TRD et al.
In Biorxiv
Functionality of chimeric TssA proteins in the type VI secretion system involves sheath docking specifictyFecht S Paracuellos P Ilangovan A Costa T Filloux A
In Research Square
Grants
Grants of specific relevance to the Centre for Molecular Cell BiologyRegulation of linear ubiquitin signaling in innate immunityBenjamin Stieglitz and Aravindan Ilangovan
£661,348 MRC Medical Research Council
01-03-2024 - 28-02-2027
Molecular mechanism of DNA processing for antibiotic resistance gene transfer in bacteriaAravindan Ilangovan
£517,030 BBSRC Biotechnology and Biological Sciences Research Council
01-11-2023 - 31-10-2026
Molecular mechanisms for loading the bacterial replicative helicaseAravindan Ilangovan
£1,329,649 Wellcome Trust
01-01-2023 - 31-12-2030
Understanding the molecular mechanism of antibiotic resistance gene transfer in bacteriaAravindan Ilangovan
£99,467 Academy of Medical Sciences
01-06-2022 - 30-11-2024
Research Group
Research Staff
PhD Students
- Luz Garcia Valencia
Cryo-EM Studies of Bacterial DNA Replication Initiation Mechanism. Towards Novel Antibiotic Discovery - Shaf Moradian
Bursty Gene Expression and Noisy Cells: Mechanistic Insights Into The Role of Premature Transcription Termination in Single-Cell Dynamics - Kaichen Peng
Structural Studies of Bacterial DNA Replication Initiation Mechanism Using Cryo Electron Microscopy (Cryo-EM) and Novel Antibiotic Discovery - James Rayner
Mathematical Modelling, Imaging, and Image Analysis of Bacterial Cell Shape Change in Response to Antibiotic Stress - Nasrin Sultana
In Vitro Reconstitution of Lubac: Regulation and Control of Linear Ubiquitin Chain Synthesis Activity
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