Dr Vladimir Volkov
Senior Lecturer in Physiology
School of Biological and Behavioural Sciences
Queen Mary University of London
Research
cell division, kinetochore, microtubules, cytoskeleton, multivalency, cryoET
Interests
Microtubules are dynamic biopolymers exerting forces when they grow or shorten. These forces are important in various contexts in living cells, such as during cell division, when microtubule ends attach to chromosomes and help them segregate to daughter cells. Microtubule ends transmit forces to cellular structures using teams of coupling protein molecules. Our research is focused on molecular and mechanical mechanisms by which these protein teams assemble and transmit the forces to cellular structures.
Publications of specific relevance to the Centre for Molecular Cell Biology
Publications of specific relevance to the Centre for Molecular Cell Biology
2023
Stable kinetochore‐microtubule attachment requires loop‐dependent Ndc80‐Ndc80 bindingPolley S, Müschenborn H, Terbeck M, De Antoni A, Vetter IR, Dogterom M, Musacchio A,
Volkov VA and Veld PJHIT
The Embo Journal,
Springer Nature vol. 42 (13), e112504-e112504.
19-05-20232022
Multivalent interactions facilitate motor-dependent protein accumulation at growing microtubule plus-endsMaan R, Reese L,
Volkov VA, King MR, van der Sluis EO, Andrea N, Evers WH, Jakobi AJ and Dogterom M
Nature Cell Biology,
Nature Research 19-12-2022 Estimation of microtubule-generated forces using a DNA origami nanospringNick Maleki A, Huis In 't Veld PJ, Akhmanova A, Dogterom M and
Volkov VA Journal of Cell Science,
The Company of Biologists vol. 136 (5)
05-10-2022 2019
Molecular determinants of the Ska-Ndc80 interaction and their influence on microtubule tracking and force-couplingVeld PJHIT,
Volkov VA, Stender ID, Musacchio A and Dogterom M
Elife,
Elife vol. 8
05-12-2019 2018
Multivalency of NDC80 in the outer kinetochore is essential to track shortening microtubules and generate forcesVolkov VA, Veld PJHIT, Dogterom M and Musacchio A
Elife,
Elife vol. 7
09-04-2018 2013
Long tethers provide high-force coupling of the Dam1 ring to shortening microtubulesVolkov VA, Zaytsev AV, Gudimchuk N, Grissom PM, Gintsburg AL, Ataullakhanov FI, McIntosh JR and Grishchuk EL
Proceedings of The National Academy of Sciences of The United States of America,
Proceedings of The National Academy of Sciences vol. 110 (19), 7708-7713.
22-04-2013
Grants
Grants of specific relevance to the Centre for Molecular Cell Biology
Career Development Award: Structural and mechanistic understanding of kinetochore-mediated control of microtubule dynamicsVladimir Volkov£2,044,077
Wellcome Trust01-01-2025 - 31-12-2032 Cooperativity and forces in molecular interactions governing chromosome stabilityVladimir Volkov and
Viji Draviam Sastry£717,413
Biotechnology and Biological Sciences Research Council20-11-2023 - 28-12-2026
Research Group
Research Staff
