Prof David Lee

David Lee
BSc (Hons), MA, PhD

Professor of Cell and Tissue Engineering
Deputy Vice Principal - Impact (Enterprise and Commercial Innovation)

School of Engineering and Materials Science
Queen Mary University of London

Research

Mechanobiology, Tissue engineering, Cell engineering, Regenerative medicine, Mesenchymal stem cell, Circadian biology

Interests

My main research interests lie in mechanobiology, a research field that lies at the interface between cell biology and bioengineering, involving studying the mechanisms by which cells and tissues resond to the application of mechanical loading. The response of our tissues to mechanical stimuli is critical to maintain healthy physiology and has been implicated in a range of pathologies, ranging from cancer to osteoarthritis. I have published over 100 refereed papers in chondrocyte and stem cell mechanobiology and my work investigating the effect of dynamic compression on inflammatory mediators was recognised by the prestigious Negma Lerads International Prize for Mechanobiology of Cartilage and Chondrocytes. I have been awarded over £5 million in grant funding as principal investigator in the past 10 years, including from the MRC, BBSRC, ESPRC, Wellcome Trust and an international multi-centre Human Frontier Science Program grant investigating mechanoregulation of nuclear organisation and genome function.

My research has largely focussed on musculoskeletal tissues, particularly cartilage and tendon. I have looked at the process by which mechanical forces become transduced into biochemical pathways, for example those linked to MAP kinases and calcium fluxes across the cell membrane. Recent work has looked at stem cells and whether they can be induced to differentiate through mechanical stimuli. My work on mesenchymal stem cells has shown that the application of mechanical force can induce more rapid and robust differentiation than traditional biochemical differentiation cues such as growth factors. Loading seems to have a particularly profound effect on the cell nucleus, inducing alterations in the packing of DNA within chromatin and stiffening the nuclear membrane through changes in the nucleoskeleton.

Recently research has investigated the interplay between mechanobiology and the circadian clock which generates 24-hour cycles of biological activity. These studies are aimed at developing more physiologically relevant in vitro models, for example organ-on-a-chip systems, that may be used in drug discovery and other applications.

Publications

solid heart iconPublications of specific relevance to the Centre for Bioengineering

2022

Relevant PublicationHeywood HK, Thorpe SD, Jeropoulos RM, Caton PW and Lee DA (2022). Modulation of sirtuins during monolayer chondrocyte culture influences cartilage regeneration upon transfer to a 3D culture environment. Frontiers in Bioengineering and Biotechnology, Frontiers Media vol. 10 
06-12-2022
Relevant PublicationHeywood HK, Gardner L, Knight MM and Lee DA (2022). Oscillations of the circadian clock protein, BMAL-1, align to daily cycles of mechanical stimuli: a novel means to integrate biological time within predictive in vitro model systems. In vitro models, Springer Nature, 1-8.  
31-08-2022
Relevant PublicationBrookes O, Thorpe SD, Evans OR, Keeling MC and Lee DA (2022). Covariation of Pluripotency Markers and Biomechanical Properties in Mouse Embryonic Stem Cells. Frontiers in Cell and Developmental Biology, Frontiers vol. 10 
16-05-2022

2021

Relevant PublicationLachowski D, Cortes E, Matellan C, Rice A, Lee DA, Thorpe SD and del Río Hernández AE (2021). G Protein-Coupled Estrogen Receptor Regulates Actin Cytoskeleton Dynamics to Impair Cell Polarization. Frontiers in Cell and Developmental Biology, Frontiers Media vol. 8, 592628-592628.  
22-01-2021

2020

Relevant PublicationRice A, Cortes E, Lachowski D, Oertle P, Matellan C, Thorpe SD, Ghose R, Wang H, Lee DA, Plodinec M and Del Río Hernández AE (2020). GPER activation inhibits cancer cell mechanotransduction and basement membrane invasion via RhoA. Cancers, MDPI AG vol. 12 (2) 
25-01-2020
Relevant PublicationThorpe S, Chronopoulos A, Cortes E, Lachowski D, Rice A, Mykuliak V, Róg T, Lee D, Hytonen V and del Río Hernández A (2020). Syndecan-4 tunes cell mechanics by activating the kindlin-integrin-RhoA pathway. Nature Materials, Nature Research 
06-01-2020

2018

Relevant PublicationCortes E, Lachowski D, Rice A, THORPE SD, Robinson B, Yeldag G, LEE DA, Ghemtio L, Rombouts K and del Río Hernández AE (2018). Tamoxifen mechanically deactivates hepatic stellate cells via the G protein-coupled estrogen receptor. Oncogene, Springer Nature [academic journals on nature.com] 
21-12-2018
Relevant PublicationCortes E, Lachowski D, Robinson B, Sarper M, Teppo JS, Thorpe SD, Lieberthal TJ, Iwamoto K, Lee DA, Okada‐Hatakeyama M, Varjosalo MT and del Río Hernández AE (2018). Tamoxifen mechanically reprograms the tumor microenvironment via HIF‐1A and reduces cancer cell survival. EMBO Reports, Springer Nature vol. 20 (1) 
12-12-2018
Relevant PublicationCortes E, Sarper M, Robinson B, Lachowski D, Chronopoulos A, Thorpe SD, Lee DA and del Río Hernández AE (2018). GPER is a mechanoregulator of pancreatic stellate cells and the tumor microenvironment. EMBO Reports, Springer Nature vol. 20 (1) 
11-12-2018
Relevant PublicationCortes E, Lachowski D, Rice A, Chronopoulos A, Robinson B, THORPE SD, LEE DA, Possamai LA, Wang H, Pinato DJ and del Rio Hernández AE (2018). RAR‐β is downregulated in HCC & cirrhosis and its expression inhibits myosin‐driven activation and durotaxis in hepatic stellate cells. Hepatology, Wiley 
28-07-2018

2017

Relevant PublicationElyasigomari V, Lee DA, Screen HRC and SHAHEED MH (2017). Development of a two-stage gene selection method that incorporates a novel hybrid approach using the cuckoo optimization algorithm and harmony search for cancer classification. Journal of Biomedical Informatics vol. 67 (2017), 11-20.  
03-02-2017
Relevant PublicationTHORPE SD and Lee DA (2017). Dynamic regulation of nuclear architecture and mechanics—a rheostatic role for the nucleus in tailoring cellular mechanosensitivity. Nucleus, Taylor & Francis vol. 8 (3), 287-300.  
02-02-2017
Relevant PublicationThorpe SD, Oti A, Mauck RL and Lee DA (2017). Stem cell differentiation state modulates Lamin AC localization and phosphorylation in response to cyclic tensile strain. 
01-01-2017
Relevant PublicationEraifej J, Thorpe SD, Martins RP and Lee DA (2017). Does lamin A/C play a role in neuronal differentiation? 
01-01-2017
Relevant PublicationHeywood HK, Thorpe SD, Jeropoulos RM and Lee DA (2017). Small molecule activators of SIRT1 augment the regenerative potential of chondrocytes for cell-based cartilage repair techniques. 
01-01-2017
Relevant PublicationPanesar KS, Thorpe SD and Lee DA (2017). Uniaxial tensile strain modulates mesenchymal stem cell nuclear structure and histone methylation in a differentiation dependent manner. 
01-01-2017

2016

Relevant PublicationHeo S-J, Driscoll TP, Thorpe SD, Nerurkar NL, Baker BM, Yang MT, Chen CS, Lee DA and Mauck RL (2016). Differentiation alters stem cell nuclear architecture, mechanics, and mechano-sensitivity. eLife, eLife Sciences Publications Ltd vol. 5 
30-11-2016
Relevant PublicationTilwani RK, Vessillier S, Pingguan-Murphy B, Lee DA, Bader DL and Chowdhury TT (2016). Oxygen tension modulates the effects of TNFα in compressed chondrocytes. Inflamm Res 
22-09-2016
Relevant PublicationHeo SJ, Han WM, Szczesny SE, Cosgrove BD, Elliott DM, Lee DA, Duncan RL and Mauck RL (2016). Mechanically Induced Chromatin Condensation Requires Cellular Contractility in Mesenchymal Stem Cells. Biophysical Journal vol. 111 (4), 864-874.  
23-08-2016
Relevant PublicationHeywood HK and Lee DA (2016). Bioenergetic reprogramming of articular chondrocytes by exposure to exogenous and endogenous reactive oxygen species and its role in the anabolic response to low oxygen. Journal of Tissue Engineering and Regenerative Medicine vol. 11 (8), 2286-2294.  
22-06-2016
Relevant PublicationSliogeryte K, Botto L, Lee DA and Knight MM (2016). Chondrocyte dedifferentiation increases cell stiffness by strengthening membrane-actin adhesion. Osteoarthritis and Cartilage, Elsevier vol. 24 (5), 912-920.  
01-05-2016
Relevant PublicationLee D (2016). States rights and Australia’s adoption of the statute of Westminster, 1931–1942. History Australia, Taylor & Francis vol. 13 (2), 258-274.  
02-04-2016
Relevant PublicationTheocharidis G, Drymoussi Z, Kao AP, Barber AH, Lee DA, Braun KM and Connelly JT (2016). Type VI Collagen Regulates Dermal Matrix Assembly and Fibroblast Motility. Journal of Investigative Dermatology, Elsevier vol. 136 (1), 74-83.  
01-01-2016
Relevant PublicationTheocharidis G, Drymoussi Z, Kao AP, Barber AH, Lee DA, Braun KM and Connelly JT (2016). Type VI Collagen Regulates Dermal Matrix Assembly and Fibroblast Motility. J Invest Dermatol vol. 136 (1), 74-83.  
01-01-2016
Relevant PublicationHeywood HK, Caton PW and Lee DA (2016). SIRT1, an enzyme vital to cartilage homeostasis, is regulated by osmolarity and glucose levels. 
01-01-2016

2015

Relevant PublicationHeo S-J, Thorpe SD, Driscoll TP, Duncan RL, Lee DA and Mauck RL (2015). Biophysical Regulation of Chromatin Architecture Instills a Mechanical Memory in Mesenchymal Stem Cells. Scientific Reports, Springer Nature vol. 5 (1) 
23-11-2015
Relevant PublicationCHEN J, BADER DL, LEE DA and KNIGHT MM (2015). FINITE ELEMENT ANALYSIS OF MECHANICAL DEFORMATION OF CHONDROCYTE TO 2D SUBSTRATE AND 3D SCAFFOLD. Journal of Mechanics in Medicine and Biology, World Scientific Publishing vol. 15 (05) 
01-10-2015

2014

Relevant PublicationSliogeryte K, Thorpe SD, Lee DA, Botto L and Knight MM (2014). Stem cell differentiation increases membrane-actin adhesion regulating cell blebability, migration and mechanics. Scientific Reports, Springer Nature vol. 4 (1) 
04-12-2014
Relevant PublicationIrianto J, Lee DA and Knight MM (2014). Quantification of chromatin condensation level by image processing. Med Eng Phys vol. 36 (3), 412-417.  
01-03-2014
Relevant PublicationHeywood HK, Nalesso G, Lee DA and Dell'accio F (2014). Culture expansion in low-glucose conditions preserves chondrocyte differentiation and enhances their subsequent capacity to form cartilage tissue in three-dimensional culture. Biores Open Access vol. 3 (1), 9-18.  
01-02-2014
Relevant PublicationThorpe SD and Lee DA (2014). Mesenchymal stem cell nuclear architecture is differentially regulated by lineage commitment and mechanical stimulation. 
01-01-2014
Relevant PublicationHeywood HK and Lee DA (2014). Reactive oxygen species drive the transformation to an oxidative energy metabolism in cultured articular chondrocytes. 
01-01-2014
Relevant PublicationTilwani RK, Lee DA, Pingguan-Murphy B, Abas WABW and Chowdhury TT (2014). Hypoxia amplified catabolic effects induced by TNFα in chondrocytes - response reduced with biomechanical signals. 
01-01-2014

2013

Relevant PublicationIrianto J, Swift J, Martins RP, McPhail GD, Knight MM, Discher DE and Lee DA (2013). Osmotic challenge drives rapid and reversible chromatin condensation in chondrocytes. Biophys J vol. 104 (4), 759-769.  
19-02-2013
Relevant PublicationPattappa G, Thorpe SD, Jegard NC, Heywood HK, de Bruijn JD and Lee DA (2013). Continuous and Uninterrupted Oxygen Tension Influences the Colony Formation and Oxidative Metabolism of Human Mesenchymal Stem Cells. TISSUE ENGINEERING PART C-METHODS vol. 19 (1) 
01-01-2013
Relevant PublicationLee D (2013). Reluctant relaxation. History Australia, Taylor & Francis vol. 10 (3), 149-170.  
01-01-2013

2012

Relevant PublicationSillitoe I, Cuff AL, Dessailly BH, Dawson NL, Furnham N, Lee D, Lees JG, Lewis TE, Studer RA, Rentzsch R, Yeats C, Thornton JM and Orengo CA (2012). New functional families (FunFams) in CATH to improve the mapping of conserved functional sites to 3D structures. Nucleic Acids Research, Oxford University Press (OUP) vol. 41 (D1), d490-d498.  
29-11-2012
Relevant PublicationChen J, Irianto J, Inamdar S, Pravincumar P, Lee DA, Bader DL and Knight MM (2012). Cell mechanics, structure, and function are regulated by the stiffness of the three-dimensional microenvironment. Biophys J vol. 103 (6), 1188-1197.  
19-09-2012
Relevant PublicationBonzani IC, Campbell JJ, Knight MM, Williams A, Lee DA, Bader DL and Stevens MM (2012). Dynamic compressive strain influences chondrogenic gene expression in human periosteal cells: a case study. J Mech Behav Biomed Mater vol. 11, 72-81.  
01-07-2012
Relevant PublicationBranford OA, Lee DA, Bader DL and Grobbelaar AO (2012). The mechanics of flexor tendon adhesions. Journal of Hand Surgery: European Volume vol. 37 (6), 555-563.  
01-07-2012
Relevant PublicationBranford OA, Lee DA, Rolfe KJ and Grobbelaar AO (2012). The attachment of intrinsic and extrinsic, mobilized and immobilized adhesion cells to collagen and fibronectin. Journal of Hand Surgery: European Volume vol. 37 (6), 564-572.  
01-07-2012
Relevant PublicationLee D, Smallbone K, Dunn WB, Murabito E, Winder CL, Kell DB, Mendes P and Swainston N (2012). Improving metabolic flux predictions using absolute gene expression data. BMC Systems Biology, Springer Nature vol. 6 (1) 
19-06-2012
Relevant PublicationFigliolini A, Archuletta M, LeClaire J, Brinkley D, Doerr D, White R, Bozak R and Lee DA (2012). Through pellicle management of haze formation in a wafer fabrication environment. 28th European Mask and Lithography Conference
16-04-2012
Relevant PublicationLee D (2012). Stanley Melbourne Bruce in London, 1938–41. The Journal of Imperial & Commonwealth History, Taylor & Francis vol. 40 (1), 45-65.  
01-03-2012
Relevant PublicationGutowski IA, Lee D, de Bruyn JR and Frisken BJ (2012). Scaling and mesostructure of Carbopol dispersions. Rheologica Acta, Springer Nature vol. 51 (5), 441-450.  
18-01-2012
Relevant PublicationHosny NA, Lee DA and Knight MM (2012). Single photon counting fluorescence lifetime detection of pericellular oxygen concentrations. J Biomed Opt vol. 17 (1) 
01-01-2012
Relevant PublicationMaeda E, Ye S, Wang W, Bader DL, Knight MM and Lee DA (2012). Gap junction permeability between tenocytes within tendon fascicles is suppressed by tensile loading. Biomechanics and Modeling in Mechanobiology vol. 11 (3-4), 439-447.  
01-01-2012
Relevant PublicationMartins RP, Finan JD, Guilak F and Lee DA (2012). Mechanical regulation of nuclear structure and function. Annu Rev Biomed Eng vol. 14, 431-455.  
01-01-2012

2011

Relevant PublicationJaimes N, Scope A, Welzel J, Wang KX, Lee DA, Siegel DM and Marghoob AA (2011). White Globules in Melanocytic Neoplasms: In Vivo and Ex Vivo Characteristics. Dermatologic Surgery, Wolters Kluwer vol. 38 (1), 128-132.  
31-10-2011
Relevant PublicationRobinson T, Yi D, Brinkley D, Roessler K, White R, Bozak R, Archuletta M and Lee D (2011). Clean and repair of EUV photomasks. Photomask Technology 2011
06-10-2011
Relevant PublicationPattappa G, Heywood HK, de Bruijn JD and Lee DA (2011). The metabolism of human mesenchymal stem cells during proliferation and differentiation. J Cell Physiol vol. 226 (10), 2562-2570.  
01-10-2011
Relevant PublicationLewinsohn AD, Anssari-Benham A, Lee DA, Taylor PM, Chester AH, Yacoub MH and Screen HRC (2011). Anisotropic strain transfer through the aortic valve and its relevance to the cellular mechanical environment. Proc Inst Mech Eng H vol. 225 (8), 821-830.  
01-08-2011
Relevant PublicationMoses SE, Osborne W, Valappil M, Collin M, Lee D, Waugh S, Jackson G, Parry CM and Crowley B (2011). Extensive oral herpes simplex virus type 1 infection in a haematopoietic stem cell transplant recipient not responding to aciclovir. Journal of Clinical Virology, Elsevier vol. 52 (2), 67-69.  
14-06-2011
Relevant PublicationLee D, Gutowski IA, Bailey AE, Rubatat L, de Bruyn JR and Frisken BJ (2011). Investigating the microstructure of a yield-stress fluid by light scattering. Physical Review E, American Physical Society (APS) vol. 83 (3) 
01-03-2011
Relevant PublicationMaeda E, Ye S, Wang W, Bader DL, Knight MM and Lee DA (2011). Gap junction permeability between tenocytes within tendon fascicles is suppressed by tensile loading. Biomechanics and Modeling in Mechanobiology, 1-9.  
01-01-2011
Relevant PublicationLewinsohn AD, Anssari-Benham A, Lee DA, Taylor PM, Chester AH, Yacoub MH and Screen HRC (2011). Anisotropic strain transfer through the aortic valve and its relevance to the cellular mechanical environment. P I MECH ENG H vol. 225 (H8), 821-830.  
01-01-2011
Relevant PublicationChen J, Bader DL, Lee DA and Knight MM (2011). Finite Element Modeling of Cell Deformation When Chondrocyte Seeded Agarose Is Subjected to Compression. 
01-01-2011
Relevant PublicationMartyn SV, Heywood HK, Rockett P, Paine MD, Wang MJ, Dobson PJ, Sheard SJ, Lee DA and Stark JPW (2011). Electrospray deposited fibronectin retains the ability to promote cell adhesion. Journal of Biomedical Materials Research - Part B Applied Biomaterials vol. 96 B (1), 110-118.  
01-01-2011
Relevant PublicationLee DA, Knight MM, Campbell JJ and Bader DL (2011). Stem cell mechanobiology. J Cell Biochem vol. 112 (1), 1-9.  
01-01-2011
Relevant PublicationLee D, de Beer TA, Laskowski RA, Thornton JM and Orengo CA (2011). 1,000 structures and more from the MCSG. BMC Molecular and Cell Biology, Springer Nature vol. 11 (1) 
01-01-2011
Relevant PublicationLee DA and Siegel DM (2011). Novel devices for diagnosis and treatment. Journal of Drugs in Dermatology vol. 10 (1), 21-22.  
01-01-2011
Relevant PublicationLee DA, Brand J, Salter D, Akanji O-O and Chowdhury TT (2011). Quantification of mRNA using real-time PCR and Western blot analysis of MAPK events in chondrocyte/agarose constructs. Methods Mol Biol vol. 695, 77-97.  
01-01-2011

2010

Relevant PublicationPattappa G, Heywood HK, de Bruijn JD and Lee DA (2010). The metabolism of human mesenchymal stem cells during proliferation and differentiation. J Cell Physiol 
28-12-2010
Relevant PublicationMaeda E, Fleischmann C, Mein CA, Shelton JC, Bader DL and Lee DA (2010). Functional analysis of tenocytes gene expression in tendon fascicles subjected to cyclic tensile strain. Connective Tissue Research vol. 51 (6), 434-444.  
01-12-2010
Relevant PublicationHeywood HK, Knight MM and Lee DA (2010). Both superficial and deep zone articular chondrocyte subpopulations exhibit the crabtree effect but have different basal oxygen consumption rates. Journal of Cellular Physiology vol. 223 (3), 630-639.  
01-06-2010
Relevant PublicationLee D (2010). Giving something back. Twist (22), 28-30.  
01-06-2010
Relevant PublicationRobinson T, White R, Bozak R, LeClaire J, Archuletta M and Lee D (2010). Through-pellicle defect repair for advanced photomasks. Photomask and Next-Generation Lithography Mask Technology XVII
29-04-2010
Relevant PublicationRobinson T, Yi D, White R, Bozak R, Archuletta M and Lee D (2010). Nanomachining of non-orthogonal mask patterns. Photomask and Next-Generation Lithography Mask Technology XVII
29-04-2010
Relevant PublicationKu T, LeClaire J, Tan SK, Chua GS, Bozak R, White R, Robinson T, Archuletta M and Lee D (2010). Preliminary results for photomask haze mitigation in a fab environment. Metrology, Inspection, and Process Control for Microlithography XXIV
11-03-2010
Relevant PublicationYe S, Maeda E, Knight M, Lee D, Bader D and Wang W (2010). A compartment model to evaluate the permeability of gap junctions between tenocytes in tendon fascicles. FASEB JOURNAL vol. 24 
01-01-2010
Relevant PublicationHeywood HK and Lee DA (2010). Low oxygen reduces the modulation to an oxidative phenotype in monolayer-expanded chondrocytes. J Cell Physiol vol. 222 (1), 248-253.  
01-01-2010
Relevant PublicationHosny NA, Lee DA and Knight MM (2010). Extracellular oxygen concentration mapping with confocal multiphoton laser scanning microscope and TCSPC card., Editors: Periasamy A, So PTC and Konig K. 
01-01-2010

2009

Relevant PublicationMaeda E, Shelton JC, Bader DL and Lee DA (2009). Effect of intermittent cyclic tensile strain on collagen synthesis by tenocytes in isolated fascicles. Journal of Biomechanical Science and Engineering vol. 4 (4), 510-517.  
01-12-2009
Relevant PublicationLee DA, Rentzsch R and Orengo C (2009). GeMMA: functional subfamily classification within superfamilies of predicted protein structural domains. Nucleic Acids Research, Oxford University Press (OUP) vol. 38 (3), 720-737.  
18-11-2009
Relevant PublicationRobinson T, White R, Bozak R, Roessler K, Arruza B, Hogle D, Archuletta M and Lee D (2009). New tools to enable photomask repair to the 32nm node. Photomask Technology 2009
23-09-2009
Relevant PublicationPattappa G, Jegard NC, Lee DA and de Bruijn JD (2009). The effect of oxygen tension on the proliferation and differentiation of human mesenchymal stem cells. European Cells and Materials vol. 18 (SUPPL. 1) 
01-08-2009
Relevant PublicationCampbell JJ, Maeda E, Ye SJ, Wang W and Lee DA (2009). Osteogenic differentiation of human mesenchymal stem cells within a perfused bioreactor system. European Cells and Materials vol. 18 (SUPPL. 2) 
01-07-2009
Relevant PublicationPattappa G, Jegard NC, de Bruijn JD and Lee DA (2009). The influence of oxygen tension on the colony formation and proliferation of human mesenchymal stem cells. European Cells and Materials vol. 18 (SUPPL. 2) 
01-07-2009
Relevant PublicationMcleod R, Pattappa G, Irianto J, Awan M, Knight MM and Lee DA (2009). Graded hydrogel constructs for cartilage tissue engineering. 
01-07-2009
Relevant PublicationRobinson T, Bozak R, White R, Archuletta M and Lee D (2009). Selective removal of persistent particles with no photomask damage. Photomask and Next-Generation Lithography Mask Technology XVI
24-04-2009
Relevant PublicationMaeda E, Shelton JC, Bader DL and Lee DA (2009). Differential regulation of gene expression in isolated tendon fascicles exposed to cyclic tensile strain in vitro. Journal of Applied Physiology vol. 106 (2), 506-512.  
01-02-2009
Relevant PublicationEniwumide JO, Lee DA and Bader DL (2009). The development of a bioreactor to perfuse radially-confined hydrogel constructs: design and characterization of mass transport properties. Biorheology vol. 46 (5), 417-437.  
01-01-2009
Relevant PublicationBerry CC, Shelton JC and Lee DA (2009). Cell-generated forces influence the viability, metabolism and mechanical properties of fibroblast-seeded collagen gel constructs. J Tissue Eng Regen Med vol. 3 (1), 43-53.  
01-01-2009

2008

Relevant PublicationPattappa G, A. Lee D and De Bruijn JD (2008). Metabolic characteristics of human mesenchymal stem cells expanded under normoxic conditions. 8th World Biomaterials Congress 2008 vol. 1 
01-12-2008
Relevant PublicationLee S-Y, Kim G-B, Sim H-S, Lee S-H, Kim H-S, Lee J-H, Seo H-S, Han H-S, Kim S-S, Moon S-Y, Woo S-G, Bozak R, Dinsdale A, Robinson T, Lee D and Cho H (2008). Analysis of process margin in EUV mask repair with nano-machining. Photomask Technology 2008
17-10-2008
Relevant PublicationLee D and Schroeder J (2008). Phenotypic analysis of Arabidopsis mutants: heavy metal stress. Cold Spring Harbor Protocols, Cold Spring Harbor Laboratory vol. 2008 (9) 
01-09-2008
Relevant PublicationHeywood HK and Lee DA (2008). Monolayer expansion induces an oxidative metabolism and ROS in chondrocytes. Biochem Biophys Res Commun vol. 373 (2), 224-229.  
22-08-2008
Relevant PublicationMaeda E, Shelton JC, Bader DL and Lee DA (2008). Collagen synthesis by tenocytes in fascicles subjected to intermittent cyclic strain. European Cells and Materials vol. 16 (SUPPL. 3) 
01-07-2008
Relevant PublicationHeywood HK and Lee DA (2008). The effect of oxygen supply on chondrocyte metabolic phenotype during monolayer culture. European Cells and Materials vol. 16 (SUPPL. 3) 
01-07-2008
Relevant PublicationChowdhury TT, Salter DM, Bader DL and Lee DA (2008). Signal transduction pathways involving p38 MAPK, JNK, NF kappa B and AP-1 influences the response of chondrocytes cultured in agarose constructs to IL-1 beta and dynamic compression. INFLAMM RES vol. 57 (7), 306-313.  
01-07-2008
Relevant PublicationHughes D, Whitaker Y, Lee D and Eckhause J (2008). Advantages, Disadvantages, and Uses of Generalized Activity Networks for Schedule Estimation. Military Operations Research, Military Operations Research Society vol. 13 (3), 27-40.  
01-06-2008
Relevant PublicationCampbell JJ, Bader DL and Lee DA (2008). Mechanical loading modulates intracellular calcium signaling in human mesenchymal stem cells. J APPL BIOMATER BIOM vol. 6 (1), 9-15.  
01-01-2008
Relevant PublicationChowdhury TT, Arghandawi S, Brand J, Akanji OO, Bader DL, Salter DM and Lee DA (2008). Dynamic compression counteracts IL-1beta induced inducible nitric oxide synthase and cyclo-oxygenase-2 expression in chondrocyte/agarose constructs. Arthritis Res Ther vol. 10 (2) 
01-01-2008
Relevant PublicationChowdhury TT, Akanji OO, Salter DM, Bader DL and Lee DA (2008). Dynamic compression influences interleukin-1 beta-induced nitric oxide and prostaglandin E-2 release by articular chondrocytes via alterations in iNOS and COX-2 expression. BIORHEOLOGY vol. 45 (3-4), 257-274.  
01-01-2008
Relevant PublicationAkanji OO, Lee DA and Bader DA (2008). The effects of direct current stimulation on isolated chondrocytes seeded in 3D agarose constructs. 
01-01-2008
Relevant PublicationLee DA (2008). Surgeons carry out first implant of pulmonary human heart valve. Biomedical Materials (MAY) 
01-01-2008

2007

Relevant PublicationChowdhury TT, Akanji OO, Arghandawi S, Salter DM, Bader DL and Lee DA (2007). 52 REAL-TIME PCR USING MOLECULAR BEACONS TO DETECT INOS AND COX-2 EXPRESSION IN CHONDROCYTE/AGAROSE CONSTRUCTS SUBJECTED TO IL-1β AND DYNAMIC COMPRESSION. Osteoarthritis and Cartilage, Elsevier vol. 15, c42-c43.  
01-12-2007
Relevant PublicationLee D, Redfern O and Orengo C (2007). Predicting protein function from sequence and structure. Nature Reviews Molecular Cell Biology, Springer Nature vol. 8 (12), 995-1005.  
01-12-2007
Relevant PublicationChen Y-H, Chang H-H, Chen Y-J, Lee D, Chiang H-H and Jane Yao C-C (2007). Root contact during insertion of miniscrews for orthodontic anchorage increases the failure rate: an animal study. Clinical Oral Implants Research, Wiley, 071025001541005-???.  
23-10-2007
Relevant PublicationMaeda E, Shelton JC, Bader DL and Lee DA (2007). Time dependence of cyclic tensile strain on collagen production in tendon fascicles. Biochem Biophys Res Commun vol. 362 (2), 399-404.  
19-10-2007
Relevant PublicationWhite R, Dinsdale A, Robinson T, Brinkley D, Csuy J and Lee D (2007). Repairing 45 nm node defects through nano-machining. Photomask Technology 2007
02-10-2007
Relevant PublicationHeywood HK and Lee DA (2007). Development of an immunoassay for determination of adsorbed fibronectin levels on bio-functionalised substrates. 
01-07-2007
Relevant PublicationCampbell JJ, Bader DL and Lee DA (2007). Mechanical loading modulates calcium signalling within mesenchymal stem cells. 
01-07-2007
Relevant PublicationPattappa G, De Bruijn JD and Lee DA (2007). Mesenchymal stem cells maintain a glycolytic metabolism under normoxic conditions. 
01-07-2007
Relevant PublicationMaeda E, Shelton JC, Bader DL and Lee DA (2007). Gene expressions in tendon fascicles subjected to cyclic tensile strain. 
01-07-2007
Relevant PublicationMcleod R, Pattappa G, Irianto J, Knight MM and Lee DA (2007). The development and characterisation of chondrocyte-seeded gradient hydrogel constructs for cartilage tissue engineering. 
01-07-2007
Relevant PublicationChowdhury TT, Akanji OO, Arghandawi , Salter DM, Bader DL and Lee DA (2007). Dynamic compression counteracts IL-1 beta b induced iNOS and COX-2 expression in chondrocytes cultured in agarose constructs. 
01-07-2007
Relevant PublicationBonzani IC, Knight MM, Lee DA, Bader DL, Williams A and Stevens MM (2007). A model for studying the influence of mechanical loading on human periosteal stem cells. 
01-07-2007
Relevant PublicationLee DA (2007). Products: CryoLife wins US patent for foam wound sealant. Biomedical Materials (JULY) 
01-01-2007
Relevant PublicationLee DA and Hall J (2007). Products: CryoLife wins rights to distribute replacement pericardium. Biomedical Materials (MAR.) 
01-01-2007
Relevant PublicationLee DA (2007). Industry news: CryoLife signs Irish distribution deal with Proxy Biomedical. Biomedical Materials (NOV.), 6-7.  
01-01-2007

2006

Relevant PublicationHeywood HK, Bader DL and Lee DA (2006). Glucose concentration and medium volume influence cell viability and glycosaminoglycan synthesis in chondrocyte-seeded alginate constructs. 
01-12-2006
Relevant PublicationLee DA and Herbiet R (2006). New aluminum hydroxide and magnesium hydroxide grades with enhanced flame retardancy. 
23-11-2006
Relevant PublicationHeywood HK, Bader DL and Lee DA (2006). Glucose Concentration and Medium Volume Influences Cell Viability and Glycosaminoglycan Synthesis in Chondrocyte-Seeded Alginate Constructs. Tissue Engineering, Mary Ann Liebert 
20-11-2006
Relevant PublicationGao J, Yang Y, Lee D, Holdcroft S and Frisken BJ (2006). Self-Assembly of Latex Particles into Proton-Conductive Membranes. Macromolecules, American Chemical Society (ACS) vol. 39 (23), 8060-8066.  
17-10-2006
Relevant PublicationWhite R, LeClaire J, Robinson T, Dinsdale A, Bozak R and Lee DA (2006). Precise and high-throughput femtopulse laser mask repair of large defects. Photomask Technology 2006
06-10-2006
Relevant PublicationRobinson T, Lewellen J, Lee DA and Brooker P (2006). Impact of AFM scan artifacts on photolithographic simulation. Photomask Technology 2006
06-10-2006
Relevant PublicationScreen HRC, Chhaya VH, Greenwald SE, Bader DL, Lee DA and Shelton JC (2006). The influence of swelling and matrix degradation on the microstructural integrity of tendon. Acta Biomater vol. 2 (5), 505-513.  
01-09-2006
Relevant PublicationAkanji OO, Bader DL and Lee DA (2006). Direct current influences Ca 2+ signalling in chondrocytes. European Cells and Materials vol. 11 (SUPPL.2) 
01-06-2006
Relevant PublicationKnight MM, Bomzon Z, Kimmel E, Sharma AM, Lee DA and Bader DL (2006). Chondrocyte deformation induces mitochondrial distortion and heterogeneous intracellular strain fields. BIOMECH MODEL MECHAN vol. 5 (2-3), 180-191.  
01-06-2006
Relevant PublicationChowdhury TT, Appleby RN, Salter DM, Bader DA and Lee DA (2006). Integrin-mediated mechanotransduction in IL-1 beta stimulated chondrocytes. Biomech Model Mechanobiol vol. 5 (2-3), 192-201.  
01-06-2006
Relevant PublicationBRANFORD O, LEE D, BADER D and GROBBELAAR A (2006). 1.3 The quantitative assessment of flexor tendon adhesion – a novel use of confocal microscopy to evaluate local strain, orientation and organisation. Journal of Hand Surgery (European Volume), SAGE Publications vol. 31, 3-3.  
01-06-2006
Relevant PublicationGhadiali F, Tolani V, Nagpal R, Robinson T, LeClaire J, Bozak R, Lee DA and White R (2006). Femtopulse laser-based mask repair in the DUV wavelength regime. Photomask and Next-Generation Lithography Mask Technology XIII
03-05-2006
Relevant PublicationRobinson T, Lewellen J, Bozak R, Lee DA and Brooker P (2006). Application of photolithographic simulation and a mask repair system in a production environment. Photomask and Next-Generation Lithography Mask Technology XIII
03-05-2006
Relevant PublicationLee D (2006). Ground plans [13]. Professional Engineering vol. 19 (6) 
22-03-2006
Relevant PublicationMarsden RL, Lee D, Maibaum M, Yeats C and Orengo CA (2006). Comprehensive genome analysis of 203 genomes provides structural genomics with new insights into protein family space. Nucleic Acids Research, Oxford University Press (OUP) vol. 34 (3), 1066-1080.  
06-02-2006
Relevant PublicationHeywood HK, Bader DL and Lee DA (2006). Rate of oxygen consumption by isolated articular chondrocytes is sensitive to medium glucose concentration. Journal of Cellular Physiology vol. 206 (2), 402-410.  
01-02-2006
Relevant PublicationMarsden RL, Ranea JAG, Sillero A, Redfern O, Yeats C, Maibaum M, Lee D, Addou S, Reeves GA, Dallman TJ and Orengo CA (2006). Exploiting protein structure data to explore the evolution of protein function and biological complexity. Philosophical Transactions of the Royal Society B Biological Sciences, The Royal Society vol. 361 (1467), 425-440.  
01-02-2006
Relevant PublicationChowdhury TT, Bader DL and Lee DA (2006). Anti-inflammatory effects of IL-4 and dynamic compression in IL-1beta stimulated chondrocytes. Biochem Biophys Res Commun vol. 339 (1), 241-247.  
06-01-2006
Relevant PublicationKnight MM, Toyoda T, Lee DA and Bader DL (2006). Mechanical compression and hydrostatic pressure induce reversible changes in actin cytoskeletal organisation in chondrocytes in agarose. J Biomech vol. 39 (8), 1547-1551.  
01-01-2006
Relevant PublicationChowdhury TT, Bader DL and Lee DA (2006). Dynamic compression counteracts IL-1beta induced iNOS and COX-2 activity by human chondrocytes cultured in agarose constructs. Biorheology vol. 43 (3,4), 413-429.  
01-01-2006
Relevant PublicationCampbell JJ, Lee DA and Bader DL (2006). Dynamic compressive strain influences chondrogenic gene expression in human mesenchymal stem cells. 
01-01-2006
Relevant PublicationBader DL, Lee DA and Knight MM (2006). Chondrocyte Deformation and Mechanotransduction in Cartilage Model Systems(International Workshop 2). The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME, Japan Society of Mechanical Engineers vol. 2005.18, 2-3.  
01-01-2006
Relevant PublicationChowdhury TT, Raveenthiran SP, Bader DL and Lee DA (2006). P140 DYNAMIC COMPRESSION COUNTERACTS FIBRONECTIN FRAGMENT INDUCED UPREGULATION OF NITRIC OXIDE. Osteoarthritis and Cartilage, Elsevier vol. 14 
01-01-2006
Relevant PublicationYeats C, Maibaum M, Marsden R, Dibley M, Lee D, Addou S and Orengo CA (2006). Gene3D: modelling protein structure, function and evolution. Nucleic Acids Research, Oxford University Press (OUP) vol. 34 (suppl_1), d281-d284.  
01-01-2006
Relevant PublicationLee DA and Gridley A (2006). Industry news: CryoLife, BioForm sign glue deal. Biomedical Materials (DEC.), 7-8.  
01-01-2006
Relevant PublicationLee DA (2006). Products: Spinal implant looks good so far. Biomedical Materials (JUNE), 4-5.  
01-01-2006
Relevant PublicationLee DA (2006). Spinal implants: CryoLife's spinal disc repair study completes enrolment. Biomedical Materials (SEP.), 9-10.  
01-01-2006
Relevant PublicationLee DA (2006). Government: US law ensures funding for protein hydrogel development. Biomedical Materials (DEC.) 
01-01-2006
Relevant PublicationEnobakhare B, Bader DL and Lee DA (2006). Concentration and M/G ratio influence the physiochemical and mechanical properties of alginate constructs for tissue engineering. J Appl Biomater Biomech vol. 4 (2), 87-96.  
01-01-2006

2005

Relevant PublicationScreen HRC, Bader DL, Shelton JC and Lee DA (2005). Cyclic mechanical conditioning of isolated tendon fascicles results in an upregulation of collagen production. Proceedings of the 2005 Summer Bioengineering Conference vol. 2005, 193-194.  
01-12-2005
Relevant PublicationChowdhury TT, Bader DL and Lee DA (2005). Dynamic compression counteracts IL-1-induced iNOS and COX-2 activity by human chondrocytes cultured in agarose constructs. Proceedings of the 2005 Summer Bioengineering Conference vol. 2005, 251-252.  
01-12-2005
Relevant PublicationChowdhury TT, Appleby RN, Salter DA, Bader DL and Lee DA (2005). Integrin mediated mechanotransduction in IL-1 stimulated bovine chondrocytes cultured in agarose constructs. Proceedings of the 2005 Summer Bioengineering Conference vol. 2005, 545-546.  
01-12-2005
Relevant PublicationPingguan B, Lee DA, Bader DL and Knight MM (2005). Dynamic compression activates chondrocyte calcium signaling in a cycle dependent manner involving the release of ATP. 
01-12-2005
Relevant PublicationWang MJ, Heywood HK, Bader DL, Paine MD, Stark JPW and Lee DA (2005). Identification and characterization of deposited fibronectin on biocompatible materials: Comparison of electrospray and wetting methods. Proceedings of the 2005 Summer Bioengineering Conference vol. 2005, 439-440.  
01-12-2005
Relevant PublicationBader DL and Lee DA (2005). Mechanical conditioning of cell-seeded constructs for soft tissue repair - Are optimisation strategies possible? 
01-12-2005
Relevant PublicationPingguan-Murphy B, Lee DA, Bader DL and Knight MM (2005). Activation of chondrocytes calcium signalling by dynamic compression is independent of number of cycles. Arch Biochem Biophys vol. 444 (1), 45-51.  
01-12-2005
Relevant PublicationScreen HRC, Shelton JC, Bader DL and Lee DA (2005). Cyclic tensile strain upregulates collagen synthesis in isolated tendon fascicles. Biochem Biophys Res Commun vol. 336 (2), 424-429.  
21-10-2005
Relevant PublicationRobinson T, Brooker P, Bozak R and Lee DA (2005). Integration of photolithographic simulation and a mask repair system into a single concurrent work cell. 25th Annual BACUS Symposium on Photomask Technology
21-10-2005
Relevant PublicationRobinson T, Dinsdale A, Bozak R, White R, Lee DA and Roessler K (2005). Mask repair for the 65-nm technology node. 25th Annual BACUS Symposium on Photomask Technology
21-10-2005
Relevant PublicationSengers BG, Heywood HK, Lee DA, Oomens CWJ and Bader DL (2005). Nutrient utilization by bovine articular chondrocytes: a combined experimental and theoretical approach. J Biomech Eng vol. 127 (5), 758-766.  
01-10-2005
Relevant PublicationScreen HRC, Shelton JC, Chhaya VH, Kayser MV, Bader DL and Lee DA (2005). The influence of noncollagenous matrix components on the micromechanical environment of tendon fascicles. Ann Biomed Eng vol. 33 (8), 1090-1099.  
01-08-2005
Relevant PublicationChowdhury TT, Bader DL and Lee DA (2005). Dynamic compression counteracts IL-1β induced INOS and COX-2 activity by human chondrocytes cultured in agarose constructs. European Cells and Materials vol. 10 (SUPPL.2) 
01-07-2005
Relevant PublicationCatuogno C, Chowdhury TT, Bader DL and Lee DA (2005). Dynamic compression influences the biochemical response of human mesenchymal stem cells cultured in agarose constructs. European Cells and Materials vol. 10 (SUPPL.2) 
01-07-2005
Relevant PublicationPingguna B, Lee DA, Bader DL and Knight MM (2005). Mechanical compression activates chondrocyte Calcium signalling in a cycle dependent Manner Involving the release of ATP. 
01-07-2005
Relevant PublicationEniwumide JO, Lee DA and Bader DL (2005). Perfusion-Enhancement of molecular transport within 3D scaffolds. European Cells and Materials vol. 10 (SUPPL.2) 
01-07-2005
Relevant PublicationHeywood HK, Bader DL and Lee DA (2005). Superficial and deep chondrocyte subpopulations both express the crabtree effect but exhibit differences in oxygen consumption rate. European Cells and Materials vol. 10 (SUPPL.2) 
01-07-2005
Relevant PublicationCampbell JJ, Lee DA and Bader DL (2005). Mechanical conditioning Influences Mesenchymal stem cell chondrogenesis. European Cells and Materials vol. 10 (SUPPL.2) 
01-07-2005
Relevant PublicationBrooker P, Robinson T, Lewellen J, Naber B, Bozak R and Lee DA (2005). Improved cycle time of mask repair by optimizing nanomachining with photolithographic imaging simulation. Photomask and Next-Generation Lithography Mask Technology XII
28-06-2005
Relevant PublicationGao J, Lee D, Yang Y, Holdcroft S and Frisken BJ (2005). Self-Assembly of Surface-Charged Latex Nanoparticles: A New Route to the Creation of Continuous Channels for Ion Conduction. Macromolecules, American Chemical Society (ACS) vol. 38 (14), 5854-5856.  
15-06-2005
Relevant PublicationScreen HRC, Shelton JC, Bader DL and Lee DA (2005). Cyclic tensile strain upregulates collagen production in isolated tendon fascicles. 
01-06-2005
Relevant PublicationHeywood HK, Bader DL and Lee DA (2005). Glucose metabolism of chondrocytes in tissue-engineered alginate constructs. 
01-06-2005
Relevant PublicationBaria KE, Bader DL, Screen HRC and Lee DA (2005). The effect of substrate and medium composition on the response of human dermal fibroblasts to cyclic tensile strain in vitro. 
01-06-2005
Relevant PublicationSharma A, Bomzon Z, Lee DA, Kimmel E, Bader DL and Knight MM (2005). Compression-induced reorganization of cytoplasmic networks in bovine chondrocytes using mitochondria as markers. 
01-06-2005
Relevant PublicationAppleby RN, Chowdhury TT, Salter DM, Bader DL and Lee DA (2005). Integrin-mediated mechanotransduction in IL-1 beta-stimulated chondrocytes. 
01-06-2005
Relevant Publication (2005). British Society for Matrix Biology Autumn Meeting Joint with the UK Tissue & Cell Engineering Society, University of Bristol, UK. International Journal of Experimental Pathology, Wiley vol. 86 (3), a1-a56.  
24-05-2005
Relevant PublicationRugg EL, Al-Rawi H, Lee D and McNeill AM (2005). Trimethylamine N-oxide reduces the effects of osmotic stress in EBS keratinocytes. 
01-04-2005
Relevant PublicationLee D, Grant A, Marsden RL and Orengo C (2005). Identification and distribution of protein families in 120 completed genomes using Gene3D. Proteins Structure Function and Bioinformatics, Wiley vol. 59 (3), 603-615.  
14-03-2005
Relevant PublicationWang Y-N, Bouten CVC, Lee DA and Bader DL (2005). Compression-induced damage in a muscle cell model in vitro. Proc Inst Mech Eng H vol. 219 (1), 1-12.  
01-01-2005
Relevant PublicationGoldberg AJ, Lee DA, Bader DL and Bentley G (2005). Autologous chondrocyte implantation. Culture in a TGF-beta-containing medium enhances the re-expression of a chondrocytic phenotype in passaged human chondrocytes in pellet culture. J Bone Joint Surg Br vol. 87 (1), 128-134.  
01-01-2005

2004

Relevant PublicationPearl F, Todd A, Sillitoe I, Dibley M, Redfern O, Lewis T, Bennett C, Marsden R, Grant A, Lee D, Akpor A, Maibaum M, Harrison A, Dallman T, Reeves G, Diboun I, Addou S, Lise S, Johnston C, Sillero A, et al. (2004). The CATH Domain Structure Database and related resources Gene3D and DHS provide comprehensive domain family information for genome analysis. Nucleic Acids Research, Oxford University Press (OUP) vol. 33 (suppl_1), d247-d251.  
17-12-2004
Relevant PublicationNordquist KJ, Dauksher WJ, Mancini DP, Resnick DJ, Hess HF, Pettibone DW, Adler D, Bertsche K, White R, Csuy JE and Lee D (2004). Inspection and repair issues for Step-and-Flash Imprint Lithography templates. 24th Annual BACUS Symposium on Photomask Technology
06-12-2004
Relevant PublicationLee DA, Randall F, Beattie G and Bentall RP (2004). Delusional discourse: An investigation comparing the spontaneous causal attributions of paranoid and non‐paranoid individuals. Psychology and Psychotherapy Theory Research and Practice, Wiley vol. 77 (4), 525-540.  
01-12-2004
Relevant PublicationBader DL, Shelton JC, Lee DA and SCREEN HRC (2004). Local Strain Measurement within Tendon. Strain vol. 40 (4), 157-163.  
01-11-2004
Relevant PublicationDauksher WJ, Nordquist KJ, Le NV, Gehoski KA, Mancini DP, Resnick DJ, Casoose L, Bozak R, White R, Csuy J and Lee D (2004). Repair of step and flash imprint lithography templates. 
01-11-2004
Relevant PublicationBryant SJ, Anseth KS, Lee DA and Bader DL (2004). Crosslinking density influences the morphology of chondrocytes photoencapsulated in PEG hydrogels during the application of compressive strain. J Orthop Res vol. 22 (5), 1143-1149.  
01-09-2004
Relevant PublicationChowdhury TT, Salter DM, Bader DL and Lee DA (2004). Integrin-mediated mechanotransduction processes in TGFbeta-stimulated monolayer-expanded chondrocytes. Biochem Biophys Res Commun vol. 318 (4), 873-881.  
11-06-2004
Relevant PublicationLee D (2004). Debt crisis looms [10]. Professional Engineering vol. 17 (8) 
28-04-2004
Relevant PublicationKim B-C, van Gelder H, Kim TA, Lee H-J, Baik KG, Chun HH, Lee DA, Choi KS and Kim S-J (2004). Activin Receptor-like Kinase-7 Induces Apoptosis through Activation of MAPKs in a Smad3-dependent Mechanism in Hepatoma Cells*. Journal of Biological Chemistry, Elsevier vol. 279 (27), 28458-28465.  
23-04-2004
Relevant PublicationBryant SJ, Chowdhury TT, Lee DA, Bader DL and Anseth KS (2004). Crosslinking density influences chondrocyte metabolism in dynamically loaded photocrosslinked poly(ethylene glycol) hydrogels. Ann Biomed Eng vol. 32 (3), 407-417.  
01-03-2004
Relevant PublicationKnight MM, Hibbs K, Roberts SR, LEE DA and Bader DL (2004). Cyclic preconditioning mediates chondrocytes calcium signaling in unstrained and compressed agarose constructs. 50th Annual Meeting of the Orthopaedic Research Society
01-01-2004
Relevant PublicationHeywood HK, DeRosa E, LEE DA, Bader DL and Netti P (2004). Non-invasive monitoring of molecular diffusion in neo-cartilage using FRAP technique. 50th Annual Meeting of the Orthopaedic Research Society
01-01-2004
Relevant PublicationLEE DA, van Osch G, Verhaar JAN, Mandl EW, van der Linden JC, van der Breevaart Bravenboer J and Weinans H (2004). Extracellular matrix influences the response of chondrocytes to dynamic compression. Trans. Orthop.Rev. Soc vol. 29, 839-839.  
01-01-2004
Relevant PublicationChowdhury TT, Bader DL and Lee DA (2004). Dynamic compression counteracts IL-1 beta-induced iNOS and COX-2 activity in human chondrocytes cultured in agarose constructs. 
01-01-2004
Relevant PublicationKnight MM, Bonzom Z, Sharma AM, LEE DA, Kimmel E and Bader DL (2004). Heterogeneity of deformation of cytoplasmic networks in compressed chondrocytes. 50th Annual Meeting of the Orthopaedic Research Society
01-01-2004
Relevant PublicationLee DA and Knight MM (2004). Mechanical loading of chondrocytes embedded in 3D constructs: in vitro methods for assessment of morphological and metabolic response to compressive strain. Methods Mol Med vol. 100, 307-324.  
01-01-2004
Relevant PublicationHeywood HK, Bader DL, Bongers M and LEE DA (2004). Glucose depletion induces an upregulation of oxygen utilisation by chondrocytes. 50th Annual Meeting of the Orthopaedic Research Society
01-01-2004
Relevant PublicationChowdhury TT, Appleby RN, Salter DM, Bader DL and Lee DA (2004). Integrin-mediated mechanotransduction in IL-1β stimulated chondrocytes. 
01-01-2004
Relevant PublicationScreen HRC, Lee DA, Bader DL and Shelton JC (2004). An investigation into the effects of the hierarchical structure of tendon fascicles on micromechanical properties. Proc Inst Mech Eng H vol. 218 (2), 109-119.  
01-01-2004
Relevant PublicationChowdhry TT, Salter DM, Bader DL and LEE DA (2004). alpha 5 beta 1 integrin mediates mechanotransduction processes in TGF-beta stimulated human chondrocytes seeded in agarose constructs and subjected to dynamic compression. 50th Annual Meeting of the Orthopaedic Research Society
01-01-2004
Relevant PublicationBader DL, KNIGHT MM, Bentley G, Kayser M and Holloway I (2004). Increased presence of cells with multiple elongated processes in osteoarthritic femoral head cartilage. Osteoarthritis Cartilage vol. 12 (1), 17-24.  
01-01-2004
Relevant PublicationLee DA and Martin I (2004). Bioreactor Culture Techniques for Cartilage-Tissue Engineering. Biopolymer Methods in Tissue Engineering  159-170.  
01-01-2004
Relevant PublicationWiseman M, Bader DL, Reisler T and Lee DA (2004). Passage in monolayer influences the response of chondrocytes to dynamic compression. Biorheology vol. 41 (3-4), 283-298.  
01-01-2004
Relevant PublicationHolloway I, Kayser M, Lee DA, Bader DL, Bentley G and Knight MM (2004). Increased presence of cells with multiple elongated processes in osteoarthritic femoral head cartilage. Osteoarthritis Cartilage vol. 12 (1), 17-24.  
01-01-2004
Relevant PublicationLee DA and Knight MM (2004). Mechanical Loading of Chondrocytes Embedded in 3D Constructs. Cartilage and Osteoarthritis  307-324.  
01-01-2004
Relevant PublicationHeywood HK, Sembi PK, Lee DA and Bader DL (2004). Cellular utilization determines viability and matrix distribution profiles in chondrocyte-seeded alginate constructs. Tissue Eng vol. 10 (9-10), 1467-1479.  
01-01-2004
Relevant PublicationChowdhury TT, Bader DL and LEE DA (2004). Combined anti-inflammatory effects of IL-4 and dynamic compression in IL-1beta stimulated bovine chondrocytes cultured in agarose constructs. 50th Annual Meeting of the Orthopaedic Research Society
01-01-2004
Relevant PublicationLee D, Grant A, Sillitoe I, Dibley M, Ranea JG and Orengo C (2004). A structural perspective on genome evolution. Proceedings of the eighth annual international conference on Computational molecular biology - RECOMB '04
01-01-2004
Relevant PublicationGrant A, Lee D and Orengo C (2004). Progress towards mapping the universe of protein folds. Genome Biology, Springer Nature vol. 5 (5) 
01-01-2004
Relevant PublicationLee DA, Fefeu S, Edo-Ukeh AA, Orengo CA and Slingsby C (2004). EyeSite: a semi‐automated database of protein families in the eye. Nucleic Acids Research, Oxford University Press (OUP) vol. 32 (suppl_1), d148-d152.  
01-01-2004

2003

Relevant PublicationChowdhury TT, Bader DL, Shelton JC and Lee DA (2003). Temporal regulation of chondrocyte metabolism in agarose constructs subjected to dynamic compression. Arch Biochem Biophys vol. 417 (1), 105-111.  
01-09-2003
Relevant PublicationChowdhury TT, Bader DL and Lee DA (2003). Dynamic compression counteracts IL-1 beta-induced release of nitric oxide and PGE2 by superficial zone chondrocytes cultured in agarose constructs. Osteoarthritis Cartilage vol. 11 (9), 688-696.  
01-09-2003
Relevant PublicationBerry CC, Shelton JC, Bader DL and Lee DA (2003). Influence of external uniaxial cyclic strain on oriented fibroblast-seeded collagen gels. Tissue Eng vol. 9 (4), 613-624.  
01-08-2003
Relevant PublicationWiseman M, Henson F, Lee DA and Bader DL (2003). Dynamic compressive strain inhibits nitric oxide synthesis by equine chondrocytes isolated from different areas of the cartilage surface. Equine Vet J vol. 35 (5), 451-456.  
01-07-2003
Relevant PublicationLee D, Grant A, Buchan D and Orengo C (2003). A structural perspective on genome evolution. Current Opinion in Structural Biology, Elsevier vol. 13 (3), 359-369.  
01-06-2003
Relevant PublicationKnight MM, Roberts SR, Lee DA and Bader DL (2003). Live cell imaging using confocal microscopy induces intracellular calcium transients and cell death. Am J Physiol Cell Physiol vol. 284 (4), C1083-C1089.  
01-04-2003
Relevant PublicationKnight MM, Roberts SR, Lee DA and Bader DL (2003). Live cell imaging using confocal microscopy induces intracellular calcium transients and cell death. 
01-04-2003
Relevant PublicationLee DA, Reisler T and Bader DL (2003). Expansion of chondrocytes for tissue engineering in alginate beads enhances chondrocytic phenotype compared to conventional monolayer techniques. Acta Orthop Scand vol. 74 (1), 6-15.  
01-02-2003
Relevant PublicationShelton JC, Bader DL and Lee DA (2003). Mechanical conditioning influences the metabolic response of cell-seeded constructs. Cells Tissues Organs vol. 175 (3), 140-150.  
01-01-2003
Relevant PublicationHernandez D, Addou S, Lee D, Orengo C, Shephard EA and Phillips IR (2003). Trimethylaminuria and a human FMO3 mutation database. HUM MUTAT vol. 22 (3), 209-213.  
01-01-2003
Relevant PublicationChowdhury TT, LEE DA, Salter DM, Shelton JC and Bader DL (2003). alpha5beta1 integrin mediates mechanotransduction processes in TGFbeta3-stimulated human chondrocytes seeded in agarose constructs and subjected to dynamic compression. ETES
01-01-2003
Relevant PublicationBerry CC, Cacou C, Lee DA, Bader DL and Shelton JC (2003). Dermal fibroblasts respond to mechanical conditioning in a strain profile dependent manner. Biorheology vol. 40 (1-3), 337-345.  
01-01-2003
Relevant PublicationScreen HRC, Lee DA, Bader DL and Shelton JC (2003). Development of a technique to determine strains in tendons using the cell nuclei. Biorheology vol. 40 (1-3), 361-368.  
01-01-2003
Relevant PublicationChowdhury TT, LEE DA, Salter DM, Shelton JC and Bader DL (2003). alpha5beta1 integrin mediates mechanotransduction processes in TGFbeta-stimulated human chondrocyte / agarose constructs and subjected to dynamic compression. Osteoarthritis Cartilage vol. 11 (Suppl 1), S2-S3.  
01-01-2003
Relevant PublicationChowdhury TT, Shelton JC, Bader DL and LEE DA (2003). Control of mechanotrasduction processes in dynamically stimulated human and bovine chondrocytes cultured in agarose constructs. Internat. J. Artificial Organs vol. 26 (9), 858-858.  
01-01-2003
Relevant PublicationSCREEN HRC, Shelton JC, Bader DL and Lee DA (2003). The effects on non-collagenous matrix components on tendon fascicle micromechanics. 49th Annual Meeting of the Orthopaedic Research Society
01-01-2003
Relevant PublicationLEE DA, Heywood HK, Baaijens FPT, Oomens CWJ and Sengers BG (2003). Experimental and theoretical analysis of glucose dependent oxygen utilization by bovine articular chondrocytes. Internat. J. Artificial Organs vol. 26, 875-875.  
01-01-2003

2002

Relevant PublicationBerry CC, Shelton JC, Bader DL and Lee DA (2002). The influence of uniaxial cyclic strain on orientated fibroblast seeded collagen gels. Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products 
01-12-2002
Relevant PublicationKnight MM, Toyoda T, Bader DL and Lee DA (2002). Mechanical strain and hydrostatic pressure induce reversible changes in actin cytoskeletal organisation in chondrocytes in agarose. 
01-12-2002
Relevant PublicationKnight MM, Roberts SR, Lee DA and Bader DL (2002). Light-induced calcium signalling in chondrocytes. 
01-12-2002
Relevant PublicationLee DA (2002). The design of bioreactor systems for cartilage tissue engineering. Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products 
01-12-2002
Relevant PublicationLee DA, Chowdhury TT, Roberts SR, Knight MM and Bader DL (2002). An in vitro investigation of cartilage mechanotransduction. 
01-07-2002
Relevant PublicationTurner JEH, Allington-Smith J, Chapman S, Content R, Done C, Haynes R, Lee D and Morris S (2002). The origin of [Fe ii] emission in NGC 4151. Monthly Notices of the Royal Astronomical Society, Oxford University Press (OUP) vol. 331 (2), 284-292.  
01-03-2002
Relevant PublicationKnight MM, van de Breevaart Bravenboer J, Lee DA, van Osch GJVM, Weinans H and Bader DL (2002). Cell and nucleus deformation in compressed chondrocyte-alginate constructs: temporal changes and calculation of cell modulus. Biochim Biophys Acta vol. 1570 (1), 1-8.  
15-02-2002
Relevant PublicationPearl FMG, Lee D, Bray JE, Buchan DWA, Shepherd AJ and Orengo CA (2002). The CATH extended protein‐family database: Providing structural annotations for genome sequences. Protein Science, Wiley vol. 11 (2), 233-244.  
01-02-2002
Relevant PublicationSCREEN HRC, Lee DA, Bader DL and Shelton JC (2002). The strain behaviour of tendon under tensile load, using cell nuclei as strain markers. 48th Annual Meeting of the Orthopaedic Research Society
01-01-2002
Relevant PublicationKnight MM, Roberts SR, LEE DA and Bader DL (2002). Light-induced calcium signalling in chondrocytes. TCES 2002 Annual meeting of the UK Tissue and Cell Engineering Society University of Glasgow, Scotland 19 Sep 2002 - 20 Sep 2002
01-01-2002
Relevant PublicationBADER DL, Shelton JC, Lee DA and Screen HRC (2002). Development of a technique to determine strains in tendons using the cell nuclei. Biorheology vol. 40, 361-368.  
01-01-2002
Relevant PublicationHolloway I, Knight MM, LEE DA, Bader DL and Bentley G (2002). Changes in cell morphology and cytoskeletal organisation in osteoarthritic cartilage. ECM III Cartilage & Joint repair Tutorials, Basic Research & Clinical Methods Davos, Switzerland 1 Jul 2002 - 3 Jul 2002
01-01-2002
Relevant PublicationKnight MM, Toyoda T, LEE DA and Bader DL (2002). Mechanical strain and hydrostatic pressure induce reversible changes in actin cytoskeletal organisation in chondrocytes in agarose. 48th Annual Meeting of the Orthopaedic Research Society
01-01-2002
Relevant PublicationBader DL, Shelton JC, Lee DA and SCREEN HRC (2002). Non-collagenous matrix components influence the micromechanical environment of tenocytes within tendon fascicles subjected to tensile strain. Eur. Cells Mat. vol. 4:S1, 41-42.  
01-01-2002
Relevant PublicationHolloway I, Knight MM, LEE DA, Bader DL and Bentley G (2002). Characterisation of cell morphology, cytoskeletal organization and apoptosis in human osteoarthritic cartilage. 48th Annual Meeting of the Orthopaedic Research Society
01-01-2002
Relevant PublicationBader DL, Ohashi T, Knight MM, Lee DA and Sato M (2002). Deformation properties of articular chondrocytes: a critique of three separate techniques. 
01-01-2002
Relevant PublicationHeywood HK, LEE DA and Bader DL (2002). Monitoring neo-cartilage formation in cell seeded alginate constructs of clinically relevant dimensions. TCES 2002 Annual meeting of the UK Tissue and Cell Engineering Society Glasgow, Scotland 19 Sep 2002 - 20 Sep 2002
01-01-2002
Relevant PublicationOrengo CA, Bray JE, Buchan DWA, Harrison A, Lee D, Pearl FMG, Sillitoe I, Todd AE and Thornton JM (2002). The CATH protein family database: A resource for structural and functional annotation of genomes. 
01-01-2002

2001

Relevant PublicationLee D, Haynes R, Ren D and Allington‐Smith J (2001). Characterization of Lenslet Arrays for Astronomical Spectroscopy. Publications of the Astronomical Society of the Pacific, IOP Publishing vol. 113 (789), 1406-1419.  
08-10-2001
Relevant PublicationBader D and Lee D (2001). Gene Therapy and Tissue Engineering in Orthopaedic and Sports Medicine (2000) Edited by Johnny Huard and Freddie H. Fu, ISBN 0-8176-4071-1, Birkhauser: Boston pages 1–286. Medical Engineering & Physics, Elsevier vol. 23 (8) 
01-10-2001
Relevant PublicationLee D, Haynes R and Skeen DJ (2001). Properties of optical fibres at cryogenic temperatures. Monthly Notices of the Royal Astronomical Society, Oxford University Press (OUP) vol. 326 (2), 774-780.  
01-09-2001
Relevant PublicationZiegler BL, Bower RG, Smail I, Davies RL and Lee D (2001). The early-type galaxy population in Abell 2218. Monthly Notices of the Royal Astronomical Society, Oxford University Press (OUP) vol. 325 (4), 1571-1590.  
21-08-2001
Relevant PublicationChowdhury TT, Bader DL and Lee DA (2001). Dynamic compression inhibits the synthesis of nitric oxide and PGE(2) by IL-1beta-stimulated chondrocytes cultured in agarose constructs. Biochem Biophys Res Commun vol. 285 (5), 1168-1174.  
03-08-2001
Relevant PublicationAntonyak MA, Singh US, Lee DA, Boehm JE, Combs C, Zgola MM, Page RL and Cerione RA (2001). Effects of Tissue Transglutaminase on Retinoic Acid-induced Cellular Differentiation and Protection against Apoptosis*. Journal of Biological Chemistry, Elsevier vol. 276 (36), 33582-33587.  
03-07-2001
Relevant PublicationKnight MM, Ross JM, Sherwin AF, Lee DA, Bader DL and Poole CA (2001). Chondrocyte deformation within mechanically and enzymatically extracted chondrons compressed in agarose. Biochim Biophys Acta vol. 1526 (2), 141-146.  
03-05-2001
Relevant PublicationKnight MM, Idowu BD, Lee DA and Bader DL (2001). Temporal changes in cytoskeletal organisation within isolated chondrocytes quantified using a novel image analysis technique. Med Biol Eng Comput vol. 39 (3), 397-404.  
01-05-2001
Relevant PublicationRoberts SR, Knight MM, Lee DA and Bader DL (2001). Mechanical compression influences intracellular Ca2+ signaling in chondrocytes seeded in agarose constructs. J Appl Physiol (1985) vol. 90 (4), 1385-1391.  
01-04-2001
Relevant PublicationBouten CV, Knight MM, Lee DA and Bade DL (2001). Compressive deformation and damage of muscle cell subpopulations in a model system. Ann Biomed Eng vol. 29 (2), 153-163.  
01-02-2001
Relevant PublicationKnight MM, van de Breevaart Brevenboer J, van Osch G, Weinans H, LEE DA and Bader DL (2001). Temporal changes in cell and nucleus deformation in isolated chondrocytes compressed in alginate scaffolds. 47th Annual Meeting, Orthopaedic Research Society San Francisco, California 25 Feb 2001 - 28 Feb 2001
01-01-2001
Relevant PublicationChowdhury T, Bader DL and LEE DA (2001). Dynamic compression influences the synthesis of nitric oxide by IL-1beta stimulated chondrocyte sub-populations cultured in agarose constructs. 47th Annual Meeting, Orthopaedic Research Society San Francisco, California 25 Feb 2001 - 28 Feb 2001
01-01-2001
Relevant PublicationBader DL, KNIGHT MM, Lee DA and Bouten CV (2001). Compressive deformation and damage of muscle cell subpopulaltions in a model system. Ann. Biomed. Eng. vol. 29 (2), 153-163.  
01-01-2001
Relevant PublicationLEE DA, Idowu BD, Knight MM and Bader DL (2001). Mechanical compression influences cytoskeletal oragnisation within chondrocytes seeded in agarose constructs. 47th Annual Meeting, Orthopaedic Research Society San Francisco, California 25 Feb 2001 - 28 Feb 2001
01-01-2001
Relevant PublicationEnobakhare B, Bader DL and LEE DA (2001). Physiochemical, biochemical and mechanical characterisation of chondrocyte-alginate constructs. 47th Annual Meeting, Orthopaedic Research Society San Francisco, California 25 Feb 2001 - 28 Feb 2001
01-01-2001
Relevant PublicationLee DA (2001). Embryonic stem cells: scientific possibilities, ethical considerations, and regulation in the UK. INTERDISCIPL SCI REV vol. 26 (2), 112-124.  
01-01-2001
Relevant PublicationAlbà MM, Lee D, Pearl FMG, Shepherd AJ, Martin N, Orengo CA and Kellam P (2001). VIDA: a virus database system for the organization of animal virus genome open reading frames. Nucleic Acids Research, Oxford University Press (OUP) vol. 29 (1), 133-136.  
01-01-2001
Relevant PublicationPearl FM, Martin N, Bray JE, Buchan DW, Harrison AP, Lee D, Reeves GA, Shepherd AJ, Sillitoe I, Todd AE, Thornton JM and Orengo CA (2001). A rapid classification protocol for the CATH Domain Database to support structural genomics. Nucleic Acids Research, Oxford University Press (OUP) vol. 29 (1), 223-227.  
01-01-2001

2000

Relevant PublicationLee D and Taylor K (2000). Fibre developments at the Anglo-Australian Observatory for SPIRAL and AUSTRALIS. 
03-12-2000
Relevant PublicationHaynes R, Baldry IK, Taylor K and Lee D (2000). Characterisation of cooled infrared fibres for the Gemini IRMOS. 
03-12-2000
Relevant PublicationBerry CC, Cacou C, Shelton JC, Bader DL and Lee DA (2000). Biological response of cyclic strain on developed cell seeded collagen gel model. Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling 
01-12-2000
Relevant PublicationRoberts SR, Knight MM, Lee DA and Bader DL (2000). Intracellular - CA2+ signalling in compressed chondrocyte agarose constructs. 
01-12-2000
Relevant PublicationKnight MM, Van De Breevaart Bravenboer J, Bader DL and Lee DA (2000). Compression induced cell and nucleus deformation in chondrocyte-alginate constructs. 
01-12-2000
Relevant PublicationEnobakhare BO, Bader DL and Lee DA (2000). Physiochemical, biochemical and mechanical characterisation of chondrocyte-alginate constructs. Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling 
01-12-2000
Relevant PublicationChowdhury TT, Bader DL and Lee DA (2000). Dynamic compression inhibits the synthesis of nitric oxide by IL-1β stimulated chondrocytes cultured in agarose constructs. Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling 
01-12-2000
Relevant PublicationCacou C, Palmer D, Lee DA, Bader DL and Shelton JC (2000). A system for monitoring the response of uniaxial strain on cell seeded collagen gels. MED ENG PHYS vol. 22 (5), 327-333.  
01-06-2000
Relevant PublicationIdowu BD, Knight MM, Bader DL and Lee DA (2000). Confocal analysis of cytoskeletal organisation within isolated chondrocyte sub-populations cultured in agarose. Histochem J vol. 32 (3), 165-174.  
01-03-2000
Relevant PublicationLee D and Allington-Smith JR (2000). An experimental investigation of immersed gratings. Monthly Notices of the Royal Astronomical Society, Oxford University Press (OUP) vol. 312 (1), 57-69.  
11-02-2000
Relevant PublicationRoberts SR, Knight MM, Lee DA and Bader DL (2000). Intracellular calcium signalling in compressed chondrocyte agarose constructs. 
01-02-2000
Relevant PublicationLee DA, Knight MM, Bolton JF, Idowu BD, Kayser MV and Bader DL (2000). Chondrocyte deformation within compressed agarose constructs at the cellular and sub-cellular levels. J Biomech vol. 33 (1), 81-95.  
01-01-2000
Relevant PublicationLee DA, Noguchi T, Frean SP, Lees P and Bader DL (2000). The influence of mechanical loading on isolated chondrocytes seeded in agarose constructs. Biorheology vol. 37 (1-2), 149-161.  
01-01-2000
Relevant PublicationPearl FM, Lee D, Bray JE, Sillitoe I, Todd AE, Harrison AP, Thornton JM and Orengo CA (2000). Assigning genomic sequences to CATH. Nucleic Acids Research, Oxford University Press (OUP) vol. 28 (1), 277-282.  
01-01-2000
Relevant PublicationBader D and Lee D (2000). Chapter 4 Structure – Properties of Soft Tissues Articular Cartilage. Structural Biological Materials - Design and Structure-Property Relationships  75-103.  
01-01-2000

1999

Relevant PublicationKang SH, Bang Y-J, Im Y-H, Yang H-K, Lee DA, Lee HY, Lee HS, Kim NK and Kim S-J (1999). Transcriptional repression of the transforming growth factor-β type I receptor gene by DNA methylation results in the development of TGF-β resistance in human gastric cancer. Oncogene, Springer Nature vol. 18 (51), 7280-7286.  
02-12-1999
Relevant PublicationLee DA (1999). Models of government regulation of privatized transit systems in five Latin American cities. Transportation Quarterly vol. 53 (1), 21-39.  
01-12-1999
Relevant PublicationHaynes R, Lee D, Allington‐Smith J, Content R, Dodsworth G, Lewis I, Sharples R, Turner J, Webster J, Done C, Peletier R, Parry I and Chapman S (1999). Multiple‐Object and Integral Field Near‐Infrared Spectroscopy Using Fibers. Publications of the Astronomical Society of the Pacific, IOP Publishing vol. 111 (765), 1451-1468.  
01-11-1999
Relevant PublicationHuang J, Hing KA, Best SM, Lee DA, Silvio LD and Bonfield W (1999). A COMPARATIVE STUDY OF VARIOUS ASSAYS FOR IN VITRO BIOCOMPATIBILITY ASSESSMENT OF EXPERIMENTAL ZIRCONIA. Bioceramics
01-10-1999
Relevant PublicationWhite AET, Bentley G, Stephens MD, Bader DL, Giddins GEB and Lee DA (1999). The effects of storage temperature on the composition, metabolism acid biomechanical properties of human articular cartilage. KNEE vol. 6 (3), 197-205.  
01-08-1999
Relevant PublicationLee DA (1999). Introducing Fare Simplification and New Convenience Fares at Connecticut Transit. Transportation Research Record Journal of the Transportation Research Board, SAGE Publications vol. 1669 (1), 109-112.  
01-01-1999

1998

Relevant PublicationLee D (1998). A Tour through through. Journal of English Linguistics, SAGE Publications vol. 26 (4), 333-351.  
01-12-1998
Relevant PublicationHaynes R, Doei AP, Content R, Allington-Smith J and Lee D (1998). TEIFU: A thousand element integral field unit for the WHT fed by the ELECTRA AO system. 
01-12-1998
Relevant PublicationLee DA, Noguchi T, Knight MM, O'Donnell L, Bentley G and Bader DL (1998). Response of chondrocyte subpopulations cultured within unloaded and loaded agarose. J Orthop Res vol. 16 (6), 726-733.  
01-11-1998
Relevant PublicationKnight MM, Lee DA and Bader DL (1998). The influence of elaborated pericellular matrix on the deformation of isolated articular chondrocytes cultured in agarose. Biochim Biophys Acta vol. 1405 (1-3), 67-77.  
21-10-1998
Relevant PublicationLee DA, Frean SP, Lees P and Bader DL (1998). Dynamic mechanical compression influences nitric oxide production by articular chondrocytes seeded in agarose. BIOCHEM BIOPH RES CO vol. 251 (2), 580-585.  
20-10-1998
Relevant PublicationHaynes R, Content R, Turner JE, Allington-Smith JR and Lee D (1998). SMIRFS-II: multiobject and integral-field near-IR spectroscopy at UKIRT. Infrared Astronomical Instrumentation
21-08-1998
Relevant PublicationLee D, Allington-Smith JR, Content R and Haynes R (1998). Characterization of microlens arrays for integral field spectroscopy. Optical Astronomical Instrumentation
09-07-1998
Relevant PublicationMurowinski RG, Bond T, Crampton D, Davidge TJ, Fletcher JM, Leckie B, Morbey CL, Roberts SC, Saddlemyer LK, Sebesta J, Stilburn JR, Szeto K, Allington-Smith JR, Content R, Davies RL, Dodsworth GN, Haynes R, Robinson DJ, Robertson DJ, Webster J, et al. (1998). Gemini multiobject spectrographs. Optical Astronomical Instrumentation
09-07-1998
Relevant PublicationLee DA and Goodfellow JM (1998). The pH-Induced Release of Iron from Transferrin Investigated with a Continuum Electrostatic Model. Biophysical Journal, Elsevier vol. 74 (6), 2747-2759.  
01-06-1998
Relevant PublicationKnight MM, Ghori SA, Lee DA and Bader DL (1998). Measurement of the deformation of isolated chondrocytes in agarose subjected to cyclic compression. Med Eng Phys vol. 20 (9), 684-688.  
01-01-1998
Relevant PublicationLee DA, Assoku E and Doyle V (1998). A specific quantitative assay for collagen synthesis by cells seeded in collagen-based biomaterials using sirius red F3B precipitation. J MATER SCI-MATER M vol. 9 (1), 47-51.  
01-01-1998
Relevant PublicationLao WC, Lee D, Burroughs AK, Lanzani G, Rolles K, Emery VC and Griffiths PD (1998). Erratum: Use of polymerase chain reaction to provide prognostic information on human cytomegalovirus disease after liver transplantation. (Journal of Medical Virology 51 (152-158)). Journal of Medical Virology vol. 54 (1) 
01-01-1998

1997

Relevant PublicationDavies RL, Allington-Smith JR, Bettess P, Chadwick E, Content R, Dodsworth GN, Haynes R, Lee D, Lewis IJ, Webster J, Atad E, Beard SM, Ellis M, Hastings PR and Williams PR (1997). GMOS: the GEMINI Multiple Object Spectrographs. 
01-12-1997
Relevant PublicationLee DA, Salih V, Stockton EF, Stanton JS and Bentley G (1997). Effect of Normal Synovial Fluid on the Metabolism of Articular Chondrocytes In Vitro. Clinical Orthopaedics and Related Research®, Wolters Kluwer vol. 342 (&NA;), 228-238.  
01-09-1997
Relevant PublicationLee D and Recce M (1997). Quantitative Evaluation of the Exploration Strategies of a Mobile Robot. The International Journal of Robotics Research, SAGE Publications vol. 16 (4), 413-447.  
01-08-1997
Relevant PublicationLee DA and Bader DL (1997). Compressive strains at physiological frequencies influence the metabolism of chondrocytes seeded in agarose. J ORTHOP RES vol. 15 (2), 181-188.  
01-03-1997
Relevant PublicationO'Neil C, Lee D, Clewley G, Johnson MA and Emery VC (1997). Prevalence of anti‐Vif antibodies in HIV‐1 infected individuals assessed using recombinant baculovirus expressed Vif protein. Journal of Medical Virology, Wiley vol. 51 (3), 139-144.  
01-03-1997
Relevant PublicationLee DA (1997). Frame conflicts and competing construals in family argument. Journal of Pragmatics, Elsevier vol. 27 (3), 339-360.  
01-03-1997
Relevant PublicationLao WC, Lee D, Burroughs AK, Lanzini G, Rolles K, Emery VC and Griffiths PD (1997). Use of polymerase chain reaction to provide prognostic information on human cytomegalovirus disease after liver transplantation. Journal of Medical Virology, Wiley vol. 51 (3), 152-158.  
01-03-1997

1996

Relevant PublicationGroup CTWPOTCRCBCT (1996). Preliminary Results From the Cancer Research Campaign Trial Evaluating Tamoxifen Duration in Women Aged Fifty Years or Older With Breast Cancer. Journal of the National Cancer Institute, Oxford University Press (OUP) vol. 88 (24), 1834-1839.  
18-12-1996
Relevant PublicationEnobakhare BO, Bader DL and Lee DA (1996). Quantification of sulfated glycosaminoglycans in chondrocyte/alginate cultures, by use of 1,9-dimethylmethylene blue. ANAL BIOCHEM vol. 243 (1), 189-191.  
01-12-1996
Relevant PublicationDoyle V, Pearson RG and Lee DA (1996). Specific quantitative assay to determine the rate of collagen synthesis in a collagen gel system. 
01-12-1996
Relevant PublicationJohnson SC, Rovinsky RB, Chin DK, Kostiuk PF, Lee DA, Hemm RV and Wingrove ER (1996). Reduction of weather-related terminal area delays in the free-flight era. 
01-12-1996
Relevant PublicationEnobakhare B, Bader D and Lee DA (1996). Novel system for the production of chondrocyte seeded alginate constructs. 
01-12-1996
Relevant PublicationLee DA and Bader DL (1996). Mechanical strain influences the metabolism of chondrocytes cultured in an artificial matrix. 
01-12-1996
Relevant PublicationPearson RG, Lee DA, Doyle V and Bader DL (1996). Cellular responses to poly-L-lactic acid degradation products. 
01-12-1996
Relevant PublicationGor D, Lee D and Emery VC (1996). J. Virol. Methods Erratum to “Detection of human cytomegalovirus polymerase chain reaction products using oligonucleotide probes directly conjugated to alkaline phosphatase” [61 (1996) 145]. Journal of Virological Methods, Elsevier vol. 62 (2) 
01-12-1996
Relevant PublicationGor D, Lee D and Emery VC (1996). Detection of human cytomegalovirus polymerase chain reaction products using oligonucleotide probes directly conjugated to alkaline phosphatase. Journal of Virological Methods, Elsevier vol. 61 (1-2), 145-150.  
01-09-1996
Relevant PublicationDoyle V, Pearson R, Lee D, Wolowacz S and Mc Taggart S (1996). An investigation of the growth of human dermal fibroblasts on poly-L-lactic acid in vitro. Journal of Materials Science: Materials in Medicine, Springer Nature vol. 7 (6), 381-385.  
01-06-1996
Relevant PublicationGorinsky B, Laskowski RA, Lee DA and Bomford A (1996). Conformational analysis of pentapeptide sequences matching a proposed recognition motif for lysosomal degradation. Biochimica et Biophysica Acta, Elsevier vol. 1293 (2), 243-253.  
01-04-1996
Relevant PublicationLee D and Sanders M (1996). Implementing a Visioning and Strategic Planning Process at CTTransit. Transportation Research Record Journal of the Transportation Research Board, SAGE Publications vol. 1521, 58-61.  
01-01-1996

1995

Relevant PublicationLee DA and Bader DL (1995). The development and characterization of an in vitro system to study strain-induced cell deformation in isolated chondrocytes. IN VITRO CELL DEV-AN vol. 31 (11), 828-835.  
01-12-1995

1994

Relevant PublicationLee D and Recce M (1994). Quantitative evaluation of the exploration strategies of a mobile robot. 
01-12-1994
Relevant PublicationLee D and Recce M (1994). Quantitative evaluation of the exploration strategies of an intelligent vehicle. 
01-12-1994
Relevant PublicationLee DA, Bentley G and Archer CW (1994). Proteoglycan depletion alone is not sufficient to stimulate proteoglycan synthesis in cultured bovine cartilage explants. Osteoarthritis and Cartilage, Elsevier vol. 2 (3), 175-185.  
01-09-1994
Relevant PublicationReissis N, Downes S, Kayser M, Lee D and Bentley G (1994). Characterization of the repair tissue in articular cartilage defects using silver-enhanced colloidal gold immunostaining. Journal of Materials Science: Materials in Medicine, Springer Nature vol. 5 (6-7), 402-406.  
01-06-1994

1993

Relevant PublicationLee DA, Bentley G and Archer CW (1993). The control of cell division in articular chondrocytes. Osteoarthritis and Cartilage, Elsevier vol. 1 (2), 137-145.  
01-04-1993

1991

Relevant PublicationLee DA (1991). Categories in the description of just. Lingua, Elsevier vol. 83 (1), 43-66.  
01-01-1991

1990

Relevant PublicationArcher CW, Cottrill CP and Lee D (1990). Effects of ascorbate on myogenesis in micromass culture. In Vitro Cellular & Developmental Biology, Springer Nature vol. 26 (3), 259-264.  
01-03-1990
Relevant PublicationLee DA (1990). Digitization of the AT&T worldwide intelligent network. AT&T technology vol. 5 (1), 14-19.  
01-01-1990

1989

Relevant PublicationHaupert D, Chen FG and Lee D (1989). VLSI package reliability risk due to accelerated environmental testing. 
01-12-1989
Relevant PublicationJones BM, Evans PM and Lee DA (1989). Relation between the rate of cell movement under agarose and the positioning of cells in heterotypic aggregates. Experimental Cell Research, Elsevier vol. 180 (1), 287-296.  
01-01-1989

1988

Relevant PublicationLee D (1988). INTEGRATED SERVICES DIGITAL NETWORK. British Telecommunications Engineering vol. 7 (pt 2), 2-12.  
01-07-1988
Relevant PublicationLee DA (1988). Moth Density and Oviposition Patterns of the European Corn Borer, Ostrinia nubilalis (Lepidoptera: Pyralidae), in Alberta. Environmental Entomology, Oxford University Press (OUP) vol. 17 (2), 220-224.  
01-04-1988

1987

Relevant PublicationLee DA and Spence JR (1987). Reproductive patterns of the European corn borer (Ostrinia nubilalis) in Alberta. Canadian Journal of Zoology, Canadian Science Publishing vol. 65 (7), 1733-1740.  
01-07-1987
Relevant PublicationLee D (1987). The semantics of just. Journal of Pragmatics, Elsevier vol. 11 (3), 377-398.  
01-06-1987

1985

Relevant PublicationLee DA (1985). MECHANICAL CONVEYING SELECTION CONSIDERATIONS. 
01-01-1985

1984

Relevant PublicationLee DA (1984). GUIDELINES FOR SELECTING PNEUMATIC CONVEYING SYSTEMS. 
01-12-1984

1983

Relevant PublicationLee DA, Winslow NR, Speight AN and Hey EN (1983). Prevalence and spectrum of asthma in childhood. The BMJ, BMJ vol. 286 (6373) 
16-04-1983
Relevant PublicationSpeight AN, Lee DA and Hey EN (1983). Underdiagnosis and undertreatment of asthma in childhood. The BMJ, BMJ vol. 286 (6373) 
16-04-1983

1981

Relevant PublicationAngelini P, Bond WD, Caputo AJ, Mack JE, Lackey WJ, Lee DA and Stinton DP (1981). Sol-Gel Technology Applied to Crystalline Ceramic Nuclear Waste Forms. 
01-01-1981

Grants

solid heart iconGrants of specific relevance to the Centre for Bioengineering
bullet iconClock-Chips - Incorporating the Circadian Clock into Organ-on-a-Chip Technology
David Lee and Lei Su
£387,326 BBSRC Biotechnology and Biological Sciences Research Council (01-10-2024 - 31-03-2026)
solid heart icon(EPSRC CDT 2023) Next Generation Organ-on-a-Chip Technologies
Hazel Screen, Martin Knight, Thomas Iskratsch, Caroline Roney, Yi Sui, David Lee, Julia Shelton, Tsz Ho Tse, John Connelly, Adrian Biddle and Lucy Norling
£7,066,811 EPSRC Engineering and Physical Sciences Research Council (01-07-2024 - 30-09-2032)
solid heart iconHarmonised IAA grant - Improve and accelerate the impact of QMUL research BBSRC
David Lee and Viji Draviam Sastry
£495,000 BBSRC Biotechnology and Biological Sciences Research Council (01-04-2022 - 31-03-2026)
solid heart iconHarmonised IAA grant - Improve and accelerate the impact of QMUL research EPSRC
David Lee and Yang Hao
£882,583 EPSRC Engineering and Physical Sciences Research Council (01-04-2022 - 31-03-2026)
solid heart iconHarmonised IAA grant - Improve and accelerate the impact of QMUL research MRC
Mauro Perretti, Tatjana Crnogorac-Jurcevic and David Lee
£457,000 MRC Medical Research Council (01-04-2022 - 31-03-2026)
solid heart iconEngineering Circadian Biology into Human Induced Pluripotent Stem Cell Organ-on-a-Chip models
David Lee and Yung-Yao Lin
£201,874 BBSRC Biotechnology and Biological Sciences Research Council (01-02-2022 - 31-01-2025)