Prof David Lee
Professor of Cell and Tissue Engineering
Deputy Vice Principal - Impact (Enterprise and Commercial Innovation)
School of Engineering and Materials Science
Queen Mary University of London
Queen Mary University of London
Research
Mechanobiology, Tissue engineering, Cell engineering, Regenerative medicine, Mesenchymal stem cell, Circadian biology
Interests
My main research interests lie in mechanobiology, a research field that lies at the interface between cell biology and bioengineering, involving studying the mechanisms by which cells and tissues resond to the application of mechanical loading. The response of our tissues to mechanical stimuli is critical to maintain healthy physiology and has been implicated in a range of pathologies, ranging from cancer to osteoarthritis. I have published over 100 refereed papers in chondrocyte and stem cell mechanobiology and my work investigating the effect of dynamic compression on inflammatory mediators was recognised by the prestigious Negma Lerads International Prize for Mechanobiology of Cartilage and Chondrocytes. I have been awarded over £5 million in grant funding as principal investigator in the past 10 years, including from the MRC, BBSRC, ESPRC, Wellcome Trust and an international multi-centre Human Frontier Science Program grant investigating mechanoregulation of nuclear organisation and genome function.My research has largely focussed on musculoskeletal tissues, particularly cartilage and tendon. I have looked at the process by which mechanical forces become transduced into biochemical pathways, for example those linked to MAP kinases and calcium fluxes across the cell membrane. Recent work has looked at stem cells and whether they can be induced to differentiate through mechanical stimuli. My work on mesenchymal stem cells has shown that the application of mechanical force can induce more rapid and robust differentiation than traditional biochemical differentiation cues such as growth factors. Loading seems to have a particularly profound effect on the cell nucleus, inducing alterations in the packing of DNA within chromatin and stiffening the nuclear membrane through changes in the nucleoskeleton.
Recently research has investigated the interplay between mechanobiology and the circadian clock which generates 24-hour cycles of biological activity. These studies are aimed at developing more physiologically relevant in vitro models, for example organ-on-a-chip systems, that may be used in drug discovery and other applications.
Publications
Publications of specific relevance to the Centre for Bioengineering2022
Heywood HK, Thorpe SD, Jeropoulos RM, Caton PW and Lee DA (2022). Modulation of sirtuins during monolayer chondrocyte culture influences cartilage regeneration upon transfer to a 3D culture environment. Frontiers in Bioengineering and Biotechnology, Frontiers Media vol. 10 06-12-2022
Heywood HK, Gardner L, Knight MM and Lee DA (2022). Oscillations of the circadian clock protein, BMAL-1, align to daily cycles of mechanical stimuli: a novel means to integrate biological time within predictive in vitro model systems. In vitro models, Springer Nature, 1-8. 31-08-2022
Brookes O, Thorpe SD, Evans OR, Keeling MC and Lee DA (2022). Covariation of Pluripotency Markers and Biomechanical Properties in Mouse Embryonic Stem Cells. Frontiers in Cell and Developmental Biology, Frontiers vol. 10 16-05-2022
2021
Lachowski D, Cortes E, Matellan C, Rice A, Lee DA, Thorpe SD and del Río Hernández AE (2021). G Protein-Coupled Estrogen Receptor Regulates Actin Cytoskeleton Dynamics to Impair Cell Polarization. Frontiers in Cell and Developmental Biology, Frontiers Media vol. 8, 592628-592628. 22-01-2021
2020
Rice A, Cortes E, Lachowski D, Oertle P, Matellan C, Thorpe SD, Ghose R, Wang H, Lee DA, Plodinec M and Del Río Hernández AE (2020). GPER activation inhibits cancer cell mechanotransduction and basement membrane invasion via RhoA. Cancers, MDPI AG vol. 12 (2) 25-01-2020
Thorpe S, Chronopoulos A, Cortes E, Lachowski D, Rice A, Mykuliak V, Róg T, Lee D, Hytonen V and del Río Hernández A (2020). Syndecan-4 tunes cell mechanics by activating
the kindlin-integrin-RhoA pathway. Nature Materials, Nature Research 06-01-2020
2018
Cortes E, Lachowski D, Rice A, THORPE SD, Robinson B, Yeldag G, LEE DA, Ghemtio L, Rombouts K and del Río Hernández AE (2018). Tamoxifen mechanically deactivates hepatic stellate cells via the G protein-coupled estrogen receptor. Oncogene, Springer Nature [academic journals on nature.com] 21-12-2018
Cortes E, Lachowski D, Robinson B, Sarper M, Teppo JS, Thorpe SD, Lieberthal TJ, Iwamoto K, Lee DA, Okada‐Hatakeyama M, Varjosalo MT and del Río Hernández AE (2018). Tamoxifen mechanically reprograms the tumor microenvironment via HIF‐1A and reduces cancer cell survival. EMBO Reports, Springer Nature vol. 20 (1) 12-12-2018
Cortes E, Sarper M, Robinson B, Lachowski D, Chronopoulos A, Thorpe SD, Lee DA and del Río Hernández AE (2018). GPER is a mechanoregulator of pancreatic stellate cells and the tumor microenvironment. EMBO Reports, Springer Nature vol. 20 (1) 11-12-2018
Cortes E, Lachowski D, Rice A, Chronopoulos A, Robinson B, THORPE SD, LEE DA, Possamai LA, Wang H, Pinato DJ and del Rio Hernández AE (2018). RAR‐β is downregulated in HCC & cirrhosis and its expression inhibits myosin‐driven activation and durotaxis in hepatic stellate cells. Hepatology, Wiley 28-07-2018
2017
Elyasigomari V, Lee DA, Screen HRC and SHAHEED MH (2017). Development of a two-stage gene selection method that incorporates a novel hybrid approach using the cuckoo optimization algorithm and harmony search for cancer classification. Journal of Biomedical Informatics vol. 67 (2017), 11-20. 03-02-2017
THORPE SD and Lee DA (2017). Dynamic regulation of nuclear architecture and mechanics—a rheostatic role for the nucleus in tailoring cellular mechanosensitivity. Nucleus, Taylor & Francis vol. 8 (3), 287-300. 02-02-2017
Thorpe SD, Oti A, Mauck RL and Lee DA (2017). Stem cell differentiation state modulates Lamin AC localization and phosphorylation in response to cyclic tensile strain. 01-01-2017
Eraifej J, Thorpe SD, Martins RP and Lee DA (2017). Does lamin A/C play a role in neuronal differentiation? 01-01-2017
Heywood HK, Thorpe SD, Jeropoulos RM and Lee DA (2017). Small molecule activators of SIRT1 augment the regenerative potential of chondrocytes for cell-based cartilage repair techniques. 01-01-2017
Panesar KS, Thorpe SD and Lee DA (2017). Uniaxial tensile strain modulates mesenchymal stem cell nuclear structure and histone methylation in a differentiation dependent manner. 01-01-2017
2016
Heo S-J, Driscoll TP, Thorpe SD, Nerurkar NL, Baker BM, Yang MT, Chen CS, Lee DA and Mauck RL (2016). Differentiation alters stem cell nuclear architecture, mechanics, and mechano-sensitivity. eLife, eLife Sciences Publications Ltd vol. 5 30-11-2016
Tilwani RK, Vessillier S, Pingguan-Murphy B, Lee DA, Bader DL and Chowdhury TT (2016). Oxygen tension modulates the effects of TNFα in compressed chondrocytes. Inflamm Res 22-09-2016
Heo SJ, Han WM, Szczesny SE, Cosgrove BD, Elliott DM, Lee DA, Duncan RL and Mauck RL (2016). Mechanically Induced Chromatin Condensation Requires Cellular Contractility in Mesenchymal Stem Cells. Biophysical Journal vol. 111 (4), 864-874. 23-08-2016
Heywood HK and Lee DA (2016). Bioenergetic reprogramming of articular chondrocytes by exposure to exogenous and endogenous reactive oxygen species and its role in the anabolic response to low oxygen. Journal of Tissue Engineering and Regenerative Medicine vol. 11 (8), 2286-2294. 22-06-2016
Sliogeryte K, Botto L, Lee DA and Knight MM (2016). Chondrocyte dedifferentiation increases cell stiffness by strengthening membrane-actin adhesion. Osteoarthritis and Cartilage, Elsevier vol. 24 (5), 912-920. 01-05-2016
Lee D (2016). States rights and Australia’s adoption of the statute of Westminster, 1931–1942. History Australia, Taylor & Francis vol. 13 (2), 258-274. 02-04-2016
Theocharidis G, Drymoussi Z, Kao AP, Barber AH, Lee DA, Braun KM and Connelly JT (2016). Type VI Collagen Regulates Dermal Matrix Assembly and Fibroblast Motility. Journal of Investigative Dermatology, Elsevier vol. 136 (1), 74-83. 01-01-2016
Theocharidis G, Drymoussi Z, Kao AP, Barber AH, Lee DA, Braun KM and Connelly JT (2016). Type VI Collagen Regulates Dermal Matrix Assembly and Fibroblast Motility. J Invest Dermatol vol. 136 (1), 74-83. 01-01-2016
Heywood HK, Caton PW and Lee DA (2016). SIRT1, an enzyme vital to cartilage homeostasis, is regulated by osmolarity and glucose levels. 01-01-2016
2015
Heo S-J, Thorpe SD, Driscoll TP, Duncan RL, Lee DA and Mauck RL (2015). Biophysical Regulation of Chromatin Architecture Instills a Mechanical Memory in Mesenchymal Stem Cells. Scientific Reports, Springer Nature vol. 5 (1) 23-11-2015
CHEN J, BADER DL, LEE DA and KNIGHT MM (2015). FINITE ELEMENT ANALYSIS OF MECHANICAL DEFORMATION OF CHONDROCYTE TO 2D SUBSTRATE AND 3D SCAFFOLD. Journal of Mechanics in Medicine and Biology, World Scientific Publishing vol. 15 (05) 01-10-2015
2014
Sliogeryte K, Thorpe SD, Lee DA, Botto L and Knight MM (2014). Stem cell differentiation increases membrane-actin adhesion regulating cell blebability, migration and mechanics. Scientific Reports, Springer Nature vol. 4 (1) 04-12-2014
Irianto J, Lee DA and Knight MM (2014). Quantification of chromatin condensation level by image processing. Med Eng Phys vol. 36 (3), 412-417. 01-03-2014
Heywood HK, Nalesso G, Lee DA and Dell'accio F (2014). Culture expansion in low-glucose conditions preserves chondrocyte differentiation and enhances their subsequent capacity to form cartilage tissue in three-dimensional culture. Biores Open Access vol. 3 (1), 9-18. 01-02-2014
Thorpe SD and Lee DA (2014). Mesenchymal stem cell nuclear architecture is differentially regulated by lineage commitment and mechanical stimulation. 01-01-2014
Heywood HK and Lee DA (2014). Reactive oxygen species drive the transformation to an oxidative energy metabolism in cultured articular chondrocytes. 01-01-2014
Tilwani RK, Lee DA, Pingguan-Murphy B, Abas WABW and Chowdhury TT (2014). Hypoxia amplified catabolic effects induced by TNFα in chondrocytes - response reduced with biomechanical signals. 01-01-2014
2013
Irianto J, Swift J, Martins RP, McPhail GD, Knight MM, Discher DE and Lee DA (2013). Osmotic challenge drives rapid and reversible chromatin condensation in chondrocytes. Biophys J vol. 104 (4), 759-769. 19-02-2013
Pattappa G, Thorpe SD, Jegard NC, Heywood HK, de Bruijn JD and Lee DA (2013). Continuous and Uninterrupted Oxygen Tension Influences the Colony Formation and Oxidative Metabolism of Human Mesenchymal Stem Cells. TISSUE ENGINEERING PART C-METHODS vol. 19 (1) 01-01-2013
Lee D (2013). Reluctant relaxation. History Australia, Taylor & Francis vol. 10 (3), 149-170. 01-01-2013
2012
Sillitoe I, Cuff AL, Dessailly BH, Dawson NL, Furnham N, Lee D, Lees JG, Lewis TE, Studer RA, Rentzsch R, Yeats C, Thornton JM and Orengo CA (2012). New functional families (FunFams) in CATH to improve the mapping of conserved functional sites to 3D structures. Nucleic Acids Research, Oxford University Press (OUP) vol. 41 (D1), d490-d498. 29-11-2012
Chen J, Irianto J, Inamdar S, Pravincumar P, Lee DA, Bader DL and Knight MM (2012). Cell mechanics, structure, and function are regulated by the stiffness of the three-dimensional microenvironment. Biophys J vol. 103 (6), 1188-1197. 19-09-2012
Bonzani IC, Campbell JJ, Knight MM, Williams A, Lee DA, Bader DL and Stevens MM (2012). Dynamic compressive strain influences chondrogenic gene expression in human periosteal cells: a case study. J Mech Behav Biomed Mater vol. 11, 72-81. 01-07-2012
Branford OA, Lee DA, Bader DL and Grobbelaar AO (2012). The mechanics of flexor tendon adhesions. Journal of Hand Surgery: European Volume vol. 37 (6), 555-563. 01-07-2012
Branford OA, Lee DA, Rolfe KJ and Grobbelaar AO (2012). The attachment of intrinsic and extrinsic, mobilized and immobilized adhesion cells to collagen and fibronectin. Journal of Hand Surgery: European Volume vol. 37 (6), 564-572. 01-07-2012
Lee D, Smallbone K, Dunn WB, Murabito E, Winder CL, Kell DB, Mendes P and Swainston N (2012). Improving metabolic flux predictions using absolute gene expression data. BMC Systems Biology, Springer Nature vol. 6 (1) 19-06-2012
Figliolini A, Archuletta M, LeClaire J, Brinkley D, Doerr D, White R, Bozak R and Lee DA (2012). Through pellicle management of haze formation in a wafer fabrication environment. 28th European Mask and Lithography Conference. 16-04-2012
Lee D (2012). Stanley Melbourne Bruce in London, 1938–41. The Journal of Imperial & Commonwealth History, Taylor & Francis vol. 40 (1), 45-65. 01-03-2012
Gutowski IA, Lee D, de Bruyn JR and Frisken BJ (2012). Scaling and mesostructure of Carbopol dispersions. Rheologica Acta, Springer Nature vol. 51 (5), 441-450. 18-01-2012
Hosny NA, Lee DA and Knight MM (2012). Single photon counting fluorescence lifetime detection of pericellular oxygen concentrations. J Biomed Opt vol. 17 (1) 01-01-2012
Maeda E, Ye S, Wang W, Bader DL, Knight MM and Lee DA (2012). Gap junction permeability between tenocytes within tendon fascicles is suppressed by tensile loading. Biomechanics and Modeling in Mechanobiology vol. 11 (3-4), 439-447. 01-01-2012
Martins RP, Finan JD, Guilak F and Lee DA (2012). Mechanical regulation of nuclear structure and function. Annu Rev Biomed Eng vol. 14, 431-455. 01-01-2012
2011
Jaimes N, Scope A, Welzel J, Wang KX, Lee DA, Siegel DM and Marghoob AA (2011). White Globules in Melanocytic Neoplasms: In Vivo and Ex Vivo Characteristics. Dermatologic Surgery, Wolters Kluwer vol. 38 (1), 128-132. 31-10-2011
Robinson T, Yi D, Brinkley D, Roessler K, White R, Bozak R, Archuletta M and Lee D (2011). Clean and repair of EUV photomasks. Photomask Technology 2011. 06-10-2011
Pattappa G, Heywood HK, de Bruijn JD and Lee DA (2011). The metabolism of human mesenchymal stem cells during proliferation and differentiation. J Cell Physiol vol. 226 (10), 2562-2570. 01-10-2011
Lewinsohn AD, Anssari-Benham A, Lee DA, Taylor PM, Chester AH, Yacoub MH and Screen HRC (2011). Anisotropic strain transfer through the aortic valve and its relevance to the cellular mechanical environment. Proc Inst Mech Eng H vol. 225 (8), 821-830. 01-08-2011
Moses SE, Osborne W, Valappil M, Collin M, Lee D, Waugh S, Jackson G, Parry CM and Crowley B (2011). Extensive oral herpes simplex virus type 1 infection in a haematopoietic stem cell transplant recipient not responding to aciclovir. Journal of Clinical Virology, Elsevier vol. 52 (2), 67-69. 14-06-2011
Lee D, Gutowski IA, Bailey AE, Rubatat L, de Bruyn JR and Frisken BJ (2011). Investigating the microstructure of a yield-stress fluid by light scattering. Physical Review E, American Physical Society (APS) vol. 83 (3) 01-03-2011
Maeda E, Ye S, Wang W, Bader DL, Knight MM and Lee DA (2011). Gap junction permeability between tenocytes within tendon fascicles is suppressed by tensile loading. Biomechanics and Modeling in Mechanobiology, 1-9. 01-01-2011
Lewinsohn AD, Anssari-Benham A, Lee DA, Taylor PM, Chester AH, Yacoub MH and Screen HRC (2011). Anisotropic strain transfer through the aortic valve and its relevance to the cellular mechanical environment. P I MECH ENG H vol. 225 (H8), 821-830. 01-01-2011
Chen J, Bader DL, Lee DA and Knight MM (2011). Finite Element Modeling of Cell Deformation When Chondrocyte Seeded Agarose Is Subjected to Compression. 01-01-2011
Martyn SV, Heywood HK, Rockett P, Paine MD, Wang MJ, Dobson PJ, Sheard SJ, Lee DA and Stark JPW (2011). Electrospray deposited fibronectin retains the ability to promote cell adhesion. Journal of Biomedical Materials Research - Part B Applied Biomaterials vol. 96 B (1), 110-118. 01-01-2011
Lee DA, Knight MM, Campbell JJ and Bader DL (2011). Stem cell mechanobiology. J Cell Biochem vol. 112 (1), 1-9. 01-01-2011
Lee D, de Beer TA, Laskowski RA, Thornton JM and Orengo CA (2011). 1,000 structures and more from the MCSG. BMC Molecular and Cell Biology, Springer Nature vol. 11 (1) 01-01-2011
Lee DA and Siegel DM (2011). Novel devices for diagnosis and treatment. Journal of Drugs in Dermatology vol. 10 (1), 21-22. 01-01-2011
Lee DA, Brand J, Salter D, Akanji O-O and Chowdhury TT (2011). Quantification of mRNA using real-time PCR and Western blot analysis of MAPK events in chondrocyte/agarose constructs. Methods Mol Biol vol. 695, 77-97. 01-01-2011
2010
Pattappa G, Heywood HK, de Bruijn JD and Lee DA (2010). The metabolism of human mesenchymal stem cells during proliferation and differentiation. J Cell Physiol 28-12-2010
Maeda E, Fleischmann C, Mein CA, Shelton JC, Bader DL and Lee DA (2010). Functional analysis of tenocytes gene expression in tendon fascicles subjected to cyclic tensile strain. Connective Tissue Research vol. 51 (6), 434-444. 01-12-2010
Heywood HK, Knight MM and Lee DA (2010). Both superficial and deep zone articular chondrocyte subpopulations exhibit the crabtree effect but have different basal oxygen consumption rates. Journal of Cellular Physiology vol. 223 (3), 630-639. 01-06-2010
Robinson T, White R, Bozak R, LeClaire J, Archuletta M and Lee D (2010). Through-pellicle defect repair for advanced photomasks. Photomask and Next-Generation Lithography Mask Technology XVII. 29-04-2010
Robinson T, Yi D, White R, Bozak R, Archuletta M and Lee D (2010). Nanomachining of non-orthogonal mask patterns. Photomask and Next-Generation Lithography Mask Technology XVII. 29-04-2010
Ku T, LeClaire J, Tan SK, Chua GS, Bozak R, White R, Robinson T, Archuletta M and Lee D (2010). Preliminary results for photomask haze mitigation in a fab environment. Metrology, Inspection, and Process Control for Microlithography XXIV. 11-03-2010
Ye S, Maeda E, Knight M, Lee D, Bader D and Wang W (2010). A compartment model to evaluate the permeability of gap junctions between tenocytes in tendon fascicles. FASEB JOURNAL vol. 24 01-01-2010
Heywood HK and Lee DA (2010). Low oxygen reduces the modulation to an oxidative phenotype in monolayer-expanded chondrocytes. J Cell Physiol vol. 222 (1), 248-253. 01-01-2010
Hosny NA, Lee DA and Knight MM (2010). Extracellular oxygen concentration mapping with confocal multiphoton laser scanning microscope and TCSPC card., Editors: Periasamy A, So PTC and Konig K. 01-01-2010
2009
Maeda E, Shelton JC, Bader DL and Lee DA (2009). Effect of intermittent cyclic tensile strain on collagen synthesis by tenocytes in isolated fascicles. Journal of Biomechanical Science and Engineering vol. 4 (4), 510-517. 01-12-2009
Lee DA, Rentzsch R and Orengo C (2009). GeMMA: functional subfamily classification within superfamilies of predicted protein structural domains. Nucleic Acids Research, Oxford University Press (OUP) vol. 38 (3), 720-737. 18-11-2009
Robinson T, White R, Bozak R, Roessler K, Arruza B, Hogle D, Archuletta M and Lee D (2009). New tools to enable photomask repair to the 32nm node. Photomask Technology 2009. 23-09-2009
Pattappa G, Jegard NC, Lee DA and de Bruijn JD (2009). The effect of oxygen tension on the proliferation and differentiation of human mesenchymal stem cells. European Cells and Materials vol. 18 (SUPPL. 1) 01-08-2009
Campbell JJ, Maeda E, Ye SJ, Wang W and Lee DA (2009). Osteogenic differentiation of human mesenchymal stem cells within a perfused bioreactor system. European Cells and Materials vol. 18 (SUPPL. 2) 01-07-2009
Pattappa G, Jegard NC, de Bruijn JD and Lee DA (2009). The influence of oxygen tension on the colony formation and proliferation of human mesenchymal stem cells. European Cells and Materials vol. 18 (SUPPL. 2) 01-07-2009
Mcleod R, Pattappa G, Irianto J, Awan M, Knight MM and Lee DA (2009). Graded hydrogel constructs for cartilage tissue engineering. 01-07-2009
Robinson T, Bozak R, White R, Archuletta M and Lee D (2009). Selective removal of persistent particles with no photomask damage. Photomask and Next-Generation Lithography Mask Technology XVI. 24-04-2009
Maeda E, Shelton JC, Bader DL and Lee DA (2009). Differential regulation of gene expression in isolated tendon fascicles exposed to cyclic tensile strain in vitro. Journal of Applied Physiology vol. 106 (2), 506-512. 01-02-2009
Eniwumide JO, Lee DA and Bader DL (2009). The development of a bioreactor to perfuse radially-confined hydrogel constructs: design and characterization of mass transport properties. Biorheology vol. 46 (5), 417-437. 01-01-2009
Berry CC, Shelton JC and Lee DA (2009). Cell-generated forces influence the viability, metabolism and mechanical properties of fibroblast-seeded collagen gel constructs. J Tissue Eng Regen Med vol. 3 (1), 43-53. 01-01-2009
2008
Pattappa G, A. Lee D and De Bruijn JD (2008). Metabolic characteristics of human mesenchymal stem cells expanded under normoxic conditions. 8th World Biomaterials Congress 2008 vol. 1 01-12-2008
Lee S-Y, Kim G-B, Sim H-S, Lee S-H, Kim H-S, Lee J-H, Seo H-S, Han H-S, Kim S-S, Moon S-Y, Woo S-G, Bozak R, Dinsdale A, Robinson T, Lee D and Cho H (2008). Analysis of process margin in EUV mask repair with nano-machining. Photomask Technology 2008. 17-10-2008
Lee D and Schroeder J (2008). Phenotypic analysis of Arabidopsis mutants: heavy metal stress. Cold Spring Harbor Protocols, Cold Spring Harbor Laboratory vol. 2008 (9) 01-09-2008
Heywood HK and Lee DA (2008). Monolayer expansion induces an oxidative metabolism and ROS in chondrocytes. Biochem Biophys Res Commun vol. 373 (2), 224-229. 22-08-2008
Maeda E, Shelton JC, Bader DL and Lee DA (2008). Collagen synthesis by tenocytes in fascicles subjected to intermittent cyclic strain. European Cells and Materials vol. 16 (SUPPL. 3) 01-07-2008
Heywood HK and Lee DA (2008). The effect of oxygen supply on chondrocyte metabolic phenotype during monolayer culture. European Cells and Materials vol. 16 (SUPPL. 3) 01-07-2008
Chowdhury TT, Salter DM, Bader DL and Lee DA (2008). Signal transduction pathways involving p38 MAPK, JNK, NF kappa B and AP-1 influences the response of chondrocytes cultured in agarose constructs to IL-1 beta and dynamic compression. INFLAMM RES vol. 57 (7), 306-313. 01-07-2008
Hughes D, Whitaker Y, Lee D and Eckhause J (2008). Advantages, Disadvantages, and Uses of Generalized Activity Networks for Schedule Estimation. Military Operations Research, Military Operations Research Society vol. 13 (3), 27-40. 01-06-2008
Campbell JJ, Bader DL and Lee DA (2008). Mechanical loading modulates intracellular calcium signaling in human mesenchymal stem cells. J APPL BIOMATER BIOM vol. 6 (1), 9-15. 01-01-2008
Chowdhury TT, Arghandawi S, Brand J, Akanji OO, Bader DL, Salter DM and Lee DA (2008). Dynamic compression counteracts IL-1beta induced inducible nitric oxide synthase and cyclo-oxygenase-2 expression in chondrocyte/agarose constructs. Arthritis Res Ther vol. 10 (2) 01-01-2008
Chowdhury TT, Akanji OO, Salter DM, Bader DL and Lee DA (2008). Dynamic compression influences interleukin-1 beta-induced nitric oxide and prostaglandin E-2 release by articular chondrocytes via alterations in iNOS and COX-2 expression. BIORHEOLOGY vol. 45 (3-4), 257-274. 01-01-2008
Akanji OO, Lee DA and Bader DA (2008). The effects of direct current stimulation on isolated chondrocytes seeded in 3D agarose constructs. 01-01-2008
Lee DA (2008). Surgeons carry out first implant of pulmonary human heart valve. Biomedical Materials (MAY) 01-01-2008
2007
Chowdhury TT, Akanji OO, Arghandawi S, Salter DM, Bader DL and Lee DA (2007). 52 REAL-TIME PCR USING MOLECULAR BEACONS TO DETECT INOS AND COX-2 EXPRESSION IN CHONDROCYTE/AGAROSE CONSTRUCTS SUBJECTED TO IL-1β AND DYNAMIC COMPRESSION. Osteoarthritis and Cartilage, Elsevier vol. 15, c42-c43. 01-12-2007
Lee D, Redfern O and Orengo C (2007). Predicting protein function from sequence and structure. Nature Reviews Molecular Cell Biology, Springer Nature vol. 8 (12), 995-1005. 01-12-2007
Chen Y-H, Chang H-H, Chen Y-J, Lee D, Chiang H-H and Jane Yao C-C (2007). Root contact during insertion of miniscrews for orthodontic anchorage increases the failure rate: an animal study. Clinical Oral Implants Research, Wiley, 071025001541005-???. 23-10-2007
Maeda E, Shelton JC, Bader DL and Lee DA (2007). Time dependence of cyclic tensile strain on collagen production in tendon fascicles. Biochem Biophys Res Commun vol. 362 (2), 399-404. 19-10-2007
White R, Dinsdale A, Robinson T, Brinkley D, Csuy J and Lee D (2007). Repairing 45 nm node defects through nano-machining. Photomask Technology 2007. 02-10-2007
Heywood HK and Lee DA (2007). Development of an immunoassay for determination of adsorbed fibronectin levels on bio-functionalised substrates. 01-07-2007
Campbell JJ, Bader DL and Lee DA (2007). Mechanical loading modulates calcium signalling within mesenchymal stem cells. 01-07-2007
Pattappa G, De Bruijn JD and Lee DA (2007). Mesenchymal stem cells maintain a glycolytic metabolism under normoxic conditions. 01-07-2007
Maeda E, Shelton JC, Bader DL and Lee DA (2007). Gene expressions in tendon fascicles subjected to cyclic tensile strain. 01-07-2007
Mcleod R, Pattappa G, Irianto J, Knight MM and Lee DA (2007). The development and characterisation of chondrocyte-seeded gradient hydrogel constructs for cartilage tissue engineering. 01-07-2007
Chowdhury TT, Akanji OO, Arghandawi , Salter DM, Bader DL and Lee DA (2007). Dynamic compression counteracts IL-1 beta b induced iNOS and COX-2 expression in chondrocytes cultured in agarose constructs. 01-07-2007
Bonzani IC, Knight MM, Lee DA, Bader DL, Williams A and Stevens MM (2007). A model for studying the influence of mechanical loading on human periosteal stem cells. 01-07-2007
Lee DA (2007). Products: CryoLife wins US patent for foam wound sealant. Biomedical Materials (JULY) 01-01-2007
Lee DA and Hall J (2007). Products: CryoLife wins rights to distribute replacement pericardium. Biomedical Materials (MAR.) 01-01-2007
Lee DA (2007). Industry news: CryoLife signs Irish distribution deal with Proxy Biomedical. Biomedical Materials (NOV.), 6-7. 01-01-2007
2006
Heywood HK, Bader DL and Lee DA (2006). Glucose concentration and medium volume influence cell viability and glycosaminoglycan synthesis in chondrocyte-seeded alginate constructs. 01-12-2006
Lee DA and Herbiet R (2006). New aluminum hydroxide and magnesium hydroxide grades with enhanced flame retardancy. 23-11-2006
Heywood HK, Bader DL and Lee DA (2006). Glucose Concentration and Medium Volume Influences Cell Viability and Glycosaminoglycan Synthesis in Chondrocyte-Seeded Alginate Constructs. Tissue Engineering, Mary Ann Liebert 20-11-2006
Gao J, Yang Y, Lee D, Holdcroft S and Frisken BJ (2006). Self-Assembly of Latex Particles into Proton-Conductive Membranes. Macromolecules, American Chemical Society (ACS) vol. 39 (23), 8060-8066. 17-10-2006
White R, LeClaire J, Robinson T, Dinsdale A, Bozak R and Lee DA (2006). Precise and high-throughput femtopulse laser mask repair of large defects. Photomask Technology 2006. 06-10-2006
Robinson T, Lewellen J, Lee DA and Brooker P (2006). Impact of AFM scan artifacts on photolithographic simulation. Photomask Technology 2006. 06-10-2006
Screen HRC, Chhaya VH, Greenwald SE, Bader DL, Lee DA and Shelton JC (2006). The influence of swelling and matrix degradation on the microstructural integrity of tendon. Acta Biomater vol. 2 (5), 505-513. 01-09-2006
Akanji OO, Bader DL and Lee DA (2006). Direct current influences Ca 2+ signalling in chondrocytes. European Cells and Materials vol. 11 (SUPPL.2) 01-06-2006
Knight MM, Bomzon Z, Kimmel E, Sharma AM, Lee DA and Bader DL (2006). Chondrocyte deformation induces mitochondrial distortion and heterogeneous intracellular strain fields. BIOMECH MODEL MECHAN vol. 5 (2-3), 180-191. 01-06-2006
Chowdhury TT, Appleby RN, Salter DM, Bader DA and Lee DA (2006). Integrin-mediated mechanotransduction in IL-1 beta stimulated chondrocytes. Biomech Model Mechanobiol vol. 5 (2-3), 192-201. 01-06-2006
BRANFORD O, LEE D, BADER D and GROBBELAAR A (2006). 1.3 The quantitative assessment of flexor tendon adhesion – a novel use of confocal microscopy to evaluate local strain, orientation and organisation. Journal of Hand Surgery (European Volume), SAGE Publications vol. 31, 3-3. 01-06-2006
Ghadiali F, Tolani V, Nagpal R, Robinson T, LeClaire J, Bozak R, Lee DA and White R (2006). Femtopulse laser-based mask repair in the DUV wavelength regime. Photomask and Next-Generation Lithography Mask Technology XIII. 03-05-2006
Robinson T, Lewellen J, Bozak R, Lee DA and Brooker P (2006). Application of photolithographic simulation and a mask repair system in a production environment. Photomask and Next-Generation Lithography Mask Technology XIII. 03-05-2006
Marsden RL, Lee D, Maibaum M, Yeats C and Orengo CA (2006). Comprehensive genome analysis of 203 genomes provides structural genomics with new insights into protein family space. Nucleic Acids Research, Oxford University Press (OUP) vol. 34 (3), 1066-1080. 06-02-2006
Heywood HK, Bader DL and Lee DA (2006). Rate of oxygen consumption by isolated articular chondrocytes is sensitive to medium glucose concentration. Journal of Cellular Physiology vol. 206 (2), 402-410. 01-02-2006
Marsden RL, Ranea JAG, Sillero A, Redfern O, Yeats C, Maibaum M, Lee D, Addou S, Reeves GA, Dallman TJ and Orengo CA (2006). Exploiting protein structure data to explore the evolution of protein function and biological complexity. Philosophical Transactions of the Royal Society B Biological Sciences, The Royal Society vol. 361 (1467), 425-440. 01-02-2006
Chowdhury TT, Bader DL and Lee DA (2006). Anti-inflammatory effects of IL-4 and dynamic compression in IL-1beta stimulated chondrocytes. Biochem Biophys Res Commun vol. 339 (1), 241-247. 06-01-2006
Knight MM, Toyoda T, Lee DA and Bader DL (2006). Mechanical compression and hydrostatic pressure induce reversible changes in actin cytoskeletal organisation in chondrocytes in agarose. J Biomech vol. 39 (8), 1547-1551. 01-01-2006
Chowdhury TT, Bader DL and Lee DA (2006). Dynamic compression counteracts IL-1beta induced iNOS and COX-2 activity by human chondrocytes cultured in agarose constructs. Biorheology vol. 43 (3,4), 413-429. 01-01-2006
Campbell JJ, Lee DA and Bader DL (2006). Dynamic compressive strain influences chondrogenic gene expression in human mesenchymal stem cells. 01-01-2006
Bader DL, Lee DA and Knight MM (2006). Chondrocyte Deformation and Mechanotransduction in Cartilage Model Systems(International Workshop 2). The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME, Japan Society of Mechanical Engineers vol. 2005.18, 2-3. 01-01-2006
Chowdhury TT, Raveenthiran SP, Bader DL and Lee DA (2006). P140 DYNAMIC COMPRESSION COUNTERACTS FIBRONECTIN FRAGMENT INDUCED UPREGULATION OF NITRIC OXIDE. Osteoarthritis and Cartilage, Elsevier vol. 14 01-01-2006
Yeats C, Maibaum M, Marsden R, Dibley M, Lee D, Addou S and Orengo CA (2006). Gene3D: modelling protein structure, function and evolution. Nucleic Acids Research, Oxford University Press (OUP) vol. 34 (suppl_1), d281-d284. 01-01-2006
Lee DA and Gridley A (2006). Industry news: CryoLife, BioForm sign glue deal. Biomedical Materials (DEC.), 7-8. 01-01-2006
Lee DA (2006). Products: Spinal implant looks good so far. Biomedical Materials (JUNE), 4-5. 01-01-2006
Lee DA (2006). Spinal implants: CryoLife's spinal disc repair study completes enrolment. Biomedical Materials (SEP.), 9-10. 01-01-2006
Lee DA (2006). Government: US law ensures funding for protein hydrogel development. Biomedical Materials (DEC.) 01-01-2006
Enobakhare B, Bader DL and Lee DA (2006). Concentration and M/G ratio influence the physiochemical and mechanical properties of alginate constructs for tissue engineering. J Appl Biomater Biomech vol. 4 (2), 87-96. 01-01-2006
2005
Screen HRC, Bader DL, Shelton JC and Lee DA (2005). Cyclic mechanical conditioning of isolated tendon fascicles results in an upregulation of collagen production. Proceedings of the 2005 Summer Bioengineering Conference vol. 2005, 193-194. 01-12-2005
Chowdhury TT, Bader DL and Lee DA (2005). Dynamic compression counteracts IL-1-induced iNOS and COX-2 activity by human chondrocytes cultured in agarose constructs. Proceedings of the 2005 Summer Bioengineering Conference vol. 2005, 251-252. 01-12-2005
Chowdhury TT, Appleby RN, Salter DA, Bader DL and Lee DA (2005). Integrin mediated mechanotransduction in IL-1 stimulated bovine chondrocytes cultured in agarose constructs. Proceedings of the 2005 Summer Bioengineering Conference vol. 2005, 545-546. 01-12-2005
Pingguan B, Lee DA, Bader DL and Knight MM (2005). Dynamic compression activates chondrocyte calcium signaling in a cycle dependent manner involving the release of ATP. 01-12-2005
Wang MJ, Heywood HK, Bader DL, Paine MD, Stark JPW and Lee DA (2005). Identification and characterization of deposited fibronectin on biocompatible materials: Comparison of electrospray and wetting methods. Proceedings of the 2005 Summer Bioengineering Conference vol. 2005, 439-440. 01-12-2005
Bader DL and Lee DA (2005). Mechanical conditioning of cell-seeded constructs for soft tissue repair - Are optimisation strategies possible? 01-12-2005
Pingguan-Murphy B, Lee DA, Bader DL and Knight MM (2005). Activation of chondrocytes calcium signalling by dynamic compression is independent of number of cycles. Arch Biochem Biophys vol. 444 (1), 45-51. 01-12-2005
Screen HRC, Shelton JC, Bader DL and Lee DA (2005). Cyclic tensile strain upregulates collagen synthesis in isolated tendon fascicles. Biochem Biophys Res Commun vol. 336 (2), 424-429. 21-10-2005
Robinson T, Brooker P, Bozak R and Lee DA (2005). Integration of photolithographic simulation and a mask repair system into a single concurrent work cell. 25th Annual BACUS Symposium on Photomask Technology. 21-10-2005
Robinson T, Dinsdale A, Bozak R, White R, Lee DA and Roessler K (2005). Mask repair for the 65-nm technology node. 25th Annual BACUS Symposium on Photomask Technology. 21-10-2005
Sengers BG, Heywood HK, Lee DA, Oomens CWJ and Bader DL (2005). Nutrient utilization by bovine articular chondrocytes: a combined experimental and theoretical approach. J Biomech Eng vol. 127 (5), 758-766. 01-10-2005
Screen HRC, Shelton JC, Chhaya VH, Kayser MV, Bader DL and Lee DA (2005). The influence of noncollagenous matrix components on the micromechanical environment of tendon fascicles. Ann Biomed Eng vol. 33 (8), 1090-1099. 01-08-2005
Chowdhury TT, Bader DL and Lee DA (2005). Dynamic compression counteracts IL-1β induced INOS and COX-2 activity by human chondrocytes cultured in agarose constructs. European Cells and Materials vol. 10 (SUPPL.2) 01-07-2005
Catuogno C, Chowdhury TT, Bader DL and Lee DA (2005). Dynamic compression influences the biochemical response of human mesenchymal stem cells cultured in agarose constructs. European Cells and Materials vol. 10 (SUPPL.2) 01-07-2005
Pingguna B, Lee DA, Bader DL and Knight MM (2005). Mechanical compression activates chondrocyte Calcium signalling in a cycle dependent Manner Involving the release of ATP. 01-07-2005
Eniwumide JO, Lee DA and Bader DL (2005). Perfusion-Enhancement of molecular transport within 3D scaffolds. European Cells and Materials vol. 10 (SUPPL.2) 01-07-2005
Heywood HK, Bader DL and Lee DA (2005). Superficial and deep chondrocyte subpopulations both express the crabtree effect but exhibit differences in oxygen consumption rate. European Cells and Materials vol. 10 (SUPPL.2) 01-07-2005
Campbell JJ, Lee DA and Bader DL (2005). Mechanical conditioning Influences Mesenchymal stem cell chondrogenesis. European Cells and Materials vol. 10 (SUPPL.2) 01-07-2005
Brooker P, Robinson T, Lewellen J, Naber B, Bozak R and Lee DA (2005). Improved cycle time of mask repair by optimizing nanomachining with photolithographic imaging simulation. Photomask and Next-Generation Lithography Mask Technology XII. 28-06-2005
Gao J, Lee D, Yang Y, Holdcroft S and Frisken BJ (2005). Self-Assembly of Surface-Charged Latex Nanoparticles: A New Route to the Creation of Continuous Channels for Ion Conduction. Macromolecules, American Chemical Society (ACS) vol. 38 (14), 5854-5856. 15-06-2005
Screen HRC, Shelton JC, Bader DL and Lee DA (2005). Cyclic tensile strain upregulates collagen production in isolated tendon fascicles. 01-06-2005
Heywood HK, Bader DL and Lee DA (2005). Glucose metabolism of chondrocytes in tissue-engineered alginate constructs. 01-06-2005
Baria KE, Bader DL, Screen HRC and Lee DA (2005). The effect of substrate and medium composition on the response of human dermal fibroblasts to cyclic tensile strain in vitro. 01-06-2005
Sharma A, Bomzon Z, Lee DA, Kimmel E, Bader DL and Knight MM (2005). Compression-induced reorganization of cytoplasmic networks in bovine chondrocytes using mitochondria as markers. 01-06-2005
Appleby RN, Chowdhury TT, Salter DM, Bader DL and Lee DA (2005). Integrin-mediated mechanotransduction in IL-1 beta-stimulated chondrocytes. 01-06-2005
(2005). British Society for Matrix Biology Autumn Meeting Joint with the UK Tissue & Cell Engineering Society, University of Bristol, UK. International Journal of Experimental Pathology, Wiley vol. 86 (3), a1-a56. 24-05-2005
Rugg EL, Al-Rawi H, Lee D and McNeill AM (2005). Trimethylamine N-oxide reduces the effects of osmotic stress in EBS keratinocytes. 01-04-2005
Lee D, Grant A, Marsden RL and Orengo C (2005). Identification and distribution of protein families in 120 completed genomes using Gene3D. Proteins Structure Function and Bioinformatics, Wiley vol. 59 (3), 603-615. 14-03-2005
Wang Y-N, Bouten CVC, Lee DA and Bader DL (2005). Compression-induced damage in a muscle cell model in vitro. Proc Inst Mech Eng H vol. 219 (1), 1-12. 01-01-2005
Goldberg AJ, Lee DA, Bader DL and Bentley G (2005). Autologous chondrocyte implantation. Culture in a TGF-beta-containing medium enhances the re-expression of a chondrocytic phenotype in passaged human chondrocytes in pellet culture. J Bone Joint Surg Br vol. 87 (1), 128-134. 01-01-2005
2004
Pearl F, Todd A, Sillitoe I, Dibley M, Redfern O, Lewis T, Bennett C, Marsden R, Grant A, Lee D, Akpor A, Maibaum M, Harrison A, Dallman T, Reeves G, Diboun I, Addou S, Lise S, Johnston C, Sillero A, et al. (2004). The CATH Domain Structure Database and related resources Gene3D and DHS provide comprehensive domain family information for genome analysis. Nucleic Acids Research, Oxford University Press (OUP) vol. 33 (suppl_1), d247-d251. 17-12-2004
Nordquist KJ, Dauksher WJ, Mancini DP, Resnick DJ, Hess HF, Pettibone DW, Adler D, Bertsche K, White R, Csuy JE and Lee D (2004). Inspection and repair issues for Step-and-Flash Imprint Lithography templates. 24th Annual BACUS Symposium on Photomask Technology. 06-12-2004
Lee DA, Randall F, Beattie G and Bentall RP (2004). Delusional discourse: An investigation comparing the spontaneous causal attributions of paranoid and non‐paranoid individuals. Psychology and Psychotherapy Theory Research and Practice, Wiley vol. 77 (4), 525-540. 01-12-2004
Bader DL, Shelton JC, Lee DA and SCREEN HRC (2004). Local Strain Measurement within Tendon. Strain vol. 40 (4), 157-163. 01-11-2004
Dauksher WJ, Nordquist KJ, Le NV, Gehoski KA, Mancini DP, Resnick DJ, Casoose L, Bozak R, White R, Csuy J and Lee D (2004). Repair of step and flash imprint lithography templates. 01-11-2004
Bryant SJ, Anseth KS, Lee DA and Bader DL (2004). Crosslinking density influences the morphology of chondrocytes photoencapsulated in PEG hydrogels during the application of compressive strain. J Orthop Res vol. 22 (5), 1143-1149. 01-09-2004
Chowdhury TT, Salter DM, Bader DL and Lee DA (2004). Integrin-mediated mechanotransduction processes in TGFbeta-stimulated monolayer-expanded chondrocytes. Biochem Biophys Res Commun vol. 318 (4), 873-881. 11-06-2004
Kim B-C, van Gelder H, Kim TA, Lee H-J, Baik KG, Chun HH, Lee DA, Choi KS and Kim S-J (2004). Activin Receptor-like Kinase-7 Induces Apoptosis through Activation of MAPKs in a Smad3-dependent Mechanism in Hepatoma Cells*. Journal of Biological Chemistry, Elsevier vol. 279 (27), 28458-28465. 23-04-2004
Bryant SJ, Chowdhury TT, Lee DA, Bader DL and Anseth KS (2004). Crosslinking density influences chondrocyte metabolism in dynamically loaded photocrosslinked poly(ethylene glycol) hydrogels. Ann Biomed Eng vol. 32 (3), 407-417. 01-03-2004
Knight MM, Hibbs K, Roberts SR, LEE DA and Bader DL (2004). Cyclic preconditioning mediates chondrocytes calcium signaling in unstrained and compressed agarose constructs. 50th Annual Meeting of the Orthopaedic Research Society. 01-01-2004
Heywood HK, DeRosa E, LEE DA, Bader DL and Netti P (2004). Non-invasive monitoring of molecular diffusion in neo-cartilage using FRAP technique. 50th Annual Meeting of the Orthopaedic Research Society. 01-01-2004
LEE DA, van Osch G, Verhaar JAN, Mandl EW, van der Linden JC, van der Breevaart Bravenboer J and Weinans H (2004). Extracellular matrix influences the response of chondrocytes to dynamic compression. Trans. Orthop.Rev. Soc vol. 29, 839-839. 01-01-2004
Chowdhury TT, Bader DL and Lee DA (2004). Dynamic compression counteracts IL-1 beta-induced iNOS and COX-2 activity in human chondrocytes cultured in agarose constructs. 01-01-2004
Knight MM, Bonzom Z, Sharma AM, LEE DA, Kimmel E and Bader DL (2004). Heterogeneity of deformation of cytoplasmic networks in compressed chondrocytes. 50th Annual Meeting of the Orthopaedic Research Society. 01-01-2004
Lee DA and Knight MM (2004). Mechanical loading of chondrocytes embedded in 3D constructs: in vitro methods for assessment of morphological and metabolic response to compressive strain. Methods Mol Med vol. 100, 307-324. 01-01-2004
Heywood HK, Bader DL, Bongers M and LEE DA (2004). Glucose depletion induces an upregulation of oxygen utilisation by chondrocytes. 50th Annual Meeting of the Orthopaedic Research Society. 01-01-2004
Chowdhury TT, Appleby RN, Salter DM, Bader DL and Lee DA (2004). Integrin-mediated mechanotransduction in IL-1β stimulated chondrocytes. 01-01-2004
Screen HRC, Lee DA, Bader DL and Shelton JC (2004). An investigation into the effects of the hierarchical structure of tendon fascicles on micromechanical properties. Proc Inst Mech Eng H vol. 218 (2), 109-119. 01-01-2004
Chowdhry TT, Salter DM, Bader DL and LEE DA (2004). alpha 5 beta 1 integrin mediates mechanotransduction processes in TGF-beta stimulated human chondrocytes seeded in agarose constructs and subjected to dynamic compression. 50th Annual Meeting of the Orthopaedic Research Society. 01-01-2004
Bader DL, KNIGHT MM, Bentley G, Kayser M and Holloway I (2004). Increased presence of cells with multiple elongated processes in osteoarthritic femoral head cartilage. Osteoarthritis Cartilage vol. 12 (1), 17-24. 01-01-2004
Lee DA and Martin I (2004). Bioreactor Culture Techniques for Cartilage-Tissue Engineering. Biopolymer Methods in Tissue Engineering 159-170. 01-01-2004
Wiseman M, Bader DL, Reisler T and Lee DA (2004). Passage in monolayer influences the response of chondrocytes to dynamic compression. Biorheology vol. 41 (3-4), 283-298. 01-01-2004
Holloway I, Kayser M, Lee DA, Bader DL, Bentley G and Knight MM (2004). Increased presence of cells with multiple elongated processes in osteoarthritic femoral head cartilage. Osteoarthritis Cartilage vol. 12 (1), 17-24. 01-01-2004
Lee DA and Knight MM (2004). Mechanical Loading of Chondrocytes Embedded in 3D Constructs. Cartilage and Osteoarthritis 307-324. 01-01-2004
Heywood HK, Sembi PK, Lee DA and Bader DL (2004). Cellular utilization determines viability and matrix distribution profiles in chondrocyte-seeded alginate constructs. Tissue Eng vol. 10 (9-10), 1467-1479. 01-01-2004
Chowdhury TT, Bader DL and LEE DA (2004). Combined anti-inflammatory effects of IL-4 and dynamic compression in IL-1beta stimulated bovine chondrocytes cultured in agarose constructs. 50th Annual Meeting of the Orthopaedic Research Society. 01-01-2004
Lee D, Grant A, Sillitoe I, Dibley M, Ranea JG and Orengo C (2004). A structural perspective on genome evolution. Proceedings of the eighth annual international conference on Computational molecular biology - RECOMB '04. 01-01-2004
Grant A, Lee D and Orengo C (2004). Progress towards mapping the universe of protein folds. Genome Biology, Springer Nature vol. 5 (5) 01-01-2004
Lee DA, Fefeu S, Edo-Ukeh AA, Orengo CA and Slingsby C (2004). EyeSite: a semi‐automated database of protein families in the eye. Nucleic Acids Research, Oxford University Press (OUP) vol. 32 (suppl_1), d148-d152. 01-01-2004
2003
Chowdhury TT, Bader DL, Shelton JC and Lee DA (2003). Temporal regulation of chondrocyte metabolism in agarose constructs subjected to dynamic compression. Arch Biochem Biophys vol. 417 (1), 105-111. 01-09-2003
Chowdhury TT, Bader DL and Lee DA (2003). Dynamic compression counteracts IL-1 beta-induced release of nitric oxide and PGE2 by superficial zone chondrocytes cultured in agarose constructs. Osteoarthritis Cartilage vol. 11 (9), 688-696. 01-09-2003
Berry CC, Shelton JC, Bader DL and Lee DA (2003). Influence of external uniaxial cyclic strain on oriented fibroblast-seeded collagen gels. Tissue Eng vol. 9 (4), 613-624. 01-08-2003
Wiseman M, Henson F, Lee DA and Bader DL (2003). Dynamic compressive strain inhibits nitric oxide synthesis by equine chondrocytes isolated from different areas of the cartilage surface. Equine Vet J vol. 35 (5), 451-456. 01-07-2003
Lee D, Grant A, Buchan D and Orengo C (2003). A structural perspective on genome evolution. Current Opinion in Structural Biology, Elsevier vol. 13 (3), 359-369. 01-06-2003
Knight MM, Roberts SR, Lee DA and Bader DL (2003). Live cell imaging using confocal microscopy induces intracellular calcium transients and cell death. Am J Physiol Cell Physiol vol. 284 (4), C1083-C1089. 01-04-2003
Knight MM, Roberts SR, Lee DA and Bader DL (2003). Live cell imaging using confocal microscopy induces intracellular calcium transients and cell death. 01-04-2003
Lee DA, Reisler T and Bader DL (2003). Expansion of chondrocytes for tissue engineering in alginate beads enhances chondrocytic phenotype compared to conventional monolayer techniques. Acta Orthop Scand vol. 74 (1), 6-15. 01-02-2003
Shelton JC, Bader DL and Lee DA (2003). Mechanical conditioning influences the metabolic response of cell-seeded constructs. Cells Tissues Organs vol. 175 (3), 140-150. 01-01-2003
Hernandez D, Addou S, Lee D, Orengo C, Shephard EA and Phillips IR (2003). Trimethylaminuria and a human FMO3 mutation database. HUM MUTAT vol. 22 (3), 209-213. 01-01-2003
Chowdhury TT, LEE DA, Salter DM, Shelton JC and Bader DL (2003). alpha5beta1 integrin mediates mechanotransduction processes in TGFbeta3-stimulated human chondrocytes seeded in agarose constructs and subjected to dynamic compression. ETES. 01-01-2003
Berry CC, Cacou C, Lee DA, Bader DL and Shelton JC (2003). Dermal fibroblasts respond to mechanical conditioning in a strain profile dependent manner. Biorheology vol. 40 (1-3), 337-345. 01-01-2003
Screen HRC, Lee DA, Bader DL and Shelton JC (2003). Development of a technique to determine strains in tendons using the cell nuclei. Biorheology vol. 40 (1-3), 361-368. 01-01-2003
Chowdhury TT, LEE DA, Salter DM, Shelton JC and Bader DL (2003). alpha5beta1 integrin mediates mechanotransduction processes in TGFbeta-stimulated human chondrocyte / agarose constructs and subjected to dynamic compression. Osteoarthritis Cartilage vol. 11 (Suppl 1), S2-S3. 01-01-2003
Chowdhury TT, Shelton JC, Bader DL and LEE DA (2003). Control of mechanotrasduction processes in dynamically stimulated human and bovine chondrocytes cultured in agarose constructs. Internat. J. Artificial Organs vol. 26 (9), 858-858. 01-01-2003
SCREEN HRC, Shelton JC, Bader DL and Lee DA (2003). The effects on non-collagenous matrix components on tendon fascicle micromechanics. 49th Annual Meeting of the Orthopaedic Research Society. 01-01-2003
LEE DA, Heywood HK, Baaijens FPT, Oomens CWJ and Sengers BG (2003). Experimental and theoretical analysis of glucose dependent oxygen utilization by bovine articular chondrocytes. Internat. J. Artificial Organs vol. 26, 875-875. 01-01-2003
2002
Berry CC, Shelton JC, Bader DL and Lee DA (2002). The influence of uniaxial cyclic strain on orientated fibroblast seeded collagen gels. Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products 01-12-2002
Knight MM, Toyoda T, Bader DL and Lee DA (2002). Mechanical strain and hydrostatic pressure induce reversible changes in actin cytoskeletal organisation in chondrocytes in agarose. 01-12-2002
Knight MM, Roberts SR, Lee DA and Bader DL (2002). Light-induced calcium signalling in chondrocytes. 01-12-2002
Lee DA (2002). The design of bioreactor systems for cartilage tissue engineering. Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products 01-12-2002
Lee DA, Chowdhury TT, Roberts SR, Knight MM and Bader DL (2002). An in vitro investigation of cartilage mechanotransduction. 01-07-2002
Turner JEH, Allington-Smith J, Chapman S, Content R, Done C, Haynes R, Lee D and Morris S (2002). The origin of [Fe ii] emission in NGC 4151. Monthly Notices of the Royal Astronomical Society, Oxford University Press (OUP) vol. 331 (2), 284-292. 01-03-2002
Knight MM, van de Breevaart Bravenboer J, Lee DA, van Osch GJVM, Weinans H and Bader DL (2002). Cell and nucleus deformation in compressed chondrocyte-alginate constructs: temporal changes and calculation of cell modulus. Biochim Biophys Acta vol. 1570 (1), 1-8. 15-02-2002
Pearl FMG, Lee D, Bray JE, Buchan DWA, Shepherd AJ and Orengo CA (2002). The CATH extended protein‐family database: Providing structural annotations for genome sequences. Protein Science, Wiley vol. 11 (2), 233-244. 01-02-2002
SCREEN HRC, Lee DA, Bader DL and Shelton JC (2002). The strain behaviour of tendon under tensile load, using cell nuclei as strain markers. 48th Annual Meeting of the Orthopaedic Research Society. 01-01-2002
Knight MM, Roberts SR, LEE DA and Bader DL (2002). Light-induced calcium signalling in chondrocytes. TCES 2002 Annual meeting of the UK Tissue and Cell Engineering Society University of Glasgow, Scotland 19 Sep 2002 - 20 Sep 2002. 01-01-2002
BADER DL, Shelton JC, Lee DA and Screen HRC (2002). Development of a technique to determine strains in tendons using the cell nuclei. Biorheology vol. 40, 361-368. 01-01-2002
Holloway I, Knight MM, LEE DA, Bader DL and Bentley G (2002). Changes in cell morphology and cytoskeletal organisation in osteoarthritic cartilage. ECM III Cartilage & Joint repair Tutorials, Basic Research & Clinical Methods Davos, Switzerland 1 Jul 2002 - 3 Jul 2002. 01-01-2002
Knight MM, Toyoda T, LEE DA and Bader DL (2002). Mechanical strain and hydrostatic pressure induce reversible changes in actin cytoskeletal organisation in chondrocytes in agarose. 48th Annual Meeting of the Orthopaedic Research Society. 01-01-2002
Bader DL, Shelton JC, Lee DA and SCREEN HRC (2002). Non-collagenous matrix components influence the micromechanical environment of tenocytes within tendon fascicles subjected to tensile strain. Eur. Cells Mat. vol. 4:S1, 41-42. 01-01-2002
Holloway I, Knight MM, LEE DA, Bader DL and Bentley G (2002). Characterisation of cell morphology, cytoskeletal organization and apoptosis in human osteoarthritic cartilage. 48th Annual Meeting of the Orthopaedic Research Society. 01-01-2002
Bader DL, Ohashi T, Knight MM, Lee DA and Sato M (2002). Deformation properties of articular chondrocytes: a critique of three separate techniques. 01-01-2002
Heywood HK, LEE DA and Bader DL (2002). Monitoring neo-cartilage formation in cell seeded alginate constructs of clinically relevant dimensions. TCES 2002 Annual meeting of the UK Tissue and Cell Engineering Society Glasgow, Scotland 19 Sep 2002 - 20 Sep 2002. 01-01-2002
Orengo CA, Bray JE, Buchan DWA, Harrison A, Lee D, Pearl FMG, Sillitoe I, Todd AE and Thornton JM (2002). The CATH protein family database: A resource for structural and functional annotation of genomes. 01-01-2002
2001
Lee D, Haynes R, Ren D and Allington‐Smith J (2001). Characterization of Lenslet Arrays for Astronomical Spectroscopy. Publications of the Astronomical Society of the Pacific, IOP Publishing vol. 113 (789), 1406-1419. 08-10-2001
Bader D and Lee D (2001). Gene Therapy and Tissue Engineering in Orthopaedic and Sports Medicine (2000) Edited by Johnny Huard and Freddie H. Fu, ISBN 0-8176-4071-1, Birkhauser: Boston pages 1–286. Medical Engineering & Physics, Elsevier vol. 23 (8) 01-10-2001
Lee D, Haynes R and Skeen DJ (2001). Properties of optical fibres at cryogenic temperatures. Monthly Notices of the Royal Astronomical Society, Oxford University Press (OUP) vol. 326 (2), 774-780. 01-09-2001
Ziegler BL, Bower RG, Smail I, Davies RL and Lee D (2001). The early-type galaxy population in Abell 2218. Monthly Notices of the Royal Astronomical Society, Oxford University Press (OUP) vol. 325 (4), 1571-1590. 21-08-2001
Chowdhury TT, Bader DL and Lee DA (2001). Dynamic compression inhibits the synthesis of nitric oxide and PGE(2) by IL-1beta-stimulated chondrocytes cultured in agarose constructs. Biochem Biophys Res Commun vol. 285 (5), 1168-1174. 03-08-2001
Antonyak MA, Singh US, Lee DA, Boehm JE, Combs C, Zgola MM, Page RL and Cerione RA (2001). Effects of Tissue Transglutaminase on Retinoic Acid-induced Cellular Differentiation and Protection against Apoptosis*. Journal of Biological Chemistry, Elsevier vol. 276 (36), 33582-33587. 03-07-2001
Knight MM, Ross JM, Sherwin AF, Lee DA, Bader DL and Poole CA (2001). Chondrocyte deformation within mechanically and enzymatically extracted chondrons compressed in agarose. Biochim Biophys Acta vol. 1526 (2), 141-146. 03-05-2001
Knight MM, Idowu BD, Lee DA and Bader DL (2001). Temporal changes in cytoskeletal organisation within isolated chondrocytes quantified using a novel image analysis technique. Med Biol Eng Comput vol. 39 (3), 397-404. 01-05-2001
Roberts SR, Knight MM, Lee DA and Bader DL (2001). Mechanical compression influences intracellular Ca2+ signaling in chondrocytes seeded in agarose constructs. J Appl Physiol (1985) vol. 90 (4), 1385-1391. 01-04-2001
Bouten CV, Knight MM, Lee DA and Bade DL (2001). Compressive deformation and damage of muscle cell subpopulations in a model system. Ann Biomed Eng vol. 29 (2), 153-163. 01-02-2001
Knight MM, van de Breevaart Brevenboer J, van Osch G, Weinans H, LEE DA and Bader DL (2001). Temporal changes in cell and nucleus deformation in isolated chondrocytes compressed in alginate scaffolds. 47th Annual Meeting, Orthopaedic Research Society San Francisco, California 25 Feb 2001 - 28 Feb 2001. 01-01-2001
Chowdhury T, Bader DL and LEE DA (2001). Dynamic compression influences the synthesis of nitric oxide by IL-1beta stimulated chondrocyte sub-populations cultured in agarose constructs. 47th Annual Meeting, Orthopaedic Research Society San Francisco, California 25 Feb 2001 - 28 Feb 2001. 01-01-2001
Bader DL, KNIGHT MM, Lee DA and Bouten CV (2001). Compressive deformation and damage of muscle cell subpopulaltions in a model system. Ann. Biomed. Eng. vol. 29 (2), 153-163. 01-01-2001
LEE DA, Idowu BD, Knight MM and Bader DL (2001). Mechanical compression influences cytoskeletal oragnisation within chondrocytes seeded in agarose constructs. 47th Annual Meeting, Orthopaedic Research Society San Francisco, California 25 Feb 2001 - 28 Feb 2001. 01-01-2001
Enobakhare B, Bader DL and LEE DA (2001). Physiochemical, biochemical and mechanical characterisation of chondrocyte-alginate constructs. 47th Annual Meeting, Orthopaedic Research Society San Francisco, California 25 Feb 2001 - 28 Feb 2001. 01-01-2001
Lee DA (2001). Embryonic stem cells: scientific possibilities, ethical considerations, and regulation in the UK. INTERDISCIPL SCI REV vol. 26 (2), 112-124. 01-01-2001
Albà MM, Lee D, Pearl FMG, Shepherd AJ, Martin N, Orengo CA and Kellam P (2001). VIDA: a virus database system for the organization of animal virus genome open reading frames. Nucleic Acids Research, Oxford University Press (OUP) vol. 29 (1), 133-136. 01-01-2001
Pearl FM, Martin N, Bray JE, Buchan DW, Harrison AP, Lee D, Reeves GA, Shepherd AJ, Sillitoe I, Todd AE, Thornton JM and Orengo CA (2001). A rapid classification protocol for the CATH Domain Database to support structural genomics. Nucleic Acids Research, Oxford University Press (OUP) vol. 29 (1), 223-227. 01-01-2001
2000
Lee D and Taylor K (2000). Fibre developments at the Anglo-Australian Observatory for SPIRAL and AUSTRALIS. 03-12-2000
Haynes R, Baldry IK, Taylor K and Lee D (2000). Characterisation of cooled infrared fibres for the Gemini IRMOS. 03-12-2000
Berry CC, Cacou C, Shelton JC, Bader DL and Lee DA (2000). Biological response of cyclic strain on developed cell seeded collagen gel model. Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling 01-12-2000
Roberts SR, Knight MM, Lee DA and Bader DL (2000). Intracellular - CA2+ signalling in compressed chondrocyte agarose constructs. 01-12-2000
Knight MM, Van De Breevaart Bravenboer J, Bader DL and Lee DA (2000). Compression induced cell and nucleus deformation in chondrocyte-alginate constructs. 01-12-2000
Enobakhare BO, Bader DL and Lee DA (2000). Physiochemical, biochemical and mechanical characterisation of chondrocyte-alginate constructs. Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling 01-12-2000
Chowdhury TT, Bader DL and Lee DA (2000). Dynamic compression inhibits the synthesis of nitric oxide by IL-1β stimulated chondrocytes cultured in agarose constructs. Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling 01-12-2000
Cacou C, Palmer D, Lee DA, Bader DL and Shelton JC (2000). A system for monitoring the response of uniaxial strain on cell seeded collagen gels. MED ENG PHYS vol. 22 (5), 327-333. 01-06-2000
Idowu BD, Knight MM, Bader DL and Lee DA (2000). Confocal analysis of cytoskeletal organisation within isolated chondrocyte sub-populations cultured in agarose. Histochem J vol. 32 (3), 165-174. 01-03-2000
Lee D and Allington-Smith JR (2000). An experimental investigation of immersed gratings. Monthly Notices of the Royal Astronomical Society, Oxford University Press (OUP) vol. 312 (1), 57-69. 11-02-2000
Roberts SR, Knight MM, Lee DA and Bader DL (2000). Intracellular calcium signalling in compressed chondrocyte agarose constructs. 01-02-2000
Lee DA, Knight MM, Bolton JF, Idowu BD, Kayser MV and Bader DL (2000). Chondrocyte deformation within compressed agarose constructs at the cellular and sub-cellular levels. J Biomech vol. 33 (1), 81-95. 01-01-2000
Lee DA, Noguchi T, Frean SP, Lees P and Bader DL (2000). The influence of mechanical loading on isolated chondrocytes seeded in agarose constructs. Biorheology vol. 37 (1-2), 149-161. 01-01-2000
Pearl FM, Lee D, Bray JE, Sillitoe I, Todd AE, Harrison AP, Thornton JM and Orengo CA (2000). Assigning genomic sequences to CATH. Nucleic Acids Research, Oxford University Press (OUP) vol. 28 (1), 277-282. 01-01-2000
Bader D and Lee D (2000). Chapter 4 Structure – Properties of Soft Tissues Articular Cartilage. Structural Biological Materials - Design and Structure-Property Relationships 75-103. 01-01-2000
1999
Kang SH, Bang Y-J, Im Y-H, Yang H-K, Lee DA, Lee HY, Lee HS, Kim NK and Kim S-J (1999). Transcriptional repression of the transforming growth factor-β type I receptor gene by DNA methylation results in the development of TGF-β resistance in human gastric cancer. Oncogene, Springer Nature vol. 18 (51), 7280-7286. 02-12-1999
Lee DA (1999). Models of government regulation of privatized transit systems in five Latin American cities. Transportation Quarterly vol. 53 (1), 21-39. 01-12-1999
Haynes R, Lee D, Allington‐Smith J, Content R, Dodsworth G, Lewis I, Sharples R, Turner J, Webster J, Done C, Peletier R, Parry I and Chapman S (1999). Multiple‐Object and Integral Field Near‐Infrared Spectroscopy Using Fibers. Publications of the Astronomical Society of the Pacific, IOP Publishing vol. 111 (765), 1451-1468. 01-11-1999
Huang J, Hing KA, Best SM, Lee DA, Silvio LD and Bonfield W (1999). A COMPARATIVE STUDY OF VARIOUS ASSAYS FOR IN VITRO BIOCOMPATIBILITY ASSESSMENT OF EXPERIMENTAL ZIRCONIA. Bioceramics. 01-10-1999
White AET, Bentley G, Stephens MD, Bader DL, Giddins GEB and Lee DA (1999). The effects of storage temperature on the composition, metabolism acid biomechanical properties of human articular cartilage. KNEE vol. 6 (3), 197-205. 01-08-1999
Lee DA (1999). Introducing Fare Simplification and New Convenience Fares at Connecticut Transit. Transportation Research Record Journal of the Transportation Research Board, SAGE Publications vol. 1669 (1), 109-112. 01-01-1999
1998
Lee D (1998). A Tour through through. Journal of English Linguistics, SAGE Publications vol. 26 (4), 333-351. 01-12-1998
Haynes R, Doei AP, Content R, Allington-Smith J and Lee D (1998). TEIFU: A thousand element integral field unit for the WHT fed by the ELECTRA AO system. 01-12-1998
Lee DA, Noguchi T, Knight MM, O'Donnell L, Bentley G and Bader DL (1998). Response of chondrocyte subpopulations cultured within unloaded and loaded agarose. J Orthop Res vol. 16 (6), 726-733. 01-11-1998
Knight MM, Lee DA and Bader DL (1998). The influence of elaborated pericellular matrix on the deformation of isolated articular chondrocytes cultured in agarose. Biochim Biophys Acta vol. 1405 (1-3), 67-77. 21-10-1998
Lee DA, Frean SP, Lees P and Bader DL (1998). Dynamic mechanical compression influences nitric oxide production by articular chondrocytes seeded in agarose. BIOCHEM BIOPH RES CO vol. 251 (2), 580-585. 20-10-1998
Haynes R, Content R, Turner JE, Allington-Smith JR and Lee D (1998). SMIRFS-II: multiobject and integral-field near-IR spectroscopy at UKIRT. Infrared Astronomical Instrumentation. 21-08-1998
Lee D, Allington-Smith JR, Content R and Haynes R (1998). Characterization of microlens arrays for integral field spectroscopy. Optical Astronomical Instrumentation. 09-07-1998
Murowinski RG, Bond T, Crampton D, Davidge TJ, Fletcher JM, Leckie B, Morbey CL, Roberts SC, Saddlemyer LK, Sebesta J, Stilburn JR, Szeto K, Allington-Smith JR, Content R, Davies RL, Dodsworth GN, Haynes R, Robinson DJ, Robertson DJ, Webster J, et al. (1998). Gemini multiobject spectrographs. Optical Astronomical Instrumentation. 09-07-1998
Lee DA and Goodfellow JM (1998). The pH-Induced Release of Iron from Transferrin Investigated with a Continuum Electrostatic Model. Biophysical Journal, Elsevier vol. 74 (6), 2747-2759. 01-06-1998
Knight MM, Ghori SA, Lee DA and Bader DL (1998). Measurement of the deformation of isolated chondrocytes in agarose subjected to cyclic compression. Med Eng Phys vol. 20 (9), 684-688. 01-01-1998
Lee DA, Assoku E and Doyle V (1998). A specific quantitative assay for collagen synthesis by cells seeded in collagen-based biomaterials using sirius red F3B precipitation. J MATER SCI-MATER M vol. 9 (1), 47-51. 01-01-1998
Lao WC, Lee D, Burroughs AK, Lanzani G, Rolles K, Emery VC and Griffiths PD (1998). Erratum: Use of polymerase chain reaction to provide prognostic information on human cytomegalovirus disease after liver transplantation. (Journal of Medical Virology 51 (152-158)). Journal of Medical Virology vol. 54 (1) 01-01-1998
1997
Davies RL, Allington-Smith JR, Bettess P, Chadwick E, Content R, Dodsworth GN, Haynes R, Lee D, Lewis IJ, Webster J, Atad E, Beard SM, Ellis M, Hastings PR and Williams PR (1997). GMOS: the GEMINI Multiple Object Spectrographs. 01-12-1997
Lee DA, Salih V, Stockton EF, Stanton JS and Bentley G (1997). Effect of Normal Synovial Fluid on the Metabolism of Articular Chondrocytes In Vitro. Clinical Orthopaedics and Related Research®, Wolters Kluwer vol. 342 (&NA;), 228-238. 01-09-1997
Lee D and Recce M (1997). Quantitative Evaluation of the Exploration Strategies of a Mobile Robot. The International Journal of Robotics Research, SAGE Publications vol. 16 (4), 413-447. 01-08-1997
Lee DA and Bader DL (1997). Compressive strains at physiological frequencies influence the metabolism of chondrocytes seeded in agarose. J ORTHOP RES vol. 15 (2), 181-188. 01-03-1997
O'Neil C, Lee D, Clewley G, Johnson MA and Emery VC (1997). Prevalence of anti‐Vif antibodies in HIV‐1 infected individuals assessed using recombinant baculovirus expressed Vif protein. Journal of Medical Virology, Wiley vol. 51 (3), 139-144. 01-03-1997
Lee DA (1997). Frame conflicts and competing construals in family argument. Journal of Pragmatics, Elsevier vol. 27 (3), 339-360. 01-03-1997
Lao WC, Lee D, Burroughs AK, Lanzini G, Rolles K, Emery VC and Griffiths PD (1997). Use of polymerase chain reaction to provide prognostic information on human cytomegalovirus disease after liver transplantation. Journal of Medical Virology, Wiley vol. 51 (3), 152-158. 01-03-1997
1996
Group CTWPOTCRCBCT (1996). Preliminary Results From the Cancer Research Campaign Trial Evaluating Tamoxifen Duration in Women Aged Fifty Years or Older With Breast Cancer. Journal of the National Cancer Institute, Oxford University Press (OUP) vol. 88 (24), 1834-1839. 18-12-1996
Enobakhare BO, Bader DL and Lee DA (1996). Quantification of sulfated glycosaminoglycans in chondrocyte/alginate cultures, by use of 1,9-dimethylmethylene blue. ANAL BIOCHEM vol. 243 (1), 189-191. 01-12-1996
Doyle V, Pearson RG and Lee DA (1996). Specific quantitative assay to determine the rate of collagen synthesis in a collagen gel system. 01-12-1996
Johnson SC, Rovinsky RB, Chin DK, Kostiuk PF, Lee DA, Hemm RV and Wingrove ER (1996). Reduction of weather-related terminal area delays in the free-flight era. 01-12-1996
Enobakhare B, Bader D and Lee DA (1996). Novel system for the production of chondrocyte seeded alginate constructs. 01-12-1996
Lee DA and Bader DL (1996). Mechanical strain influences the metabolism of chondrocytes cultured in an artificial matrix. 01-12-1996
Pearson RG, Lee DA, Doyle V and Bader DL (1996). Cellular responses to poly-L-lactic acid degradation products. 01-12-1996
Gor D, Lee D and Emery VC (1996). J. Virol. Methods Erratum to “Detection of human cytomegalovirus polymerase chain reaction products using oligonucleotide probes directly conjugated to alkaline phosphatase” [61 (1996) 145]. Journal of Virological Methods, Elsevier vol. 62 (2) 01-12-1996
Gor D, Lee D and Emery VC (1996). Detection of human cytomegalovirus polymerase chain reaction products using oligonucleotide probes directly conjugated to alkaline phosphatase. Journal of Virological Methods, Elsevier vol. 61 (1-2), 145-150. 01-09-1996
Doyle V, Pearson R, Lee D, Wolowacz S and Mc Taggart S (1996). An investigation of the growth of human dermal fibroblasts on poly-L-lactic acid in vitro. Journal of Materials Science: Materials in Medicine, Springer Nature vol. 7 (6), 381-385. 01-06-1996
Gorinsky B, Laskowski RA, Lee DA and Bomford A (1996). Conformational analysis of pentapeptide sequences matching a proposed recognition motif for lysosomal degradation. Biochimica et Biophysica Acta, Elsevier vol. 1293 (2), 243-253. 01-04-1996
Lee D and Sanders M (1996). Implementing a Visioning and Strategic Planning Process at CTTransit. Transportation Research Record Journal of the Transportation Research Board, SAGE Publications vol. 1521, 58-61. 01-01-1996
1995
Lee DA and Bader DL (1995). The development and characterization of an in vitro system to study strain-induced cell deformation in isolated chondrocytes. IN VITRO CELL DEV-AN vol. 31 (11), 828-835. 01-12-1995
1994
Lee D and Recce M (1994). Quantitative evaluation of the exploration strategies of a mobile robot. 01-12-1994
Lee D and Recce M (1994). Quantitative evaluation of the exploration strategies of an intelligent vehicle. 01-12-1994
Lee DA, Bentley G and Archer CW (1994). Proteoglycan depletion alone is not sufficient to stimulate proteoglycan synthesis in cultured bovine cartilage explants. Osteoarthritis and Cartilage, Elsevier vol. 2 (3), 175-185. 01-09-1994
Reissis N, Downes S, Kayser M, Lee D and Bentley G (1994). Characterization of the repair tissue in articular cartilage defects using silver-enhanced colloidal gold immunostaining. Journal of Materials Science: Materials in Medicine, Springer Nature vol. 5 (6-7), 402-406. 01-06-1994
1993
Lee DA, Bentley G and Archer CW (1993). The control of cell division in articular chondrocytes. Osteoarthritis and Cartilage, Elsevier vol. 1 (2), 137-145. 01-04-1993
1991
Lee DA (1991). Categories in the description of just. Lingua, Elsevier vol. 83 (1), 43-66. 01-01-1991
1990
Archer CW, Cottrill CP and Lee D (1990). Effects of ascorbate on myogenesis in micromass culture. In Vitro Cellular & Developmental Biology, Springer Nature vol. 26 (3), 259-264. 01-03-1990
Lee DA (1990). Digitization of the AT&T worldwide intelligent network. AT&T technology vol. 5 (1), 14-19. 01-01-1990
1989
Haupert D, Chen FG and Lee D (1989). VLSI package reliability risk due to accelerated environmental testing. 01-12-1989
Jones BM, Evans PM and Lee DA (1989). Relation between the rate of cell movement under agarose and the positioning of cells in heterotypic aggregates. Experimental Cell Research, Elsevier vol. 180 (1), 287-296. 01-01-1989
1988
Lee D (1988). INTEGRATED SERVICES DIGITAL NETWORK. British Telecommunications Engineering vol. 7 (pt 2), 2-12. 01-07-1988
Lee DA (1988). Moth Density and Oviposition Patterns of the European Corn Borer, Ostrinia nubilalis (Lepidoptera: Pyralidae), in Alberta. Environmental Entomology, Oxford University Press (OUP) vol. 17 (2), 220-224. 01-04-1988
1987
Lee DA and Spence JR (1987). Reproductive patterns of the European corn borer (Ostrinia nubilalis) in Alberta. Canadian Journal of Zoology, Canadian Science Publishing vol. 65 (7), 1733-1740. 01-07-1987
Lee D (1987). The semantics of just. Journal of Pragmatics, Elsevier vol. 11 (3), 377-398. 01-06-1987
1985
1984
1983
Lee DA, Winslow NR, Speight AN and Hey EN (1983). Prevalence and spectrum of asthma in childhood. The BMJ, BMJ vol. 286 (6373) 16-04-1983
Speight AN, Lee DA and Hey EN (1983). Underdiagnosis and undertreatment of asthma in childhood. The BMJ, BMJ vol. 286 (6373) 16-04-1983
1981
Angelini P, Bond WD, Caputo AJ, Mack JE, Lackey WJ, Lee DA and Stinton DP (1981). Sol-Gel Technology Applied to Crystalline Ceramic Nuclear Waste Forms. 01-01-1981
Grants
Grants of specific relevance to the Centre for Bioengineering
Clock-Chips - Incorporating the Circadian Clock into Organ-on-a-Chip TechnologyDavid Lee and Lei Su
£387,326 BBSRC Biotechnology and Biological Sciences Research Council (01-10-2024 - 31-03-2026)
(EPSRC CDT 2023) Next Generation Organ-on-a-Chip TechnologiesHazel Screen, Martin Knight, Thomas Iskratsch, Caroline Roney, Yi Sui, David Lee, Julia Shelton, Tsz Ho Tse, John Connelly, Adrian Biddle and Lucy Norling
£7,066,811 EPSRC Engineering and Physical Sciences Research Council (01-07-2024 - 30-09-2032)
Harmonised IAA grant - Improve and accelerate the impact of QMUL research BBSRCDavid Lee and Viji Draviam Sastry
£495,000 BBSRC Biotechnology and Biological Sciences Research Council (01-04-2022 - 31-03-2026)
Harmonised IAA grant - Improve and accelerate the impact of QMUL research EPSRCDavid Lee and Yang Hao
£882,583 EPSRC Engineering and Physical Sciences Research Council (01-04-2022 - 31-03-2026)
Harmonised IAA grant - Improve and accelerate the impact of QMUL research MRCMauro Perretti, Tatjana Crnogorac-Jurcevic and David Lee
£457,000 MRC Medical Research Council (01-04-2022 - 31-03-2026)
Engineering Circadian Biology into Human Induced Pluripotent Stem Cell Organ-on-a-Chip modelsDavid Lee and Yung-Yao Lin
£201,874 BBSRC Biotechnology and Biological Sciences Research Council (01-02-2022 - 31-01-2025)