Research
Cell biomechanics, Biofluids, Flow and solute transport in tissues, Cardiovascular disease, Arterial haemodynamics, Microcirculation
Interests
My work focuses on vascular bioengineering and biomaterial mechanics, including studies on the endothelial glycocalyx, vascular stem cells and progenitor cells, transmembrane and transcapillary exchange. Working at the interface between biomedical engineering, biomaterials and cell mechanics, I have led a number of multidisciplinary projects in the UK, as well as international projects between the UK, US, China and Japan. Due to limitation of the space, I will only present our research on the vascular endothelial glycocalyx. We have a number of other projects, including microcapsules as vehicles for drug delivery and vascular stem cells in collaboration with colleagues in Medical Schools at Queen Mary and King's College London. Details of these studies can be found in our publication lists.
Studies on the glycocalyx
a) its spatial distribution and temporal development on the endothelial cell membrane;
b) mechanical properties of the glycocalyx;
c) effects of fluid shear stress on its distribution on the cell membrane; and
d) its stability and interplay with the cytoskeletal actin network.
The endothelial glycocalyx is a carbohydrate–protein layer that lines the luminal surface of the endothelium. It anchors to the cell membrane via its core proteins that share extended link to the actin cytoskeleton. Those protein domains and the attached carbohydrates are susceptible to pathological changes, contributing to vascular diseases.
a) Spatio-temporal development of the glycocalyx
We observe the spatial distribution of the endothelial glycocalyx layer using laser-scanning confocal microscopy. Cells after different days in culture are studied to evaluate the temporal development of the glycocalyx layer. Comparisons are made between the controls and enzyme-treated groups.
Our in vitro results using confocal microscopy show the development of the endothelial glycocalyx over time. The growth appears to initiate from the edge of cells and takes up to two weeks to cover the apical region of the cell membrane (i.e. region above the nucleus). The mechanism underlining this spatial distribution and temporal change needs further investigation, but it seems functionally beneficial as the glycocalyx layer covers the intercellular gaps for the endothelium to fulfil its role as a selective semi-permeable membrane for the circulating blood. Our three-dimensional reconstructed images, although limited by the confocal resolution in the z-direction, indicate that the thickness of the glycocalyx layer is approximately 1 μm. This finding agrees reasonably well with previous studies.
b) Mechanical property of the glycocalyx
we have investigated mechanical properties of the glycocalyx layer using AFM nano-indentation. The Young's modulus of the glycocalyx is calculated by analysing testing results on the HUVEC cell membrane with and without the glycocalyx layer.
Indentation of the cell membrane of the initial 200 nm (after bending of the cantilever is deducted) enables us to estimate the Young's modulus of the glycocalyx layer by comparing the change in the cell membrane Young's modulus with and without the glycocalyx. We can simplify the flexible glycocalyx layer on a deformable cell membrane to a two springs in series system. Our results suggest that the cell membrane Young's modulus without the glycocalyx layer is approximately 2.13 kPa (average of day 14 and 21), and with the glycocalyx layer, the overall Young's modulus is approximately 0.34 kPa (average of day 14 and 21 control groups). This leads to the Young's modulus of the glycocalyx layer alone to be approx. 0.39 kPa.
c) Shear stress-induced redistribution of the glycocalyx
We study the effects of shear stress on the spatial distribution of the glycocalyx on endothelial cell membranes, using a flow chamber. Two parameters are used to characterize the spatial distribution of the glycocalyx: (a) the percentage area of the cell membrane covered by the glycocalyx layer and (b) the fluorescence intensity ratio between the apical and edge regions of endothelial cells. They give quantitative measures of the observed changes in the distribution of the glycocalyx following shear exposure. Comparisons are made at different time points after shear stimulation to study the redistribution of the glycocalyx on the cell membrane. Further studies are carried out to analyse the recovery of the glycocalyx layer following its enzyme degradation in either static or shear flow conditions.
d) Stability of the glycocalyx
We investigate the contribution of the actin cytoskeleton to the structural stability of the glycocalyx in vitro. Specifically, we establish two states of actin depolymerisation with the use of cytochalasin D (CD). One is rapid depolymerisation which quickly disrupts the actin using a high concentration of CD, and the other is prolonged actin disruption by employing a low CD concentration to persistently depolymerise the actin cytoskeleton.
Publications
![Relevant Publication](/common/publications/images/fav.png)
Publications of specific relevance to the Centre for Bioengineering
2024
![Relevant Publication](/common/publications/images/fav.png)
Xiao Y, Luo S, Qiu J, Zhang Y, Liu W, Zhao Y, Zhu Y, Deng Y, Lu M, Liu S, Lin Y, Huang A,
Wang W, Hu X and Gu B (2024).
Highly sensitive SERS platform for pathogen analysis by cyclic DNA nanostructure@AuNP tags and cascade primer exchange reaction. Journal of Nanobiotechnology vol. 22
26-02-20242023
![Relevant Publication](/common/publications/images/fav.png)
Li W,
Wang W, Luo S, Chen S, Ji T, Li N, Pan W, Zhang X, Wang X, Li K, Zhang Y and Yan X (2023).
A sensitive and rapid electrochemical biosensor for sEV-miRNA detection based on domino-type localized catalytic hairpin assembly. Journal of Nanobiotechnology,
Springer Nature vol. 21 (1)
09-09-2023![Relevant Publication](/common/publications/images/fav.png)
Chen S, Cheng Y, Zhao Z, Zhang K, Hao T,
Sui Y,
Wang W, Zhao J and Li Y (2023).
Core–Shell-Structured Electrorheological Fluid with a Polarizability-Tunable Nanocarbon Shell for Enhanced Stimuli-Responsive Activity. ACS Applied Materials & Interfaces,
American Chemical Society (ACS) vol. 15 (29), 35741-35749.
14-07-2023![Relevant Publication](/common/publications/images/fav.png)
Feng J, Jia L, Pan W, Fan Y, Guo J, Luo T, Liu C,
Wang W, Zheng L and Li B (2023).
Rapid and efficient fluorescent aptasensor for PD-L1 positive extracellular vesicles isolation and analysis: EV-ANCHOR. Chemical Engineering Journal,
Elsevier vol. 465
01-06-2023![Relevant Publication](/common/publications/images/fav.png)
Guo Z, Lin T, Jing D,
Wang W and
Sui Y (2023).
A method for real-time mechanical characterisation of microcapsules. Biomechanics and Modeling in Mechanobiology,
Springer Nature vol. 22 (4), 1209-1220.
24-03-2023![Relevant Publication](/common/publications/images/fav.png)
Wang Z, Lu R,
Wang W, Tian FB, Feng JJ and
Sui Y (2023).
A computational model for the transit of a cancer cell through a constricted microchannel. Biomechanics and Modeling in Mechanobiology,
Springer Nature vol. 22 (4), 1129-1143.
28-02-2023![Relevant Publication](/common/publications/images/fav.png)
Zhang X, Jiang X,
Wang W, Luo S, Guan S, Li W, Situ B, Li B, Zhang Y and Zheng L (2023).
A simple and sensitive electrochemical biosensor for circulating tumor cell determination based on dual-toehold accelerated catalytic hairpin assembly. Microchimica Acta,
Springer Nature vol. 190 (2)
24-01-20232022
![Relevant Publication](/common/publications/images/fav.png)
Zhang Y, Li W, Ji T, Luo S, Qiu J, Situ B, Li B, Zhang X, Zhang T,
Wang W, Xiao Y, Zheng L and Yan X (2022).
Localized DNA tetrahedrons assisted catalytic hairpin assembly for the rapid and sensitive profiling of small extracellular vesicle-associated microRNAs. Journal of Nanobiotechnology,
Springer Nature vol. 20 (1)
01-12-2022![Relevant Publication](/common/publications/images/fav.png)
Gao F, Yin J, Long Y, Zhu S, Huang Z, Wang J, Zheng H,
Wang W and Zheng L (2022).
Diagnostic Value of IGFBP-2 in Predicting Preeclampsia before 20 Weeks of Pregnancy: A Prospective Nested Case-Control Study. Computational and Mathematical Methods in Medicine,
Hindawi vol. 2022
28-09-2022![Relevant Publication](/common/publications/images/fav.png)
Jia L, Li B, Fang C, Liang X, Xie Y, Sun X,
Wang W, Zheng L and Wang D (2022).
Extracellular Vesicles of Mesenchymal Stem Cells Are More Effectively Accessed through Polyethylene Glycol-Based Precipitation than by Ultracentrifugation. Stem Cells International,
Hindawi vol. 2022
06-09-2022![Relevant Publication](/common/publications/images/fav.png)
Wu Y, Yang J, van Teijlingen A, Berardo A, Corridori I, Feng J, Xu J, Titirici MM, Rodriguez-Cabello JC,
Pugno NM, Sun J,
Wang W, Tuttle T and Mata A (2022).
Disinfector-Assisted Low Temperature Reduced Graphene Oxide-Protein Surgical Dressing for the Postoperative Photothermal Treatment of Melanoma. Advanced Functional Materials 08-07-2022![Relevant Publication](/common/publications/images/fav.png)
Lin T, Wang Z, Lu RX, Wang W and
Sui Y (2022).
Characterising Mechanical Properties of Flowing Microcapsules Using a Deep Convolutional Neural Network. Advances in Applied Mathematics and Mechanics,
Global Science Press vol. 14 (1), 79-100.
01-06-2022![Relevant Publication](/common/publications/images/fav.png)
Zhang Y, Hollis D, Ross R, Snow T, Terrill NJ, Lu Y,
Wang W, Connelly J, Tozzi G and
Gupta HS (2022).
Investigating the Fibrillar Ultrastructure and Mechanics in Keloid Scars Using In Situ Synchrotron X-ray Nanomechanical Imaging. Materials (Basel),
MDPI vol. 15 (5)
01-03-20222021
![Relevant Publication](/common/publications/images/fav.png)
Pu JH, Wang SK, Sun J,
Wang W and
Wang HS (2021).
Growth and self-jumping of single condensed droplet on nanostructured surfaces: A molecular dynamics simulation. Journal of Molecular Liquids,
Elsevier vol. 340
01-10-2021![Relevant Publication](/common/publications/images/fav.png)
Li W and
Wang W (2021).
The role of actomyosin in the regulation of syndecan-1 in hyperosmosis. BBA - General Subjects,
Elsevier vol. 1865 (10)
31-07-2021![Relevant Publication](/common/publications/images/fav.png)
Lu RX, Wang Z, Salsac A-V, Barthès-Biesel D,
Wang W and
Sui Y (2021).
Path selection of a train of spherical capsules in a branched microchannel. Journal of Fluid Mechanics,
Cambridge University Press (CUP) vol. 923
22-07-2021![Relevant Publication](/common/publications/images/fav.png)
Pang X, Li W, Chang L,
Gautrot JE,
Wang W and Azevedo HS (2021).
Hyaluronan (HA) Immobilized on Surfaces via Self-Assembled Monolayers of HA-Binding Peptide Modulates Endothelial Cell Spreading and Migration through Focal Adhesion. ACS Applied Materials and Interfaces,
American Chemical Society vol. 13 (22), 25792-25804.
26-05-2021![Relevant Publication](/common/publications/images/fav.png)
Wu Y, Fortunato GM, Okesola BO, Brocchetti FLPD, Suntornnond R, Connelly J, De Maria C, Rodriguez-Cabello JC, Vozzi G,
Wang W and Mata A (2021).
An interfacial self-assembling bioink for the manufacturing of capillary-like structures with tuneable and anisotropic permeability. Biofabrication,
IOP Publishing vol. 13 (3)
08-04-2021![Relevant Publication](/common/publications/images/fav.png)
Pu JH, Wang SK, Sun J,
Wang W and
Wang HS (2021).
Stable and Efficient Nanofilm Pure Evaporation on Nanopillar Surfaces. Langmuir vol. 37 (12), 3731-3739.
08-03-2021![Relevant Publication](/common/publications/images/fav.png)
Guo T,
Wang Y, Jia J, Mao X, Stankiewicz E, Scandura G, Burke E, Xu L, Marzec J, Davies CR, Lu JJ, Rajan P, Grey A, Tipples K, Hines J, Kudahetti S, Oliver T, Powles T, Alifrangis C, Kohli M,
et al. (2021).
The Identification of Plasma Exosomal miR-423-3p as a Potential Predictive Biomarker for Prostate Cancer Castration-Resistance Development by Plasma Exosomal miRNA Sequencing. Frontiers in Cell and Developmental Biology,
Frontiers vol. 8
07-01-2021![Relevant Publication](/common/publications/images/fav.png)
Lin T, Wang Z, Lu R,
Wang W and
Sui Y (2021).
A high-throughput method to characterize membrane viscosity of flowing microcapsules. Physics of Fluids,
AIP Publishing vol. 33 (1)
01-01-2021![Relevant Publication](/common/publications/images/fav.png)
Lin T, Wang Z,
Wang W and
Sui Y (2021).
A neural network-based algorithm for high-throughput characterisation of viscoelastic properties of flowing microcapsules. Soft Matter,
Royal Society of Chemistry (RSC) vol. 17 (15), 4027-4039.
01-01-2021![Relevant Publication](/common/publications/images/fav.png)
Lin T, Wang Z,
Wang W and Sui Y (2021).
Correction: A neural network-based algorithm for high-throughput characterisation of viscoelastic properties of flowing microcapsules. Soft Matter,
Royal Society of Chemistry (RSC) vol. 17 (15), 4213-4213.
01-01-2021![Relevant Publication](/common/publications/images/fav.png)
Fu S, Meng H, Inamdar S, Das B,
Gupta H,
Wang W, Thompson C and
Knight M (2021).
Activation of TRPV4 by mechanical, osmotic or pharmaceutical stimulation is anti-inflammatory blocking IL-1β mediated articular cartilage matrix destruction., Editors: Block JA.
Osteoarthritis and Cartilage,
Elsevier 01-01-2021![Relevant Publication](/common/publications/images/fav.png)
Pu JH, Sheng Q, Sun J,
Wang W and
Wang HS (2021).
Molecular Dynamics Simulation of Effect of Temperature Difference on Surface Condensation. Advances in Heat Transfer and Thermal Engineering 99-103.
01-01-20212020
![Relevant Publication](/common/publications/images/fav.png)
He S, Yang F, Yang M, An W, Maguire EM, Chen Q, Xiao R, Wu W, Zhang L,
Wang W and Xiao Q (2020).
miR-214-3p-Sufu-GLI1 is a novel regulatory axis controlling inflammatory smooth muscle cell differentiation from stem cells and neointimal hyperplasia. Stem Cell Research & Therapy,
Springer Nature vol. 11 (1)
03-11-2020![Relevant Publication](/common/publications/images/fav.png)
Wu Y,
Wang W, Mata A,
Pugno N, Azevedo H,
Karabasov S and Titirici M-M (2020).
Disordered protein-graphene oxide co-assembly and supramolecular biofabrication of functional fluidic devices. Nature Communications,
Nature Research (part of Springer Nature) 04-03-2020![Relevant Publication](/common/publications/images/fav.png)
Pu JH, Sun J,
Wang W and
Wang HS (2020).
Generation and Evolution of Nanobubbles on Heated Nanoparticles: A Molecular Dynamics Study. Langmuir: the ACS journal of surfaces and colloids,
American Chemical Society vol. 36, 2375-2382.
03-02-2020![Relevant Publication](/common/publications/images/fav.png)
Yang J, Moraga A, Xu J, Zhao Y, Luo P, Lao KH, Margariti A, Zhao Q, Ding W, Wang G, Zhang M, Zheng L, Zhang Z, Hu Y,
Wang W, Shen L, Smith A, Shah AM, Wang Q and Zeng L (2020).
A histone deacetylase 7‐derived peptide promotes vascular regeneration via facilitating 14‐3‐3γ phosphorylation. Stem Cells,
Oxford University Press (OUP) vol. 38 (4), 556-573.
29-01-2020![Relevant Publication](/common/publications/images/fav.png)
Fan B,
Wang W, Wang T, Xie B, Zhang H, Liao Y, Lu C and Guo L (2020).
Problematic Internet Use, Non-Medical Use of Prescription Drugs, and Depressive Symptoms among Adolescents: A Large-Scale Study in China. International Journal of Environmental Research and Public Health,
MDPI vol. 17 (3)
26-01-20202019
![Relevant Publication](/common/publications/images/fav.png)
Pu JH, Sun J, Sheng Q,
Wang W and
Wang HS (2019).
Dependences of Formation and Transition of the Surface Condensation Mode on Wettability and Temperature Difference. Langmuir: the ACS journal of surfaces and colloids,
American Chemical Society vol. 36, 456-464.
15-12-2019![Relevant Publication](/common/publications/images/fav.png)
Arokiasamy S, King R, Boulaghrasse H, Poston R, Nourshargh S,
Wang W and Voisin M-B (2019).
Heparanase-dependent Remodelling of Initial Lymphatic Glycocalyx 1 Regulates Tissue-fluid Drainage during Acute Inflammation in vivo. Frontiers in Immunology,
Frontiers Media 04-10-2019![Relevant Publication](/common/publications/images/fav.png)
Li W and
Wang W (2019).
Membrane tension regulates syndecan-1 expression through actin remodelling. Biochim Biophys Acta Gen Subj vol. 1863 (11), 129413-129413.
08-08-2019![Relevant Publication](/common/publications/images/fav.png)
Pang X, Li W, Landwehr E, Yuan Y,
Wang W and Azevedo HS (2019).
Mimicking the endothelial glycocalyx through the supramolecular presentation of hyaluronan on patterned surfaces. Faraday Discuss 15-07-2019![Relevant Publication](/common/publications/images/fav.png)
Fu S, Thompson CL, Ali A,
Wang W, Chapple JP, Mitchison HM, Beales PL, Wann AKT and
Knight MM (2019).
Mechanical loading inhibits cartilage inflammatory signalling via an HDAC6 and IFT-dependent mechanism regulating primary cilia elongation. Osteoarthritis and Cartilage,
Elsevier vol. 27 (7), 1064-1074.
25-03-2019![Relevant Publication](/common/publications/images/fav.png)
PU JH, SHENG Q, Sun J,
WANG W and
WANG H (2019).
Dependence of nano-confined surface condensation on tangentially external force field. Journal of Molecular Liquids,
Elsevier 21-03-2019![Relevant Publication](/common/publications/images/fav.png)
Wang F, Contò FP, Naz N, Castrejón-Pita JR, Castrejón-Pita AA,
Bailey CG,
Wang W, Feng JJ and
Sui Y (2019).
A fate-alternating transitional regime in contracting liquid filaments. Journal of Fluid Mechanics vol. 860, 640-653.
10-02-2019![Relevant Publication](/common/publications/images/fav.png)
Lu Y and Wang W (2019).
Biofluids: Microcirculation. Comprehensive Biotechnology 32-46.
01-01-2019![Relevant Publication](/common/publications/images/fav.png)
Wang Z,
Sui Y,
Wang W, Barthѐs-Biesel D and Salsac A-V (2019).
Path Selection of a Spherical Capsule in a Branched Channel. Molecular & Cellular Biomechanics,
Computers, Materials and Continua (Tech Science Press) vol. 16 (S2), 42-43.
01-01-20192018
![Relevant Publication](/common/publications/images/fav.png)
Peng J,
Wang W, Zheng L, Guan Y, Ye G, Tong H, Wang Y and Wang Q (2018).
Serum Cystatin C Levels in Twin Pregnancy versus Singleton Pregnancy. Lab Medicine,
Oxford University Press (OUP) vol. 50 (2), 163-167.
04-12-2018![Relevant Publication](/common/publications/images/fav.png)
Tang P, di Cio S, Wang W and E Gautrot J (2018).
Surface-Initiated Poly(oligo(2-alkyl-2-oxazoline)methacrylate) Brushes. Langmuir vol. 34 (34), 10019-10027.
28-08-2018![Relevant Publication](/common/publications/images/fav.png)
Sheng Q, Sun J, You X,
Wang W and
Wang HS (2018).
Detection of liquid-vapour interface in molecular dynamics simulation. 16th International Heat Transfer Conference.
10-08-2018![Relevant Publication](/common/publications/images/fav.png)
ZHAO T, DENG L, WANG W, Elson D and
SU L (2018).
Bayes’ theorem based binary algorithm for fast reference-less calibration of a multimode fiber. Optics Express,
Optical Society of America (OSA) 06-08-2018![Relevant Publication](/common/publications/images/fav.png)
Wang Z,
Sui Y, Salsac AV, Barthès-Biesel D and
Wang W (2018).
Path selection of a spherical capsule in a microfluidic branched channel: Towards the design of an enrichment device. Journal of Fluid Mechanics vol. 849, 136-162.
18-06-2018![Relevant Publication](/common/publications/images/fav.png)
Liu J, Zhang Y, Zhao Q, Situ B, Zhao J, Luo S, Li B, Yan X, Vadgama P,
Su L, Ma W,
Wang W and Zheng L (2018).
Bifunctional aptamer-mediated catalytic hairpin assembly for the sensitive and homogenous detection of rare cancer cells. Anal Chim Acta vol. 1029, 58-64.
04-05-2018![Relevant Publication](/common/publications/images/fav.png)
Yang J, Xu J, Danniel M, Wang X,
Wang W, Zeng L and Shen L (2018).
The interaction between XBP1 and eNOS contributes to endothelial cell migration. Experimental Cell Research,
Elsevier vol. 363 (2), 262-270.
17-01-2018![Relevant Publication](/common/publications/images/fav.png)
Zhao K, Zhao Q, Guo Z, Chen Z, Hu Y, Su J, Chen L, He Z, Cai X, Chen M, Zheng L,
Wang W and Wang Q (2018).
Hsa_Circ_0001275: A Potential Novel Diagnostic Biomarker for Postmenopausal Osteoporosis. Cellular Physiology and Biochemistry,
Karger Publishers vol. 46 (6), 2508-2516.
01-01-20182017
![Relevant Publication](/common/publications/images/fav.png)
SHENG Q, SUN J,
WANG W,
WANG HS and
BAILEY CG (2017).
How solid surface free energy determines coalescence-induced nanodroplet jumping: A molecular dynamics investigation. Journal of Applied Physics,
AIP Publishing vol. 122, 245301 (2017)
27-12-2017![Relevant Publication](/common/publications/images/fav.png)
Hughes-Brittain NF, Qiu L,
Wang W, Peijs T and Bastiaansen CWM (2017).
Degradation and biocompatibility of photoembossed PLGA-acrylate blend for improved cell adhesion. J Biomed Mater Res B Appl Biomater vol. 106 (1), 163-171.
08-12-2017![Relevant Publication](/common/publications/images/fav.png)
Norton R, Honarbakshs S,
Wang W, Schilling R and Hunter R (2017).
118A novel method to determine left atrial compliance in vivo: relationship with markers of remodelling in AF. EP Europace,
Oxford University Press (OUP) vol. 19 (suppl_1), i49-i49.
01-10-2017
WANG W (2017).
Effects of High Pressure on Phospholipid Bilayers. Journal of Physical Chemistry B,
American Chemical Society 19-09-2017![Relevant Publication](/common/publications/images/fav.png)
Li W and
Wang W (2017).
Structural alteration of the endothelial glycocalyx: contribution of the actin cytoskeleton. Biomech Model Mechanobiol 14-08-2017![Relevant Publication](/common/publications/images/fav.png)
Hughes-Brittain NF, Qiu L, Picot OT,
Wang W, Peijs T and Bastiaansen CWM (2017).
Surface texturing of electrospun fibres by photoembossing using pulsed laser interference holography and its effects on endothelial cell adhesion. Polymer (United Kingdom) vol. 125, 40-49.
26-07-2017![Relevant Publication](/common/publications/images/fav.png)
Yu B, Kiechl S, Qi D, Wang X, Song Y, Weger S, Mayr A, Le Bras A, Karamariti E, Zhang Z, Barco Barrantes ID, Niehrs C, Schett G, Hu Y,
Wang W, Willeit J, Qu A and Xu Q (2017).
A Cytokine-Like Protein Dickkopf-Related Protein 3 Is Atheroprotective. Circulation vol. 136 (11), 1022-1036.
03-07-2017![Relevant Publication](/common/publications/images/fav.png)
Arokiasamy S, Nourshargh S,
Wang W and Voisin M-B (2017).
Characterisation of the lymphatic endothelium glycocalyx and its regulation during acute inflammation in vivo. NA.
01-06-2017![Relevant Publication](/common/publications/images/fav.png)
VOISIN M (2017).
Endogenous TNFα orchestrates the trafficking of neutrophils into and within lymphatic vessels during acute inflammation. Scientific Reports,
Nature Publishing Group 13-03-20172016
![Relevant Publication](/common/publications/images/fav.png)
Qiu L, Hughes-Brittain NF, Bastiaansen CWM, Peijs T and
Wang W (2016).
Responses of Vascular Endothelial Cells to Photoembossed Topographies on Poly(Methyl Methacrylate) Films. J Funct Biomater vol. 7 (4)
09-12-2016![Relevant Publication](/common/publications/images/fav.png)
Wang Z,
Sui Y, Salsac AV, Barthès-Biesel D and
Wang W (2016).
Motion of a spherical capsule in branched tube flow with finite inertia. Journal of Fluid Mechanics vol. 806, 603-626.
13-10-2016![Relevant Publication](/common/publications/images/fav.png)
Mo J, Prévost SF, Blowes LM, Egertová M, Terrill NJ,
Wang W,
Elphick MR and
Gupta HS (2016).
Interfibrillar stiffening of echinoderm mutable collagenous tissue demonstrated at the nanoscale. Proc Natl Acad Sci U S A 05-10-2016![Relevant Publication](/common/publications/images/fav.png)
Sheng Q, Sun J, Wang Q,
Wang W and
Wang HS (2016).
On the onset of surface condensation: Formation and transition mechanisms of condensation mode. Scientific Reports,
Nature Publishing Group: Open Access Journals - Option C 02-08-2016![Relevant Publication](/common/publications/images/fav.png)
Yu B, Wong MM, Potter CMF, Simpson RML, Karamariti E, Zhang Z, Zeng L, Warren D, Hu Y,
Wang W and Xu Q (2016).
Vascular Stem/Progenitor Cell Migration Induced by Smooth Muscle Cell-Derived Chemokine (C-C Motif) Ligand 2 and Chemokine (C-X-C motif) Ligand 1 Contributes to Neointima Formation. Stem Cells,
Wiley vol. 34 (9), 2368-2380.
28-06-2016![Relevant Publication](/common/publications/images/fav.png)
Lv W, Zhao J, Situ B, Li B, Ma W, Liu J, Wu Z,
Wang W, Yan X and Zheng L (2016).
A target-triggered dual amplification strategy for sensitive detection of microRNA. Biosensors and Bioelectronics 19-04-2016
KNIGHT MM,
wang W, wang Z, wann A, thompson C and hassen A (2016).
IFT88 influences chondrocyte actin organization and biomechanics. Osteoarthritis and Cartilage 01-03-2016![Relevant Publication](/common/publications/images/fav.png)
Orsi M, Ding W, Palaiokostas M and
Wang W (2016).
Molecular Simulation of Lipids and Water: Atomistic, Coarse-Grained, and Mixed Resolutions. 01-02-2016![Relevant Publication](/common/publications/images/fav.png)
Ding W, Palaiokostas M,
Wang W and Orsi M (2016).
Atomistic and Coarse-Grained Molecular Simulations of Mixed Lamellar/Nonlamellar Lipid Membranes. 01-02-20162015
![Relevant Publication](/common/publications/images/fav.png)
Ma W, Situ B, Lv W, Li B, Yin X, Vadgama P, Zheng L and
Wang W (2015).
Electrochemical determination of microRNAs based on isothermal strand-displacement polymerase reaction coupled with multienzyme functionalized magnetic micro-carriers. Biosensors and Bioelectronics vol. 80, 344-351.
21-12-2015![Relevant Publication](/common/publications/images/fav.png)
Ding W, Palaiokostas M,
Wang W and Orsi M (2015).
Effects of Lipid Composition on Bilayer Membranes Quantified by All-Atom Molecular Dynamics. The Journal of Physical Chemistry B,
American Chemical Society (ACS) vol. 119 (49), 15263-15274.
24-11-2015![Relevant Publication](/common/publications/images/fav.png)
Zeng L, Li Y, Yang J, Wang G, Margariti A, Xiao Q, Zampetaki A, Yin X, Mayr M, Mori K,
Wang W, Hu Y and Xu Q (2015).
XBP 1-Deficiency Abrogates Neointimal Lesion of Injured Vessels Via Cross Talk With the PDGF Signaling. Arteriosclerosis Thrombosis and Vascular Biology,
Wolters Kluwer vol. 35 (10), 2134-2144.
27-08-2015![Relevant Publication](/common/publications/images/fav.png)
Yu X, Zhang L, Wen G, Zhao H, Luong LA, Chen Q, Huang Y, Zhu J, Ye S, Xu Q, Wang W and Xiao Q (2015).
Upregulated sirtuin 1 by miRNA-34a is required for smooth muscle cell differentiation from pluripotent stem cells. Cell Death and Differentiation vol. 22 (7), 1170-1180.
01-07-2015![Relevant Publication](/common/publications/images/fav.png)
Wang X, Karamariti E, Simpson R,
Wang W and Xu Q (2015).
Dickkopf Homolog 3 Induces Stem Cell Differentiation into Smooth Muscle Lineage via ATF6 Signalling*. Journal of Biological Chemistry,
Elsevier vol. 290 (32), 19844-19852.
23-06-2015![Relevant Publication](/common/publications/images/fav.png)
Yang J, Zeng L,
Wang W and Li Y (2015).
Abstract 662: X-box Binding Protein 1 Splicing Promotes Wound Healing via Modulating Endothelial Nitric Oxide Synthase. Arteriosclerosis Thrombosis and Vascular Biology,
Wolters Kluwer vol. 35 (suppl_1)
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In vivo measurements and theoretical modelling of oxygen partial pressure in outer layers of human skin. European Cells and Materials vol. 10 (SUPPL.2)
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Concentration polarization of hyaluronan on the surface of the synovial lining of infused joints. J PHYSIOL-LONDON vol. 561 (2), 559-573.
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