Professor of Microbiology
Bacteriology Theme Lead
Cyanobacteria, Photosynthesis, Bacterial cell biology
Publications of specific relevance to the Centre for Molecular Cell BiologyNonlinear frequency doubling up-conversion of geothermal radiation cannot provide sufficient light to support oxygenic photosynthesis at deep-sea hydrothermal ventsBeyond movement: the dynamic roles of Type IV pili in cyanobacterial life.The RRM domain-containing protein Rbp3 interacts with ribosomes and the 3' ends of mRNAs encoding photosynthesis proteins.RNA-FISH as a probe for heterogeneity at the cellular and subcellular levels in cyanobacteriaDoes mRNA targeting explain gene retention in chloroplasts?mRNA localization and thylakoid protein biogenesis in the filamentous heterocyst-forming cyanobacterium Anabaena sp. PCC 7120Optimizing photosynthetic light-harvesting under stars: simple and general antenna modelsLighting the way: Compelling open questions in photosynthesis researchThermodynamic limits on oxygenic photosynthesis around M-dwarf stars: Generalized models and strategies for optimizationPhotosynthesis under a red Sun: predicting the absorption characteristics of an extraterrestrial light-harvesting antennaPhotosynthesis Under a Red Sun: Predicting the absorption characteristics of an extraterrestrial light-harvesting antennaCP12 fine-tunes the Calvin-Benson cycle and carbohydrate metabolism in cyanobacteria.A kaleidoscope of photosynthetic antenna proteins and their emerging rolesChapter 8 Improving the transport of electronsDevelopment of a highly sensitive luciferase-based reporter system to study two-step protein secretion in cyanobacteria.The social life of cyanobacteriaProbing the biogenesis pathway and dynamics of thylakoid membranesCoexistence of Communicating and Noncommunicating Cells in the Filamentous Cyanobacterium Anabaena.The Role of the Cyanobacterial Type IV Pilus Machinery in Finding and Maintaining a Favourable EnvironmentMembrane Dynamics in Phototrophic Bacteria.Structural variability, coordination and adaptation of a native photosynthetic machineryLoss of Filamentous Multicellularity in Cyanobacteria: the Extremophile Gloeocapsopsis sp. Strain UTEX B3054 Retained Multicellular Features at the Genomic and Behavioral LevelsFactors controlling floc formation and structure in the cyanobacterium synechocystis sp. strain pcc 6803Using Nature's polyenes as templates: studies of synthetic xanthomonadin analogues and realising their potential as antioxidants.Cyanobacterial Septal Junctions: Properties and Regulation.Corrigendum to Single-molecule in vivo imaging of bacterial respiratory complexes indicates delocalized oxidative phosphorylation [Biochim. Biophys. Acta 1837(6) (2014) 811-824 DOI: 10.1016/j.bbabio.2014.01.020].How bacteria keep proteins moving.Light-Controlled Motility in Prokaryotes and the Problem of Directional Light PerceptionDissecting the native architecture and dynamics of cyanobacterial photosynthetic machineryRole of Two Cell Wall Amidases in Septal Junction and Nanopore Formation in the Multicellular Cyanobacterium Anabaena sp. PCC 7120Classic Spotlights: Selected Highlights from the First 100 Years of the Journal of Bacteriology.Biomining for Mother Nature's SuperlensesCyanobacteria in motionSpecific Glucoside Transporters Influence Septal Structure and Function in the Filamentous, Heterocyst-Forming Cyanobacterium Anabaena sp. Strain PCC 7120Molecular Diffusion through Cyanobacterial Septal Junctions.Hydrocarbons Are Essential for Optimal Cell Size, Division, and Growth of Cyanobacteria.Classic Spotlight: Green Fluorescent Protein in Bacillus subtilis and the Birth of Bacterial Cell Biology.Classic Spotlight: to the Periplasm and Beyond-Protein Secretion in Escherichia coli.In vivo imaging of the supramolecular organisation of Escherichia coli OxPhos complexesEfficient targeting of recombinant proteins to the thylakoid lumen in Chlamydomonas reinhardtii using a bacterial Tat signal peptideOverexpression of SepJ alters septal morphology and heterocyst pattern regulated by diffusible signals in AnabaenaClassic Spotlight: Dynamics of the Bacterial CytoplasmPhotosynthesis: Rewiring an angiospermPreface to BBA special issue: “Organisation and dynamics of bioenergetic systems in bacteria”Cyanobacteria use micro-optics to sense light directionMembrane Organisation and Electron Transport Switches in CyanobacteriaMotility in cyanobacteria: polysaccharide tracks and Type IV pilus motorsIntercellular diffusion of a fluorescent sucrose analog via the septal junctions in a filamentous cyanobacterium.PilB localization correlates with the direction of twitching motility in the cyanobacterium Synechocystis sp. PCC 6803Sub‐cellular location of FtsH proteases in the cyanobacterium Synechocystis sp. PCC 6803 suggests localised PSII repair zones in the thylakoid membranesBacteria in Solitary ConfinementTracing the path of a prokaryotic paracrine signal.Localisation and interactions of the Vipp1 protein in cyanobacteria.Subcellular localization and clues for the function of the HetN factor influencing heterocyst distribution in Anabaena sp. strain PCC 7120.Phycobilisome Mobility and Its Role in the Regulation of Light Harvesting in Red Algae.Delocalised electron transport and chemiosmosis in Escherichia coliIn vivo imaging of the supramolecular organization of Escherichia coli OxPhos complexesSingle-molecule in vivo imaging of bacterial respiratory complexes indicates delocalized oxidative phosphorylation.Independent mobility of proteins and lipids in the plasma membrane of Escherichia coli.Binding of the RNA chaperone Hfq to the type IV pilus base is crucial for its function in Synechocystis sp. PCC 6803.Co-existence of photosynthetic and respiratory activities in cyanobacterial thylakoid membranes.Branching and intercellular communication in the Section V cyanobacterium Mastigocladus laminosus, a complex multicellular prokaryote.Electron transport and light-harvesting switches in cyanobacteria.Solar powered biohydrogen production requires specific localization of the hydrogenaseVisualization of Cell Complexity in the Filamentous Cyanobacterium Mastigocladus laminosus by Transmission Electron Microscopy (TEM)Non-Photochemical Fluorescence Quenching and the Dynamics of Photosystem II Structure2-epi-5-epi-Valiolone synthase activity is essential for maintaining phycobilisome composition in the cyanobacterium Anabaena variabilis ATCC 29413 when grown in the presence of a carbon source.Control of electron transport routes through redox-regulated redistribution of respiratory complexes.Light-harvesting antenna composition controls the macrostructure and dynamics of thylakoid membranes in Arabidopsis.Control of electron transport routes through redox-regulated redistribution of respiratory complexesSub-micron scale distribution of electron transport compelxes in bacterial membranes, and its influence on electron transfer pathwaysFraH is required for reorganization of intracellular membranes during heterocyst differentiation in Anabaena sp. strain PCC 7120.Degradation of cyanobacterial biosignatures by ionizing radiation.FraC/FraD-dependent intercellular molecular exchange in the filaments of a heterocyst-forming cyanobacterium, Anabaena sp.The plasma membrane of the cyanobacterium Gloeobacter violaceus contains segregated bioenergetic domains.Photoprotective energy dissipation involves the reorganization of photosystem II light-harvesting complexes in the grana membranes of spinach chloroplasts.Functional dissection of the three-domain SepJ protein joining the cells in cyanobacterial trichomes.Loss of the SPHF homologue Slr1768 leads to a catastrophic failure in the maintenance of thylakoid membranes in Synechocystis sp. PCC 6803.Size dependence of protein diffusion in the cytoplasm of Escherichia coli.Visualizing the mobility and distribution of chlorophyll proteins in higher plant thylakoid membranes: effects of photoinhibition and protein phosphorylationFra proteins influencing filament integrity, diazotrophy and localization of septal protein SepJ in the heterocyst-forming cyanobacterium Anabaena sp.Fra proteins influencing filament integrity, diazotrophy and localization of septal protein SepJ in the heterocyst-forming cyanobacterium Anabaena sp.ApcD is necessary for efficient energy transfer from phycobilisomes to photosystem I and helps to prevent photoinhibition in the cyanobacterium Synechococcus sp. PCC 7002.The rolex and the hourglass: a simplified circadian clock in prochlorococcus?Significance of protein order in thylakoid membranes for photosynthetic energy conversionDistinct roles of CpcG1-phycobilisome and CpcG2-phycobilisome in state transitions in a cyanobacterium Synechocystis sp. PCC 6803.Immobility of phycobilins in the thylakoid lumen of a cryptophyte suggests that protein diffusion in the lumen is very restricted.Role of Lipids in the Dynamics of Thylakoid MembranesClustering and dynamics of cytochrome bd-I complexes in the Escherichia coli plasma membrane in vivo.Are Escherichia coli OXPHOS complexes concentrated in specialized zones within the plasma membrane?Mechanism of intercellular molecular exchange in heterocyst-forming cyanobacteria.Protein diffusion and macromolecular crowding in thylakoid membranesPhotosynthetic light harvesting - IntroductionPhycobilisome-reaction centre interaction in cyanobacteriaIntroduction: a selection of work from the recent Satellite Meeting on Photosynthetic Light Harvesting.Factors controlling the mobility of photosynthetic proteins.Molecular crowding and photosynthetic energy transformationLocalization and Mobility of Bacterial Proteins by Confocal Microscopy and Fluorescence Recovery After PhotobleachingSignificance of molecular crowding for the functional protein organisation in grana membranesUsing fluorescence recovery after photobleaching to measure lipid diffusion in membranes.Localization and mobility of bacterial proteins by confocal microscopy and fluorescence recovery after photobleaching.Using Fluorescence Recovery After Photobleaching to measure lipid diffusion in membranesLocalization and Mobility of Bacterial Proteins by Confocal Microscopy and Fluorescence Recovery After PhotobleachingDiffusion of green fluorescent protein in three cell environments in Escherichia coliMobilization of photosystem II induced by intense red light in the Cyanobacterium Synechococcus sp PCC7942.The FtsH protease slr0228 is important for quality control of photosystem II in the thylakoid membrane of Synechocystis sp PCC 6803The PsbU subunit of photosystem II stabilizes energy transfer and primary photochemistry in the phycobilisome - Photosystem II assembly of Synechocystis sp PCC 6803NAB1 is an RNA binding protein involved in the light-regulated differential expression of the light-harvesting antenna of Chlamydomonas reinhardtiiFunction and evolution of granaThe rpaC gene product regulates phycobilisome-photosystem II interaction in cyanobacteria.The influence of acetyl phosphate on DspA signalling in the Cyanobacterium Synechocystis sp. PCC6803.Involvement of phycobilisome diffusion in energy quenching in cyanobacteriaLocation and mobility of twin arginine translocase subunits in the Escherichia coli plasma membrane.Probing the dynamics of bacterial membranes in vivo with FRAPState transitions: an example of acclimation to low-light stress.The trimeric organisation of photosystem I is not necessary for the iron-stress induced CP43' protein to functionally associate with this reaction centre.Mobility of the IsiA chlorophyll-binding protein in cyanobacterial thylakoid membranes.Phycobilisome diffusion is required for light-state transitions in cyanobacteria.FRAP analysis of photosynthetic membranesProbing the mechanism of state transitions in oxygenic photosynthesis by chlorophyll fluorescence spectroscopy, kinetics and imagingPhotosystem II mobilisation and redistribution induced by high light: visualising the PSII repair cycle in vivo?Phycobilisome mobility in the cyanobacterium Synechococcus sp PCC7942 is influenced by the trimerisation of Photosystem IProbing the mechanism of state transitions in oxygenic photosynthesis by chlorophyll fluorescence spectroscopy, kinetics and imaging.Regulation of photosynthetic electron transport.Lipid diffusion in the thylakoid membranes of the cyanobacterium Synechococcus sp.: effect of fatty acid desaturationPhotophysical properties of Prochlorococcus marinus SS120 divinyl chlorophylls and phycoerythrin in vitro and in vivo.FtsH is involved in the early stages of repair of photosystem II in Synechocystis sp PCC 6803Membrane-specific targeting of green fluorescent protein by the Tat pathway in the cyanobacterium Synechocystis PCC6803The ycf27 genes from cyanobacteria and eukaryotic algae: distribution and implications for chloroplast evolution.Probing the dynamics of photosynthetic membranes with fluorescence recovery after photobleachingA critical role for the Var2 FtsH homologue of Arabidopsis thaliana in the photosystem II repair cycle in vivoA possible retinal longwave detecting system in a myctophid fish without far-red bioluminescence; evidence for a sensory arms race in the deep-sea.Mobility of proteins and lipids in the photosynthetic membranes of cyanobacteriaDiffusion of phycobilisomes on the thylakoid membranes of the cyanobacterium Synechococcus 7942 - Effects of phycobilisome size, temperature, and membrane lipid compositionHow do cyanobacteria sense and respond to light?Auxiliary functions in photosynthesis: the role of the FtsH protease.Identification of a protease involved in the repair of photosystem two in Synechocystis 6803Var2 mutation in Arabidopsis affects D1 degradationBacterial orthologues indicate the malarial plastid gene ycf24 is essentialUltrafast spectroscopy of trimeric light-harvesting complex II from higher plantsPROMPT HEAT RELEASE ASSOCIATED WITH DELTA-PH-DEPENDENT QUENCHING IN SPINACH THYLAKOID MEMBRANESState-1-State-2 Transitions in the Cyanobacterium Synechococcus 6301 Are Controlled by the Redox State of Electron Carriers between Photosystem-I and Photosystem-IiPicosecond Time-Resolved Fluorescence Emission-Spectra Indicate Decreased Energy-Transfer from the Phycobilisome to Photosystem-Ii in Light-State-2 in the Cyanobacterium-Synechococcus 6301Co-Resistance of Atrazine-Resistant Chenopodium and Amaranthus Biotypes to other Photosystem II Inhibiting HerbicidesState Transitions, Photosystem Stoichiometry Adjustment and Non-Photochemical Quenching in Cyanobacterial Cells Acclimated to Light Absorbed by Photosystem-I or Photosystem-IiFluorescence Induction Transients Indicate Dissociation of Photosystem-Ii from the Phycobilisome During the State-2 Transition in the Cyanobacterium Synechococcus 6301Fluorescence Induction Transients Indicate Altered Absorption Cross-Section During Light-State Transitions in the Cyanobacterium Synechococcus 6301The State-2 Transition in the Cyanobacterium Synechococcus-6301 Can Be Driven by Respiratory Electron Flow into the Plastoquinone PoolMore on Thylakoid Membrane StackingmRNA localization, reaction centre biogenesis and thylakoid membrane targeting in cyanobacteriaProbing the biogenesis pathway and dynamics of thylakoid membranesDevelopment of a highly sensitive luciferase-based reporter system to study two-step protein secretion in cyanobacteriaLocations of membrane protein production in a cyanobacteriummRNA localization and thylakoid protein biogenesis in the filamentous heterocyst-forming cyanobacterium Anabaena sp. PCC 7120Optimizing photosynthetic light-harvesting under stars: Generalized thermodynamic modelsThe RRM domain-containing protein Rbp3 interacts with ribosomes and the 3′ ends of mRNAs encoding photosynthesis proteinsGrants of specific relevance to the Centre for Molecular Cell BiologyTowards precision engineering of cyanobacterial cellsPhotosynthesis on Alien Worlds: What might it look like, and can it be detected?Pump prime I2BC (France) QMUL (UK) photosynthetic improvementA confocal microscope for multidisciplinary dynamic studies of complex biological systemsMembrane protein targeting and assembly in cyanobacteriaSuper-Resolution Microscopy of live cells in 3DFlocculation in cyanobacteria: from mechanism to ecologyOrganisation, dynamics & biogenesis of a photosynthetic membraneMicro-optics and Photosynthetic Light Trapping in CyanobacteriaMaintenance of Photosystem 11 in PlantsSolar Energy to Biomass-Optimisation of light energy conversion in plants and microalgaeQueen Mary's new inter-school astrobiology initiative has been awarded a prestigious Leverhulme Trust Research Project grant. Led by Thomas Haworth from the Queen Mary Astronomy Unit and Christopher Duffy from the Digital Environment Research Institute (DERI), with involvement from Conrad Mullineaux from the School of Biological and Behavioural Sciences (SBBS), ... [more]
