Professor of Biomedical Engineering
Operational Director, Centre for Doctoral Training in Next Generation Organ-Chip Technologies
orthopaedic systems, FE modelling in bioengineering, tissue engineering, wear of TJRs, organ-on-a-chip technologies
Publications of specific relevance to the Centre for BioengineeringInfluence of Taper surface topographies on contact deformation and stressesInfluence of taper design and loading on taper micromotionSub-toxic levels of cobalt ions impair mechanostranduction via HDAC6-depedent primary cilia shortening.Activation of synovial fibroblasts from patients at revision of their metal-on-metal total hip arthroplasty3D models of chondrocytes within biomimetic scaffolds: Effects of cell deformation from loading regimensSub-toxic levels of Co2+ are anti-inflammatory and protect cartilage from degradation caused by IL-1β
An electrochemical study of acrylate bone adhesive permeability and selectivity change during in vitro ageing: a model approach to the study of biomaterials and membrane barriersMechanical loading induces primary cilia disassembly in tendon cells via TGFβ and HDAC6Cobalt ions stimulate a fibrotic response through matrix remodelling, fibroblast contraction and release of pro-fibrotic signals from macrophagesPrediction of taper performance using quasi static FE models: The influence of loading and taper clearance and trunnion lengthCobalt (II) ions and nanoparticles induce macrophage retention by ROS-mediated down-regulation of RhoA expression.Cobalt (II) ions and nanoparticles induce macrophage retention by ROS-mediated downregulation of RhoA expressionSimulator Study of MOM using Steep-cup Flexion - A Clinically Relevant Incorporation of Intermittent Edge-loadingComplex mechanical conditioning of cell-seeded agarose constructs can influence chondrocyte biosynthetic activityMeasurement outcomes from hip simulatorsThe increase in cobalt release in metal-on-polyethylene hip bearings in tests with third body abrasivesChromium nitride coating for large diameter metal-on-polyethylene hip bearings under extreme adverse hip simulator conditionsDesign and validation of an in vitro loading system for the combined application of cyclic compression and shear to 3D chondrocytes-seeded agarose constructs.Microstructural stress relaxation mechanics in functionally different tendons.Microstructural stress relaxation mechanics in functionally different tendonsSimple isolation method for the bulk isolation of wear particles from metal on metal bearing surfaces generated in a hip simulator testSimple isolation method for the bulk isolation of wear particles from metal on metal bearing surfaces generated in a hip simulator testDeformation of uncemented metal acetabular cups following impaction: Experimental and finite element studyQuantifying the wear of acetabular cups using coordinate metrologyExplicit finite element modelling of the impaction of metal press-fit acetabular componentsChallenges of developing engineering students' writing through peer assessmentFunctional analysis of tenocytes gene expression in tendon fascicles subjected to cyclic tensile strainEffect of intermittent cyclic tensile strain on collagen synthesis by tenocytes in isolated fasciclesInfluence of cup orientation on the wear performance of metal-on-metal hip replacementsDifferential regulation of gene expression in isolated tendon fascicles exposed to cyclic tensile strain in vitroCell-generated forces influence the viability, metabolism and mechanical properties of fibroblast-seeded collagen gel constructs.Characterizing structure-function relationships in tendonAffect of cup positioning on the wear performance and wear particles from metal-on-metal hip replacementsCollagen synthesis by tenocytes in fascicles subjected to intermittent cyclic strainDevelopment and validation of a novel bioreactor system for load- and perfusion-controlled tissue engineering of chondrocyte-constructsConfiguration of anchorage holes affects cemented fixation of the acetabular component in total hip replacement: an in vitro study.Configuration of anchorage holes affects fixation of the acetabular component in cemented total hip replacement--a finite element study.Time dependence of cyclic tensile strain on collagen production in tendon fascicles.Gene expressions in tendon fascicles subjected to cyclic tensile strainThe relationship between tendon composition, structure, and mechanical characteristicsThe influence of swelling and matrix degradation on the microstructural integrity of tendon.'Severe' wear challenge to 'as-cast' and 'double heat-treated' large-diameter metal-on-metal hip bearingsMetal-on-metal hip simulator study of increased wear particle surface area due to 'severe' patient activity.Cyclic mechanical conditioning of isolated tendon fascicles results in an upregulation of collagen productionCyclic tensile strain upregulates collagen synthesis in isolated tendon fascicles.The influence of noncollagenous matrix components on the micromechanical environment of tendon fascicles.Cyclic tensile strain upregulates collagen production in isolated tendon fasciclesBlood flow and damage by the roller pumps during cardiopulmonary bypassEffect of ion implantation on the tribology of metal-on-metal hip prostheses.Local Strain Measurement within TendonConfocal analysis of local and cellular strains in chondrocyte-agarose constructs subjected to mechanical shear.Investigation of the molecular nature of low-molecular-mass cobalt(II) ions in isolated osteoarthritic knee-joint synovial fluid.Total hip replacement: Results of a postal survey of current practice on the cement fixation of the acetubular cup in the UKAn investigation into the effects of the hierarchical structure of tendon fascicles on micromechanical properties.Metallurgical Considerations in the Wear of Metal-Metal Hip BearingsTemporal regulation of chondrocyte metabolism in agarose constructs subjected to dynamic compression.Influence of external uniaxial cyclic strain on oriented fibroblast-seeded collagen gels.Confocal Analysis of Local and Cellular Strains in Chondrocyte - Agarose Constructs Subjected to Shear.Mechanical conditioning influences the metabolic response of cell-seeded constructs.alpha5beta1 integrin mediates mechanotransduction processes in TGFbeta3-stimulated human chondrocytes seeded in agarose constructs and subjected to dynamic compression.Dermal fibroblasts respond to mechanical conditioning in a strain profile dependent manner.Development of a technique to determine strains in tendons using the cell nuclei.alpha5beta1 integrin mediates mechanotransduction processes in TGFbeta-stimulated human chondrocyte / agarose constructs and subjected to dynamic compression.Control of mechanotrasduction processes in dynamically stimulated human and bovine chondrocytes cultured in agarose constructs.The effects on non-collagenous matrix components on tendon fascicle micromechanics.The influence of uniaxial cyclic strain on orientated fibroblast seeded collagen gelsProfile measurement of worn acetabular cup by holographic contouringThe strain behaviour of tendon under tensile load, using cell nuclei as strain markers.Enhancement of cancellous bone repair using particulatesDevelopment of a technique to determine strains in tendons using the cell nuclei.Comparison of influence of cortical bone repair using autologous and Endobon particulatesComparison between commercial calcium phosphate bone cementsThe effects of bovine trabecular bone matrix particulates on cortical bone repair.Non-collagenous matrix components influence the micromechanical environment of tenocytes within tendon fascicles subjected to tensile strain.Cancellous bone repair using bovine trabecular bone matrix particulates.Measurements of sequential impressions of acetabula cups from a total hip joint replacement using a non-contact measurement systemA hip simulator study of the influence of patient activity level on the wear of crosslinked polyethylene under smooth and roughened femoral conditionsHip simulator study of the influence of patient activity level on the wear of crosslinked polyethylene under smooth and roughened femoral conditionsInfluence of training on reliability of surgical knotsBiological response of cyclic strain on developed cell seeded collagen gel modelInvestigation and quantification of the blood trauma caused by the combined dynamic forces experienced during cardiopulmonary bypass.A system for monitoring the response of uniaxial strain on cell seeded collagen gelsFixation of the acetabular cup in cemented total hip replacement: improving the anchorage hole profile using finite element method.Influence of aging heat treatment on mechanical properties of biomedical Ti-Zr based ternary alloys containing niobium.Laser speckle photography to measure surface displacements on cortical bone--verification of an automated analysis system.Quantification of holographic fringe data: comparison of intact and implanted femurs.Fatigue failure in a plasma sprayed hydroxyapatite coated titanium alloyMultiaxial fatigue testing of medical grade titanium alloyAlloy-design of titanium-zirconium based alloys containing niobium as biomedical materialsCutting thread at flexible endoscopy.Strengths and weaknesses of laparoscopic and open mesh inguinal hernia repair: a randomized controlled experimental study.Pull-out strength of screws from cortical bone in the maxillo-facial regionA comparison of the strength of knots tied by hand and at laparoscopy.Mechanical analysis of maxillofacial miniplates.ARE KNOTS TIED AT LAPAROSCOPY AS SECURE AS HAND TIED KNOTSHydrogels as an interface between bone and an implant.OBTAINING AUTHENTIC RESULTS USING HOLOGRAPHIC-INTERFEROMETRYLaser interferometric techniques in orthopaedics.THE APPLICATION OF HOLOGRAPHY TO EXAMINE PLATED FRACTURE FIXATION SYSTEMSDouble exposure holographic interferometric evaluation of plated fracture systemsGrants of specific relevance to the Centre for BioengineeringEPSRC Centre for Doctoral Training in Next Generation Organ-on-a-Chip Technology (COaCT)
Association of British HealthTech Industries
A team of bioengineers led by Professor Hazel Screen have been awarded a £7 million grant to establish an EPSRC Centre for Doctoral Training (CDT) in Next Generation Organ-on-a-Chip Technologies. Queen Mary University of London is one of sixty-five universities chosen to receive funding from the Engineering and Physical Sciences Research ... [more]
