Dr Isabel M Palacios

Research

Drosophila, human organoids, human iPSCs, organogenesis, cell biophysics, cytoskeleton

Publications

Publications of specific relevance to the Centre for Molecular Cell Biology

2025

Artificial Cells Evidence Apical Compressive Forces Building up During Neuroepithelial Organoid Early Development
Kanso H Di Cio S Rose R Palacios I Gautrot JE
Biomaterials, Elsevier 

DOI 10.1016/j.biomaterials.2025.123870

01-11-2025

2024

Essential conserved neuronal motors kinesin-1 and kinesin-3 regulate Aβ42 toxicity in vivo
Palacios IM
Biorxiv Journal 

DOI 10.1101/2024.04.23.590704

QMRO

24-04-2024

2023

Constriction imposed by basement membrane regulates developmental cell migration
López EM Kabanova A Palacios IM
Plos Biology, Public Library of Science vol. 21 (6) 

DOI 10.1371/journal.pbio.3002172

QMRO

28-06-2023

2020

The humble fruit fly is helping the African science community to thrive
Palacios I Vicente-Crespo M Martín-Bermudo MD
Nature Reviews Molecular Cell Biology, Springer Nature vol. 21 (10), 558-559.  

DOI 10.1038/s41580-020-00283-0

17-08-2020

Integrins regulate epithelial cell shape by controlling the architecture and mechanical properties of basal actomyosin networks
Santa-Cruz Mateos C Valencia-Expósito A Palacios IM
Plos Genetics, Public Library of Science (Plos) vol. 16 (6), e1008717-e1008717.  

DOI 10.1371/journal.pgen.1008717

QMRO

01-06-2020

Optical flow analysis reveals that Kinesin-mediated advection impacts on the orientation of microtubules in the Drosophila oocyte.
Drechsler M Lang LF Al-Khatib L Burger M Schönlieb C-B
Molecular Biology of The Cell, American Society For Cell Biology, mbcE19080440-mbcE19080440.  

DOI 10.1091/mbc.E19-08-0440

QMRO

08-04-2020

2019

YAP/Yorkie in the germline modulates the age-related decline of germline stem cells and niche cells
Francis D Chanana B Fernandez B Gordon B Palacios IM
Plos One, Public Library of Science (Plos) vol. 14 (4) 

DOI 10.1371/journal.pone.0213327

QMRO

03-04-2019

2017

Active diffusion and advection in Drosophila oocytes result from the interplay of actin and microtubules
PALACIOS IM
Nature Communications, Nature Publishing Group vol. 8 

DOI 10.1038/s41467-017-01414-6

QMRO

15-11-2017

DrosAfrica: Building an African biomedical research community using Drosophila
Martín-Bermudo MD Palacios IM
Seminars in Cell & Developmental Biology, Elsevier Bv vol. 70, 58-64.  

DOI 10.1016/j.semcdb.2017.08.044

QMRO

30-08-2017

2016

α-Spectrin and integrins act together to regulate actomyosin and columnarization, and to maintain a monolayered follicular epithelium
Ng BF Selvaraj GK Santa-Cruz Mateos C Grosheva I Martín-Bermudo MD
Journal of Cell Science, The Company of Biologists vol. 129 (9), e1.2-e1.2.  

DOI 10.1242/jcs.191288

01-05-2016

Workshop‐Based Training for Capacity Building: Using Drosophila to Bring Research Skills to Africa
Vicente‐Crespo M Muñoz‐Descalzo S Martín‐Bermudo MD
The FASEB Journal. vol. 30 (S1) 

DOI 10.1096/fasebj.30.1_supplement.663.2

01-04-2016

α-Spectrin and integrins act together to regulate actomyosin and columnarization, and to maintain a monolayered follicular epithelium
Ng BF Selvaraj GK Grosheva I Alvarez-Garcia I Martín-Bermudo MD
Development, The Company of Biologists vol. 143 (8), 1388-1399.  

DOI 10.1242/dev.130070

07-03-2016

Planar cell polarity: the Dachsous/Fat system contributes differently to the embryonic and larval stages of Drosophila
Saavedra P Brittle A Palacios IM Strutt D Lawrence PA
Biology Open, The Company of Biologists vol. 5 (4), 397-408.  

DOI 10.1242/bio.017152

02-03-2016

2015

A complex relationship between motor activity, cytoplasmic flows and the organisation of the actin and microtubule cytoskeletons
Palacios IM Drechsler M Ganguly S
MOLECULAR BIOLOGY OF THE CELL. vol. 26 
01-01-2015

Alpha-spectrin is essential for septate junction formation and columnarization, but not for proliferation control, in the follicular epithelium
Palacios IM Martin-Bermudo M
MOLECULAR BIOLOGY OF THE CELL. vol. 26 
01-01-2015

A complex relationship between motor activity, cytoplasmic flows and the organisation of the actin and microtubule cytoskeletons.
Palacios IM Drechsler M
MOLECULAR BIOLOGY OF THE CELL. vol. 26 
01-01-2015

2014

Hop-on hop-off: Polysomes take a tour of the cell on endosomes
Palacios IM
Journal of Cell Biology, Rockefeller University Press vol. 204 (3), 287-289.  

DOI 10.1083/jcb.201401019

03-02-2014

Plasticity of both planar cell polarity and cell identity during the development of Drosophila
Saavedra P Vincent J-P Palacios IM Lawrence PA
Elife, Elife vol. 3 

DOI 10.7554/elife.01569

01-01-2014

Integrins regulate epithelial cell differentiation by modulating Notch activity
Gómez-Lamarca MJ Cobreros-Reguera L Palacios IM
Journal of Cell Science, The Company of Biologists vol. 127 (21), 4667-4678.  

DOI 10.1242/jcs.153122

01-01-2014

Epithelia patterning and body plan mapping in the Drosophila egg chamber: cell fate specific screen
Braun AL Chanana B
MOLECULAR BIOLOGY OF THE CELL. vol. 25 
01-01-2014

A combined cell biological and biophysical strategy to analyze actin/microtubule crosstalk and its relation to cytoplasmic streaming.
Drechsler M Goldstein R
MOLECULAR BIOLOGY OF THE CELL. vol. 25 
01-01-2014

The auto-inhibitory domain and ATP-independent microtubulebinding region of Kinesin heavy chain are major functional domains for transport in the Drosophila germline
Williams LS Ganguly S Loiseau P Ng BF
Journal of Cell Science, The Company of Biologists vol. 127 (1), e1-e1.  

DOI 10.1242/jcs.147793

01-01-2014

2013

How are spoken skills assessed in proficiency tests of general English as a Foreign Language? A preliminary survey
Roca-Varela ML Palacios IM
International Journal of English Studies, Servicio De Publicaciones De La Universidad De Murcia vol. 13 (2), 53-68.  

DOI 10.6018/ijes.13.2.185901

01-12-2013

The auto-inhibitory domain and ATP-independent microtubule-binding region of Kinesin heavy chain are major functional domains for transport in the Drosophila germline
Williams LS Ganguly S Loiseau P
Development, The Company of Biologists vol. 141 (1), 176-186.  

DOI 10.1242/dev.097592

20-11-2013

2012

Nonsense-mediated mRNA decay: from mechanistic insights to impacts on human health
Palacios IM
Briefings in Functional Genomics, Oxford University Press (OUP) vol. 12 (1), 25-36.  

DOI 10.1093/bfgp/els051

11-11-2012

Cytoplasmic streaming in Drosophila oocytes varies with kinesin activity and correlates with the microtubule cytoskeleton architecture
Ganguly S Williams LS
Proceedings of The National Academy of Sciences of The United States of America, Proceedings of The National Academy of Sciences vol. 109 (38), 15109-15114.  

DOI 10.1073/pnas.1203575109

04-09-2012

HIGHER EDUCATION IN THE DEVELOPING WORLD: DROSOPHILA NEUROGENETICS, UGANDA
Baden T Palacios I Vicente M Godino LP
INTED2012: INTERNATIONAL TECHNOLOGY, EDUCATION AND DEVELOPMENT CONFERENCE., 5347-5347.  
01-01-2012

2011

Drosophila Upf1 and Upf2 loss of function inhibits cell growth and causes animal death in a Upf3-independent manner
Avery P Vicente-Crespo M Francis D Nashchekina O
Rna, Cold Spring Harbor Laboratory vol. 17 (4), 624-638.  

DOI 10.1261/rna.2404211

11-02-2011

Nonsense-mediated mRNA decay and development: shoot the messenger to survive?
Vicente-Crespo M Palacios IM
Biochemical Society Transactions, Portland Press vol. 39 (1), 411-411.  

DOI 10.1042/bst0390411v

19-01-2011

2010

Nonsense-mediated mRNA decay and development: shoot the messenger to survive?
Vicente-Crespo M Palacios IM
Biochemical Society Transactions, Portland Press vol. 38 (6), 1500-1505.  

DOI 10.1042/bst0381500

24-11-2010

Drosophila PAT1 is required for Kinesin-1 to transport cargo and to maximize its motility
Loiseau P Davies T Williams LS
Journal of Cell Science, The Company of Biologists vol. 123 (16), e1-e1.  

DOI 10.1242/jcs.078287

15-08-2010

Drosophila PAT1 is required for Kinesin-1 to transport cargo and to maximize its motility
Loiseau P Davies T Williams LS
Development, The Company of Biologists vol. 137 (16), 2763-2772.  

DOI 10.1242/dev.048108

14-07-2010

2007

The Salvador-Warts-Hippo Pathway Is Required for Epithelial Proliferation and Axis Specification in Drosophila
Meignin C Alvarez-Garcia I Davis I
Current Biology, Elsevier vol. 17 (21), 1871-1878.  

DOI 10.1016/j.cub.2007.09.062

25-10-2007

How does an mRNA find its way? Intracellular localisation of transcripts
Palacios IM
Seminars in Cell and Developmental Biology, Elsevier vol. 18 (2), 163-170.  

DOI 10.1016/j.semcdb.2007.01.008

26-01-2007

2004

An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay
Palacios IM Gatfield D St Johnston D
Nature, Springer Nature vol. 427 (6976), 753-757.  

DOI 10.1038/nature02351

01-02-2004

2003

Barentsz, a New Component of the Staufen-Containing Ribonucleoprotein Particles in Mammalian Cells, Interacts with Staufen in an RNA-Dependent Manner
Macchi P Kroening S Palacios IM Baldassa S Grunewald B Ambrosino C
Journal of Neuroscience, Society For Neuroscience vol. 23 (13), 5778-5788.  

DOI 10.1523/jneurosci.23-13-05778.2003

02-07-2003

2002

Kinesin light chain-independent function of the Kinesin heavy chain in cytoplasmic streaming and posterior localisation in theDrosophila oocyte
Palacios IM
Development, The Company of Biologists vol. 129 (23), 5473-5485.  

DOI 10.1242/dev.00119

01-12-2002

Drosophila 14-3-3/PAR-5 Is an Essential Mediator of PAR-1 Function in Axis Formation
Benton R Palacios IM
Developmental Cell, Elsevier vol. 3 (5), 659-671.  

DOI 10.1016/s1534-5807(02)00320-9

01-11-2002

RNA Processing: Splicing and the Cytoplasmic Localisation of mRNA
Palacios IM
Current Biology, Elsevier vol. 12 (2), r50-r52.  

DOI 10.1016/s0960-9822(01)00671-6

01-01-2002

2001

GETTING THE MESSAGE ACROSS: The Intracellular Localization of mRNAs in Higher Eukaryotes
Palacios IM Johnston DS
Annual Review of Cell and Developmental Biology, Annual Reviews vol. 17 (1), 569-614.  

DOI 10.1146/annurev.cellbio.17.1.569

01-11-2001

Dimerization of the 3′UTR of bicoid mRNA involves a two-step mechanism11Edited by J. Doudna
Wagner C Palacios I Jaeger L St Johnston D Ehresmann B
Journal of Molecular Biology, Elsevier vol. 313 (3), 511-524.  

DOI 10.1006/jmbi.2001.5057

01-10-2001

Barentsz is essential for the posterior localization of oskar mRNA and colocalizes with it to the posterior pole
van Eeden FJM Palacios IM Petronczki M St Johnston D
Journal of Cell Biology, Rockefeller University Press vol. 154 (3), 511-524.  

DOI 10.1083/jcb.200105056

30-07-2001

RNA Intracellular Transport
Palacios I
In Encyclopedia of Life Sciences, Wiley 

DOI 10.1038/npg.els.0000896

19-04-2001

1997

Nuclear import of U snRNPs requires importin β
Palacios I Hetzer M Adam SA
The Embo Journal, Springer Nature vol. 16 (22), 6783-6792.  

DOI 10.1093/emboj/16.22.6783

15-11-1997

An immersion in nucleocytoplasmic transport at the Garda lake
Palacios I
Trends in Cell Biology. vol. 7 (2), 81-83.  

DOI 10.1016/s0962-8924(96)30079-2

01-02-1997

Chapter 23 In Vitro Systems for the Reconstitution of snRNP and Protein Nuclear Import
Dingwall C
Methods in Cell Biology, Elsevier vol. 53, 517-543.  

DOI 10.1016/s0091-679x(08)60893-6

01-01-1997

1996

RAN/TC4 mutants identify a common requirement for snRNP and protein import into the nucleus.
Palacios I Weis K Klebe C
Journal of Cell Biology, Rockefeller University Press vol. 133 (3), 485-494.  

DOI 10.1083/jcb.133.3.485

01-05-1996

Mutational analysis identifies functional domains in the influenza A virus PB2 polymerase subunit
Perales B de la Luna S
Journal of Virology, American Society For Microbiology vol. 70 (3), 1678-1686.  

DOI 10.1128/jvi.70.3.1678-1686.1996

01-03-1996

1995

Nuclear retention of RNA as a mechanism for localization.
Boelens WC Palacios I
Rna vol. 1 (3), 273-283.  
01-05-1995

Artificial Cells Evidence Apical Compressive Forces Building up During Neuroepithelial Organoid Early Development
Kanso H Di Cio S Rose R Palacios I Gautrot JE
In Biorxiv 

DOI 10.1101/2025.06.13.659497

Mechanical context defines integrin requirement for maintaining epithelia architecture
Rincón-Ortega L Fernández-Espartero CH Palacios IM González-Reyes A Martín-Bermudo MD
In Biorxiv 

DOI 10.1101/2025.09.09.675082

Optical flow analysis reveals that Kinesin-mediated advection impacts on the orientation of microtubules in the Drosophila oocyte
Drechsler M Lang LF Al-Khatib L Dirks H Burger M Schönlieb C-B Palacios IM
In Biorxiv 

DOI 10.1101/556043

QMRO

Integrins control tissue morphogenesis and homeostasis by sustaining the different types of intracellular actin networks
Mateos CS-C Valencia-Expósito A Míguez DG Palacios IM Martín-Bermudo MD
In Biorxiv 

DOI 10.1101/639427

QMRO

Active diffusion and advection in the Drosophila ooplasm result from the interplay of the actin and microtubule cytoskeletons
Drechsler M Giavazzi F Cerbino R Palacios IM
In Biorxiv 

DOI 10.1101/098590

QMRO

Grants

Grants of specific relevance to the Centre for Molecular Cell Biology

Highthroughput Light Sheet Microscopy: Imaging Across Scales
Viji Draviam Sastry, Caroline Brennan, Vidya Chandran Darbari, Chema Martín-Durán, Ivan Kadurin, Isabel M Palacios, Richard Pickersgill, Sarah McClelland, Tyson Sharp and Martin Knight
£386,205 MRC Medical Research Council
01-10-2022 - 31-03-2023

A confocal microscope for multidisciplinary dynamic studies of complex biological systems
Conrad Mullineaux, Caroline Brennan, Alexandre De Mendoza Soler, Viji Draviam Sastry, Maurice Elphick, Christoph Engl, Isabel M Palacios, Matteo Palma, Marina Resmini, Alexander Ruban, Peter Thorpe, Angelika Stollewerk, Chema Martín-Durán, Paulo Baptista Ribeiro, Susana Alves Godinho, Richard Grose, Stephanie Kermorgant, Peter McCormick and Tyson Sharp
£390,834 BBSRC Biotechnology and Biological Sciences Research Council
01-08-2022 - 31-07-2023

Research Group

PhD Students

• Yasmín Camacho Rodríguez
  A Novel Non-Toxic Glue Based on Biometerials
• Ellie Horder
  Investigating The Effects of E-Cadherin Dynamics on Egfr, Stat and Related Signalling Pathways.
• Olga Xintarakou
  Investigating Mtor Activity Effects on Cellular Metabolism and Cytoarchitecture

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