Prof Viji Draviam Sastry
Professor of Cell and Molecular Biology
School of Biological and Behavioural Sciences
Queen Mary University of London
Queen Mary University of London
Research
Cell division, Cytoskeleton, Genomic Instability, Proteomics, Genomic variants, Cancer cell biology
Publications
Publications of specific relevance to the Centre for Molecular Cell Biology2025
Fluorescence recovery in the super-resolution regime reveals subcompartments of 53BP1 fociWu C Manjarrez-González JC Choudhury M Shamkhi N Ding S Nair VM Draviam VM
Cell Reports Methods, Elsevier vol. 5 (8)
01-08-2025
Multi-SpinX: An advanced framework for automated tracking of mitotic spindles and kinetochores in multicellular environmentsChai B Efstathiou C Choudhury MS Kuniyasu K Sanjay Jain S Maharea A-C Tanaka K Draviam VM
Computers in Biology and Medicine, Elsevier vol. 186, 109626-109626.
22-01-2025
2024
Search for chromosomal instability aiding variants reveal naturally occurring kinetochore gene variants that perturb chromosome segregationIslam A Manjarrez-González JC Song X Draviam VM
Iscience, Elsevier vol. 27 (3)
26-01-2024
2023
Opportunities and challenges for deep learning in cell dynamics researchChai B Efstathiou C Yue H
Trends in Cell Biology, Elsevier vol. 34 (11), 955-967.
28-11-2023
Opportunities and challenges for deep learning in cell dynamics researchChai B Efstathiou C Yue H Draviam VM
In Arxiv
19-07-2023
Deep learning techniques and mathematical modeling allow 3D analysis of mitotic spindle dynamicsDang D Efstathiou C Sun D Draviam VM
Journal of Cell Biology, Rockefeller University Press vol. 222 (5)
02-03-2023
2021
Counteraction between Astrin-PP1 and Cyclin-B-CDK1 pathways protects chromosome-microtubule attachments independent of biorientationSong X Conti D Shrestha RL
Nature Communications, Springer Nature vol. 12 (1)
01-12-2021
Electrically tunable lenses - Eliminating mechanical axial movements during high-speed 3D live imagingEfstathiou C
Journal of Cell Science, Company of Biologists vol. 134 (16)
01-08-2021
Multinucleation associated DNA damage blocks proliferation in p53-compromised cellsHart M Adams SD
Communications Biology, Springer Nature vol. 4 (1)
09-04-2021
2019
Kinetochores attached to microtubule-ends are stabilised by astrin bound pp1 to ensure proper chromosome segregationConti D Gul P Islam A Martín-Durán JM
Elife, Elife Sciences Publications Ltd vol. 8
24-12-2019
MARK2/Par1b kinase present at centrosomes and retraction fibres corrects spindle off-centring induced by actin disassemblyHart M Zulkipli I Shrestha RL Dang D Conti D Gul P
Open Biology, The Royal Society vol. 9 (6)
26-06-2019
2018
Spindle rotation in human cells is reliant on a MARK2-mediated equatorial spindle centering mechanismZulkipli I Clark J HART M Shrestha R GUL P DANG D SASTRY N
Journal of Cell Biology, Rockefeller University Press
25-06-2018
2017
Proper rotation of the mitotic spindle requires an equatorial spindle centering mechanism in human cells.Zulkipli I Shrestha RL
ASCB. vol. 28
15-12-2017
Aurora-B kinase pathway controls the lateral to end-on conversion of kinetochore-microtubule attachments in human cells.Shrestha RL Conti D Tamura N Braun D Ries J
Nat Commun, Macmillan Publishers Limited, Part of Springer Nature. vol. 8 (1), 150-150.
28-07-2017
How are Dynamic Microtubules Stably Tethered to Human Chromosomes?Conti D Hart M Tamura N Islam A
In Cytoskeleton - Structure, Dynamics, Function and Disease, Intechopen
17-05-2017
Outer kinetochore phosphatases-PP2A-B56 and PP1-differently contribute to the establishment of chromosome-microtubule attachments.Conti D Cieslinski KA Ries J
MOLECULAR BIOLOGY OF THE CELL. vol. 28
01-01-2017
2016
Kindlin1 regulates microtubule function to ensure normal mitosisPatel H Stavrou I Frame MC Brunton VG
Journal of Molecular Cell Biology, Oxford University Press (OUP) vol. 8 (4), 338-348.
19-08-2016
Editorial: Quantitative Biology: Dynamics of Living Systems.Hiroi N Draviam VM
Front Physiol, Frontiers Media Sa vol. 7
02-06-2016
2015
A Semi-Supervised Approach for Refining Transcriptional Signatures of Drug Response and Repositioning PredictionsIorio F Shrestha RL Levin N Boilot V Draviam VM
Plos One, Public Library of Science (Plos) vol. 10 (10)
09-10-2015
Modeling of Noisy Spindle Dynamics Reveals Separable Contributions to Achieving Correct OrientationCorrigan AM Shrestha R Draviam VM Donald AM
Biophysical Journal, Elsevier vol. 109 (7), 1398-1409.
01-10-2015
A proteomic study of mitotic phase-specific interactors of EB1 reveals a role for SXIP-mediated protein interactions in anaphase onsetTamura N Simon JE Nayak A Shenoy R Hiroi N Funahashi A Draviam VM
Biology Open, The Company of Biologists vol. 4 (2), 155-169.
16-01-2015
PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repairOchi T Blackford AN Coates J Jhujh S Mehmood S Tamura N Travers J Draviam VM et al.
Science, American Association For The Advancement of Science (Aaas) vol. 347 (6218), 185-188.
09-01-2015
High-speed microscopy with an electrically tunable lens to image the dynamics of in vivo molecular complexesNakai Y Ozeki M Hiraiwa T Funahashi A Hiroi N Taniguchi A Nonaka S Boilot V et al.
Review of Scientific Instruments, Aip Publishing vol. 86 (1)
01-01-2015
2014
Need for multi-scale systems to identify spindle orientation regulators relevant to tissue disorganization in solid cancersChin HMS Nandra K
Frontiers in Physiology, Frontiers vol. 5
25-07-2014
TAO1 kinase maintains chromosomal stability by facilitating proper congression of chromosomesShrestha RL Tamura N Fries A Clark J
Open Biology, The Royal Society vol. 4 (6)
01-06-2014
Lateral to End-on Conversion of Chromosome-Microtubule Attachment Requires Kinesins CENP-E and MCAK.Shrestha RL Draviam VM
MOLECULAR BIOLOGY OF THE CELL. vol. 25
01-01-2014
Role of phosphatases in chromosome segregationConti D
MOLECULAR BIOLOGY OF THE CELL. vol. 25
01-01-2014
2013
Lateral to End-on Conversion of Chromosome-Microtubule Attachment Requires Kinesins CENP-E and MCAKShrestha RL
Current Biology, Elsevier vol. 23 (23), 2440-2441.
01-12-2013
Automated tracking of mitotic spindle pole positions shows that LGN is required for spindle rotation but not orientation maintenanceCorrigan AM Shrestha RL Zulkipli I Hiroi N Liu Y Tamura N Patel J
Cell Cycle, Taylor & Francis vol. 12 (16), 2643-2655.
15-08-2013
Lateral to End-on Conversion of Chromosome-Microtubule Attachment Requires Kinesins CENP-E and MCAKShrestha RL
Current Biology, Elsevier vol. 23 (16), 1514-1526.
25-07-2013
Meeting report of the International Workshop on Quantitative Biology 2012: mesoscopic and microscopic worlds meetDraviam VM Funahashi A Hiroi N
Frontiers in Physiology, Frontiers vol. 3
01-01-2013
2012
Microtubule plus-ends within a mitotic cell are ‘moving platforms’ with anchoring, signalling and force-coupling rolesTamura N
Open Biology, The Royal Society vol. 2 (11)
01-11-2012
TAO1 maintains genome integrity by mediating the timely maturation of chromosome attachments made to lateral walls of microtubules.Shrestha RL Draviam VM
MOLECULAR BIOLOGY OF THE CELL. vol. 23
01-01-2012
Microtubule-end bound complexes power chromosome movement during chromosome segregationTamura N Shrestha RL Draviam VM
MOLECULAR BIOLOGY OF THE CELL. vol. 23
01-01-2012
2011
A mechanism linking microtubule destabilisation to maturation of chromosome-microtubule attachmentsShrestha RL Tamura N Draviam VM
MOLECULAR BIOLOGY OF THE CELL. vol. 22
01-01-2011
2009
Roles for the Conserved Spc105p/Kre28p Complex in Kinetochore-Microtubule Binding and the Spindle Assembly CheckpointPagliuca C Draviam VM Marco E Sorger PK De Wulf P
Plos One, Public Library of Science (Plos) vol. 4 (10)
28-10-2009
Erratum To: The human kinetochore proteins Nnf1R and Mcm21R are required for accurate chromosome segregationMcAinsh AD Meraldi P Draviam VM Sorger PK
The Embo Journal, Springer Nature vol. 28 (9), 1374-1374.
06-05-2009
2008
Studying chromosome instability in the mouseFoijer F Draviam VM
Biochimica Et Biophysica Acta, Elsevier vol. 1786 (1), 73-82.
26-07-2008
2007
Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activitiesStegmeier F Rape M Nalepa G Sowa ME Ang XL McDonald ER Li MZ Hannon GJ et al.
Nature vol. 447 (7141), 876-881.
10-05-2007
A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signallingDraviam VM Stegmeier F Nalepa G Sowa ME Chen J Sorger PK Harper JW
Nature Cell Biology, Springer Nature vol. 9 (5), 556-564.
08-04-2007
Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activitiesStegmeier F Rape M Draviam VM Nalepa G Sowa ME McDonald III ER Hannon GJ Kirschner MW et al.
Nature, Springer Nature vol. 446 (7138), 876-881.
01-04-2007
Hsp90 is required to localise cyclin B and Msps/ch-TOG to the mitotic spindle in Drosophila and humansBasto R Gergely F Draviam VM Liley K
Journal of Cell Science, The Company of Biologists vol. 120 (7), 1278-1287.
01-04-2007
2006
The human kinetochore proteins Nnf1R and Mcm21R are required for accurate chromosome segregationMcAinsh AD Meraldi P Draviam VM
The Embo Journal, Springer Nature vol. 25 (17), 4033-4049.
24-08-2006
Misorientation and reduced stretching of aligned sister kinetochores promote chromosome missegregation in EB1‐ or APC‐depleted cellsDraviam VM Shapiro I Aldridge B
The Embo Journal, Springer Nature vol. 25 (12), 2814-2827.
08-06-2006
Functional Genomic Screen Reveals the Role of a Novel Checkpoint Kinase, TAO1 in Mitosis and Cell Cycle ProgressionDraviam VM Stegmeier F Nalepa G Sowa M Harper W Sorger P
MOLECULAR BIOLOGY OF THE CELL. vol. 17
01-01-2006
2004
Timing and Checkpoints in the Regulation of Mitotic ProgressionMeraldi P Draviam VM
Developmental Cell, Elsevier vol. 7 (1), 45-60.
01-07-2004
Chromosome segregation and genomic stabilityDraviam VM Xie S
Current Opinion in Genetics & Development, Elsevier vol. 14 (2), 120-125.
01-04-2004
2003
The ch-TOG/XMAP215 protein is essential for spindle pole organization in human somatic cellsGergely F Draviam VM
Genes & Development, Cold Spring Harbor Laboratory vol. 17 (3), 336-341.
01-02-2003
2001
The Localization of Human Cyclins B1 and B2 Determines Cdk1 Substrate Specificity and Neither Enzyme Requires Mek to Disassemble the Golgi ApparatusDraviam VM Orrechia S Lowe M
Journal of Cell Biology, Rockefeller University Press vol. 152 (5), 945-958.
05-03-2001
1999
Pleiotropic effects of human papillomavirus type 16 E6 oncogene expression in human epithelial cell lines.Mythily DV Krishna S
Journal of General Virology, Microbiology Society vol. 80 (7), 1707-1713.
01-07-1999
1997
Cytokeratin patterns of expression in human epithelial cell lines correlate with transcriptional activity of the human papillomavirus type 16 upstream regulatory region.Tergaonkar V Mythily DV
Journal of General Virology, Microbiology Society vol. 78 (10), 2601-2606.
01-10-1997
FRAP-in-SR: Fluorescence recovery in the Super-Resolution regime reveals subcompartments of 53BP1 fociWu C Manjarrez-González JC Choudhury M Shamkhi N Ding S Nair VM Draviam VM
In Biorxiv
Dynein synergises with EB1 to facilitate cortex-microtubule encounter and proper spindle positioning in metaphaseEfstathiou C Ojkic N Draviam VM
In Biorxiv
Human genetic variations reveal Chromosomal Instability aiding Variants (CIVa) in kinetochore-microtubule associated proteinsIslam A Manjarrez-González JC Gore T Song X Draviam VM
In Biorxiv
SpinX: Time-resolved 3D Analysis of Mitotic Spindle Dynamics using Deep Learning Techniques and Mathematical ModellingDang D Efstathiou C Sastry N Draviam VM
In Biorxiv
Cells protect chromosome-microtubule attachments, independent of biorientation, using an Astrin-PP1 and CyclinB-CDK1 feedback loopConti D Song X Shrestha RL Braun D Draviam VM
In Biorxiv
Multinucleation Associated DNA Damage causes quiescence despite compromised p53Hart M Adams SD Draviam VM
In Biorxiv
MARK2/Par1b present at retraction fibres corrects spindle off-centering induced by actin disassemblyHart M Zulkipli I Shrestha RL Dang D Conti D Kujawiak I Draviam V
In Biorxiv
Multi-SpinX: An Advanced Framework for Automated Tracking of Mitotic Spindles and Kinetochores in Multicellular EnvironmentsChai B Efstathiou C Choudhury MS Kuniyasu K Jain SS Maharea A-C Tanaka K Draviam VM
In Biorxiv
Grants
Grants of specific relevance to the Centre for Molecular Cell BiologyLiDO iCASE PhD Studentship Illuminating the Dark Genome's Role in Chromosome Segregation and Cellular AgingViji Draviam Sastry
£38,000 NonExomics Inc
01-10-2025 - 30-09-2029
Development of AI framework for iPSC image analysis and integration with transcriptomics Viji Draviam Sastry
£127,935 Biotechnology and Biological Sciences Research Council
01-10-2024 - 30-09-2028
Cooperativity and forces in molecular interactions governing chromosome stabilityVladimir Volkov and Viji Draviam Sastry
£717,413 Biotechnology and Biological Sciences Research Council
20-11-2023 - 28-12-2026
How are mono-oriented chromosome-microtubule attachments protected to prevent errors in mitosis and associated cellular ageing?Viji Draviam Sastry
£403,926 BBSRC Biotechnology and Biological Sciences Research Council
28-11-2022 - 31-07-2026
Harmonised IAA grant - Improve and accelerate the impact of QMUL research BBSRCDavid Lee and Viji Draviam Sastry
£495,000 BBSRC Biotechnology and Biological Sciences Research Council
01-04-2022 - 31-03-2026
KTP Capacity Building Competition 2022Akram Alomainy, Greg Slabaugh, Alastair Noyce, Vahitha Abdul Salam and Viji Draviam Sastry
£34,544 Innovate UK
01-12-2022 - 31-03-2023
Highthroughput Light Sheet Microscopy: Imaging Across ScalesViji Draviam Sastry, Caroline Brennan, Vidya Chandran Darbari, Chema Martín-Durán, Ivan Kadurin, Isabel M Palacios, Richard Pickersgill, Sarah McClelland, Tyson Sharp and Martin Knight
£386,205 MRC Medical Research Council
01-10-2022 - 31-03-2023
Joint-PhD Studentship with Carl ZeissViji Draviam Sastry
£42,636 Carl Zeiss Ltd
01-10-2022 - 30-09-2025
A confocal microscope for multidisciplinary dynamic studies of complex biological systemsConrad Mullineaux, Caroline Brennan, Alexandre De Mendoza Soler, Viji Draviam Sastry, Maurice Elphick, Christoph Engl, Isabel M Palacios, Matteo Palma, Marina Resmini, Alexander Ruban, Peter Thorpe, Angelika Stollewerk, Chema Martín-Durán, Paulo Baptista Ribeiro, Susana Alves Godinho, Richard Grose, Stephanie Kermorgant, Peter McCormick and Tyson Sharp
£390,834 BBSRC Biotechnology and Biological Sciences Research Council
01-08-2022 - 31-07-2023
The Lexicon of miRISC: Deconstructing the functional complexity of the miRNA induced silencing complexTyson Sharp, Faraz Mardakheh, Jun Wang and Viji Draviam Sastry
£527,571 Biotechnology and Biological Sciences Research Council
01-01-2022 - 31-12-2024
KTP Project with Zeiss- Generalisation of SpinX software (Deep Learning based system and 3D modellingViji Draviam Sastry and Chema Martín-Durán
£142,038 Innovate UK
01-11-2021 - 30-04-2023
UK-China partnership: Chromosomal Instability aiding Genetic Variants (CIVa) linked to human ageingViji Draviam Sastry and Chema Martín-Durán
£23,873 Biotechnology and Biological Sciences Research Council
01-08-2021 - 31-07-2024
Super-Resolution Microscopy of live cells in 3DViji Draviam Sastry, Conrad Mullineaux, Vidya Chandran Darbari, Lakxmi Subramanian, Fabrice Caudron, Richard Pickersgill, Guy Hanke, Alexander Ruban, Peter Thorpe, Christopher Duffy, Chema Martín-Durán, John Connelly, Peter McCormick, James Chapple, Vardhman Rakyan, Tyson Sharp, Susana Alves Godinho and David Lee
£369,201 BBSRC Biotechnology and Biological Sciences Research Council
01-12-2020 - 31-03-2022
Protecting Chromosome Number: how cells establish, monitor and maintain chromosome-microtubule interaction?Viji Draviam Sastry
£406,947 BBSRC Biotechnology and Biological Sciences Research Council
01-05-2018 - 31-12-2022
Research Group
PhD Students
- Muntaqa Choudhury
Establishing Photokinetic Studies in The Super-Resolution Regime to Understand Cell Division Process - Ding
Centromeric Architecture Control in Distinct Cell Types and Fates - Steffi Manetta
Lido - Catalina Manjarrez González
A Molecular Study of Mechanisms That Drive Aneuploidy in Cancers: Naturally Occurring Variants in Cenpc and Ska3 - Chimmy Nguyen
Lido Icase Sept 2025 - Jasmine Pilgir
Expanding Predictive Toxicity With Multimodal Models of High - Tara Shutes
Chemical Biology Approaches to Study and Modulate Protein Phosphatases - Roop Singh Virk
Lido Dtp Sept 2025 - Keyan Zhou
Uncovering Molecular Drivers of Chromosomal Instability Seen
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