Prof Caroline Brennan
Professor of Molecular Genetics
Interim Head of The School of Biological and Behavioural Sciences
School of Biological and Behavioural Sciences
Queen Mary University of London
Queen Mary University of London
Research
zebrafish, development, comparative cognition, addiction, neurobiology
Interests
All aspects of the use of zebrafish as a developmental and behavioural model organism including cell biological and behavioural analysis in this species. Current research focuses on cell and developmental processes underlying vulnerability to behavioural and metabolic disease as well as comparative psychology approaches to cognition and psychiatric disorders. We collaborate with human geneticists to explore the cell biology underlying genetic variants associated with human disease phenotypes, and to test hypotheses regarding mechanisms of gene action, and with evolutionary geneticists to explore genetic control of behaviour.Research web page : brennanlab.sbcs.qmul.ac.uk/
Publications
Publications of specific relevance to the Centre for Molecular Cell Biology2025
OR25-07 A Novel and Severe Multisystem Metabolic Disease due to Homozygous AIP VariantsKorbonits M Wang X Barry S Suleyman O Stefano DT Uddin N Hall CL Laura P et al.
Journal of The Endocrine Society, The Endocrine Society vol. 9 (Supplement_1)
22-10-2025
Lack of Williams syndrome-associated genes alters quantity discrimination in zebrafishTorres-Pérez JV Anagianni S Sheardown E Miletto-Petrazzini ME Fraser SE Butterworth B Vallortigara G Brennan CH
Behavioural Brain Research, Elsevier vol. 496
01-10-2025
Zebrafish exposed to a cocktail of pesticides during early development display long-lasting neurobehavioral alterationsAbellán-Álvaro M Forner-Piquer I Chousidis I Godden E García-Deante A Marchi N Brennan CH Torres-Pérez JV
Archives of Toxicology, Springer Nature vol. 99 (10), 4181-4195.
25-08-2025
Housing and husbandry factors affecting zebrafish novel tank test responses: a global multi-laboratory studyHillman C Fontana BD Amstislavskaya TG Gorbunova MA Altenhofen S Barthelson K Bastos LM Borba JV et al.
Lab Animal, Springer Nature vol. 54 (6), 156-164.
26-05-2025
AIP deficiency in zebrafish causes loss of intestinal epithelial differentiation via disrupted wnt signalingWang X Haworth O Barry S Leggieri A Hall C Martin J Korbonits M Brennan C
Endocrine Abstracts, Bioscientifica
09-05-2025
2024
Housing and Husbandry Factors Affecting Zebrafish (Danio rerio) Novel Tank Test Responses: A Global Multi-Laboratory Study.Hillman C Fontana BD Amstislavskaya TG Gorbunova MA Altenhofen S Barthelson K Bastos LM Borba JV et al.
Res Sq
16-10-2024
Pleiotropic contribution of rbfox1 to psychiatric and neurodevelopmental phenotypes in two zebrafish modelsAntón-Galindo E Adel MR García-González J Leggieri A López-Blanch L Irimia M Norton WHJ Brennan CH et al.
Translational Psychiatry, Springer Nature vol. 14 (1)
19-02-2024
2023
Aryl hydrocarbon receptor-interacting protein (aip) loss causes failure-to-thrive and cardiac defects in zebrafishWang X Haworth O Abdi-Aziz N Leggieri A Jhosadara E-FA Korbonits M Brennan CH
Endocrine Abstracts, Bioscientifica
31-10-2023
THU079 Danio Rerio (Zebrafish): A New Model Of AIP Loss Of FunctionWang X Leggieri A Anagianni S Brennan CH Korbonits M
Journal of The Endocrine Society, The Endocrine Society vol. 7 (Supplement_1)
05-10-2023
EXPLORING THE GENETICS OF NUMEROSITY, FROM FISH TO MANBrennan C Sheardown E Pérez JVT Petrazzini MEM Messina A Potrich D Anagianni S Perrino M et al.
Ibro Neuroscience Reports, Elsevier vol. 15
01-10-2023
LOSS-OF-FUNCTION ZEBRAFISH (DANIO RERIO) FOR GENES ASSOCIATED WITH WILLIAMS SYNDROME SHOW ALTERED QUANTITY DISCRIMINATIONPérez JVT Anagianni S Sheardown E Petrazzini MEM Fraser S Butterworth B Vallortigara G Brennan C
Ibro Neuroscience Reports, Elsevier vol. 15
01-10-2023
The Role of Crosslinker Content of Positively Charged NIPAM Nanogels on the In Vivo Toxicity in ZebrafishBilardo R Traldi F Brennan CH Resmini M
Pharmaceutics, Mdpi vol. 15 (7)
07-07-2023
2022
baz1b loss-of-function in zebrafish produces phenotypic alterations consistent with the domestication syndromeTorres-Pérez JV Anagianni S Mech AM Havelange W García-González J Fraser SE Vallortigara G Brennan CH
Iscience, Elsevier vol. 26 (1)
01-12-2022
A zebrafish model of AIP loss of functionWang X Leggieri A Anagianni S Brennan CH Korbonits M
Endocrine Abstracts, Bioscientifica
27-10-2022
Quantity as a Fish Views It: Behavior and NeurobiologyMessina A Potrich D Perrino M Sheardown E Petrazzini MEM Luu P Nadtochiy A Truong TV et al.
Frontiers in Neuroanatomy, Frontiers vol. 16
14-07-2022
Characterizing ontogeny of quantity discrimination in zebrafishSheardown E Torres-Perez JV Anagianni S Fraser SE Vallortigara G Butterworth B Miletto-Petrazzini ME Brennan CH
Proceedings of The Royal Society B: Biological Sciences, The Royal Society vol. 289 (1968)
09-02-2022
Ankk1 Loss of Function Disrupts Dopaminergic Pathways in ZebrafishLeggieri A García-González J Torres-Perez JV Havelange W Hosseinian S Mech AM Keatinge M Busch-Nentwich EM et al.
Frontiers in Neuroscience, Frontiers vol. 16
08-02-2022
Translational relevance of forward genetic screens in animal models for the study of psychiatric diseaseSheardown E Mech AM Petrazzini MEM Leggieri A Gidziela A Hosseinian S Sealy IM Torres-Perez JV et al.
Neuroscience and Biobehavioral Reviews, Elsevier vol. 135
04-02-2022
Behavioral and Gene Regulatory Responses to Developmental Drug Exposures in ZebrafishMech AM Merteroglu M Sealy IM Teh M-T White RJ Havelange W Brennan CH Busch-Nentwich EM
Frontiers in Psychiatry, Frontiers vol. 12
10-01-2022
2021
A systematic review of the mental health risks and resilience among pollution-exposed adolescentsTheron LC Abreu-Villaça Y Augusto-Oliveira M Brennan C Crespo-Lopez ME de Paula Arrifano G Glazer L Gwata N et al.
Journal of Psychiatric Research, Elsevier vol. 146, 55-66.
23-12-2021
Developmental Exposure to Low Concentrations of Methylmercury Causes Increase in Anxiety-Related Behaviour and Locomotor Impairments in ZebrafishGlazer L Brennan CH
International Journal of Molecular Sciences, Mdpi vol. 22 (20)
11-10-2021
Neurons in the Dorso-Central Division of Zebrafish Pallium Respond to Change in Visual NumerosityMessina A Potrich D Schiona I Sovrano VA Fraser SE Brennan CH Vallortigara G
Cerebral Cortex, Oxford University Press (OUP) vol. 32 (2), 418-428.
28-07-2021
Conservation of mechanisms regulating emotional-like responses on spontaneous nicotine withdrawal in zebrafish and mammalsPonzoni L Melzi G Marabini L Martini A Petrillo G Teh M-T Torres-Perez JV Morara S et al.
Progress in Neuro-Psychopharmacology and Biological Psychiatry, Elsevier vol. 111
24-04-2021
Effects of pollution on adolescent mental health: a systematic review protocolTheron LC Abreu-Villaça Y Augusto-Oliveira M Brennan CH Crespo-Lopez ME de Paula Arrifano G Glazer L Lin L et al.
Systematic Reviews, Springer Nature vol. 10 (1)
27-03-2021
Behavioral Effects of Developmental Exposure to JWH-018 in Wild-Type and Disrupted in Schizophrenia 1 (disc1) Mutant ZebrafishGarcía-González J de Quadros B Havelange W Brock AJ Brennan CH
Biomolecules, Mdpi vol. 11 (2)
19-02-2021
Stress reactivity elicits a tissue-specific reduction in telomere length in aging zebrafish (Danio rerio)Evans JR Torres-Pérez JV Miletto Petrazzini ME Riley R Brennan CH
Scientific Reports, Nature Publishing Group vol. 11 (1)
01-01-2021
Restoring Wnt/β-catenin pathway as potential therapeutics for Williams syndrome-associated anxiety disordersTorres-Perez JV Brennan CH
BRITISH JOURNAL OF PHARMACOLOGY. vol. 178 (2), 447-448.
01-01-2021
2020
Are cerebral and behavioural lateralization related to anxiety-like traits in the animal model zebrafish (Danio rerio)?Petrazzini MEM Gambaretto L Dadda M Brennan C Agrillo C
Laterality Asymmetries of Body Brain and Cognition, Taylor & Francis vol. 26 (1-2), 144-162.
17-12-2020
Increased Response to 3,4-Methylenedioxymethamphetamine (MDMA) Reward and Altered Gene Expression in Zebrafish During Short- and Long-Term Nicotine WithdrawalPonzoni L Teh MT Torres-Perez JV Brennan CH Braida D Sala M
Molecular Neurobiology, Springer (Part of Springer Nature)
24-11-2020
Application of an abstract concept across magnitude dimensions by fishMiletto Petrazzini ME Brennan CH
Scientific Reports, Springer Nature vol. 10 (1)
09-10-2020
The effects of polygenic risk for psychiatric disorders and smoking behaviour on psychotic experiences in UK BiobankGarcía-González J Ramírez J Howard DM Brennan CH Munroe PB Keers R
Translational Psychiatry, Nature Publishing Group vol. 10 (1)
28-09-2020
Moderate early life stress improves adult zebrafish (Danio rerio) working memory but does not affect social and anxiety-like responsesFontana BD Gibbon AJ Cleal M Sudwarts A Pritchett D Miletto Petrazzini ME Brennan CH Parker MO
Developmental Psychobiology, Wiley
04-06-2020
Response to change in the number of visual stimuli in zebrafish:A behavioural and molecular studyMessina A Potrich D Schiona I Sovrano VA Fraser SE Brennan CH Vallortigara G
Scientific Reports, Nature Publishing Group vol. 10 (1)
01-04-2020
Identification of Slit3 as a locus affecting nicotine preference in zebrafish and human smoking behaviourGarcia Gonzalez J Brock A Parker M Riley R Joliffe D SUDWARTS A Teh M-T Busch-Nentwich E et al.
Elife, Elife Sciences Publications Ltd
25-03-2020
Chapter 7 Classical and operant conditioning in larval zebrafishPritchett D Brennan CH
In Behavioral and Neural Genetics of Zebrafish, Elsevier 107-122.
01-01-2020
2019
The effects of polygenic risk for psychiatric disorders and smoking behaviour on psychotic experiences in UK BiobankGarcía-González J Ramírez J Howard DM Brennan CH Munroe PB Keers R
, Cold Spring Harbor Laboratory
21-12-2019
BEHAVIOURAL EFFECTS OF DEVELOPMENTAL EXPOSURE TO THE SYNTHETIC CANNABINOID JWH-018 IN WILD TYPE AND DISRUPTED IN SCHIZOPHRENIA 1 (DISC1) MUTANT ZEBRAFISHGarcia-Gonzalez J De Quadros B Akkari M Brennan C
The XXVIth World Congress of Psychiatric Genetics (WCPG), 11 - 15 October 2018. vol. 29, 1274-1274.
26-07-2019
2018
Food or friends? What motivates zebrafish (Danio rerio) performing a visual discriminationBRENNAN CH Brown VJ Daggett J
Behavioural Brain Research vol. 359
06-11-2018
2017
Assessing the Value of the Zebrafish Conditioned Place Preference Model for Predicting Human Abuse Potential.Brock AJ Goody SMG Mead AN Sudwarts A Parker MO Brennan CH
J Pharmacol Exp Ther vol. 363 (1), 66-79.
15-09-2017
Zebrafish Behavioral Models of AgeingBrock AJ Sudwarts A Parker MO Brennan CH
In The Rights and Wrongs of Zebrafish: Behavioral Phenotyping of Zebrafish, Springer Nature 241-258.
01-01-2017
2016
Translational Pharmacology of a Putative Measure of Motor Impulsivity in Larval ZebrafishParker M Brennan C
Current Psychopharmacologye, Bentham Science Publishers vol. 5 (2), 73-84.
28-07-2016
Corrigendum: Beta 1-integrin-c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes.Barrow-McGee R Kishi N Joffre C Ménard L Hervieu A Bakhouche BA Noval AJ Mai A et al.
Nat Commun vol. 7, 12392-12392.
22-07-2016
Beta 1-integrin–c-Met cooperation reveals an\ninside-in survival signalling on autophagy-related\nendomembranesBRENNAN CH
Nature Communications, Nature Publishing Group: Nature Communications vol. 7, 11942-11942.
23-06-2016
A Small Molecule Inhibitor of PDK1/PLCγ1 Interaction Blocks Breast and Melanoma Cancer Cell InvasionRaimondi C Calleja V Ferro R Fantin A Riley AM Potter BVL Brennan CH Maffucci T et al.
Scientific Reports, Nature Publishing Group: Open Access Journals - Option C vol. 6, 26142-26142.
20-05-2016
Sustained Effects of Developmental Exposure to Ethanol on Zebrafish Anxiety-Like BehaviourBaiamonte M Parker MO Vinson GP Brennan CH
Plos One, Public Library of Science (Plos) vol. 11 (2)
10-02-2016
2015
Suppression of TGFβ and Angiogenesis by Type VII Collagen in Cutaneous SCC.Martins VL Caley MP Moore K Szentpetery Z Marsh ST Murrell DF Kim MH Avari M et al.
J Natl Cancer Inst vol. 108 (1)
16-10-2015
Developmental role of acetylcholinesterase in impulse control in zebrafishParker MO Brock AJ Sudwarts A Teh M-T Combe FJ Brennan CH
Frontiers in Behavioral Neuroscience, Frontiers vol. 9
16-10-2015
Correction: Sustained Action of Developmental Ethanol Exposure on the Cortisol Response to Stress in Zebrafish Larvae and AdultsBaiamonte M Brennan CH Vinson GP
Plos One, Public Library of Science (Plos) vol. 10 (5)
08-05-2015
Speed–accuracy trade-offs and individually consistent decision making by individuals and dyads of zebrafish in a colour discrimination taskWang M-Y Brennan CH Lachlan RF Chittka L
Animal Behaviour, Elsevier vol. 103, 277-283.
01-05-2015
Sustained Action of Developmental Ethanol Exposure on the Cortisol Response to Stress in Zebrafish Larvae and AdultsBaiamonte M Brennan CH Vinson GP
Plos One, Public Library of Science (Plos) vol. 10 (4)
13-04-2015
Molecular psychiatry of zebrafish.Stewart AM Ullmann JFP Norton WHJ Parker MO Brennan CH Gerlai R Kalueff AV
Mol Psychiatry vol. 20 (1), 2-17.
01-02-2015
2014
The utility of zebrafish to study the mechanisms by which ethanol affects social behavior and anxiety during early brain developmentParker MO Annan LV Kanellopoulos AH Brock AJ Combe FJ Baiamonte M Teh MT Brennan CH
Progress in Neuro Psychopharmacology and Biological Psychiatry vol. 55, 94-100.
03-12-2014
Moderate alcohol exposure during early brain development increases stimulus-response habits in adulthoodParker MO Evans AMD Brock AJ Combe FJ Teh MT Brennan CH
Addiction Biology
21-08-2014
The receptor tyrosine kinase Axl regulates cell-cell adhesion and stemness in cutaneous squamous cell carcinoma.Cichoń MA Szentpetery Z Caley MP Papadakis ES Mackenzie IC Brennan CH O'Toole EA
Oncogene vol. 33 (32), 4185-4192.
07-08-2014
Atomoxetine reduces anticipatory responding in a 5-choice serial reaction time task for adult zebrafish.Parker MO Brock AJ Sudwarts A Brennan CH
Psychopharmacology (Berl) vol. 231 (13), 2671-2679.
01-07-2014
The utility of zebrafish to study the mechanisms by which ethanol affects social behavior and anxiety during early brain developmentParker MO Annan LV Kanellopoulos AH Brock AJ Combe FJ Baiamonte M Teh M-T Brennan CH
Progress in Neuro-Psychopharmacology and Biological Psychiatry
01-01-2014
Parallel mechanisms for visual search in zebrafish.Proulx MJ Parker MO Tahir Y Brennan CH
Plos One vol. 9 (10)
01-01-2014
2013
Behavioural phenotyping of casper mutant and 1-pheny-2-thiourea treated adult zebrafish.Parker MO Brock AJ Millington ME Brennan CH
Zebrafish vol. 10 (4), 466-471.
01-12-2013
Addiction and the adrenal cortex.Vinson GP Brennan CH
Endocr Connect vol. 2 (3), R1-R14.
01-09-2013
The role of zebrafish (Danio rerio) in dissecting the genetics and neural circuits of executive functionParker MO Brock AJ Walton RT Brennan CH
Frontiers in Neural Circuits (MAR)
19-03-2013
S100P is a metastasis-associated gene that facilitates transendothelial migration of pancreatic cancer cells.Barry S Chelala C Lines K Sunamura M Wang A Marelli-Berg FM Brennan C Lemoine NR et al.
Clin Exp Metastasis vol. 30 (3), 251-264.
01-03-2013
Development and automation of a test of impulse control in zebrafish.Parker MO Ife D Ma J Pancholi M Smeraldi F Straw C Brennan CH
Front Syst Neurosci vol. 7
01-01-2013
2012
Zebrafish (Danio rerio) models of substance abuse: Harnessing the capabilitiesParker MO Brennan CH
Behaviour vol. 149 (10-12), 1037-1062.
05-12-2012
Low and moderate alcohol consumption during pregnancy: effects on social behaviour and propensity to develop substance abuse in later life.Parker MO Brennan CH
Bjog vol. 119 (13), 1671-1672.
01-12-2012
Low and Moderate alcohol consumption during pregnancy: effects on social behaviour and propensity to develop substance abuse in later lifePARKER M BRENNAN CH
Bjog: An International Journal of Obstetrics and Gynaecology (13), 1671-1672.
01-12-2012
The role of primary cilia in mouse adrenal and zebrafish interrenal developmentCogger K Guasti L Ashworth R Brennan C Beales P Marion V King P
Cilia, Springer Nature vol. 1 (Suppl 1)
01-11-2012
Discrimination reversal and attentional sets in zebrafish (Danio rerio).Parker MO Gaviria J Haigh A Millington ME Brown VJ Combe FJ Brennan CH
Behav Brain Res vol. 232 (1), 264-268.
15-06-2012
Development and implementation of a three-choice serial reaction time task for zebrafish (Danio rerio).Parker MO Millington ME Combe FJ Brennan CH
Behav Brain Res vol. 227 (1), 73-80.
01-02-2012
Housing conditions differentially affect physiological and behavioural stress responses of zebrafish, as well as the response to anxiolytics.Parker MO Millington ME Combe FJ Brennan CH
Plos One vol. 7 (4)
01-01-2012
2011
Ryanodine receptors, a family of intracellular calcium ion channels, are expressed throughout early vertebrate development.Wu HH Brennan C Ashworth R
Bmc Res Notes vol. 4
14-12-2011
AGR2 is a novel surface antigen that promotes the dissemination of pancreatic cancer cells through regulation of cathepsins B and D.Dumartin L Whiteman HJ Weeks ME Hariharan D Dmitrovic B Iacobuzio-Donahue CA Brentnall TA Bronner MP et al.
Cancer Res vol. 71 (22), 7091-7102.
15-11-2011
ErratumPersonalized Medicine, Taylor & Francis vol. 8 (6), 692-692.
01-11-2011
ChemInform Abstract: Modular “Click” Sensors for Zinc and Their Application in vivo.Jobe K Brennan CH Motevalli M Goldup SM Watkinson M
Cheminform, Wiley vol. 42 (40), no-no.
08-09-2011
Treatment for tobacco dependence: a potential application for stratified medicine?Brock AJ Takeda A Brennan C Walton RT
Pers Med vol. 8 (5), 571-579.
01-09-2011
USING ZEBRAFISH TO EXAMINE THE GENETICS OF DRUG SEEKING AND IMPULSIVITYBrennan CH Parker MO Millington ME
JOURNAL OF PSYCHOPHARMACOLOGY. vol. 25 (8), A6-A6.
01-08-2011
Modular 'click' sensors for zinc and their application in vivo.Jobe K Brennan CH Motevalli M Goldup SM Watkinson M
Chem Commun (Camb) vol. 47 (21), 6036-6038.
07-06-2011
Zebrafish behavioural assays of translational relevance for the study of psychiatric diseaseBrennan CH
Rev Neuroscience vol. 22 (1), 37-48.
01-01-2011
2010
AGR2 Regulates the Invasion of Pancreatic Cancer Cells Through Cathepsins B and DDumartin L Whiteman HJ Weeks ME Timms JF Brentnall TA Bronner MP Brennan C Lemoine NR et al.
Pancreas vol. 39 (8), 1318-1319.
01-11-2010
Zebrafish Conditioned Place Preference Models of Drug Reinforcement and Relapse to Drug SeekingParmar A Parmar M Brennan CH
Neuromethods, Springer Nature vol. 51, 75-84.
11-10-2010
Conditioned Place Preference Models of Drug Dependence and Relapse to Drug Seeking: Studies with Nicotine and EthanolBrennan CH Parmar A Kily LKM Ananthathevan A Doshi A Patel S
Neuromethods, Springer Nature vol. 52, 163-179.
15-09-2010
Report of the European Zebrafish Principal Investigator Meeting in Padua, Italy, March 18–22, 2010.Brennan C Dosch R Haramis A-P Luckenbach T Martinez-Morales J-R Moro E Polok B Ramesh TM et al.
Zebrafish vol. 7 (3), 305-310.
01-09-2010
2009
A Novel Role for Ryanodine Receptors during Embryonic Development: Studies in Zebrafish.Wu HHT Brennan C Ashworth R
JOURNAL OF GENERAL PHYSIOLOGY. vol. 134 (1), 17A-17A.
01-07-2009
2008
Eph receptors and zonation in the rat adrenal cortex.Brennan CH Chittka A Barker S Vinson GP
J Endocrinol vol. 198 (1), 185-191.
01-07-2008
Gene expression changes in a zebrafish model of drug dependency suggest conservation of neuro-adaptation pathways.Kily LJM Cowe YCM Hussain O Patel S McElwaine S Cotter FE Brennan CH
J Exp Biol vol. 211 (Pt 10), 1623-1634.
01-05-2008
2007
Regeneration-enhancing effects of EphA4 blocking peptide following corticospinal tract injury in adult rat spinal cord.Fabes J Anderson P Brennan C Bolsover S
Eur J Neurosci vol. 26 (9), 2496-2505.
01-11-2007
2006
Accumulation of the inhibitory receptor EphA4 may prevent regeneration of corticospinal tract axons following lesionFabes J Anderson P Yanez-Munoz RJ Thrasher A Brennan C Bolsover S
Eur J Neurosci vol. 23 (7), 1721-1730.
01-04-2006
2005
Acetylcholine and calcium signalling regulates muscle fibre formation in the zebrafish embryo.Brennan C Mangoli M Dyer CEF Ashworth R
J Cell Sci vol. 118 (Pt 22), 5181-5190.
15-11-2005
Use of transgenic zebrafish reporter lines to study calcium signalling in development.Ashworth R Brennan C
Brief Funct Genomic Proteomic vol. 4 (2), 186-193.
01-07-2005
Zebrafish in vivo modelling of the 11Q23 region of deletion in chronic lymphatic leukaemiaAuer R Costagli A Newland A Fegan C Brennan C Cotter F
ANNALS OF ONCOLOGY. vol. 16, 87-87.
01-06-2005
Definition and zebrafish modelling of the 11 q23 critical region of deletion in CLLAuer RL Costagli A Newland AC Fegan CD Brennan C Cotter FE
BRITISH JOURNAL OF HAEMATOLOGY. vol. 129, 25-26.
01-04-2005
2004
EphA/ephrin-A interactions during optic nerve regeneration: restoration of topography and regulation of ephrin-A2 expressionRodger J Vitale PN Tee LBG King CE Bartlett CA Fall A Brennan C O'Shea JE et al.
Mol Cell Neurosci vol. 25 (1), 56-68.
01-01-2004
2003
Eph/Ephrin signaling regulates the mesenchymal-to-epithelial transition of the paraxial mesoderm during somite morphogenesisBarrios A Poole RJ Durbin L Brennan C Holder N Wilson SW
Curr Biol vol. 13 (18), 1571-1582.
16-09-2003
Alkaline phosphatase fusion proteins as affinity probes for protein localization studies.Brennan C Fabes J
Sci Stke vol. 2003 (168)
04-02-2003
2002
Somitogenesis.Brennan C Amacher SL Currie PD
Results Probl Cell Differ vol. 40, 271-297.
01-01-2002
2001
Morphogenesis of prechordal plate and notochord requires intact Eph/ephrin B signalingChan J Mably JD Serluca FC Chen JN Goldstein NB Thomas MC Cleary JA Brennan C et al.
Dev Biol vol. 234 (2), 470-482.
15-06-2001
Eph signalling functions downstream of Val to regulate cell sorting and boundary formation in the caudal hindbrain.Cooke J Moens C Roth L Durbin L Shiomi K Brennan C Kimmel C Wilson S et al.
Development vol. 128 (4), 571-580.
01-02-2001
Eph Receptor Signalling and Formation of the Somites in ZebrafishBRENNAN CH Sanders EJ Lash JW Ordahl CP
In The Origin and Fate of Somites, Ios Press. 220-235.
01-01-2001
2000
Anteroposterior patterning is required within segments for somite boundary formation in developing zebrafishDurbin L Sordino P Barrios A Gering M Thisse C Thisse B Brennan C Green A et al.
Development, The Company of Biologists vol. 127 (8), 1703-1713.
15-04-2000
Ephrin-B Regulates the Ipsilateral Routing of Retinal Axons at the Optic ChiasmNakagawa S Brennan C Johnson KG Shewan D Harris WA Holt CE
Neuron, Elsevier vol. 25 (3), 599-610.
01-03-2000
1999
Requirement for the zebrafish mid-hindbrain boundary in midbrain polarisation, mapping and confinement of the retinotectal projection*Picker A Brennan C Reifers F Clarke JDW Holder N Brand M
Development, The Company of Biologists vol. 126 (13), 2967-2978.
01-07-1999
Zebrafish aussicht mutant embryos exhibit widespread overexpression of ace (fgf8) and coincident defects in CNS developmentHeisenberg C-P Brennan C Wilson SW
Development, The Company of Biologists vol. 126 (10), 2129-2140.
15-05-1999
An early developmental role for Eph-ephrin interaction during vertebrate gastrulationOates AC Lackmann M Power M-A Brennan C Down LM Do C Evans B Holder N et al.
Cells and Development, Elsevier vol. 83 (1-2), 77-94.
01-05-1999
1998
Eph signaling is required for segmentation and differentiation of the somitesDurbin L Brennan C Shiomi K Cooke J Barrios A Shanmugalingam S Guthrie B Lindberg R et al.
Genes & Development, Cold Spring Harbor Laboratory vol. 12 (19), 3096-3109.
01-10-1998
MINI‐REVIEW The Eph receptor tyrosine kinases and the ephrins – roles in nervous system developmentHolder N Cooke J Brennan C
European Journal of Neuroscience, Wiley vol. 10 (2), 405-408.
01-02-1998
1997
Analysis of axon tract formation in the zebrafish brain: the role of territories of gene expression and their boundariesWilson SW Brennan C Macdonald R Brand M Holder N
Cell and Tissue Research, Springer Nature vol. 290 (2), 189-196.
01-10-1997
The Pax protein Noi is required for commissural axon pathway formation in the rostral forebrainMacdonald R Scholes J Strähle U Brennan C Holder N Brand M Wilson SW
Development, The Company of Biologists vol. 124 (12), 2397-2408.
15-06-1997
Two Eph receptor tyrosine kinase ligands control axon growth and may be involved in the creation of the retinotectal map in the zebrafishBrennan C Monschau B Lindberg R Guthrie B Drescher U Bonhoeffer F Holder N
Development, The Company of Biologists vol. 124 (3), 655-664.
01-02-1997
1996
34 The role of signalling through eph receptors in patterning the zebrafish neural plateHolder N Brennan C Cooke J Durbin L Xu Q
International Journal of Developmental Neuroscience, Wiley vol. 14 (S1), 59-59.
01-07-1996
Effects of n-3 fatty acids on the NMR profile of plasma lipoproteins.Bell JD Barnard ML Parkes HG Thomas EL Brennan CH Cunnane SC Dagnelie PC
Journal of Lipid Research, Elsevier vol. 37 (8), 1664-1674.
01-01-1996
1995
The AMP‐activated Protein Kinase Gene is Highly Expressed in Rat Skeletal MuscleVerhoeven AJM Woods A Brennan CH Hawley SA Hardie DG Scott J Beri RK Carling D
The Febs Journal, Wiley vol. 228 (2), 236-243.
01-03-1995
1994
Mammalian AMP-activated protein kinase is homologous to yeast and plant protein kinases involved in the regulation of carbon metabolismCarling D Aguan K Woods A Verhoeven AJ Beri RK Brennan CH Sidebottom C Davison MD et al.
Journal of Biological Chemistry, Elsevier vol. 269 (15), 11442-11448.
01-04-1994
1993
Adaptive changes in numbers of calcium channels in drug dependence.Littleton J Brennan C
Biochemical Society Symposia vol. 59, 193-203.
01-01-1993
1991
The Role of Calcium Flux in the Central Nervous System Actions of EthanolLITTLETON JM BRENNAN C BOUCHENAFA O
Annals of The New York Academy of Sciences, Wiley vol. 625 (1), 388-394.
01-06-1991
Chronic exposure to anxiolytic drugs, working by different mechanisms causes up-regulation of dihydropyridine binding sites on cultured bovine adrenal chromaffin cellsBrennan CH Littleton JM
Neuropharmacology, Elsevier vol. 30 (2), 199-205.
01-02-1991
1990
Second messengers involved in genetic regulation of the number of calcium channels in bovine adrenal chromaffin cells in cultureBrennan CH Littleton JM
Neuropharmacology, Elsevier vol. 29 (7), 689-693.
01-07-1990
Genetic regulation of dihydropyridine-sensitive calcium channels in brain may determine susceptibility to physical dependence on alcoholBrennan CH Crabbe J Littleton JM
Neuropharmacology, Elsevier vol. 29 (5), 429-432.
01-05-1990
1989
Genetic up-regulation of calcium channels in a cellular model of ethanol dependenceHarper JC Brennan CH Littleton JM
Neuropharmacology, Elsevier vol. 28 (12), 1299-1302.
01-12-1989
Membrane receptors, involved in up-regulation of calcium channels in bovine adrenal chromaffin cells, chronically exposed to ethanolBrennan CH Lewis A Littleton JM
Neuropharmacology, Elsevier vol. 28 (12), 1303-1307.
01-12-1989
Chronic Exposure to Ethanol Increases Dihydropyridine‐Sensitive Calcium Channels in Excitable CellsBRENNAN CH GUPPY LJ LITTLETON JM
Annals of The New York Academy of Sciences, Wiley vol. 560 (1), 467-469.
01-06-1989
1988
Adaptation in Membrane Ca2+ Channels as a Basis for Alcohol‐Related PathologyLittleton JM Harper JC Brennan CH Guppy LJ
Drug and Alcohol Review, Wiley vol. 7 (1), 35-38.
01-01-1988
1987
Dihydropyridine‐Sensitive Ca2+ Channels and Inositol Phospholipid Metabolism in Ethanol Physical DependenceaHUDSPITH MJ BRENNAN CH CHARLES S LITTLETON JM
Annals of The New York Academy of Sciences, Wiley vol. 492 (1), 156-170.
01-04-1987
Biallelic Loss of Molecular Chaperone Molecule AIP Results in a Novel Severe Multisystem Disease Defined by Defective ProteostasisKorbonits M Wang X Barry S Lim CT Suleyman O De Tito S Uddin N Vignola ML et al.
In Biorxiv
Neural Basis of Number Sense in Larval ZebrafishLuu P Nadtochiy A Zanon M Moreno N Messina A Petrazzini MEM Torres Perez JV Keomanee-Dizon K et al.
In Biorxiv
rbfox1 LoF mutants show disrupted bdnf/trkb2 and crhb/nr3c2 expression and increased cortisol levels during development coupled with signs of allostatic overload in adulthoodLeggieri A García-González J Hosseinian S Ashdown P Anagianni S Wang X Havelange W Fernàndez-Castillo N et al.
In Biorxiv
N-isopropylacrylamide based nanogels crossing the blood-brain barrier: evidence of high in vitro internalization in human endothelial cells and in vivo permeation in zebrafishBilardo R leggieri A tomatis F Traldi F Vdovchenko A Rizzi E Lino M Mysiorek C et al.
In Chemrxiv
Chaperone AIP Couples mTORC1 Activation and Catabolic Metabolism During Neonatal DevelopmentKorbonits M Wang X Barry S Lim CT Suleyman O De Tito S Uddin N Vignola ML et al.
In Biorxiv
Behavioural analysis of loss of function zebrafish supports baz1b as master regulator of domesticationTorres-Pérez JV Anagianni S Mech AM Havelange W García-González J Fraser SE Vallortigara G Brennan CH
In Biorxiv
Characterising ontogeny of quantity discrimination in zebrafishSheardown E Torres-Perez JV Anagianni S Fraser SE Vallortigara G Butterworth B Miletto-Petrazzini ME Brennan CH
In Biorxiv
Neurons in the dorso-central division of zebrafish pallium respond to change in visual numerosityMessina A Potrich D Schiona I Sovrano VA Fraser SE Brennan CH Vallortigara G
In Biorxiv
Behavioral effects of developmental exposure to JWH-018 in wild type and disrupted in schizophrenia 1 (disc1) mutant zebrafishGarcía-González J de Quadros B Brock AJ Brennan CH
In Biorxiv
Effects of Pollution on Child and Adolescent Mental Health: A Protocol for a Systematic ReviewTheron L Abreu-Villaça Y Augusto-Oliveira M Brennan C Crespo-Lopez ME Arrifano GDP Glazer L Lin L et al.
In Research Square
Stress reactivity elicits a tissue-specific reduction in telomere length in ageing zebrafish (Danio rerio)Evans JR Torres-Pérez JV Petrazzini MEM Riley R Brennan CH
In Biorxiv
Moderate early-life stress improves adult zebrafish (Danio rerio) spatial short-term memory but does not affect social and anxiety-like responsesFontana BD Gibbon AJ Cleal M Sudwarts A Pritchett D Petrazzini MEM Brennan CH Parker MO
In Biorxiv
Identification of Slit3 as a locus affecting nicotine preference in zebrafish and human smoking behaviourGarcía-González J Brock AJ Parker MO Riley R Jolliffe D Sudwarts A Teh M-T Busch-Nentwich EM et al.
In Biorxiv
A fully automated computer-based ‘Skinner Box’ for testing learning and memory in zebrafishBrock AJ Sudwarts A Daggett J Parker MO Brennan CH
In Biorxiv
Pleiotropic contribution of rbfox1 to psychiatric and neurodevelopmental phenotypes in a zebrafish modelAntón-Galindo E Adel M García-Gonzalez J Leggieri A López-Blanch L Irimia M Norton WH Brennan CH et al.
In Biorxiv
Disrupting fzd9b in zebrafish recapitulates stress- and anxiety-like behaviours associated with Williams syndromeTorres-Perez JV Leggieri A Mech AM Anagianni S Havelange W Brennan CH
In Biorxiv
Grants
Grants of specific relevance to the Centre for Molecular Cell BiologyNIH: Zebrafish addiction screenCaroline Brennan
£466,209 National Institutes of Health - USA
01-08-2018 - 31-05-2026
Terpene enhancement of anxiolytic properties of cannabinoidsCaroline Brennan and Mohamed Elbadawi
£35,000 Innovate UK
25-03-2024 - 24-07-2024
Highthroughput Light Sheet Microscopy: Imaging Across ScalesViji Draviam Sastry, Caroline Brennan, Vidya Chandran Darbari, Chema Martín-Durán, Ivan Kadurin, Isabel M Palacios, Richard Pickersgill, Sarah McClelland, Tyson Sharp and Martin Knight
£386,205 MRC Medical Research Council
01-10-2022 - 31-03-2023
A confocal microscope for multidisciplinary dynamic studies of complex biological systemsConrad Mullineaux, Caroline Brennan, Alexandre De Mendoza Soler, Viji Draviam Sastry, Maurice Elphick, Christoph Engl, Isabel M Palacios, Matteo Palma, Marina Resmini, Alexander Ruban, Peter Thorpe, Angelika Stollewerk, Chema Martín-Durán, Paulo Baptista Ribeiro, Susana Alves Godinho, Richard Grose, Stephanie Kermorgant, Peter McCormick and Tyson Sharp
£390,834 BBSRC Biotechnology and Biological Sciences Research Council
01-08-2022 - 31-07-2023
NUMELAT - Numbers in the brain: the impact of brain lateralization on numerical abilitiesCaroline Brennan
£156,364 EU Commission - Horizon 2020
01-06-2018 - 31-05-2020
Programme grant: Imaging the neurobiology transformationsCaroline Brennan
£282,872 Human Frontier Science Program (HFSP)
01-12-2017 - 30-06-2022
GSTHgNDD - Role of GST gene variation in susceptibility to mercury (Hg)-induced neurodevelopmental disorders (NDD) in zebrafishCaroline Brennan
£146,763 EU Commission - Horizon 2020
20-06-2017 - 04-06-2020
The Genetics of Numeracy & the Evolutionary Basis of NumberCaroline Brennan
£312,614 Leverhulme Trust
12-06-2017 - 01-12-2021
Research Group
PhD Students
- Waqas Ahmad
Identification and Functional Studies of Genetic Variants Causing Neurodevelopmental Disorders in The Pakistani Population - Luisa Fernanda Cerda Osnaya
Molecular Genetic Mechanisms of Fibromyalgia - Saeedeh Hosseinian
Genetics of Impulsivity: Identification of Genes and Pathways Associated With Impulsivity in Zebrafish and Humans - Siddharth Roy
Molecular Mechanisms of Impulse Control - Shiyao Zhang
The Protective Role of Acute Exercise on Stress Induced Social Behavior Changes
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